Mib1 (MIB E3 ubiquitin protein ligase 1) - Rat Genome Database

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Pathways
Gene: Mib1 (MIB E3 ubiquitin protein ligase 1) Mus musculus
Analyze
Symbol: Mib1
Name: MIB E3 ubiquitin protein ligase 1
RGD ID: 1316243
MGI Page MGI
Description: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including Notch signaling pathway; chordate embryonic development; and circulatory system development. Located in cytoplasmic vesicle. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAPK-interacting protein 1; DAPK-interacting protein-1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; MGC18948; Mi; Mib; mind bomb homolog 1; mind bomb-1; mindbomb; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,725,523 - 10,822,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,725,548 - 10,818,704 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381810,725,625 - 10,818,578 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,725,548 - 10,818,704 (+)Ensemblmm10GRCm38
MGSCv371810,725,623 - 10,812,215 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361810,725,623 - 10,812,215 (+)NCBIMGSCv36mm8
Celera1810,755,617 - 10,842,201 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal digit development  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal dorsal-ventral polarity of the somites  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal heart looping  (IAGP)
abnormal interdigital cell death  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal interventricular septum membranous part morphology  (IAGP)
abnormal interventricular septum muscular part morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal somite shape  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal vascular regression  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent intersomitic vessels  (IAGP)
absent pancreatic duct  (IAGP)
absent second pharyngeal arch  (IAGP)
absent vitelline blood vessels  (IAGP)
aortic valve regurgitation  (IAGP)
bicuspid aortic valve  (IAGP)
cardiac fibrosis  (IAGP)
caudal body truncation  (IAGP)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased hair follicle number  (IAGP)
delayed neuronal migration  (IAGP)
dilated heart  (IAGP)
dilated heart ventricle  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
epidermal cyst  (IAGP)
failure of chorioallantoic fusion  (IAGP)
failure of heart looping  (IAGP)
failure of somite differentiation  (IAGP)
fused phalanges  (IAGP)
fused somites  (IAGP)
hairless  (IAGP)
incomplete somite formation  (IAGP)
increased cardiac output  (IAGP)
increased heart left ventricle weight  (IAGP)
kinked neural tube  (IAGP)
lethality during fetal growth through weaning, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
poor arterial differentiation  (IAGP)
premature death  (IAGP)
premature hair loss  (IAGP)
premature neuronal precursor differentiation  (IAGP)
reduced cerebellar foliation  (IAGP)
small cerebellum  (IAGP)
small heart  (IAGP)
syndactyly  (IAGP)
thick epidermis  (IAGP)
thin left ventricle myocardium compact layer  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12351649   PMID:12477932   PMID:12520002   PMID:12530964   PMID:14610273   PMID:14621295  
PMID:15489334   PMID:15824097   PMID:16000382   PMID:16061358   PMID:16141072   PMID:16141073   PMID:16857196   PMID:17003037   PMID:17397913   PMID:17728463   PMID:17987667   PMID:18043734  
PMID:18498734   PMID:18505817   PMID:18818392   PMID:18824586   PMID:19015276   PMID:19710364   PMID:19855135   PMID:20018188   PMID:20506192   PMID:21267068   PMID:21624809   PMID:21677750  
PMID:21873635   PMID:21875946   PMID:21903422   PMID:21985982   PMID:22529374   PMID:22558446   PMID:23111145   PMID:23162128   PMID:23223237   PMID:23314057   PMID:23478405   PMID:23988635  
PMID:24068960   PMID:24952961   PMID:25347788   PMID:25594189   PMID:25658372   PMID:25918341   PMID:26147083   PMID:26496610   PMID:27056911   PMID:27407072   PMID:28402857   PMID:28808228  
PMID:29956664   PMID:30093553   PMID:30590051   PMID:31073041   PMID:31138677   PMID:32059775   PMID:32325033   PMID:33637766   PMID:33892704   PMID:34321999   PMID:34838591   PMID:36325906  
PMID:39057643   PMID:40183391   PMID:40334239   PMID:40558659  


Genomics

Comparative Map Data
Mib1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,725,523 - 10,822,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,725,548 - 10,818,704 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381810,725,625 - 10,818,578 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,725,548 - 10,818,704 (+)Ensemblmm10GRCm38
MGSCv371810,725,623 - 10,812,215 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361810,725,623 - 10,812,215 (+)NCBIMGSCv36mm8
Celera1810,755,617 - 10,842,201 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.35NCBI
MIB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381821,704,916 - 21,870,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1821,704,957 - 21,870,953 (+)Ensemblhg38GRCh38
GRCh371819,320,753 - 19,450,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361817,575,543 - 17,704,912 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341817,575,542 - 17,698,625NCBI
Celera1816,127,511 - 16,257,232 (+)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1816,168,524 - 16,298,317 (+)NCBIHuRef
CHM1_11819,248,386 - 19,377,981 (+)NCBICHM1_1
T2T-CHM13v2.01821,925,869 - 22,056,013 (+)NCBIT2T-CHM13v2.0
Mib1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8182,075,309 - 2,199,774 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl182,075,309 - 2,193,475 (+)EnsemblGRCr8
mRatBN7.2181,802,519 - 1,926,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,802,519 - 1,920,689 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx182,032,154 - 2,150,308 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,819,855 - 2,938,010 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,034,031 - 2,152,191 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,970,914 - 2,094,920 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,970,914 - 2,094,920 (+)Ensemblrn6Rnor6.0
Rnor_5.0182,003,879 - 2,127,899 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,106,102 - 2,224,819 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera181,683,253 - 1,800,466 (+)NCBICelera
RGSC_v3.1182,106,102 - 2,224,819 (+)NCBI
Cytogenetic Map18p13NCBI
Mib1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540210,392,308 - 10,502,576 (+)Ensembl
ChiLan1.0NW_00495540210,392,308 - 10,502,576 (+)NCBIChiLan1.0ChiLan1.0
MIB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21739,155,332 - 39,292,680 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11824,816,043 - 24,985,261 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,944,432 - 15,113,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11818,579,023 - 18,746,335 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1818,641,135 - 18,740,813 (+)EnsemblpanPan2panpan1.1
MIB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,173,414 - 66,289,477 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,178,594 - 66,289,491 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha765,628,018 - 65,764,934 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0766,238,156 - 66,375,191 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,242,080 - 66,375,797 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1765,904,113 - 66,040,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0765,927,024 - 66,063,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,227,376 - 66,364,261 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mib1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494462,237,105 - 62,376,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365501,439,646 - 1,573,637 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365501,439,652 - 1,577,804 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,917,718 - 107,040,079 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16106,917,995 - 107,043,144 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2699,440,567 - 99,565,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11858,628,381 - 58,759,692 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1858,633,926 - 58,759,609 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605033,405,263 - 33,537,457 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mib1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247709,941,706 - 10,051,024 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247709,936,202 - 10,051,018 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mib1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11533,280,666 - 33,392,954 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mib1
2558 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2914
Count of miRNA genes:797
Interacting mature miRNAs:1102
Transcripts:ENSMUST00000052838, ENSMUST00000124288, ENSMUST00000131073, ENSMUST00000150000, ENSMUST00000165555
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
11354953Mom21_mmodifier of Min 21 (mouse)18128893823Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421646477Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse

Markers in Region
RH126294  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381810,817,129 - 10,817,328UniSTSGRCm38
MGSCv371810,817,127 - 10,817,326UniSTSGRCm37
Celera1810,847,113 - 10,847,312UniSTS
Cytogenetic Map18A1UniSTS
UniSTS:224884  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381810,817,494 - 10,817,674UniSTSGRCm38
MGSCv371810,817,492 - 10,817,672UniSTSGRCm37
Celera1810,847,478 - 10,847,658UniSTS
Cytogenetic Map18A1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001364997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY147848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY149907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY245539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY974091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000052838   ⟹   ENSMUSP00000054428
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,725,548 - 10,818,578 (+)Ensembl
GRCm38.p6 Ensembl1810,725,548 - 10,818,578 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124288   ⟹   ENSMUSP00000114289
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,760,809 - 10,818,704 (+)Ensembl
GRCm38.p6 Ensembl1810,760,809 - 10,818,704 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,725,744 - 10,755,699 (+)Ensembl
GRCm38.p6 Ensembl1810,725,744 - 10,755,699 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150000   ⟹   ENSMUSP00000122879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,798,365 - 10,817,628 (+)Ensembl
GRCm38.p6 Ensembl1810,798,365 - 10,817,628 (+)Ensembl
Ensembl Acc Id: ENSMUST00000165555   ⟹   ENSMUSP00000131712
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,725,655 - 10,812,174 (+)Ensembl
GRCm38.p6 Ensembl1810,725,655 - 10,812,174 (+)Ensembl
Ensembl Acc Id: ENSMUST00000234047
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,726,524 - 10,768,799 (+)Ensembl
GRCm38.p6 Ensembl1810,726,524 - 10,768,799 (+)Ensembl
RefSeq Acc Id: NM_001364997   ⟹   NP_001351926
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,725,625 - 10,818,578 (+)NCBI
GRCm381810,725,625 - 10,818,578 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144860   ⟹   NP_659109
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,725,625 - 10,818,578 (+)NCBI
GRCm381810,725,625 - 10,818,578 (+)NCBI
MGSCv371810,725,623 - 10,812,215 (+)RGD
Celera1810,755,617 - 10,842,201 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525811   ⟹   XP_006525874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,725,526 - 10,817,362 (+)NCBI
GRCm381810,726,132 - 10,817,344 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004939840
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,725,523 - 10,817,767 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004939841
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,725,523 - 10,822,969 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004939842
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,725,523 - 10,817,754 (+)NCBI
Sequence:
RefSeq Acc Id: NP_659109   ⟸   NM_144860
- UniProtKB: Q8C6W2 (UniProtKB/Swiss-Prot),   Q8BNR1 (UniProtKB/Swiss-Prot),   Q6ZPT8 (UniProtKB/Swiss-Prot),   Q6YI52 (UniProtKB/Swiss-Prot),   Q6IS57 (UniProtKB/Swiss-Prot),   Q5XK51 (UniProtKB/Swiss-Prot),   Q921Q1 (UniProtKB/Swiss-Prot),   Q80SY4 (UniProtKB/Swiss-Prot),   A2RRJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525874   ⟸   XM_006525811
- Peptide Label: isoform X1
- UniProtKB: Q8C6W2 (UniProtKB/Swiss-Prot),   Q8BNR1 (UniProtKB/Swiss-Prot),   Q6ZPT8 (UniProtKB/Swiss-Prot),   Q6YI52 (UniProtKB/Swiss-Prot),   Q6IS57 (UniProtKB/Swiss-Prot),   Q5XK51 (UniProtKB/Swiss-Prot),   Q921Q1 (UniProtKB/Swiss-Prot),   Q80SY4 (UniProtKB/Swiss-Prot),   A2RRJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351926   ⟸   NM_001364997
- UniProtKB: Q8C6W2 (UniProtKB/Swiss-Prot),   Q8BNR1 (UniProtKB/Swiss-Prot),   Q80SY4 (UniProtKB/Swiss-Prot),   Q6ZPT8 (UniProtKB/Swiss-Prot),   Q6YI52 (UniProtKB/Swiss-Prot),   Q6IS57 (UniProtKB/Swiss-Prot),   Q5XK51 (UniProtKB/Swiss-Prot),   Q921Q1 (UniProtKB/Swiss-Prot),   A2RRJ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000054428   ⟸   ENSMUST00000052838
Ensembl Acc Id: ENSMUSP00000122879   ⟸   ENSMUST00000150000
Ensembl Acc Id: ENSMUSP00000114289   ⟸   ENSMUST00000124288
Ensembl Acc Id: ENSMUSP00000131712   ⟸   ENSMUST00000165555
Protein Domains
MIB/HERC2   RING-type   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80SY4-F1-model_v2 AlphaFold Q80SY4 1-1006 view protein structure

