Twist1 (twist basic helix-loop-helix transcription factor 1) - Rat Genome Database

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Gene: Twist1 (twist basic helix-loop-helix transcription factor 1) Mus musculus
Analyze
Symbol: Twist1
Name: twist basic helix-loop-helix transcription factor 1
RGD ID: 1553211
MGI Page MGI
Description: Enables several functions, including E-box binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including heart valve development; regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Acts upstream of or within several processes, including chordate embryonic development; limb morphogenesis; and negative regulation of cytokine production. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and genitourinary system. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in Sweeney-Cox syndrome; breast cancer (multiple); and synostosis (multiple). Orthologous to human TWIST1 (twist family bHLH transcription factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA960487; bHLHa; bHLHa38; charlie chaplin; M-Twi; M-Twist; MGC103391; pd; Pde; pdt; Pluri; Pluridigite; polydactyly EMS; Ska; Ska10; Ska; Skam10Jus; Twist; twist gene homolog 1; twist homolog 1; twist-related protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)EnsemblGRCm39 Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBIMGSCv36mm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethylhexan-1-ol  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cordycepin  (EXP,ISO)
coumestrol  (ISO)
crizotinib  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dieckol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
erlotinib hydrochloride  (EXP,ISO)
finasteride  (ISO)
flurbiprofen  (EXP)
folic acid  (EXP)
fonofos  (ISO)
gefitinib  (ISO)
glucose  (ISO)
Honokiol  (ISO)
isobutanol  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lapatinib  (ISO)
loliolide  (ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nisin  (ISO)
osimertinib  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
Pachymic acid  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
progesterone  (ISO)
quartz  (EXP)
quercetin  (ISO)
reparixin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sorafenib  (EXP)
stattic  (ISO)
sunitinib  (ISO)
Swertiamarin  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetraethylenepentamine  (EXP,ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triticonazole  (ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IMP,ISO)
bone development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IMP)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IMP)
cell proliferation involved in heart valve development  (IMP,ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hypoxia  (IMP,ISO)
cranial suture morphogenesis  (IMP)
developmental process  (IBA)
embryonic camera-type eye formation  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IGI,IMP,ISO)
embryonic digit morphogenesis  (IMP)
embryonic forelimb morphogenesis  (IMP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IMP)
embryonic skeletal system morphogenesis  (IMP)
endocardial cushion morphogenesis  (IMP)
energy homeostasis  (IDA)
eyelid development in camera-type eye  (IEA,ISO)
hindlimb morphogenesis  (IMP)
in utero embryonic development  (IMP)
mitral valve morphogenesis  (IMP)
muscle organ development  (IEA)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cell differentiation  (IDA)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of double-strand break repair  (IEA,ISO)
negative regulation of macrophage cytokine production  (IGI)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of osteoblast differentiation  (IDA,ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (IDA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of skeletal muscle tissue development  (IDA)
negative regulation of striated muscle tissue development  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of tumor necrosis factor production  (IGI)
neural tube closure  (IMP)
neuron migration  (IMP)
ossification  (IMP)
osteoblast differentiation  (IMP)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell motility  (IMP)
positive regulation of DNA-templated transcription initiation  (IEA,ISO)
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation  (IDA)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP,ISO)
positive regulation of fatty acid beta-oxidation  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO,TAS)
positive regulation of tumor necrosis factor production  (IEA,ISO)
regulation of bone mineralization  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
rhythmic process  (IEA)
roof of mouth development  (IEA,ISO)
stem cell differentiation  (IMP)

Cellular Component
nucleoplasm  (TAS)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autopod morphology  (IEA)
abnormal bone ossification  (IAGP)
abnormal brain morphology  (IEA)
abnormal clavicle morphology  (IAGP)
abnormal cranium morphology  (IEA)
abnormal digit morphology  (IEA)
abnormal forelimb morphology  (IAGP)
abnormal gait  (IEA)
abnormal limb bone morphology  (IEA)
abnormal limb morphology  (IAGP)
abnormal muscle development  (IAGP)
abnormal nail morphology  (IEA)
abnormal osteoblast differentiation  (IAGP)
abnormal pelvic girdle bone morphology  (IEA)
abnormal rib morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skin morphology  (IEA)
abnormal vertebrae morphology  (IEA)
abnormal vertebral arch morphology  (IEA)
abnormal zygomatic bone morphology  (IEA)
absent gastric milk in neonates  (IAGP)
cachexia  (IAGP)
clavicle hypoplasia  (IAGP)
cleft palate  (IAGP)
cleft soft palate  (IAGP)
decreased body size  (IEA)
decreased prepulse inhibition  (IEA)
decreased total body fat amount  (IEA)
distended abdomen  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged interparietal bone  (IAGP)
exencephaly  (IAGP)
frontal bone foramen  (IAGP)
increased lean body mass  (IEA)
internal hemorrhage  (IAGP)
lowered ear position  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
open neural tube  (IAGP)
polydactyly  (IAGP)
premature coronal suture closure  (IAGP)
premature cranial suture closure  (IAGP)
premature endochondral bone ossification  (IAGP)
premature lambdoid suture closure  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
short limbs  (IAGP)
short temporal bone squamous part  (IAGP)
temporal bone hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling of pulmonary fibrosis identifies Twist1 as an antiapoptotic molecular "rectifier" of growth factor signaling. Bridges RS, etal., Am J Pathol. 2009 Dec;175(6):2351-61. Epub 2009 Nov 5.
2. FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patients. He S, etal., J Exp Clin Cancer Res. 2017 Dec 6;36(1):175. doi: 10.1186/s13046-017-0646-6.
3. Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Howard TD, etal., Nat Genet. 1997 Jan;15(1):36-41.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
13. Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression. Xu Y, etal., Oncogene. 2017 Feb 23;36(8):1157-1166. doi: 10.1038/onc.2016.286. Epub 2016 Aug 15.
Additional References at PubMed
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PMID:9739106   PMID:9851841   PMID:10079226   PMID:10079236   PMID:10195895   PMID:10498685   PMID:10518210   PMID:10557208   PMID:10585775   PMID:10589677   PMID:10700192   PMID:10704861  
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PMID:15162501   PMID:15210113   PMID:15306564   PMID:15361870   PMID:15366017   PMID:15489334   PMID:15618518   PMID:15735646   PMID:15802514   PMID:15885504   PMID:15906377   PMID:15936751  
PMID:16028273   PMID:16093716   PMID:16096654   PMID:16100003   PMID:16221730   PMID:16291796   PMID:16293629   PMID:16314491   PMID:16368934   PMID:16495310   PMID:16502419   PMID:16537918  
PMID:16540516   PMID:16602821   PMID:16683987   PMID:16751104   PMID:16765933   PMID:16831897   PMID:16884697   PMID:16887829   PMID:16887830   PMID:17050674   PMID:17204263   PMID:17222543  
PMID:17223098   PMID:17325035   PMID:17332324   PMID:17442300   PMID:17609112   PMID:17652084   PMID:17652354   PMID:17662069   PMID:17868088   PMID:17890670   PMID:17893140   PMID:17931618  
PMID:18287559   PMID:18297062   PMID:18330926   PMID:18353781   PMID:18397758   PMID:18471809   PMID:18539270   PMID:18557763   PMID:18612084   PMID:18655182   PMID:18663125   PMID:18667074  
PMID:18697225   PMID:18701545   PMID:18832392   PMID:19029138   PMID:19040081   PMID:19103755   PMID:19201948   PMID:19217897   PMID:19345188   PMID:19383905   PMID:19386269   PMID:19389359  
PMID:19414008   PMID:19439447   PMID:19782673   PMID:19851501   PMID:19932774   PMID:19950203   PMID:19952280   PMID:20059953   PMID:20534379   PMID:20547147   PMID:20564211   PMID:20570969  
PMID:20714342   PMID:20727876   PMID:20732316   PMID:20737509   PMID:20804746   PMID:20826535   PMID:20890042   PMID:21051860   PMID:21150899   PMID:21167473   PMID:21199805   PMID:21267068  
PMID:21307093   PMID:21317430   PMID:21455939   PMID:21558373   PMID:21559426   PMID:21609622   PMID:21610693   PMID:21660050   PMID:21769775   PMID:21779394   PMID:21811467   PMID:21873635  
PMID:21876526   PMID:21905163   PMID:21983003   PMID:22056872   PMID:22174793   PMID:22178153   PMID:22241470   PMID:22242143   PMID:22275227   PMID:22395741   PMID:22411303   PMID:22411556  
PMID:22427063   PMID:22438573   PMID:22442009   PMID:22532563   PMID:22654667   PMID:22685315   PMID:22689267   PMID:22815831   PMID:22903506   PMID:22972545   PMID:22975381   PMID:22982861  
PMID:22988430   PMID:23029012   PMID:23095887   PMID:23112163   PMID:23181698   PMID:23261931   PMID:23354436   PMID:23395635   PMID:23424071   PMID:23477786   PMID:23555309   PMID:23741524  
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PMID:34330896   PMID:34369383   PMID:34376651   PMID:34845879   PMID:34878091   PMID:34908123   PMID:34936613   PMID:35133601   PMID:35137168   PMID:35182235   PMID:35236825   PMID:35364055  
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PMID:37702066   PMID:37730988   PMID:37748319   PMID:37767575   PMID:37863055   PMID:37917195   PMID:38134227   PMID:38134595   PMID:38198889   PMID:38355793   PMID:38416830   PMID:38760896  
PMID:38923264   PMID:39024569   PMID:39032603   PMID:39478207   PMID:39707586   PMID:39982400  


Genomics

Comparative Map Data
Twist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)EnsemblGRCm39 Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBIMGSCv36mm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
TWIST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38719,113,047 - 19,117,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl719,020,991 - 19,117,636 (-)EnsemblGRCh38hg38GRCh38
GRCh37719,152,670 - 19,157,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,121,616 - 19,123,820 (-)NCBINCBI36Build 36hg18NCBI36
Build 34718,928,330 - 18,930,265NCBI
Celera719,134,693 - 19,136,894 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef719,039,766 - 19,041,695 (-)NCBIHuRef
CHM1_1719,155,871 - 19,158,073 (-)NCBICHM1_1
T2T-CHM13v2.0719,242,984 - 19,247,572 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2719,206,542 - 19,208,746 (-)NCBI
Twist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8656,402,309 - 56,404,303 (+)NCBIGRCr8
mRatBN7.2650,674,910 - 50,676,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl650,674,678 - 50,677,653 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx650,955,709 - 50,957,706 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0651,270,651 - 51,272,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0650,726,837 - 50,728,832 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0653,401,241 - 53,403,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl653,401,109 - 53,403,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0663,023,523 - 63,025,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4652,605,869 - 52,607,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1652,609,172 - 52,609,784 (+)NCBI
Celera649,841,416 - 49,843,227 (+)NCBICelera
Cytogenetic Map6q16NCBI
Twist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541022,003,981 - 22,005,483 (-)NCBIChiLan1.0ChiLan1.0
TWIST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2623,940,627 - 23,944,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1772,265,343 - 72,268,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0719,761,041 - 19,765,665 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1719,086,842 - 19,088,398 (-)NCBIpanpan1.1PanPan1.1panPan2
TWIST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1433,304,421 - 33,305,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBIUU_Cfam_GSD_1.0
Twist1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365465,331,863 - 5,332,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl988,289,407 - 88,290,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12139,040,178 - 39,042,384 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2139,040,547 - 39,041,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604265,498,692 - 65,500,893 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Twist1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473911,352,141 - 11,352,809 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473911,352,040 - 11,354,019 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Twist1
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:478
Count of miRNA genes:308
Interacting mature miRNAs:351
Transcripts:ENSMUST00000049089
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse

Markers in Region
AA960487  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,959,431 - 33,959,543UniSTSGRCm38
MGSCv371234,644,296 - 34,644,408UniSTSGRCm37
Celera1235,392,899 - 35,393,011UniSTS
Cytogenetic Map12B-C1UniSTS
Whitehead/MRC_RH12318.19UniSTS
Twist  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,958,315 - 33,958,653UniSTSGRCm38
MGSCv371234,643,180 - 34,643,518UniSTSGRCm37
Celera1235,391,783 - 35,392,121UniSTS
Cytogenetic Map12B-C1UniSTS
cM Map1216.0UniSTS
MARC_39127-39128:1075469460:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,958,534 - 33,959,521UniSTSGRCm38
MGSCv371234,643,399 - 34,644,386UniSTSGRCm37
Celera1235,392,002 - 35,392,989UniSTS
Cytogenetic Map12B-C1UniSTS
M63649  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,959,208 - 33,959,396UniSTSGRCm38
MGSCv371234,644,073 - 34,644,261UniSTSGRCm37
Celera1235,392,676 - 35,392,864UniSTS
Cytogenetic Map12B-C1UniSTS
Whitehead_YAC12 UniSTS
Twist1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12B-C1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000049089   ⟹   ENSMUSP00000040089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)Ensembl
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)Ensembl
RefSeq Acc Id: NM_011658   ⟹   NP_035788
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391234,007,670 - 34,009,830 (+)NCBI
GRCm381233,957,671 - 33,959,831 (+)ENTREZGENE
MGSCv371234,642,536 - 34,644,696 (+)RGD
Celera1235,391,139 - 35,393,299 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035788 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40514 (Get FASTA)   NCBI Sequence Viewer  
  AAA40515 (Get FASTA)   NCBI Sequence Viewer  
  AAH33434 (Get FASTA)   NCBI Sequence Viewer  
  AAH83139 (Get FASTA)   NCBI Sequence Viewer  
  EDL36871 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000040089
  ENSMUSP00000040089.6
GenBank Protein P26687 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035788   ⟸   NM_011658
- UniProtKB: P26687 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000040089   ⟸   ENSMUST00000049089
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26687-F1-model_v2 AlphaFold P26687 1-206 view protein structure

Promoters
RGD ID:8678134
Promoter ID:EPDNEW_M17098
Type:single initiation site
Name:Twist1_1
Description:Mus musculus twist basic helix-loop-helix transcription factor1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381233,957,656 - 33,957,716EPDNEW
RGD ID:6823502
Promoter ID:MM_KWN:11486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B4,   MEF_B6
Transcripts:NM_011658
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361234,642,141 - 34,643,392 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98872 AgrOrtholog
Ensembl Genes ENSMUSG00000035799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049089 ENTREZGENE
  ENSMUST00000049089.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  E-box_TF_Regulators UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  TWIST1_bHLH UniProtKB/Swiss-Prot
KEGG Report mmu:22160 UniProtKB/Swiss-Prot
MGD MGI:98872 ENTREZGENE
NCBI Gene 22160 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/Swiss-Prot
  PTHR23349:SF64 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PharmGKB TWIST1 RGD
PhenoGen Twist1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt P26687 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Twist1  twist basic helix-loop-helix transcription factor 1    twist homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED