Pdx1 (pancreatic and duodenal homeobox 1) - Rat Genome Database

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Gene: Pdx1 (pancreatic and duodenal homeobox 1) Mus musculus
Analyze
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
RGD ID: 736368
MGI Page MGI
Description: Exhibits DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of apoptotic process; pancreas development; and regulation of transcription by RNA polymerase II. Localizes to nuclear speck. Is expressed in several structures, including genitourinary system; gut; liver and biliary system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; type 2 diabetes mellitus pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-phenylbutyric acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IDX-; IDX-1; insulin promoter factor 1, homeodomain transcription factor; Ip; IPF; IPF-1; Ipf1; islet/duodenum homeobox 1; Mody; Mody4; pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; pdx-; pdx-1; somatostatin-transactivating factor 1; STF-; STF-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,206,907 - 147,212,658 (+)NCBIGRCm39mm39
GRCm39 Ensembl5147,206,769 - 147,212,658 (+)Ensembl
GRCm385147,270,097 - 147,275,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv375148,081,707 - 148,086,725 (+)NCBIGRCm37mm9NCBIm37
MGSCv365147,580,475 - 147,586,196 (+)NCBImm8
Celera5145,261,170 - 145,266,188 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
animal organ senescence  (ISO)
cell differentiation  (IMP,ISO)
central nervous system development  (ISO)
detection of glucose  (ISO)
digestive tract development  (IMP)
endocrine pancreas development  (IMP)
exocrine pancreas development  (IMP)
glucose homeostasis  (IGI,IMP,ISO)
glucose metabolic process  (IDA)
insulin secretion  (ISO)
liver development  (IMP)
morphogenesis of embryonic epithelium  (IMP)
multicellular organism development  (IEA)
negative regulation of cell population proliferation  (IMP)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
nitric oxide mediated signal transduction  (ISO)
pancreas development  (IMP,ISO)
positive regulation of cell death  (ISO)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of DNA binding  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
regulation of cell population proliferation  (IDA)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,IMP)
regulation of transcription, DNA-templated  (IEA)
response to alkaloid  (ISO)
response to chlorate  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to iron(II) ion  (ISO)
response to leucine  (ISO)
response to lipid  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to vitamin  (ISO)
response to wounding  (ISO)
smoothened signaling pathway  (ISO)
stem cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
transcription, DNA-templated  (ISO)
transdifferentiation  (ISO)
type B pancreatic cell differentiation  (IBA,ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (TAS)
nuclear speck  (IDA)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile duct development  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal embryo size  (IEA)
abnormal endocrine pancreas morphology  (IAGP)
abnormal enteroendocrine cell morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic beta cell apoptosis  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic delta cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal pancreatic endocrine progenitor cell physiology  (IAGP)
abnormal pancreatic epsilon cell morphology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal pancreatic islet size  (IAGP)
abnormal placenta size  (IEA)
abnormal PP cell morphology  (IAGP)
abnormal pyloric sphincter morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal small intestine placement  (IAGP)
abnormal stomach enteroendocrine cell morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal stomach pyloric region morphology  (IAGP)
abnormal tricarboxylic acid cycle  (IAGP)
absent Brunner's glands  (IAGP)
absent pancreas  (IAGP)
decreased amylin secretion  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IEA)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased insulin secretion  (IAGP)
decreased pancreas weight  (IAGP)
decreased pancreatic alpha cell mass  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pancreatic islet number  (IAGP)
dehydration  (IAGP)
disorganized pancreatic islets  (IAGP)
distended stomach  (IAGP)
exocrine pancreas hyperplasia  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased cell proliferation  (IAGP)
increased circulating glucose level  (IAGP)
increased glucagon secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic alpha cell proliferation  (IAGP)
increased pancreatic beta cell apoptosis  (IAGP)
increased pancreatic delta cell number  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased PP cell number  (IAGP)
increased urine glucose level  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IEA)
pancreas cysts  (IAGP)
pancreas hypoplasia  (IAGP)
pancreas inflammation  (IAGP)
pancreatic acinar hypoplasia  (IAGP)
pancreatic islet hyperplasia  (IAGP)
pancreatic islet hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small pancreas  (IAGP)
small pancreatic islets  (IAGP)
sparse hair  (IAGP)
stomach epithelial hyperplasia  (IAGP)
thin skin  (IAGP)
weight loss  (IAGP)
References

