Exo1 (exonuclease 1) - Rat Genome Database

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Gene: Exo1 (exonuclease 1) Mus musculus
Analyze
Symbol: Exo1
Name: exonuclease 1
RGD ID: 1319821
MGI Page MGI
Description: Enables chromatin binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin; isotype switching; and somatic hypermutation of immunoglobulin genes. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb segment; and nose. Orthologous to human EXO1 (exonuclease 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730442G03Rik; exonuclease I; M; mExo1; Msa; RIKEN cDNA 5730442G03 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,708,334 - 175,738,962 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,708,147 - 175,741,055 (+)EnsemblGRCm39 Ensembl
GRCm381175,880,768 - 175,911,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,880,581 - 175,913,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,810,909 - 177,841,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,717,473 - 177,745,968 (+)NCBIMGSCv36mm8
Celera1182,960,192 - 182,991,063 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map181.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(-)-demecolcine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
barium sulfate  (ISO)
belinostat  (EXP)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
ceric oxide  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
flumequine  (EXP)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glyphosate  (ISO)
idarubicin  (EXP)
kenpaullone  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lucanthone  (ISO)
MeIQx  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phosphoramide mustard  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
succimer  (EXP)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO,ISS)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
2. The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Laulederkind SJ, etal., Database (Oxford). 2011 Feb 14;2011:bar002. Print 2011.
3. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10497278   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12506350   PMID:12517792   PMID:12520002   PMID:12629043  
PMID:12904583   PMID:14610273   PMID:14681479   PMID:14716311   PMID:15489334   PMID:15859354   PMID:16141072   PMID:16141073   PMID:17452984   PMID:17803909   PMID:18057311   PMID:18287559  
PMID:18799693   PMID:18940926   PMID:19124772   PMID:19339515   PMID:19420220   PMID:19553545   PMID:21242524   PMID:21267068   PMID:21425081   PMID:21873635   PMID:22748632   PMID:23062884  
PMID:23254285   PMID:23435420   PMID:23610439   PMID:23754438   PMID:24420907   PMID:24842372   PMID:26160886   PMID:27694478   PMID:28115467   PMID:28711786   PMID:29620483   PMID:30312299  
PMID:31053472   PMID:32051414   PMID:34321999   PMID:35849338   PMID:36546838   PMID:38126949  


Genomics

Comparative Map Data
Exo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,708,334 - 175,738,962 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,708,147 - 175,741,055 (+)EnsemblGRCm39 Ensembl
GRCm381175,880,768 - 175,911,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,880,581 - 175,913,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,810,909 - 177,841,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,717,473 - 177,745,968 (+)NCBIMGSCv36mm8
Celera1182,960,192 - 182,991,063 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map181.9NCBI
EXO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,847,986 - 241,889,939 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1241,847,967 - 241,895,148 (+)EnsemblGRCh38hg38GRCh38
GRCh371242,011,506 - 242,053,241 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361240,078,158 - 240,119,671 (+)NCBINCBI36Build 36hg18NCBI36
Build 341238,337,575 - 238,379,088NCBI
Celera1215,267,055 - 215,308,778 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,470,280 - 212,512,011 (+)NCBIHuRef
CHM1_11243,284,062 - 243,325,806 (+)NCBICHM1_1
T2T-CHM13v2.01241,253,764 - 241,301,952 (+)NCBIT2T-CHM13v2.0
Exo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,341,947 - 90,366,861 (+)NCBIGRCr8
mRatBN7.21387,809,725 - 87,834,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,809,810 - 87,834,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,302,568 - 90,327,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,702,852 - 91,727,700 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,880,238 - 88,905,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,936,989 - 93,962,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,939,022 - 93,960,342 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,401,025 - 98,427,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,619,024 - 91,644,366 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,809,937 - 91,831,012 (+)NCBI
Celera1387,401,444 - 87,426,359 (+)NCBICelera
Cytogenetic Map13q24NCBI
Exo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540610,245,886 - 10,275,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540610,248,981 - 10,276,207 (-)NCBIChiLan1.0ChiLan1.0
EXO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,257,728 - 7,299,702 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,480,934 - 7,522,838 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,410,175 - 217,451,982 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,389,684 - 222,431,556 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,389,684 - 222,431,556 (+)Ensemblpanpan1.1panPan2
EXO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1733,237,124 - 33,268,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl733,237,593 - 33,268,254 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,715,899 - 32,747,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0733,063,694 - 33,095,420 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl733,064,115 - 33,094,883 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,898,615 - 32,930,322 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,921,322 - 32,953,099 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0733,172,357 - 33,204,106 (+)NCBIUU_Cfam_GSD_1.0
Exo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934446,119,726 - 46,144,065 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365268,570,488 - 8,627,004 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1015,317,581 - 15,359,839 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11015,317,555 - 15,360,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,632,191 - 17,673,665 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,934,337 - 78,976,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2578,934,459 - 78,976,219 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605581,071,662 - 81,113,887 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477112,215,957 - 12,230,908 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:959
Count of miRNA genes:537
Interacting mature miRNAs:667
Transcripts:ENSMUST00000039725
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
10045887Cplaq13_mcircadian period of locomotor activity 13 (mouse)Not determined1172831765181400659Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
13207571Tcq11_mtotal cholesterol QTL 11 (mouse)1169137569179647565Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1300960Hpic2_mhaloperidol induced catalepsy 2 (mouse)Not determined1175468817181400659Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse

Markers in Region
AJ238213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,908,569 - 175,908,682UniSTSGRCm38
MGSCv371177,838,700 - 177,838,813UniSTSGRCm37
Celera1182,988,236 - 182,988,349UniSTS
Cytogenetic Map1H4UniSTS
cM Map197.0UniSTS
Whitehead/MRC_RH12197.48UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000039725   ⟹   ENSMUSP00000039376
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,147 - 175,741,055 (+)Ensembl
GRCm38.p6 Ensembl1175,880,581 - 175,913,489 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191680   ⟹   ENSMUSP00000141526
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,720,448 - 175,728,484 (+)Ensembl
GRCm38.p6 Ensembl1175,892,882 - 175,900,918 (+)Ensembl
Ensembl Acc Id: ENSMUST00000192378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,735,135 - 175,736,310 (+)Ensembl
GRCm38.p6 Ensembl1175,907,569 - 175,908,744 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193610
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,731,801 - 175,736,115 (+)Ensembl
GRCm38.p6 Ensembl1175,904,235 - 175,908,549 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193822   ⟹   ENSMUSP00000141624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,379 - 175,719,649 (+)Ensembl
GRCm38.p6 Ensembl1175,880,813 - 175,892,083 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193858   ⟹   ENSMUSP00000141568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,749 - 175,719,645 (+)Ensembl
GRCm38.p6 Ensembl1175,881,183 - 175,892,079 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194306   ⟹   ENSMUSP00000141770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,362 - 175,719,627 (+)Ensembl
GRCm38.p6 Ensembl1175,880,796 - 175,892,061 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194636   ⟹   ENSMUSP00000141316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,728,935 - 175,736,298 (+)Ensembl
GRCm38.p6 Ensembl1175,901,369 - 175,908,732 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194816   ⟹   ENSMUSP00000142091
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,731,939 - 175,733,762 (+)Ensembl
GRCm38.p6 Ensembl1175,904,373 - 175,906,196 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195196   ⟹   ENSMUSP00000141870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,360 - 175,715,178 (+)Ensembl
GRCm38.p6 Ensembl1175,880,794 - 175,887,612 (+)Ensembl
RefSeq Acc Id: NM_012012   ⟹   NP_036142
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,344 - 175,738,962 (+)NCBI
GRCm381175,880,778 - 175,911,396 (+)NCBI
MGSCv371177,810,909 - 177,841,527 (+)RGD
Celera1182,960,192 - 182,991,063 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496862   ⟹   XP_006496925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,334 - 175,736,306 (+)NCBI
GRCm381175,880,768 - 175,908,737 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254499   ⟹   XP_030110359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,334 - 175,736,303 (+)NCBI
GRCm381175,881,139 - 175,908,737 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004942539
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,334 - 175,736,303 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036142   ⟸   NM_012012
- UniProtKB: Q3TLM4 (UniProtKB/Swiss-Prot),   Q923A5 (UniProtKB/Swiss-Prot),   Q9QZ11 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006496925   ⟸   XM_006496862
- Peptide Label: isoform X1
- UniProtKB: Q3TLM4 (UniProtKB/Swiss-Prot),   Q923A5 (UniProtKB/Swiss-Prot),   Q9QZ11 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110359   ⟸   XM_030254499
- Peptide Label: isoform X1
- UniProtKB: Q9QZ11 (UniProtKB/Swiss-Prot),   Q3TLM4 (UniProtKB/Swiss-Prot),   Q923A5 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000141526   ⟸   ENSMUST00000191680
Ensembl Acc Id: ENSMUSP00000141770   ⟸   ENSMUST00000194306
Ensembl Acc Id: ENSMUSP00000141568   ⟸   ENSMUST00000193858
Ensembl Acc Id: ENSMUSP00000141624   ⟸   ENSMUST00000193822
Ensembl Acc Id: ENSMUSP00000039376   ⟸   ENSMUST00000039725
Ensembl Acc Id: ENSMUSP00000141870   ⟸   ENSMUST00000195196
Ensembl Acc Id: ENSMUSP00000141316   ⟸   ENSMUST00000194636
Ensembl Acc Id: ENSMUSP00000142091   ⟸   ENSMUST00000194816
Protein Domains
XPG N-terminal   XPG-I

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ11-F1-model_v2 AlphaFold Q9QZ11 1-837 view protein structure

Promoters
RGD ID:6875850
Promoter ID:EPDNEW_M1376
Type:multiple initiation site
Name:Exo1_1
Description:Mus musculus exonuclease 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381175,880,798 - 175,880,858EPDNEW
RGD ID:6817692
Promoter ID:MM_KWN:3020
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell
Transcripts:NM_012012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361177,810,781 - 177,811,281 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349427 AgrOrtholog
Ensembl Genes ENSMUSG00000039748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039725 ENTREZGENE
  ENSMUST00000039725.12 UniProtKB/Swiss-Prot
  ENSMUST00000191680.2 UniProtKB/TrEMBL
  ENSMUST00000193822.6 UniProtKB/TrEMBL
  ENSMUST00000193858.2 UniProtKB/TrEMBL
  ENSMUST00000194306.6 UniProtKB/TrEMBL
  ENSMUST00000194636.2 UniProtKB/TrEMBL
  ENSMUST00000194816.2 UniProtKB/TrEMBL
  ENSMUST00000195196.6 UniProtKB/TrEMBL
Gene3D-CATH 5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5'-nuclease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5-3_exonuclease_C_sf UniProtKB/Swiss-Prot
  EXO1_H3TH UniProtKB/Swiss-Prot
  HhH2 UniProtKB/Swiss-Prot
  PIN-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIN-like_EXO1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPG-I_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPG/Rad2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPG_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPG_DNA_repair_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26909 UniProtKB/Swiss-Prot
MGD MGI:1349427 ENTREZGENE
NCBI Gene 26909 ENTREZGENE
PANTHER PTHR11081 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11081:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam XPG_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPG_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Exo1 PhenoGen
PRINTS XPGRADSUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE XPG_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPG_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HhH2 UniProtKB/Swiss-Prot
  XPGI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPGN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47807 UniProtKB/Swiss-Prot
  SSF88723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVY2_MOUSE UniProtKB/TrEMBL
  A0A0A6YWF4_MOUSE UniProtKB/TrEMBL
  A0A0A6YWI7_MOUSE UniProtKB/TrEMBL
  A0A0A6YWN5_MOUSE UniProtKB/TrEMBL
  A0A0A6YWZ8_MOUSE UniProtKB/TrEMBL
  A0A0A6YX74_MOUSE UniProtKB/TrEMBL
  A0A0A6YXQ6_MOUSE UniProtKB/TrEMBL
  EXO1_MOUSE UniProtKB/Swiss-Prot
  Q3TLM4 ENTREZGENE
  Q923A5 ENTREZGENE
  Q9QZ11 ENTREZGENE
UniProt Secondary Q3TLM4 UniProtKB/Swiss-Prot
  Q923A5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Exo1  exonuclease 1  5730442G03Rik  RIKEN cDNA 5730442G03 gene  Data merged from RGD:1612297 737654 PROVISIONAL