Promoters
RGD ID:6829367
Promoter ID:MM_KWN:24582
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000070815,   UC008EBB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361810,725,491 - 10,726,507 (+)MPROMDB
RGD ID:13677098
Promoter ID:EPDNEW_M22698
Type:initiation region
Name:Mib1_1
Description:Mus musculus mindbomb E3 ubiquitin protein ligase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381810,725,625 - 10,725,685EPDNEW
RGD ID:6829366
Promoter ID:MM_KWN:24586
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC008EBF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361810,798,016 - 10,798,516 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443157 AgrOrtholog
Ensembl Genes ENSMUSG00000024294 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052838 ENTREZGENE
  ENSMUST00000052838.11 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.30.60.90 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  MIB1/2_ZZ UniProtKB/Swiss-Prot
  Mib_Herc2 UniProtKB/Swiss-Prot
  Mib_Herc2_sf UniProtKB/Swiss-Prot
  SH3_15 UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_ZZ UniProtKB/Swiss-Prot
  Znf_ZZ_sf UniProtKB/Swiss-Prot
KEGG Report mmu:225164 UniProtKB/Swiss-Prot
MGD MGI:2443157 ENTREZGENE
NCBI Gene 225164 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MIB1 UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE MIB2 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  MIB_HERC2 UniProtKB/Swiss-Prot
  PF00569 UniProtKB/Swiss-Prot
  SH3_15 UniProtKB/Swiss-Prot
  zf-C3HC4_3 UniProtKB/Swiss-Prot
PhenoGen Mib1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  MIB_HERC2 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
  ZF_ZZ_1 UniProtKB/Swiss-Prot
  ZF_ZZ_2 UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
  ZnF_ZZ UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF159034 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
UniProt A2RRJ6 ENTREZGENE, UniProtKB/TrEMBL
  F6YFW9_MOUSE UniProtKB/TrEMBL
  F6ZBL2_MOUSE UniProtKB/TrEMBL
  MIB1_MOUSE UniProtKB/Swiss-Prot
  Q3TSS1_MOUSE UniProtKB/TrEMBL
  Q3UTL6_MOUSE UniProtKB/TrEMBL
  Q5XK51 ENTREZGENE
  Q6IS57 ENTREZGENE
  Q6YI52 ENTREZGENE
  Q6ZPT8 ENTREZGENE
  Q80SY4 ENTREZGENE
  Q8BNR1 ENTREZGENE
  Q8C6W2 ENTREZGENE
  Q921Q1 ENTREZGENE
UniProt Secondary Q5XK51 UniProtKB/Swiss-Prot
  Q6IS57 UniProtKB/Swiss-Prot
  Q6YI52 UniProtKB/Swiss-Prot
  Q6ZPT8 UniProtKB/Swiss-Prot
  Q8BNR1 UniProtKB/Swiss-Prot
  Q8C6W2 UniProtKB/Swiss-Prot
  Q921Q1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-02 Mib1  MIB E3 ubiquitin protein ligase 1  Mib1  mindbomb E3 ubiquitin protein ligase 1  Symbol and/or name change 5135510 APPROVED
2016-02-17 Mib1  mindbomb E3 ubiquitin protein ligase 1    mindbomb homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED