Exo1 (exonuclease 1) - Rat Genome Database

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Gene: Exo1 (exonuclease 1) Mus musculus
Analyze
Symbol: Exo1
Name: exonuclease 1
RGD ID: 1319821
MGI Page MGI
Description: Enables chromatin binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin; isotype switching; and somatic hypermutation of immunoglobulin genes. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb segment; and nose. Orthologous to human EXO1 (exonuclease 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730442G03Rik; exonuclease I; M; mExo1; Msa; RIKEN cDNA 5730442G03 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,708,334 - 175,738,962 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,708,147 - 175,741,055 (+)EnsemblGRCm39 Ensembl
GRCm381175,880,768 - 175,911,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,880,581 - 175,913,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,810,909 - 177,841,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,717,473 - 177,745,968 (+)NCBIMGSCv36mm8
Celera1182,960,192 - 182,991,063 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map181.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Exo1MouseCOVID-19  ISOEXO1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
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Original Reference(s)
Exo1Mousedevelopmental and epileptic encephalopathy 54  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 54ClinVarPMID:25741868
Exo1Mousefumarase deficiency  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Fumarase deficiencyClinVarPMID:11865300 more ...
Exo1Mousegastrointestinal stromal tumor  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Exo1Mousehereditary breast ovarian cancer syndrome  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:25741868
Exo1MouseHereditary Leiomyomatosis and Renal Cell Cancer  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary leiomyomatosis and renal cell cancerClinVarPMID:29909963
Exo1MouseMegalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2ClinVarPMID:28492532
Exo1MouseNeurodevelopmental Disorders  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Exo1Mouseparathyroid carcinoma  ISOEXO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
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Original Reference(s)
Exo1MouseBreast Neoplasms  ISOEXO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25751625
Exo1MouseColorectal Neoplasms  ISOEXO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17656264
Exo1Mousehepatocellular carcinoma  ISOEXO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560

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Original Reference(s)
Exo1Mouse(+)-dexrazoxane multiple interactionsEXP 6480464Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA] and Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein]CTDPMID:28973540
Exo1Mouse(-)-demecolcine decreases expressionISOEXO1 (Homo sapiens)6480464Demecolcine results in decreased expression of EXO1 mRNACTDPMID:23649840
Exo1Mouse1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Exo1Mouse1-naphthyl isothiocyanate increases expressionISOExo1 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of EXO1 mRNACTDPMID:30723492
Exo1Mouse17beta-estradiol increases expressionISOEXO1 (Homo sapiens)6480464Estradiol results in increased expression of EXO1 mRNACTDPMID:19167446
Exo1Mouse17beta-estradiol increases expressionISOExo1 (Rattus norvegicus)6480464Estradiol results in increased expression of EXO1 mRNACTDPMID:32145629
Exo1Mouse2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Exo1Mouse2,2',5,5'-tetrachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Exo1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of EXO1 mRNACTDPMID:19465110
Exo1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOEXO1 (Homo sapiens)6480464[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of EXO1 mRNA and [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of EXO1 proteinCTDPMID:26159488 and PMID:36753968
Exo1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of EXO1 mRNACTDPMID:21570461
Exo1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOEXO1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of EXO1 mRNACTDPMID:21802500
Exo1Mouse2,4,4'-trichlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Exo1Mouse2,4-diaminotoluene increases expressionEXP 64804642 and 4-diaminotoluene results in increased expression of EXO1 mRNACTDPMID:20713471
Exo1Mouse2-methylcholine affects expressionISOEXO1 (Homo sapiens)6480464beta-methylcholine affects the expression of EXO1 mRNACTDPMID:21179406
Exo1Mouse2-palmitoylglycerol increases expressionISOEXO1 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of EXO1 mRNACTDPMID:37199045
Exo1Mouse3-methylcholanthrene increases expressionEXP 6480464Methylcholanthrene results in increased expression of EXO1 mRNACTDPMID:20713471
Exo1Mouse4,4'-sulfonyldiphenol decreases methylationEXP 6480464bisphenol S results in decreased methylation of EXO1 promoterCTDPMID:33297965
Exo1Mouse5-fluorouracil affects response to substanceISOEXO1 (Homo sapiens)6480464HEXO1 protein affects the susceptibility to FluorouracilCTDPMID:16477629
Exo1Mouse6-propyl-2-thiouracil increases expressionISOExo1 (Rattus norvegicus)6480464Propylthiouracil results in increased expression of EXO1 mRNACTDPMID:24780913

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Biological Process
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Original Reference(s)
Exo1MouseDNA recombination involved_inISSUniProtKB:Q9UQ842290270 UniProtGO_REF:0000024
Exo1MouseDNA recombination involved_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1MouseDNA recombination involved_inIBAPANTHER:PTN000118621 more ...2290270 GO_CentralGO_REF:0000033
Exo1MouseDNA strand resection involved in replication fork processing involved_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1MouseDNA strand resection involved in replication fork processing involved_inIEAUniProtKB:Q9UQ84 and ensembl:ENSP000003555062290270 EnsemblGO_REF:0000107
Exo1Mousehumoral immune response mediated by circulating immunoglobulin acts_upstream_of_or_withinIMPMGI:26539252290270 PMID:14716311MGIPMID:14716311
Exo1Mouseisotype switching acts_upstream_of_or_withinIMPMGI:26539252290270 PMID:14716311MGIPMID:14716311
Exo1Mousemeiotic cell cycle involved_inIEAUniProtKB-KW:KW-04692290270 UniProtGO_REF:0000043
Exo1Mousemismatch repair involved_inIBAPANTHER:PTN000118621 more ...2290270 GO_CentralGO_REF:0000033
Exo1Mousemismatch repair involved_inISSUniProtKB:Q9UQ842290270 UniProtGO_REF:0000024
Exo1Mousemismatch repair involved_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mousenucleobase-containing compound metabolic process acts_upstream_of_or_withinISOEMBL:AF0422822290270 PMID:10497278MGIPMID:10497278
Exo1Mousesomatic hypermutation of immunoglobulin genes acts_upstream_of_or_withinIMPMGI:26539252290270 PMID:14716311MGIPMID:14716311
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Cellular Component

  
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Original Reference(s)
Exo1Mousenuclear body located_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mousenuclear body located_inIEAUniProtKB:Q9UQ84 and ensembl:ENSP000003555062290270 EnsemblGO_REF:0000107
Exo1Mousenucleoplasm located_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mousenucleus located_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mousenucleus located_inISSUniProtKB:Q9UQ842290270 UniProtGO_REF:0000024
Exo1Mousenucleus is_active_inIBAPANTHER:PTN000118621 and UniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000033
Exo1Mouseplasma membrane located_inIEAUniProtKB:Q9UQ84 and ensembl:ENSP000003555062290270 EnsemblGO_REF:0000107
Exo1Mouseplasma membrane located_inISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119

Molecular Function
1 to 20 of 22 rows

  
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Original Reference(s)
Exo1Mouse5'-3' DNA exonuclease activity enablesIBAPANTHER:PTN000118621 more ...2290270 GO_CentralGO_REF:0000033
Exo1Mouse5'-3' DNA exonuclease activity enablesISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mouse5'-3' exonuclease activity enablesISOEMBL:AF0422822290270 PMID:10497278MGIPMID:10497278
Exo1Mouse5'-flap endonuclease activity enablesIBAPANTHER:PTN000118612 more ...2290270 GO_CentralGO_REF:0000033
Exo1Mousechromatin binding enablesIDA 2290270 PMID:14716311MGIPMID:14716311
Exo1MouseDNA binding enablesIEAUniProtKB:Q9UQ84 and ensembl:ENSP000003555062290270 EnsemblGO_REF:0000107
Exo1MouseDNA binding enablesISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mousedouble-stranded DNA 5'-3' DNA exonuclease activity enablesISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mousedouble-stranded DNA 5'-3' DNA exonuclease activity enablesIEAUniProtKB:Q9UQ84 and ensembl:ENSP000003555062290270 EnsemblGO_REF:0000107
Exo1Mouseflap endonuclease activity enablesISOUniProtKB:Q9UQ842290270 GO_CentralGO_REF:0000119
Exo1Mouseflap endonuclease activity enablesISSUniProtKB:Q9UQ842290270 UniProtGO_REF:0000024
Exo1Mousemetal ion binding enablesIEAUniProtKB-KW:KW-04792290270 UniProtGO_REF:0000043
Exo1Mouseprotein binding enablesISOUniProtKB:Q86YA39068941 PMID:34552057UniProtPMID:34552057
Exo1Mouseprotein binding enablesISOUniProtKB:P20585 more ...9068941 PMID:11427529UniProtPMID:11427529
Exo1Mouseprotein binding enablesISOUniProtKB:P40692 and UniProtKB:P432469068941 PMID:11429708 and PMID:14676842UniProtPMID:11429708 and PMID:14676842
Exo1Mouseprotein binding enablesISOUniProtKB:P406929068941 PMID:2414623UniProtPMID:2414623
Exo1Mouseprotein binding enablesISOUniProtKB:P432469068941 PMID:10856833 more ...UniProtPMID:10856833 more ...
Exo1Mouseprotein binding enablesISOUniProtKB:P120049068941 PMID:15225546UniProtPMID:15225546
Exo1Mouseprotein binding enablesISOUniProtKB:P460639068941 PMID:15886194UniProtPMID:15886194
Exo1Mouseprotein binding enablesISOUniProtKB:Q997089068941 PMID:21052091 and PMID:26807646IntActPMID:21052091 and PMID:26807646
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RGD Manual Annotations


  
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Original Reference(s)
Exo1Mousehomologous recombination pathway of double-strand break repair   ISOEXO1 (Homo sapiens)8662366 RGD 
Exo1Mousemismatch repair pathway   ISOEXO1 (Homo sapiens)2306716 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Exo1Mousemismatch repair pathway   IEA 6907045 KEGGmmu:03430
1 to 20 of 36 rows
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Original Reference(s)
Exo1Mouseabnormal chiasmata formation  IAGP 5509061 MGIPMID:12629043
Exo1Mouseabnormal chromosome stability  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabnormal class switch recombination  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabnormal double-strand DNA break repair  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabnormal immunoglobulin heavy chain V(D)J recombination  IAGP 5509061 MGIPMID:23254285
Exo1Mouseabnormal male germ cell apoptosis  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabnormal male meiosis  IAGP 5509061 MGIPMID:12629043
Exo1Mouseabnormal male meiosis  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabnormal meiotic configurations  IAGP 5509061 MGIPMID:12629043
Exo1Mouseabnormal meiotic spindle morphology  IAGP 5509061 MGIPMID:12629043
Exo1Mouseabnormal mismatch repair  IAGP 5509061 MGIPMID:12629043
Exo1Mouseabnormal mismatch repair  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabnormal ovary morphology  IAGP 5509061 MGIPMID:12629043
Exo1Mouseabnormal somatic hypermutation frequency  IAGP 5509061 MGIPMID:23754438
Exo1Mouseabsent chiasmata formation  IAGP 5509061 MGIPMID:12629043
Exo1Mouseasthenozoospermia  IAGP 5509061 MGIPMID:12629043
Exo1Mousechromosomal instability  IAGP 5509061 MGIPMID:12629043
Exo1Mousechromosomal instability  IAGP 5509061 MGIPMID:23754438
Exo1Mousedecreased oocyte number  IAGP 5509061 MGIPMID:12629043
Exo1Mousedecreased testis weight  IAGP 5509061 MGIPMID:23754438
1 to 20 of 36 rows

1 to 10 of 10 rows
#
Reference Title
Reference Citation
1. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
2. The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Laulederkind SJ, etal., Database (Oxford). 2011 Feb 14;2011:bar002. Print 2011.
3. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 10 of 10 rows
PMID:8889548   PMID:10349636   PMID:10497278   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12506350   PMID:12517792   PMID:12520002   PMID:12629043  
PMID:12904583   PMID:14610273   PMID:14681479   PMID:14716311   PMID:15489334   PMID:15859354   PMID:16141072   PMID:16141073   PMID:17452984   PMID:17803909   PMID:18057311   PMID:18287559  
PMID:18799693   PMID:18940926   PMID:19124772   PMID:19339515   PMID:19420220   PMID:19553545   PMID:21242524   PMID:21267068   PMID:21425081   PMID:21873635   PMID:22748632   PMID:23062884  
PMID:23254285   PMID:23435420   PMID:23610439   PMID:23754438   PMID:24420907   PMID:24842372   PMID:26160886   PMID:27694478   PMID:28115467   PMID:28711786   PMID:29620483   PMID:30312299  
PMID:31053472   PMID:32051414   PMID:34321999   PMID:35849338   PMID:36546838   PMID:38126949  



Exo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,708,334 - 175,738,962 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,708,147 - 175,741,055 (+)EnsemblGRCm39 Ensembl
GRCm381175,880,768 - 175,911,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,880,581 - 175,913,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,810,909 - 177,841,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,717,473 - 177,745,968 (+)NCBIMGSCv36mm8
Celera1182,960,192 - 182,991,063 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map181.9NCBI
EXO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,847,986 - 241,889,939 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1241,847,967 - 241,895,148 (+)EnsemblGRCh38hg38GRCh38
GRCh371242,011,506 - 242,053,241 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361240,078,158 - 240,119,671 (+)NCBINCBI36Build 36hg18NCBI36
Build 341238,337,575 - 238,379,088NCBI
Celera1215,267,055 - 215,308,778 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,470,280 - 212,512,011 (+)NCBIHuRef
CHM1_11243,284,062 - 243,325,806 (+)NCBICHM1_1
T2T-CHM13v2.01241,253,764 - 241,301,952 (+)NCBIT2T-CHM13v2.0
Exo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,341,947 - 90,366,861 (+)NCBIGRCr8
mRatBN7.21387,809,725 - 87,834,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,809,810 - 87,834,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,302,568 - 90,327,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,702,852 - 91,727,700 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,880,238 - 88,905,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,936,989 - 93,962,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,939,022 - 93,960,342 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,401,025 - 98,427,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,619,024 - 91,644,366 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,809,937 - 91,831,012 (+)NCBI
Celera1387,401,444 - 87,426,359 (+)NCBICelera
Cytogenetic Map13q24NCBI
Exo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540610,245,886 - 10,275,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540610,248,981 - 10,276,207 (-)NCBIChiLan1.0ChiLan1.0
EXO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,257,728 - 7,299,702 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,480,934 - 7,522,838 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,410,175 - 217,451,982 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,389,684 - 222,431,556 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,389,684 - 222,431,556 (+)Ensemblpanpan1.1panPan2
EXO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1733,237,124 - 33,268,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl733,237,593 - 33,268,254 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,715,899 - 32,747,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0733,063,694 - 33,095,420 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl733,064,115 - 33,094,883 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,898,615 - 32,930,322 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,921,322 - 32,953,099 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0733,172,357 - 33,204,106 (+)NCBIUU_Cfam_GSD_1.0
Exo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934446,119,726 - 46,144,065 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365268,570,488 - 8,627,004 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1015,317,581 - 15,359,839 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11015,317,555 - 15,360,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,632,191 - 17,673,665 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,934,337 - 78,976,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2578,934,459 - 78,976,219 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605581,071,662 - 81,113,887 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477112,215,957 - 12,230,908 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Exo1
2065 total Variants

Predicted Target Of
Summary Value
Count of predictions:959
Count of miRNA genes:537
Interacting mature miRNAs:667
Transcripts:ENSMUST00000039725
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 99 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse

1 to 10 of 99 rows
AJ238213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,908,569 - 175,908,682UniSTSGRCm38
MGSCv371177,838,700 - 177,838,813UniSTSGRCm37
Celera1182,988,236 - 182,988,349UniSTS
Cytogenetic Map1H4UniSTS
cM Map197.0UniSTS
Whitehead/MRC_RH12197.48UniSTS







Ensembl Acc Id: ENSMUST00000039725   ⟹   ENSMUSP00000039376
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,147 - 175,741,055 (+)Ensembl
GRCm38.p6 Ensembl1175,880,581 - 175,913,489 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191680   ⟹   ENSMUSP00000141526
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,720,448 - 175,728,484 (+)Ensembl
GRCm38.p6 Ensembl1175,892,882 - 175,900,918 (+)Ensembl
Ensembl Acc Id: ENSMUST00000192378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,735,135 - 175,736,310 (+)Ensembl
GRCm38.p6 Ensembl1175,907,569 - 175,908,744 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193610
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,731,801 - 175,736,115 (+)Ensembl
GRCm38.p6 Ensembl1175,904,235 - 175,908,549 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193822   ⟹   ENSMUSP00000141624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,379 - 175,719,649 (+)Ensembl
GRCm38.p6 Ensembl1175,880,813 - 175,892,083 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193858   ⟹   ENSMUSP00000141568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,749 - 175,719,645 (+)Ensembl
GRCm38.p6 Ensembl1175,881,183 - 175,892,079 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194306   ⟹   ENSMUSP00000141770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,362 - 175,719,627 (+)Ensembl
GRCm38.p6 Ensembl1175,880,796 - 175,892,061 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194636   ⟹   ENSMUSP00000141316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,728,935 - 175,736,298 (+)Ensembl
GRCm38.p6 Ensembl1175,901,369 - 175,908,732 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194816   ⟹   ENSMUSP00000142091
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,731,939 - 175,733,762 (+)Ensembl
GRCm38.p6 Ensembl1175,904,373 - 175,906,196 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195196   ⟹   ENSMUSP00000141870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,708,360 - 175,715,178 (+)Ensembl
GRCm38.p6 Ensembl1175,880,794 - 175,887,612 (+)Ensembl
RefSeq Acc Id: NM_012012   ⟹   NP_036142
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,344 - 175,738,962 (+)NCBI
GRCm381175,880,778 - 175,911,396 (+)NCBI
MGSCv371177,810,909 - 177,841,527 (+)RGD
Celera1182,960,192 - 182,991,063 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496862   ⟹   XP_006496925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,334 - 175,736,306 (+)NCBI
GRCm381175,880,768 - 175,908,737 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254499   ⟹   XP_030110359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,334 - 175,736,303 (+)NCBI
GRCm381175,881,139 - 175,908,737 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004942539
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,708,334 - 175,736,303 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_036142 (Get FASTA)   NCBI Sequence Viewer  
  XP_006496925 (Get FASTA)   NCBI Sequence Viewer  
  XP_030110359 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH06671 (Get FASTA)   NCBI Sequence Viewer  
  BAC26086 (Get FASTA)   NCBI Sequence Viewer  
  BAE38768 (Get FASTA)   NCBI Sequence Viewer  
  CAB51863 (Get FASTA)   NCBI Sequence Viewer  
  EDL13202 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000039376
  ENSMUSP00000039376.7
GenBank Protein Q9QZ11 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_036142   ⟸   NM_012012
- UniProtKB: Q3TLM4 (UniProtKB/Swiss-Prot),   Q923A5 (UniProtKB/Swiss-Prot),   Q9QZ11 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006496925   ⟸   XM_006496862
- Peptide Label: isoform X1
- UniProtKB: Q3TLM4 (UniProtKB/Swiss-Prot),   Q923A5 (UniProtKB/Swiss-Prot),   Q9QZ11 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110359   ⟸   XM_030254499
- Peptide Label: isoform X1
- UniProtKB: Q9QZ11 (UniProtKB/Swiss-Prot),   Q3TLM4 (UniProtKB/Swiss-Prot),   Q923A5 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000141526   ⟸   ENSMUST00000191680
Ensembl Acc Id: ENSMUSP00000141770   ⟸   ENSMUST00000194306
XPG N-terminal   XPG-I

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ11-F1-model_v2 AlphaFold Q9QZ11 1-837 view protein structure

RGD ID:6875850
Promoter ID:EPDNEW_M1376
Type:multiple initiation site
Name:Exo1_1
Description:Mus musculus exonuclease 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381175,880,798 - 175,880,858EPDNEW
RGD ID:6817692
Promoter ID:MM_KWN:3020
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell
Transcripts:NM_012012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361177,810,781 - 177,811,281 (+)MPROMDB


1 to 40 of 43 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000039748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039725 ENTREZGENE
  ENSMUST00000039725.12 UniProtKB/Swiss-Prot
Gene3D-CATH 5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot
  5'-nuclease UniProtKB/Swiss-Prot
InterPro 5-3_exonuclease_C_sf UniProtKB/Swiss-Prot
  EXO1_H3TH UniProtKB/Swiss-Prot
  HhH2 UniProtKB/Swiss-Prot
  PIN-like_dom_sf UniProtKB/Swiss-Prot
  PIN-like_EXO1 UniProtKB/Swiss-Prot
  XPG-I_dom UniProtKB/Swiss-Prot
  XPG/Rad2 UniProtKB/Swiss-Prot
  XPG_CS UniProtKB/Swiss-Prot
  XPG_DNA_repair_N UniProtKB/Swiss-Prot
KEGG Report mmu:26909 UniProtKB/Swiss-Prot
MGD MGI:1349427 ENTREZGENE
NCBI Gene 26909 ENTREZGENE
PANTHER PTHR11081 UniProtKB/Swiss-Prot
  PTHR11081:SF8 UniProtKB/Swiss-Prot
Pfam XPG_I UniProtKB/Swiss-Prot
  XPG_N UniProtKB/Swiss-Prot
PhenoGen Exo1 PhenoGen
PRINTS XPGRADSUPER UniProtKB/Swiss-Prot
PROSITE XPG_1 UniProtKB/Swiss-Prot
  XPG_2 UniProtKB/Swiss-Prot
SMART HhH2 UniProtKB/Swiss-Prot
  XPGI UniProtKB/Swiss-Prot
  XPGN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47807 UniProtKB/Swiss-Prot
  SSF88723 UniProtKB/Swiss-Prot
UniProt A0A0A6YVY2_MOUSE UniProtKB/TrEMBL
  A0A0A6YWF4_MOUSE UniProtKB/TrEMBL
  A0A0A6YWI7_MOUSE UniProtKB/TrEMBL
  A0A0A6YWN5_MOUSE UniProtKB/TrEMBL
  A0A0A6YWZ8_MOUSE UniProtKB/TrEMBL
  A0A0A6YX74_MOUSE UniProtKB/TrEMBL
  A0A0A6YXQ6_MOUSE UniProtKB/TrEMBL
  EXO1_MOUSE UniProtKB/Swiss-Prot
  Q3TLM4 ENTREZGENE
  Q923A5 ENTREZGENE
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Exo1  exonuclease 1  5730442G03Rik  RIKEN cDNA 5730442G03 gene  Data merged from RGD:1612297 737654 PROVISIONAL