Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Casp12 (caspase 12) Mus musculus
Symbol: Casp12
Name: caspase 12
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity; cysteine-type peptidase activity (ortholog); endopeptidase activity (ortholog); INVOLVED IN apoptotic process; endoplasmic reticulum unfolded protein response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; apoptotic cell death pathway; ASSOCIATED WITH abnormal locomotor coordination; decreased sensitivity to induced cell death; decreased susceptibility to bacterial infection; ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN endoplasmic reticulum; cytosol (ortholog); intracellular membrane-bounded organelle (ortholog); INTERACTS WITH (+)-dexrazoxane; (S)-nicotine; 1,1-dichloroethene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CASP-12; caspase-12
Homo sapiens (human) : CASP12 (caspase 12 (gene/pseudogene))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casp12 (caspase 12)  Alliance
Canis lupus familiaris (dog) : CASP12 (caspase 12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3895,345,442 - 5,373,034 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3795,345,476 - 5,373,034 (+)NCBIGRCm37mm9NCBIm37
MGSCv3695,345,502 - 5,373,034 (+)NCBImm8
Celera3117,331,063 - 117,358,628 (-)NCBICelera
Cytogenetic Map9 A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Casp12
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731442
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.