Dgat2 (diacylglycerol O-acyltransferase 2) - Rat Genome Database

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Gene: Dgat2 (diacylglycerol O-acyltransferase 2) Mus musculus
Analyze
Symbol: Dgat2
Name: diacylglycerol O-acyltransferase 2
RGD ID: 1551902
MGI Page MGI
Description: Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including acylglycerol biosynthetic process; cellular response to oleic acid; and cholesterol homeostasis. Located in endoplasmic reticulum; membrane; and perinuclear region of cytoplasm. Is active in endoplasmic reticulum membrane. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0610010B06Rik; acyl-CoA retinol O-fatty-acyltransferase; ARAT; DGAT-2; diacylglycerol acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,802,870 - 98,831,920 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,802,865 - 98,831,926 (-)EnsemblGRCm39 Ensembl
GRCm38799,153,663 - 99,182,713 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,153,658 - 99,182,719 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,302,173 - 106,331,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,028,855 - 99,057,905 (-)NCBIMGSCv36mm8
Celera799,478,097 - 99,506,939 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzylpenicillin  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorothalonil  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (EXP)
chrysene  (EXP)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
dieldrin  (ISO)
difenoconazole  (EXP)
dioscin  (EXP,ISO)
diquat  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
erythromycin A  (EXP)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenthion  (EXP)
flutamide  (ISO)
fructose  (EXP)
genistein  (ISO)
gentamycin  (ISO)
graphite  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lead(0)  (EXP)
lipoic acid  (ISO)
mangiferin  (ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
nordihydroguaiaretic acid  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium cyanide  (EXP)
potassium dichromate  (EXP)
procymidone  (EXP)
propamocarb  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
rebaudioside A  (EXP)
rifaximin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
sucrose  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tamoxifen  (EXP)
tectoridin  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (EXP)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP,ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vanillic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. Choi CS, etal., J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.
2. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
3. Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. Gandhi R, etal., J Rheumatol. 2011 Sep;38(9):1966-72. Epub 2011 Jul 15.
4. Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. Jin K, etal., Nephrol Dial Transplant. 2013 Feb;28(2):313-20. doi: 10.1093/ndt/gfs350. Epub 2012 Oct 8.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Monetti M, etal., Cell Metab. 2007 Jul;6(1):69-78.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats. Seo M, etal., Dig Dis Sci. 2013 Dec;58(12):3534-44. doi: 10.1007/s10620-013-2879-3. Epub 2013 Oct 29.
14. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11481335   PMID:12032764   PMID:12077311   PMID:12413942   PMID:12477932   PMID:14521909   PMID:14668353   PMID:14681479   PMID:15258194  
PMID:15489334   PMID:15550388   PMID:15797871   PMID:16001399   PMID:16141072   PMID:16141073   PMID:16751624   PMID:16877777   PMID:17035227   PMID:17504763   PMID:18175806   PMID:18252207  
PMID:18280001   PMID:18757836   PMID:19049983   PMID:19092943   PMID:20562862   PMID:20739640   PMID:21267068   PMID:21317108   PMID:21436037   PMID:21680734   PMID:21873635   PMID:22055502  
PMID:22355095   PMID:22872236   PMID:22927462   PMID:23066022   PMID:23489367   PMID:23643496   PMID:23988655   PMID:24358267   PMID:24953780   PMID:25602705   PMID:26508642   PMID:27531967  
PMID:27731369   PMID:27754788   PMID:27836993   PMID:27858140   PMID:28249764   PMID:28369476   PMID:29563512   PMID:29706567   PMID:30397187   PMID:30929916   PMID:30936184   PMID:31081165  
PMID:31693883   PMID:32325033   PMID:32561790   PMID:32749667   PMID:33147469   PMID:34493722   PMID:34681759   PMID:34813948   PMID:37115925   PMID:37225978  


Genomics

Comparative Map Data
Dgat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,802,870 - 98,831,920 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,802,865 - 98,831,926 (-)EnsemblGRCm39 Ensembl
GRCm38799,153,663 - 99,182,713 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,153,658 - 99,182,719 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,302,173 - 106,331,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,028,855 - 99,057,905 (-)NCBIMGSCv36mm8
Celera799,478,097 - 99,506,939 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.01NCBI
DGAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,768,778 - 75,801,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,759,512 - 75,801,535 (+)EnsemblGRCh38hg38GRCh38
GRCh371175,479,823 - 75,512,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,157,456 - 75,190,225 (+)NCBINCBI36Build 36hg18NCBI36
Build 341175,157,455 - 75,190,225NCBI
Celera1172,787,576 - 72,820,377 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1171,776,445 - 71,809,321 (+)NCBIHuRef
CHM1_11175,363,395 - 75,396,193 (+)NCBICHM1_1
T2T-CHM13v2.01175,698,501 - 75,731,257 (+)NCBIT2T-CHM13v2.0
Dgat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,454,078 - 153,484,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,454,080 - 153,484,428 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,450,259 - 161,480,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,630,412 - 168,660,798 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,503,932 - 161,534,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,113,459 - 164,143,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,113,459 - 164,143,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,316,041 - 170,346,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,447,588 - 156,478,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,529,080 - 156,531,888 (-)NCBI
Celera1151,539,454 - 151,569,146 (-)NCBICelera
Cytogenetic Map1q32NCBI
Dgat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,059,781 - 16,089,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,059,781 - 16,089,727 (-)NCBIChiLan1.0ChiLan1.0
DGAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11177,738,170 - 77,770,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,824,791 - 70,857,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11174,109,523 - 74,158,854 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,126,169 - 74,158,854 (+)Ensemblpanpan1.1panPan2
DGAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,833,659 - 22,850,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,834,518 - 22,851,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,599,527 - 22,636,714 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,036,854 - 23,073,838 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,036,854 - 23,069,245 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,835,850 - 22,868,136 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,032,018 - 23,064,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02122,949,639 - 22,986,269 (-)NCBIUU_Cfam_GSD_1.0
Dgat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,914,608 - 62,944,920 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,514,184 - 4,544,527 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,514,212 - 4,544,523 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,032,128 - 10,068,437 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,032,163 - 10,066,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,160,734 - 11,176,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,985,413 - 67,018,058 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,985,466 - 67,021,182 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604358,785,359 - 58,818,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,386,764 - 1,418,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,386,876 - 1,418,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgat2
964 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:273
Interacting mature miRNAs:292
Transcripts:ENSMUST00000033001
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
27226792Feml7_mfemur length 7, 5 week (mouse)78614920898949207Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse

Markers in Region
D7Mit185  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,180,038 - 99,180,164UniSTSGRCm38
MGSCv377106,328,548 - 106,328,674UniSTSGRCm37
Celera799,504,277 - 99,504,407UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.0UniSTS
Whitehead Genetic737.2UniSTS
Dgat2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377106,305,663 - 106,306,784UniSTSGRCm37
Celera799,481,381 - 99,482,502UniSTS
cM Map7 UniSTS
G42985  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,154,423 - 99,154,570UniSTSGRCm38
MGSCv377106,302,933 - 106,303,080UniSTSGRCm37
Celera799,478,855 - 99,479,002UniSTS
Cytogenetic Map7F1UniSTS
Dgat2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,157,153 - 99,158,274UniSTSGRCm38
MGSCv377106,305,663 - 106,306,784UniSTSGRCm37
Celera799,481,381 - 99,482,502UniSTS
Cytogenetic Map7F1UniSTS
cM Map7 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033001   ⟹   ENSMUSP00000033001
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,802,865 - 98,831,926 (-)Ensembl
GRCm38.p6 Ensembl799,153,658 - 99,182,719 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207491   ⟹   ENSMUSP00000146342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,808,040 - 98,831,884 (-)Ensembl
GRCm38.p6 Ensembl799,158,833 - 99,182,677 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207611   ⟹   ENSMUSP00000146391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,813,849 - 98,829,500 (-)Ensembl
GRCm38.p6 Ensembl799,164,642 - 99,180,293 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,817,971 - 98,831,903 (-)Ensembl
GRCm38.p6 Ensembl799,168,764 - 99,182,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,808,191 - 98,819,313 (-)Ensembl
GRCm38.p6 Ensembl799,158,984 - 99,170,106 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208591   ⟹   ENSMUSP00000147074
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,808,240 - 98,831,926 (-)Ensembl
GRCm38.p6 Ensembl799,159,033 - 99,182,719 (-)Ensembl
RefSeq Acc Id: NM_026384   ⟹   NP_080660
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,802,870 - 98,831,920 (-)NCBI
GRCm38799,153,663 - 99,182,713 (-)ENTREZGENE
MGSCv377106,302,173 - 106,331,223 (-)RGD
Celera799,478,097 - 99,506,939 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080660   ⟸   NM_026384
- UniProtKB: Q9DCV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033001   ⟸   ENSMUST00000033001
RefSeq Acc Id: ENSMUSP00000147074   ⟸   ENSMUST00000208591
RefSeq Acc Id: ENSMUSP00000146342   ⟸   ENSMUST00000207491
RefSeq Acc Id: ENSMUSP00000146391   ⟸   ENSMUST00000207611

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DCV3-F1-model_v2 AlphaFold Q9DCV3 1-388 view protein structure

Promoters
RGD ID:8664863
Promoter ID:EPDNEW_M10462
Type:multiple initiation site
Name:Dgat2_1
Description:Mus musculus diacylglycerol O-acyltransferase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38799,182,720 - 99,182,780EPDNEW
RGD ID:6848118
Promoter ID:MM_ACW:45421
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:DGAT2.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367106,306,346 - 106,306,846 (-)MPROMDB
RGD ID:6840934
Promoter ID:MM_KWN:51656
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000033001
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367106,330,761 - 106,331,662 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915050 AgrOrtholog
Ensembl Genes ENSMUSG00000030747 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033001 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000207491.2 UniProtKB/TrEMBL
  ENSMUST00000207611.2 UniProtKB/TrEMBL
  ENSMUST00000208591.2 UniProtKB/TrEMBL
InterPro DAGAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67800 UniProtKB/Swiss-Prot
MGD MGI:1915050 ENTREZGENE
NCBI Gene 67800 ENTREZGENE
PANTHER DIACYLGLYCEROL O-ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIACYLGLYCEROL O-ACYLTRANSFERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAGAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dgat2 PhenoGen
UniProt A0A140LHA9_MOUSE UniProtKB/TrEMBL
  A0A140LHF3_MOUSE UniProtKB/TrEMBL
  A0A140LJ48_MOUSE UniProtKB/TrEMBL
  DGAT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE