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Gene: Nefm (neurofilament, medium polypeptide) Mus musculus
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Symbol: Nefm
Name: neurofilament, medium polypeptide
Description: Predicted to have signaling receptor binding activity and toxic substance binding activity. Involved in axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter. Localizes to several cellular components, including intermediate filament cytoskeleton; neuromuscular junction; and postsynaptic density. Is expressed in several structures, including alimentary system; branchial arch; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human NEFM (neurofilament medium); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 160 kDa neurofilament protein; Nef3; neurofilament 3, medium; neurofilament medium polypeptide; neurofilament protein M; neurofilament triplet M protein; neurofilament-M; NF-M; NF160; NF165; Nfm
Orthologs:
Homo sapiens (human) : NEFM (neurofilament medium)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nefm (neurofilament medium)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefm (neurofilament medium)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFM (neurofilament medium)
Canis lupus familiaris (dog) : NEFM (neurofilament medium)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefm (neurofilament medium)
Sus scrofa (pig) : NEFM (neurofilament medium)
Chlorocebus sabaeus (African green monkey) : NEFM (neurofilament medium)
Heterocephalus glaber (naked mole-rat) : Nefm (neurofilament medium)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1468,082,590 - 68,124,846 (-)EnsemblGRCm38mm10GRCm38
GRCm381468,119,545 - 68,125,004 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371468,737,602 - 68,743,061 (-)NCBIGRCm37mm9NCBIm37
MGSCv361467,073,367 - 67,078,143 (-)NCBImm8
Celera1465,887,284 - 65,892,688 (-)NCBICelera
Cytogenetic Map14D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nefm
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10970
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.