Car14 (carbonic anhydrase 14) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Car14 (carbonic anhydrase 14) Mus musculus
Analyze
Symbol: Car14
Name: carbonic anhydrase 14
RGD ID: 1317437
MGI Page MGI
Description: Exhibits carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to localize to plasma membrane. Is expressed in several structures, including central nervous system; cranium; epiblast; eye; and urinary system. Orthologous to human CA14 (carbonic anhydrase 14); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW536446; CA XIV; CA-XIV; Ca14; carbonate dehydratase XIV; carbonic anhydrase XIV
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,805,080 - 95,812,443 (-)NCBIGRCm39mm39
GRCm39 Ensembl395,805,080 - 95,812,003 (-)Ensembl
GRCm38395,897,768 - 95,905,117 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,897,768 - 95,904,691 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,701,723 - 95,708,562 (-)NCBIGRCm37mm9NCBIm37
MGSCv36395,983,205 - 95,990,044 (-)NCBImm8
Celera397,331,353 - 97,338,218 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10336468   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12033992   PMID:12477932   PMID:14610273   PMID:14660577   PMID:14681479   PMID:15489334   PMID:15901897  
PMID:16141072   PMID:16141073   PMID:16260723   PMID:16602821   PMID:16924128   PMID:17362527   PMID:17459948   PMID:17485676   PMID:17504127   PMID:17626619   PMID:18003750   PMID:19279262  
PMID:19692653   PMID:21179203   PMID:21873635   PMID:22227327   PMID:23175829   PMID:23233153   PMID:24789143   PMID:30026265  


Genomics

Comparative Map Data
Car14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,805,080 - 95,812,443 (-)NCBIGRCm39mm39
GRCm39 Ensembl395,805,080 - 95,812,003 (-)Ensembl
GRCm38395,897,768 - 95,905,117 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,897,768 - 95,904,691 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,701,723 - 95,708,562 (-)NCBIGRCm37mm9NCBIm37
MGSCv36395,983,205 - 95,990,044 (-)NCBImm8
Celera397,331,353 - 97,338,218 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
CA14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1150,257,251 - 150,265,078 (+)EnsemblGRCh38hg38GRCh38
GRCh381150,257,258 - 150,265,862 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,230,169 - 150,237,478 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,488,047 - 148,504,102 (+)NCBINCBI36hg18NCBI36
Build 341147,043,290 - 147,050,549NCBI
Celera1123,345,949 - 123,353,209 (+)NCBI
Cytogenetic Map1q21.2NCBI
HuRef1121,608,885 - 121,616,145 (+)NCBIHuRef
CHM1_11151,625,869 - 151,633,204 (+)NCBICHM1_1
Ca14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,442,263 - 183,449,207 (-)NCBI
Rnor_6.0 Ensembl2198,010,349 - 198,016,898 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02198,010,142 - 198,017,635 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,500,302 - 217,507,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,683,916 - 190,690,229 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2175,971,924 - 175,978,237 (-)NCBICelera
Cytogenetic Map2q34NCBI
Ca14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413510,089 - 516,892 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955413510,089 - 516,892 (-)NCBIChiLan1.0ChiLan1.0
CA14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,253,787 - 129,261,676 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,253,787 - 129,261,676 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01125,602,521 - 125,610,323 (+)NCBIMhudiblu_PPA_v0panPan3
CA14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,504,181 - 59,510,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,504,483 - 59,510,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,950,038 - 58,956,854 (+)NCBI
ROS_Cfam_1.01760,519,100 - 60,525,928 (+)NCBI
UMICH_Zoey_3.11759,349,547 - 59,356,380 (+)NCBI
UNSW_CanFamBas_1.01759,433,284 - 59,440,110 (+)NCBI
UU_Cfam_GSD_1.01760,161,286 - 60,168,105 (+)NCBI
Ca14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,514,788 - 21,521,689 (+)NCBI
SpeTri2.0NW_004936580545,221 - 552,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,821,578 - 98,828,736 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,821,577 - 98,828,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CA14
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Ca14
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477218,011,094 - 18,018,585 (+)NCBI