References - curated
1. Ahlgren U, etal., Genes Dev. 1998 Jun 15;12(12):1763-8.
2. Buffat C, etal., J Pathol. 2007 Nov;213(3):337-46.
3. Cao LZ, etal., Diabetes. 2004 Dec;53(12):3168-78.
4. Chen S, etal., Gene Ther. 2007 Jul;14(14):1102-10. Epub 2007 Apr 26.
5. Del Guerra S, etal., Diabetes. 2005 Mar;54(3):727-35.
6. Fodor A, etal., Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.
7. Hagman DK, etal., Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.
8. Hani EH, etal., J Clin Invest. 1999 Nov;104(9):R41-8.
9. Harmon JS, etal., Diabetes. 1999 Oct;48(10):1995-2000.
10. Ishikawa M, etal., J Lipid Res. 2008 Dec;49(12):2524-34. Epub 2008 Aug 5.
11. Jetton TL, etal., Diabetes. 2005 Aug;54(8):2294-304.
12. Kojima I and Umezawa K, Int J Biochem Cell Biol. 2006;38(5-6):923-30. Epub 2005 Oct 26.
13. Krishnamurthy M, etal., Endocrinology. 2007 Nov;148(11):5520-30. Epub 2007 Aug 2.
14. Kwon DY, etal., Eur J Nutr. 2007 Feb;46(1):44-52. Epub 2007 Jan 2.
15. Laybutt DR, etal., Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.
16. Laybutt DR, etal., J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.
17. Leonard J, etal., Mol Endocrinol 1993 Oct;7(10):1275-83.
18. Li H, etal., J Biomed Sci. 2008 Jul;15(4):487-97. Epub 2008 Feb 6.
19. Li L, etal., Diabetes 2004 Mar;53(3):608-15.
20. Li Y, etal., J Cell Physiol. 2007 Apr;211(1):36-44.
21. Lin G, etal., Stem Cells Dev. 2009 Feb 26.
22. Liu T, etal., Hepatobiliary Pancreat Dis Int. 2007 Aug;6(4):424-9.
23. MGD and Homologene mouse data transfer
24. MGD data from the GO Consortium
25. MGD IEA
26. Moibi JA, etal., Diabetes. 2007 Jan;56(1):88-95.
27. Moritoh Y, etal., Br J Pharmacol. 2009 Jun;157(3):415-26. Epub 2009 Apr 3.
28. Muharram G, etal., Biochem Biophys Res Commun. 2005 Aug 12;333(4):1153-9.
29. O'Reilly LA, etal., Diabetes. 1997 Apr;46(4):599-606.
30. OMIM Disease Annotation Pipeline
31. Owen KR, etal., Diabetologia. 2004 May;47(5):957-8. Epub 2004 May 7.
32. Park JH, etal., J Clin Invest. 2008 Jun;118(6):2316-24.
33. Park S, etal., J Appl Physiol. 2007 Nov;103(5):1764-71. Epub 2007 Aug 30.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. RGD automated import pipeline
37. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. RGD automated import pipeline for gene-chemical interactions
