Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | Lgals4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of LGALS4 mRNA | CTD | PMID:26496021 | 17beta-estradiol | increases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of LGALS4 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LGALS4 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of LGALS4 mRNA | CTD | PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LGALS4 mRNA | CTD | PMID:21570461 | 2-palmitoylglycerol | increases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of LGALS4 mRNA | CTD | PMID:37199045 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of LGALS4 mRNA | CTD | PMID:18648102 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of LGALS4 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of LGALS4 mRNA | CTD | PMID:27153756 | ammonium chloride | affects expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of LGALS4 mRNA | CTD | PMID:16483693 | amphotericin B | increases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Amphotericin B analog results in increased expression of LGALS4 mRNA | CTD | PMID:28534445 | aristolochic acid A | increases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of LGALS4 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of LGALS4 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of LGALS4 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | LGALS4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of LGALS4 promoter | CTD | PMID:27901495 | benzo[b]fluoranthene | increases expression | EXP | | 6480464 | benzo(b)fluoranthene results in increased expression of LGALS4 mRNA | CTD | PMID:26377693 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of LGALS4 mRNA | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of LGALS4 mRNA] | CTD | PMID:19850644 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LGALS4 mRNA | CTD | PMID:26063408 and PMID:32156529 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LGALS4 mRNA | CTD | PMID:34585602 | bisphenol A | decreases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of LGALS4 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | Lgals4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of LGALS4 mRNA | CTD | PMID:26496021 | cadmium atom | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Cadmium results in decreased expression of LGALS4 mRNA | CTD | PMID:24376830 | cadmium dichloride | affects expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Cadmium Chloride affects the expression of LGALS4 mRNA | CTD | PMID:22110744 | capecitabine | increases response to substance | ISO | LGALS4 (Homo sapiens) | 6480464 | LGALS4 protein results in increased susceptibility to Capecitabine | CTD | PMID:16734730 | carbon nanotube | affects expression | EXP | | 6480464 | Nanotubes and Carbon affects the expression of LGALS4 mRNA | CTD | PMID:25620056 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon analog results in increased expression of LGALS4 mRNA | CTD | PMID:25620056 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | ciguatoxin CTX1B | affects expression | EXP | | 6480464 | Ciguatoxins affects the expression of LGALS4 mRNA | CTD | PMID:18353800 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of LGALS4 mRNA | CTD | PMID:23811191 | cyclosporin A | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of LGALS4 mRNA | CTD | PMID:20106945 | diazinon | decreases methylation | ISO | LGALS4 (Homo sapiens) | 6480464 | Diazinon results in decreased methylation of LGALS4 gene | CTD | PMID:22964155 | dichloroacetic acid | increases expression | EXP | | 6480464 | Dichloroacetic Acid results in increased expression of LGALS4 mRNA | CTD | PMID:28962523 | diquat | increases expression | EXP | | 6480464 | Diquat results in increased expression of LGALS4 mRNA | CTD | PMID:36851058 | disodium selenite | increases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of LGALS4 mRNA | CTD | PMID:18175754 | diuron | increases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Diuron results in increased expression of LGALS4 mRNA | CTD | PMID:21551480 | diuron | decreases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Diuron metabolite results in decreased expression of LGALS4 mRNA | CTD | PMID:24172598 | doxifluridine | increases response to substance | ISO | LGALS4 (Homo sapiens) | 6480464 | LGALS4 protein results in increased susceptibility to doxifluridine | CTD | PMID:16734730 | ethanol | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LGALS4 mRNA | CTD | PMID:30517762 | folic acid | increases expression | EXP | | 6480464 | Folic Acid results in increased expression of LGALS4 mRNA | CTD | PMID:25629700 | fulvestrant | increases methylation | ISO | LGALS4 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of LGALS4 gene | CTD | PMID:31601247 | furan | increases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | furan results in increased expression of LGALS4 mRNA | CTD | PMID:26194646 and PMID:27387713 | Licochalcone B | increases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of LGALS4 mRNA | CTD | PMID:33647349 | lipopolysaccharide | multiple interactions | ISO | LGALS4 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LGALS4 mRNA | CTD | PMID:35811015 | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of LGALS4 mRNA | CTD | PMID:18502557 | monosodium L-glutamate | increases expression | EXP | | 6480464 | Sodium Glutamate results in increased expression of LGALS4 mRNA | CTD | PMID:22078008 | N-methyl-4-phenylpyridinium | decreases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of LGALS4 mRNA | CTD | PMID:28801915 | O-methyleugenol | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of LGALS4 mRNA | CTD | PMID:32234424 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of LGALS4 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of LGALS4 mRNA | CTD | PMID:27106289 and PMID:34911549 | paclitaxel | decreases response to substance | ISO | LGALS4 (Homo sapiens) | 6480464 | LGALS4 protein results in decreased susceptibility to Paclitaxel | CTD | PMID:16734730 | perfluorohexanesulfonic acid | increases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in increased expression of LGALS4 mRNA | CTD | PMID:37995155 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of LGALS4 mRNA | CTD | PMID:19270015 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of LGALS4 mRNA | CTD | PMID:23091169 | phenobarbital | affects expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of LGALS4 mRNA | CTD | PMID:19159669 | phenobarbital | decreases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Phenobarbital results in decreased expression of LGALS4 mRNA | CTD | PMID:19162173 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LGALS4 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of LGALS4 mRNA | CTD | PMID:18301758 and PMID:23811191 | pravastatin | decreases expression | EXP | | 6480464 | Pravastatin results in decreased expression of LGALS4 mRNA | CTD | PMID:27225895 | pravastatin | increases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Pravastatin results in increased expression of LGALS4 mRNA | CTD | PMID:27225895 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of LGALS4 mRNA | CTD | PMID:19162173 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of LGALS4 mRNA | CTD | PMID:21278054 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | LGALS4 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LGALS4 mRNA | CTD | PMID:35811015 | silicon dioxide | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of LGALS4 mRNA | CTD | PMID:25895662 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of LGALS4 mRNA | CTD | PMID:17350061 | sodium arsenite | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of LGALS4 mRNA | CTD | PMID:34032870 | tetrachloroethene | increases expression | EXP | | 6480464 | Tetrachloroethylene results in increased expression of LGALS4 mRNA | CTD | PMID:28973375 | tetrachloromethane | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LGALS4 mRNA | CTD | PMID:30517762 | tetraphene | affects expression | EXP | | 6480464 | benz(a)anthracene affects the expression of LGALS4 mRNA | CTD | PMID:26377693 | thioacetamide | increases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of LGALS4 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of LGALS4 mRNA | CTD | PMID:23557971 | tributylstannane | increases expression | EXP | | 6480464 | tributyltin results in increased expression of LGALS4 mRNA | CTD | PMID:31939706 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of LGALS4 mRNA | CTD | PMID:25549359 | triclosan | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of LGALS4 mRNA | CTD | PMID:30510588 | triticonazole | decreases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | triticonazole results in decreased expression of LGALS4 mRNA | CTD | PMID:36084822 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of LGALS4 mRNA | CTD | PMID:17292431 | valproic acid | decreases expression | ISO | LGALS4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of LGALS4 mRNA | CTD | PMID:29154799 | zaragozic acid A | increases expression | ISO | Lgals4 (Rattus norvegicus) | 6480464 | squalestatin 1 results in increased expression of LGALS4 mRNA | CTD | PMID:27225895 | zaragozic acid A | affects expression | EXP | | 6480464 | squalestatin 1 affects the expression of LGALS4 mRNA | CTD | PMID:27225895 | |