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Gene: Nefm (neurofilament, medium polypeptide) Mus musculus
Symbol: Nefm
Name: neurofilament, medium polypeptide
Description: Predicted to have signaling receptor binding activity and toxic substance binding activity. Involved in axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter. Localizes to several cellular components, including intermediate filament cytoskeleton; neuromuscular junction; and postsynaptic density. Is expressed in several structures, including alimentary system; branchial arch; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human NEFM (neurofilament medium); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 160 kDa neurofilament protein; Nef3; neurofilament 3, medium; neurofilament medium polypeptide; neurofilament protein M; neurofilament triplet M protein; neurofilament-M; NF-M; NF160; NF165; Nfm
Homo sapiens (human) : NEFM (neurofilament medium)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nefm (neurofilament medium)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefm (neurofilament medium)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFM (neurofilament medium)
Canis lupus familiaris (dog) : NEFM (neurofilament medium)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefm (neurofilament medium)
Sus scrofa (pig) : NEFM (neurofilament medium)
Chlorocebus sabaeus (African green monkey) : NEFM (neurofilament medium)
Heterocephalus glaber (naked mole-rat) : Nefm (neurofilament medium)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1468,082,590 - 68,124,846 (-)EnsemblGRCm38mm10GRCm38
GRCm381468,119,545 - 68,125,004 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371468,737,602 - 68,743,061 (-)NCBIGRCm37mm9NCBIm37
MGSCv361467,073,367 - 67,078,143 (-)NCBImm8
Celera1465,887,284 - 65,892,688 (-)NCBICelera
Cytogenetic Map14D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nefm
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10970
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.