Fas (Fas (TNF receptor superfamily member 6)) - Rat Genome Database
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Gene: Fas (Fas (TNF receptor superfamily member 6)) Mus musculus
Symbol: Fas
Name: Fas (TNF receptor superfamily member 6)
RGD ID: 1552455
Description: Exhibits identical protein binding activity. Involved in several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Localizes to CD95 death-inducing signaling complex; external side of plasma membrane; and extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; leukemia (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; INTERACTS WITH (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI196731; AP; APO-1; apo-1 antigen; APO1; apoptosis-mediating surface antigen FAS; APT1; CD95; Fas (TNF receptor superfamily member); Fas antigen; FASLG receptor; lpr; lymphoproliferation; TNF; Tnfr; TNFR6; Tnfrsf6; tumor necrosis factor receptor superfamily member 6
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391934,267,926 - 34,305,175 (+)NCBIGRCm39mm39
GRCm381934,290,647 - 34,327,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,290,666 - 34,327,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371934,365,149 - 34,402,260 (+)NCBIGRCm37mm9NCBIm37
MGSCv361934,356,663 - 34,393,767 (+)NCBImm8
Celera1935,067,780 - 35,104,920 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (IEP,IMP,ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adult T-cell leukemia  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (IEP,ISO)
autoimmune lymphoproliferative syndrome  (IEA,IMP,ISO)
Autoimmune Lymphoproliferative Syndrome, Type IA  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
brain glioma  (ISO)
Brain Injuries  (IMP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chest Trauma  (ISO)
chorioamnionitis  (ISO)
chronic conjunctivitis  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Uveitis  (ISO)
clonorchiasis  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (IMP)
cryptorchidism  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Autoimmune Uveitis  (IMP)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IMP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Pancreatitis, Acute  (IEP,IMP)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (IMP,ISO)
Graft vs Host Disease  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hematopoietic system disease  (ISO)
hepatitis B  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IMP,ISO)
heroin dependence  (ISO)
high grade glioma  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperoxia  (IMP,ISO)
hypersplenism  (ISO)
Hypothermia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (IMP)
IgA glomerulonephritis  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
limited scleroderma  (IMP)
liver disease  (ISO)
Liver Injury  (IMP)
Liver Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
Lymphomatoid Papulosis  (ISO)
lymphoproliferative syndrome  (IMP,ISO)
macular degeneration  (ISO)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (IMP)
melanoma  (ISO)
Metabolic Brain Diseases  (ISO)
mixed connective tissue disease  (ISO)
Moyamoya disease  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Multisystemic Smooth Muscle Dysfunction Syndrome  (ISO)
myasthenia gravis  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (IEP,ISO)
nephritis  (ISO)
non-alcoholic fatty liver disease  (ISO)
ocular hypertension  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (IEP)
Parkinson's disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (IAGP)
proteinuria  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
Radiation Injuries, Experimental  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (IAGP,ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinoblastoma  (ISO)
rheumatoid arthritis  (ISO)
sciatic neuropathy  (ISO)
seminoma  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (IEA,IEP,IMP,ISO)
Spinal Cord Compression  (IMP,ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (IEA,ISO)
Taste Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (ISO)
Testicular Injury  (ISO)