Twist1 (twist basic helix-loop-helix transcription factor 1) - Rat Genome Database

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Gene: Twist1 (twist basic helix-loop-helix transcription factor 1) Mus musculus
Analyze
Symbol: Twist1
Name: twist basic helix-loop-helix transcription factor 1
RGD ID: 1553211
MGI Page MGI
Description: Enables several functions, including E-box binding activity; bHLH transcription factor binding activity; and protein homodimerization activity. Involved in several processes, including embryonic morphogenesis; heart valve development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ morphogenesis; chordate embryonic development; and limb morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and genitourinary system. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA960487; bHLHa; bHLHa38; charlie chaplin; M-Twi; M-Twist; MGC103391; pd; Pde; pdt; Pluri; Pluridigite; polydactyly EMS; Ska; Ska10; Ska; Skam10Jus; Twist; twist gene homolog 1; twist homolog 1; twist-related protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBImm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethylhexan-1-ol  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dieckol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
erlotinib hydrochloride  (EXP,ISO)
finasteride  (ISO)
flurbiprofen  (EXP)
folic acid  (EXP)
fonofos  (ISO)
gefitinib  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
lapatinib  (ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
malathion  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
osimertinib  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
Pachymic acid  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
parathion  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
progesterone  (ISO)
quercetin  (ISO)
reparixin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sorafenib  (EXP)
stattic  (ISO)
sunitinib  (ISO)
Swertiamarin  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetraethylenepentamine  (EXP,ISO)
thymoquinone  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IMP,ISO)
bone development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IMP)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IMP)
cell differentiation  (IMP)
cell proliferation involved in heart valve development  (IMP,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (IMP,ISO)
cranial suture morphogenesis  (IMP)
developmental process  (IBA)
embryonic camera-type eye formation  (ISO)
embryonic cranial skeleton morphogenesis  (IGI,IMP,ISO)
embryonic digit morphogenesis  (IMP)
embryonic forelimb morphogenesis  (IMP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IMP)
embryonic skeletal system morphogenesis  (IMP)
endocardial cushion morphogenesis  (IMP)
eyelid development in camera-type eye  (ISO)
hindlimb morphogenesis  (IMP)
in utero embryonic development  (IMP)
mitral valve morphogenesis  (IMP)
muscle organ development  (IEA)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cell differentiation  (IDA)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of double-strand break repair  (ISO)
negative regulation of histone acetylation  (IDA)
negative regulation of histone phosphorylation  (ISO)
negative regulation of molecular function  (IDA)
negative regulation of osteoblast differentiation  (IDA,ISO)
negative regulation of oxidative phosphorylation uncoupler activity  (IDA)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (IDA)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISO)
negative regulation of skeletal muscle tissue development  (IDA)
negative regulation of striated muscle tissue development  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription, DNA-templated  (IDA,ISO)
negative regulation of tumor necrosis factor production  (IGI)
neural tube closure  (IMP)
neuron migration  (IMP)
odontogenesis  (ISO)
ossification  (IMP)
osteoblast differentiation  (IMP)
positive regulation of cell motility  (IMP,ISO)
positive regulation of DNA-templated transcription, initiation  (ISO)
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation  (IDA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IMP,ISO)
positive regulation of fatty acid beta-oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO,TAS)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of bone mineralization  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
rhythmic process  (IEA)
roof of mouth development  (ISO)

Cellular Component
nucleoplasm  (TAS)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1280141   PMID:1280901   PMID:1840517   PMID:3710160   PMID:7547472   PMID:7588068   PMID:7589808   PMID:7664846   PMID:7729687   PMID:7734393   PMID:7789282   PMID:7924997  
PMID:7958419   PMID:8041747   PMID:8069909   PMID:8187635   PMID:8431638   PMID:8565825   PMID:8573722   PMID:8622765   PMID:8672127   PMID:8812055   PMID:8901056   PMID:8988167  
PMID:9061034   PMID:9073070   PMID:9106663   PMID:9168805   PMID:9226440   PMID:9299114   PMID:9300656   PMID:9343420   PMID:9373037   PMID:9520323   PMID:9580658   PMID:9585583  
PMID:9739106   PMID:9851841   PMID:10079226   PMID:10079236   PMID:10195895   PMID:10498685   PMID:10518210   PMID:10557208   PMID:10585775   PMID:10589677   PMID:10700192   PMID:10704861  
PMID:10751173   PMID:10906457   PMID:11001584   PMID:11017084   PMID:11044609   PMID:11180952   PMID:11350121   PMID:11440720   PMID:11517919   PMID:11532923   PMID:11784053   PMID:11823447  
PMID:12086465   PMID:12117810   PMID:12124942   PMID:12141426   PMID:12142027   PMID:12175489   PMID:12221714   PMID:12414734   PMID:12471260   PMID:12477932   PMID:12480539   PMID:12522767  
PMID:12523351   PMID:12553906   PMID:12736212   PMID:12737212   PMID:12805229   PMID:12925589   PMID:12925591   PMID:14597577   PMID:14645221   PMID:14724733   PMID:15030764   PMID:15136147  
PMID:15162501   PMID:15210113   PMID:15306564   PMID:15361870   PMID:15366017   PMID:15489334   PMID:15618518   PMID:15735646   PMID:15802514   PMID:15885504   PMID:15906377   PMID:15936751  
PMID:16028273   PMID:16093716   PMID:16096654   PMID:16100003   PMID:16221730   PMID:16291796   PMID:16293629   PMID:16314491   PMID:16368934   PMID:16495310   PMID:16502419   PMID:16537918  
PMID:16540516   PMID:16602821   PMID:16683987   PMID:16751104   PMID:16765933   PMID:16831897   PMID:16884697   PMID:16887829   PMID:16887830   PMID:17050674   PMID:17204263   PMID:17222543  
PMID:17223098   PMID:17325035   PMID:17332324   PMID:17442300   PMID:17609112   PMID:17652084   PMID:17652354   PMID:17662069   PMID:17868088   PMID:17890670   PMID:17893140   PMID:17931618  
PMID:18287559   PMID:18297062   PMID:18330926   PMID:18353781   PMID:18471809   PMID:18539270   PMID:18557763   PMID:18612084   PMID:18655182   PMID:18663125   PMID:18667074   PMID:18697225  
PMID:18701545   PMID:18832392   PMID:19029138   PMID:19040081   PMID:19103755   PMID:19201948   PMID:19217897   PMID:19345188   PMID:19383905   PMID:19386269   PMID:19389359   PMID:19414008  
PMID:19439447   PMID:19782673   PMID:19851501   PMID:19932774   PMID:19950203   PMID:19952280   PMID:20059953   PMID:20534379   PMID:20547147   PMID:20564211   PMID:20570969   PMID:20714342  
PMID:20727876   PMID:20732316   PMID:20737509   PMID:20804746   PMID:20826535   PMID:20890042   PMID:21051860   PMID:21150899   PMID:21167473   PMID:21199805   PMID:21267068   PMID:21307093  
PMID:21317430   PMID:21455939   PMID:21558373   PMID:21559426   PMID:21609622   PMID:21610693   PMID:21660050   PMID:21769775   PMID:21779394   PMID:21811467   PMID:21873635   PMID:21876526  
PMID:21905163   PMID:21983003   PMID:22056872   PMID:22174793   PMID:22178153   PMID:22241470   PMID:22242143   PMID:22275227   PMID:22395741   PMID:22411303   PMID:22411556   PMID:22427063  
PMID:22438573   PMID:22442009   PMID:22532563   PMID:22654667   PMID:22685315   PMID:22689267   PMID:22815831   PMID:22903506   PMID:22972545   PMID:22975381   PMID:22982861   PMID:22988430  
PMID:23029012   PMID:23095887   PMID:23112163   PMID:23181698   PMID:23261931   PMID:23354436   PMID:23395635   PMID:23477786   PMID:23555309   PMID:23741524   PMID:23836893   PMID:23863481  
PMID:23898200   PMID:23906809   PMID:23935104   PMID:24009529   PMID:24011070   PMID:24023872   PMID:24038871   PMID:24129179   PMID:24188104   PMID:24218595   PMID:24278323   PMID:24415953  
PMID:24585549   PMID:24590176   PMID:24631216   PMID:24671096   PMID:24893291   PMID:24927592   PMID:24952961   PMID:24971743   PMID:24996922   PMID:25044936   PMID:25053435   PMID:25077968  
PMID:25082703   PMID:25100001   PMID:25124681   PMID:25128964   PMID:25336743   PMID:25344368   PMID:25368021   PMID:25414194   PMID:25446074   PMID:25486906   PMID:25575080   PMID:25596548  
PMID:25661109   PMID:25892968   PMID:25893917   PMID:26013710   PMID:26134413   PMID:26202447   PMID:26212662   PMID:26229009   PMID:26236991   PMID:26278035   PMID:26288816   PMID:26317648  
PMID:26318343   PMID:26361389   PMID:26441343   PMID:26453795   PMID:26487719   PMID:26525672   PMID:26545946   PMID:26560028   PMID:26582088   PMID:26598619   PMID:26677825   PMID:26695186  
PMID:26718114   PMID:26812015   PMID:26859889   PMID:26959361   PMID:27178982   PMID:27245171   PMID:27281171   PMID:27352137   PMID:27395007   PMID:27544279   PMID:27546376   PMID:27618486  
PMID:27664421   PMID:27756203   PMID:27798109   PMID:27825360   PMID:28172500   PMID:28179498   PMID:28340616   PMID:28455376   PMID:28484075   PMID:28538179   PMID:28566723   PMID:28644763  
PMID:28769044   PMID:28790014   PMID:28844842   PMID:28915063   PMID:29073077   PMID:29084802   PMID:29277613   PMID:29523871   PMID:29852132   PMID:29853617   PMID:29891550   PMID:29920276  
PMID:30026340   PMID:30069061   PMID:30120146   PMID:30135600   PMID:30201295   PMID:30372441   PMID:30375332   PMID:30376688   PMID:30424580   PMID:30567998   PMID:30735538   PMID:31130868  
PMID:31131995   PMID:31235507   PMID:31308417   PMID:31315922   PMID:31323030   PMID:31351040   PMID:31442251   PMID:31505764   PMID:31676574   PMID:31677482   PMID:31685313   PMID:31776330  
PMID:31813126   PMID:32005677   PMID:32051525   PMID:32105214   PMID:32145039   PMID:32179550   PMID:32278689   PMID:32344102   PMID:32427396   PMID:32640236   PMID:32913205   PMID:33127760  
PMID:33190845   PMID:33417861   PMID:33482080   PMID:33713497   PMID:33972536  


Genomics

Comparative Map Data
Twist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBImm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
TWIST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl719,020,991 - 19,117,636 (-)EnsemblGRCh38hg38GRCh38
GRCh38719,113,047 - 19,117,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37719,152,670 - 19,157,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,121,616 - 19,123,820 (-)NCBINCBI36hg18NCBI36
Build 34718,928,330 - 18,930,265NCBI
Celera719,134,693 - 19,136,894 (-)NCBI
Cytogenetic Map7p21.1NCBI
HuRef719,039,766 - 19,041,695 (-)NCBIHuRef
CHM1_1719,155,871 - 19,158,073 (-)NCBICHM1_1
CRA_TCAGchr7v2719,206,542 - 19,208,746 (-)NCBI
Twist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2650,674,910 - 50,676,904 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl650,674,678 - 50,677,653 (+)Ensembl
Rnor_6.0653,401,241 - 53,403,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl653,401,109 - 53,403,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0663,023,523 - 63,025,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4652,605,869 - 52,607,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1652,609,172 - 52,609,784 (+)NCBI
Celera649,841,416 - 49,843,227 (+)NCBICelera
Cytogenetic Map6q16NCBI
Twist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541022,003,981 - 22,005,483 (-)NCBIChiLan1.0ChiLan1.0
TWIST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1719,086,842 - 19,088,398 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0719,761,041 - 19,765,665 (-)NCBIMhudiblu_PPA_v0panPan3
TWIST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBI
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBI
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBI
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBI
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBI
Twist1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBI
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12139,040,178 - 39,042,384 (+)NCBI
ChlSab1.1 Ensembl2139,040,547 - 39,041,146 (+)Ensembl
Vero_WHO_p1.0NW_02366604265,498,692 - 65,500,893 (-)NCBI
Twist1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473911,352,040 - 11,354,019 (+)NCBI

Position Markers
AA960487  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,959,431 - 33,959,543UniSTSGRCm38
MGSCv371234,644,296 - 34,644,408UniSTSGRCm37
Celera1235,392,899 - 35,393,011UniSTS
Cytogenetic Map12B-C1UniSTS
Whitehead/MRC_RH12318.19UniSTS
Twist  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,958,315 - 33,958,653UniSTSGRCm38
MGSCv371234,643,180 - 34,643,518UniSTSGRCm37
Celera1235,391,783 - 35,392,121UniSTS
Cytogenetic Map12B-C1UniSTS
cM Map1216.0UniSTS
MARC_39127-39128:1075469460:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,958,534 - 33,959,521UniSTSGRCm38
MGSCv371234,643,399 - 34,644,386UniSTSGRCm37
Celera1235,392,002 - 35,392,989UniSTS
Cytogenetic Map12B-C1UniSTS
M63649  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381233,959,208 - 33,959,396UniSTSGRCm38
MGSCv371234,644,073 - 34,644,261UniSTSGRCm37
Celera1235,392,676 - 35,392,864UniSTS
Cytogenetic Map12B-C1UniSTS
Whitehead_YAC12 UniSTS
Twist1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12B-C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1229013334290301Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12536844076984429Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12767315941673302Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12800000040000000Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12830244542302582Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12944100543441113Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12950000084100000Mouse
14746972Manh72_mmandible shape 72 (mouse)121056528244565282Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121057064344570810Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121161000097210000Mouse
4141516slwr_mslowlearner (mouse)Not determined1234247646342615Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121509733249097332Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121529102578993590Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121610000047700000Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121754644680910109Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121777585351775853Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121778994051790082Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121820996752210068Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121968983453689834Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122209886756099017Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122911390263114101Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122911390263114101Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122975480163754950Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122981673963816739Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir214mmu-miR-214-3pOncomiRDBexternal_infoNANA22540680

Predicted Target Of
Summary Value
Count of predictions:478
Count of miRNA genes:308
Interacting mature miRNAs:351
Transcripts:ENSMUST00000049089
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049089   ⟹   ENSMUSP00000040089
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)Ensembl
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)Ensembl
RefSeq Acc Id: NM_011658   ⟹   NP_035788
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391234,007,670 - 34,009,830 (+)NCBI
GRCm381233,957,671 - 33,959,831 (+)ENTREZGENE
MGSCv371234,642,536 - 34,644,696 (+)RGD
Celera1235,391,139 - 35,393,299 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035788   ⟸   NM_011658
- UniProtKB: P26687 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040089   ⟸   ENSMUST00000049089
Protein Domains
bHLH

Promoters
RGD ID:8678134
Promoter ID:EPDNEW_M17098
Type:single initiation site
Name:Twist1_1
Description:Mus musculus twist basic helix-loop-helix transcription factor1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381233,957,656 - 33,957,716EPDNEW
RGD ID:6823502
Promoter ID:MM_KWN:11486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B4,   MEF_B6
Transcripts:NM_011658
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361234,642,141 - 34,643,392 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98872 AgrOrtholog
Ensembl Genes ENSMUSG00000035799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000040089 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049089 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Twist-related UniProtKB/Swiss-Prot
KEGG Report mmu:22160 UniProtKB/Swiss-Prot
MGD MGI:98872 ENTREZGENE
NCBI Gene 22160 ENTREZGENE
PANTHER PTHR23349:SF64 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PharmGKB TWIST1 RGD
PhenoGen Twist1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt P26687 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Twist1  twist basic helix-loop-helix transcription factor 1    twist homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED