Ppp1r3c (protein phosphatase 1, regulatory subunit 3C) - Rat Genome Database
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Gene: Ppp1r3c (protein phosphatase 1, regulatory subunit 3C) Mus musculus
Analyze
Symbol: Ppp1r3c
Name: protein phosphatase 1, regulatory subunit 3C
RGD ID: 1319303
MGI Page MGI
Description: Exhibits protein phosphatase binding activity. Is predicted to contribute to phosphoprotein phosphatase activity. Involved in glycogen biosynthetic process. Predicted to localize to glycogen granule; intracellular membrane-bounded organelle; and protein phosphatase type 1 complex. Is expressed in genitourinary system; liver; and nasal capsule. Used to study type 2 diabetes mellitus. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; insulin signaling pathway; INTERACTS WITH (S)-amphetamine; 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pp; PP1 subunit R5; Ppp1r5; protein phosphatase 1 binding protein PTG; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 5; protein targeting to glicogen; protein targeting to glycogen; PT; PTG
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,709,131 - 36,714,004 (-)NCBIGRCm39mm39
GRCm39 Ensembl1936,709,131 - 36,714,053 (-)Ensembl
GRCm381936,731,731 - 36,736,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,731,731 - 36,736,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv371936,806,221 - 36,811,094 (-)NCBIGRCm37mm9NCBIm37
MGSCv361936,796,877 - 36,801,797 (-)NCBImm8
Celera1937,506,440 - 37,511,313 (-)NCBICelera
Cytogenetic Map19C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clofibric acid  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (EXP)
diethyl maleate  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
glutathione  (ISO)
GW 4064  (EXP)
hydrogen peroxide  (ISO)
imiquimod  (EXP)
L-methionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
menadione  (ISO)
metformin  (ISO)
methotrexate  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
obeticholic acid  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9045612   PMID:10349636   PMID:10683377   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12727934   PMID:12805359   PMID:16141072   PMID:16141073   PMID:16354703  
PMID:16602821   PMID:16627590   PMID:17952067   PMID:18165236   PMID:18287559   PMID:18852261   PMID:19334288   PMID:21267068   PMID:21386911   PMID:21471512   PMID:21552327   PMID:21677750  
PMID:21873635   PMID:24419970   PMID:24722244   PMID:27591083   PMID:28215940   PMID:28299379   PMID:31181215  


Genomics

Comparative Map Data
Ppp1r3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,709,131 - 36,714,004 (-)NCBIGRCm39mm39
GRCm39 Ensembl1936,709,131 - 36,714,053 (-)Ensembl
GRCm381936,731,731 - 36,736,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,731,731 - 36,736,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv371936,806,221 - 36,811,094 (-)NCBIGRCm37mm9NCBIm37
MGSCv361936,796,877 - 36,801,797 (-)NCBImm8
Celera1937,506,440 - 37,511,313 (-)NCBICelera
Cytogenetic Map19C2NCBI
PPP1R3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1091,628,442 - 91,633,071 (-)EnsemblGRCh38hg38GRCh38
GRCh381091,628,442 - 91,633,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371093,388,199 - 93,392,828 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361093,378,179 - 93,382,838 (-)NCBINCBI36hg18NCBI36
Build 341093,378,180 - 93,382,838NCBI
Celera1087,131,841 - 87,136,500 (-)NCBI
Cytogenetic Map10q23.32NCBI
HuRef1087,016,754 - 87,021,415 (-)NCBIHuRef
CHM1_11093,669,964 - 93,674,625 (-)NCBICHM1_1
Ppp1r3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,460,958 - 234,465,961 (-)NCBI
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01255,371,830 - 255,376,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01262,628,937 - 262,633,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,991,884 - 240,996,887 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11241,175,278 - 241,180,280 (-)NCBI
Celera1231,556,257 - 231,561,260 (-)NCBICelera
Cytogenetic Map1q53NCBI
Ppp1r3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554251,606,069 - 1,611,586 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554251,606,069 - 1,611,001 (+)NCBIChiLan1.0ChiLan1.0
PPP1R3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11091,900,112 - 91,904,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,900,112 - 91,904,764 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01088,377,396 - 88,382,205 (-)NCBIMhudiblu_PPA_v0panPan3
PPP1R3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,167,532 - 6,172,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,168,917 - 6,172,004 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha286,341,554 - 6,346,099 (-)NCBI
ROS_Cfam_1.0286,423,121 - 6,427,666 (-)NCBI
UMICH_Zoey_3.1286,146,246 - 6,150,797 (-)NCBI
UNSW_CanFamBas_1.0286,178,972 - 6,183,517 (-)NCBI
UU_Cfam_GSD_1.0286,342,849 - 6,347,399 (-)NCBI
Ppp1r3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440721341,297,720 - 41,302,426 (+)NCBI
SpeTri2.0NW_0049366012,930,250 - 2,935,024 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,273,401 - 103,278,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,273,401 - 103,278,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214112,652,689 - 112,657,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1984,918,592 - 84,923,281 (-)NCBI
ChlSab1.1 Ensembl984,918,591 - 84,923,334 (-)Ensembl
Ppp1r3c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247372,896,677 - 2,901,393 (-)NCBI

Position Markers
PMC154451P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381936,733,985 - 36,734,172UniSTSGRCm38
MGSCv371936,808,475 - 36,808,662UniSTSGRCm37
Celera1937,508,694 - 37,508,881UniSTS
Cytogenetic Map19C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19533596239336106Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19932831543328421Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19981005343810202Mouse
14928311Manh85_mmandible shape 85 (mouse)191193738945937389Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191494561648945738Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191593520749935319Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191593520749935319Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191831776252317981Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191831776252317981Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192025691554257062Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192025691554257062Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192139025755390480Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192233596253923073Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192515863842400477Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse
4141562Pas3b_mpulmonary adenoma susceptibility 3b (mouse)Not determined2977296261431566Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193015278561431566Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193015279261431566Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193015279261431566Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193090944161431566Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193300371961431566Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193396351461431566Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3460834861431566Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193603954446773082Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:570
Count of miRNA genes:396
Interacting mature miRNAs:448
Transcripts:ENSMUST00000087321
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000087321   ⟹   ENSMUSP00000084578
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1936,731,731 - 36,736,653 (-)Ensembl
RefSeq Acc Id: NM_016854   ⟹   NP_058550
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391936,709,131 - 36,714,004 (-)NCBI
GRCm381936,731,731 - 36,736,604 (-)ENTREZGENE
MGSCv371936,806,221 - 36,811,094 (-)RGD
Celera1937,506,440 - 37,511,313 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058550   ⟸   NM_016854
- UniProtKB: Q7TMB3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000084578   ⟸   ENSMUST00000087321
Protein Domains
CBM21

Promoters
RGD ID:13679368
Promoter ID:EPDNEW_M23833
Type:single initiation site
Name:Ppp1r3c_1
Description:Mus musculus protein phosphatase 1, regulatory subunit 3C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381936,736,663 - 36,736,723EPDNEW
RGD ID:6849111
Promoter ID:MM_XEF:3707
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3
Transcripts:NM_001076164,   NM_001093339,   NM_001113108,   NM_005398
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361936,808,626 - 36,809,126 (-)MPROMDB
RGD ID:6830322
Promoter ID:MM_KWN:26938
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000087321
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361936,810,796 - 36,811,877 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858229 AgrOrtholog
Ensembl Genes ENSMUSG00000067279 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000084578 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087321 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot
InterPro CBM21_dom UniProtKB/Swiss-Prot
  CBM21_dom_sf UniProtKB/Swiss-Prot
  Pase-1_reg-su_3B/C/D_met UniProtKB/Swiss-Prot
  PP1_3C UniProtKB/Swiss-Prot
KEGG Report mmu:53412 UniProtKB/Swiss-Prot
MGD MGI:1858229 ENTREZGENE
NCBI Gene 53412 ENTREZGENE
PANTHER PTHR12307:SF15 UniProtKB/Swiss-Prot
Pfam CBM_21 UniProtKB/Swiss-Prot
PhenoGen Ppp1r3c PhenoGen
PIRSF PP1_GT_animal UniProtKB/Swiss-Prot
  PP1_PTG UniProtKB/Swiss-Prot
PROSITE CBM21 UniProtKB/Swiss-Prot
UniProt PPR3C_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08541 UniProtKB/Swiss-Prot
  Q8BJW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Ppp1r3c  protein phosphatase 1, regulatory subunit 3C    protein phosphatase 1, regulatory (inhibitor) subunit 3C  Symbol and/or name change 5135510 APPROVED