Position Markers
AI173904  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,901,964 - 95,902,108UniSTSGRCm38
MGSCv37395,705,887 - 95,706,031UniSTSGRCm37
Celera397,335,516 - 97,335,660UniSTS
Cytogenetic Map3F2.1UniSTS
Whitehead/MRC_RH31087.63UniSTS
Car14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.1UniSTS
cM Map3 UniSTS
AB005450  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,897,926 - 95,898,053UniSTSGRCm38
MGSCv37395,701,849 - 95,701,976UniSTSGRCm37
Celera397,331,479 - 97,331,606UniSTS
Cytogenetic Map3F2.1UniSTS
Whitehead/MRC_RH31087.63UniSTS
Whitehead/MRC_RH31087.74UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390603910100556821Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1040
Count of miRNA genes:559
Interacting mature miRNAs:642
Transcripts:ENSMUST00000036181, ENSMUST00000126722, ENSMUST00000147962, ENSMUST00000149202
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036181   ⟹   ENSMUSP00000036983
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl395,897,768 - 95,904,691 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126722
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl395,901,894 - 95,903,748 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147962   ⟹   ENSMUSP00000117464
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl395,899,740 - 95,904,685 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149202
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl395,901,513 - 95,904,684 (-)Ensembl
RefSeq Acc Id: NM_001355750   ⟹   NP_001342679
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,805,080 - 95,811,997 (-)NCBI
GRCm38395,897,768 - 95,904,685 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355751   ⟹   NP_001342680
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,805,080 - 95,811,997 (-)NCBI
GRCm38395,897,768 - 95,904,685 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355752   ⟹   NP_001342681
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,809,206 - 95,811,997 (-)NCBI
GRCm38395,901,894 - 95,904,685 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011797   ⟹   NP_035927
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,805,080 - 95,811,997 (-)NCBI
GRCm38395,897,768 - 95,904,685 (-)NCBI
MGSCv37395,701,723 - 95,708,562 (-)RGD
Celera397,331,353 - 97,338,218 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501442   ⟹   XP_006501505
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,805,080 - 95,812,443 (-)NCBI
GRCm38395,897,768 - 95,905,112 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501443   ⟹   XP_006501506
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,805,080 - 95,812,443 (-)NCBI
GRCm38395,897,768 - 95,905,117 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035927   ⟸   NM_011797
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9WVT6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501506   ⟸   XM_006501443
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006501505   ⟸   XM_006501442
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001342679   ⟸   NM_001355750
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: NP_001342680   ⟸   NM_001355751
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001342681   ⟸   NM_001355752
- Peptide Label: isoform 4 precursor
RefSeq Acc Id: ENSMUSP00000117464   ⟸   ENSMUST00000147962
RefSeq Acc Id: ENSMUSP00000036983   ⟸   ENSMUST00000036181
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:6847737
Promoter ID:MM_ACW:32577
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney
Transcripts:CAR14.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,701,941 - 95,702,441 (-)MPROMDB
RGD ID:6847734
Promoter ID:MM_ACW:32578
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney,   MEF_B6
Transcripts:CAR14.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,703,564 - 95,704,064 (-)MPROMDB
RGD ID:6833532
Promoter ID:MM_KWN:35339
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:OTTMUST00000052682
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,707,586 - 95,708,086 (-)MPROMDB
RGD ID:6833530
Promoter ID:MM_KWN:35340
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000052679,   OTTMUST00000052680,   OTTMUST00000052681
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,708,581 - 95,709,232 (-)MPROMDB
RGD ID:6881694
Promoter ID:EPDNEW_M4263
Type:multiple initiation site
Name:Car14_1
Description:Mus musculus carbonic anhydrase 14 , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38395,904,638 - 95,904,698EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344341 AgrOrtholog
Ensembl Genes ENSMUSG00000038526 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000036983 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117464 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000036181 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000147962 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_CA14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23831 UniProtKB/Swiss-Prot
MGD MGI:1344341 ENTREZGENE
NCBI Gene 23831 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF84 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car14 PhenoGen
PROSITE ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CAH14_MOUSE UniProtKB/Swiss-Prot
  D3Z4J8_MOUSE UniProtKB/TrEMBL
  Q8CEY0_MOUSE UniProtKB/TrEMBL
  Q9WVT6 ENTREZGENE