39. Rooman I, etal., Am J Pathol. 2006 Oct;169(4):1206-14.
40. Shimada K, etal., J Surg Res. 2008 Apr;145(2):229-37. Epub 2007 Aug 30.
41. Shimada K, etal., Transplant Proc. 2008 Mar;40(2):438-40.
42. Shternhall-Ron K, etal., J Autoimmun. 2007 Mar-May;28(2-3):134-42. Epub 2007 Mar 23.
43. Stoffers DA, etal., Diabetes. 2003 Mar;52(3):734-40.
44. Taguchi M, etal., J Pathol. 2002 Aug;197(5):638-46.
45. Tanabe K, etal., PLoS Biol. 2008 Feb;6(2):e37.
46. Tiemann K, etal., Virchows Arch. 2007 Mar;450(3):261-6. Epub 2007 Jan 18.
47. Wang GS, etal., J Autoimmun. 2000 Dec;15(4):407-16.
48. Yamada S, etal., Endocr J. 2006 Dec;53(6):789-95. Epub 2006 Sep 19.
49. Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
Additional References at PubMed
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PMID:25576928   PMID:25652387   PMID:25695968   PMID:25713082   PMID:25715394   PMID:25715395   PMID:25784544   PMID:25786211   PMID:25801033   PMID:25817342   PMID:25918232   PMID:26015547  
PMID:26021489   PMID:26057579   PMID:26085571   PMID:26156633   PMID:26169832   PMID:26180087   PMID:26440894   PMID:26450967   PMID:26494286   PMID:26494792   PMID:26516699   PMID:26518685  
PMID:26534984   PMID:26554594   PMID:26564177   PMID:26631740   PMID:26657766   PMID:26752640   PMID:26771085   PMID:26887806   PMID:26901059   PMID:26932670   PMID:26994512   PMID:27068127  
PMID:27130279   PMID:27137932   PMID:27181524   PMID:27270601   PMID:27292642   PMID:27349930   PMID:27406855   PMID:27572106   PMID:27736991   PMID:27740873   PMID:27747430   PMID:27789228  
PMID:27892540   PMID:27993987   PMID:28017717   PMID:28052057   PMID:28071588   PMID:28087712   PMID:28100774   PMID:28100871   PMID:28118981   PMID:28193997   PMID:28248965   PMID:28290604  
PMID:28441528   PMID:28501476   PMID:28576773   PMID:28580283   PMID:28705881   PMID:28793255   PMID:28922976   PMID:28928395   PMID:28934293   PMID:29023691   PMID:29058721   PMID:29079704  
PMID:29180572   PMID:29259128   PMID:29272356   PMID:29351489   PMID:29637395   PMID:29700203   PMID:29723041   PMID:29798841   PMID:29875165   PMID:29910119   PMID:30026551   PMID:30065074  
PMID:30093553   PMID:30174228   PMID:30305368   PMID:30333365   PMID:30472119   PMID:30487608   PMID:30504829   PMID:30523046   PMID:30590051   PMID:30620902   PMID:30733468   PMID:30853440  
PMID:31006513   PMID:31138815   PMID:31160417   PMID:31201281   PMID:31208980   PMID:31240701   PMID:31323030   PMID:31337977   PMID:31345937   PMID:31412250   PMID:31604927   PMID:31682591  
PMID:31776260   PMID:31806625   PMID:31875961   PMID:31953387   PMID:32059775   PMID:32165492   PMID:32243891   PMID:32245798   PMID:32350257   PMID:32404350   PMID:32690606   PMID:32857951  


Genomics

Comparative Map Data
Pdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,206,907 - 147,212,658 (+)NCBIGRCm39mm39
GRCm39 Ensembl5147,206,769 - 147,212,658 (+)Ensembl
GRCm385147,270,097 - 147,275,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv375148,081,707 - 148,086,725 (+)NCBIGRCm37mm9NCBIm37
MGSCv365147,580,475 - 147,586,196 (+)NCBImm8
Celera5145,261,170 - 145,266,188 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.84NCBI
PDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1327,920,000 - 27,926,313 (+)EnsemblGRCh38hg38GRCh38
GRCh381327,919,982 - 27,926,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,494,137 - 28,500,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,392,157 - 27,397,394 (+)NCBINCBI36hg18NCBI36
Build 341327,392,176 - 27,397,394NCBI
Celera139,568,879 - 9,575,162 (+)NCBI
Cytogenetic Map13q12.2NCBI
HuRef139,314,253 - 9,320,535 (+)NCBIHuRef
CHM1_11328,462,445 - 28,468,728 (+)NCBICHM1_1
Pdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,757,865 - 7,763,064 (-)NCBI
Rnor_6.0 Ensembl129,496,044 - 9,501,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0129,496,044 - 9,501,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01211,609,488 - 11,614,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,495,501 - 9,500,668 (-)NCBICelera
Cytogenetic Map12p11NCBI
Pdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554977,281,886 - 7,307,969 (+)NCBIChiLan1.0ChiLan1.0
PDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11327,545,855 - 27,553,118 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0139,199,572 - 9,206,202 (+)NCBIMhudiblu_PPA_v0panPan3
PDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,741,863 - 11,746,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,741,863 - 11,746,885 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,805,337 - 11,810,359 (-)NCBI
ROS_Cfam_1.02511,870,873 - 11,875,895 (-)NCBI
UMICH_Zoey_3.12511,765,554 - 11,770,575 (-)NCBI
UNSW_CanFamBas_1.02511,758,195 - 11,763,217 (-)NCBI
UU_Cfam_GSD_1.02511,802,135 - 11,807,157 (-)NCBI
Pdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,845,028 - 172,849,677 (-)NCBI
SpeTri2.0NW_00493647223,102,534 - 23,107,127 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,303,639 - 5,310,843 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,303,609 - 5,309,063 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,961,177 - 4,966,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,038,088 - 7,046,593 (+)NCBI
ChlSab1.1 Ensembl37,041,466 - 7,045,976 (+)Ensembl
Pdx1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477610,591,855 - 10,596,738 (-)NCBI

Position Markers
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375148,086,473 - 148,086,617UniSTSGRCm37
MGSCv375148,085,982 - 148,086,125UniSTSGRCm37
MGSCv375148,086,131 - 148,086,439UniSTSGRCm37
MGSCv375148,086,105 - 148,086,723UniSTSGRCm37
Celera5145,265,936 - 145,266,080UniSTS
Celera5145,265,445 - 145,265,588UniSTS
Celera5145,265,568 - 145,266,186UniSTS
Celera5145,265,594 - 145,265,902UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
cM Map582.0UniSTS
cM Map582.0UniSTS
PMC316911P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,276 - 147,274,521UniSTSGRCm38
MGSCv375148,085,852 - 148,086,097UniSTSGRCm37
Celera5145,265,315 - 145,265,560UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
PMC317250P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,416 - 147,275,095UniSTSGRCm38
MGSCv375148,085,992 - 148,086,671UniSTSGRCm37
Celera5145,265,455 - 145,266,134UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,406 - 147,274,549UniSTSGRCm38
MGSCv375148,085,982 - 148,086,125UniSTSGRCm37
Celera5145,265,445 - 145,265,588UniSTS
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,897 - 147,275,041UniSTSGRCm38
MGSCv375148,086,473 - 148,086,617UniSTSGRCm37
Celera5145,265,936 - 145,266,080UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,529 - 147,275,147UniSTSGRCm38
MGSCv375148,086,105 - 148,086,723UniSTSGRCm37
Celera5145,265,568 - 145,266,186UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,555 - 147,274,863UniSTSGRCm38
MGSCv375148,086,131 - 148,086,439UniSTSGRCm37
Celera5145,265,594 - 145,265,902UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5140000000153000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1178
Count of miRNA genes:635
Interacting mature miRNAs:772
Transcripts:ENSMUST00000085591
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000085591   ⟹   ENSMUSP00000082729
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)Ensembl
RefSeq Acc Id: NM_008814   ⟹   NP_032840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395147,206,907 - 147,212,658 (+)NCBI
GRCm385147,270,097 - 147,275,848 (+)NCBI
MGSCv375148,081,707 - 148,086,725 (+)RGD
Celera5145,261,170 - 145,266,188 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032840   ⟸   NM_008814
- UniProtKB: P52946 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000082729   ⟸   ENSMUST00000085591

Promoters
RGD ID:6888802
Promoter ID:EPDNEW_M7852
Type:initiation region
Name:Pdx1_1
Description:Mus musculus pancreatic and duodenal homeobox 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385147,270,097 - 147,270,157EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102851 AgrOrtholog
Ensembl Genes ENSMUSG00000029644 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000082729 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000085591 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_antennapedia UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:18609 UniProtKB/Swiss-Prot
MGD MGI:102851 ENTREZGENE
NCBI Gene 18609 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Pdx1 PhenoGen
PRINTS ANTENNAPEDIA UniProtKB/Swiss-Prot
  HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P52946 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6LEB3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3ZB03 UniProtKB/Swiss-Prot