Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif 2) - Rat Genome Database

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Gene: Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif 2) Mus musculus
Analyze
Symbol: Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2 (Ensembl:a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2)
RGD ID: 1321434
MGI Page MGI
Description: Enables peptidase activity. Acts upstream of or within several processes, including collagen fibril organization; protein processing; and spermatogenesis. Located in extracellular matrix. Is expressed in several structures, including brain and visceral pericardium. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome dermatosparaxis type. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 4732482M10; A disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin and metalloproteinase with thrombospondin repeats; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; A430089F14; ADAM-; ADAM-TS 2; ADAM-TS2; ADAMTS-2; ADAMTS-3; hP; hPCPNI; KIAA4060; mKIAA4060; PC I-NP; PCINP; pNPI; procollagen I N-proteinase; procollagen I/II amino propeptide-processing enzyme; procollagen N-endopeptidase; procollagen N-proteinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,492,912 - 50,698,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,492,911 - 50,698,400 (+)EnsemblGRCm39 Ensembl
GRCm381150,602,085 - 50,807,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,602,084 - 50,807,573 (+)EnsemblGRCm38mm10GRCm38
MGSCv371150,415,587 - 50,617,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,445,508 - 50,647,472 (+)NCBIMGSCv36mm8
Celera1155,162,823 - 55,366,156 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (EXP)
cantharidin  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
indole-3-methanol  (ISO)
inulin  (EXP)
L-methionine  (EXP)
lead(0)  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-nitrosodiethylamine  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
Phenelzine  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
sulfadimethoxine  (ISO)
tacrolimus hydrate  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
tributylstannane  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke. Arning A, etal., Blood. 2012 Dec 20;120(26):5231-6. doi: 10.1182/blood-2012-07-442038. Epub 2012 Sep 18.
2. Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. Colige A, etal., Am J Hum Genet. 1999 Aug;65(2):308-17.
3. Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene. Colige A, etal., J Invest Dermatol. 2004 Oct;123(4):656-63.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10464288   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11284712   PMID:11831030   PMID:12477932   PMID:14610273   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16452166   PMID:16556917   PMID:17929299   PMID:18799693   PMID:19795413   PMID:20436479   PMID:20574651   PMID:20637190   PMID:21873635   PMID:23376466  
PMID:23491141   PMID:24006456   PMID:24125951   PMID:25770910   PMID:25863161   PMID:26025392   PMID:26740262   PMID:26927563   PMID:28373586   PMID:29649548   PMID:29791855   PMID:31152061  
PMID:31491533   PMID:31624071   PMID:32274496   PMID:32325033   PMID:33932339   PMID:34248495   PMID:36124393   PMID:36142585   PMID:37929635  


Genomics

Comparative Map Data
Adamts2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,492,912 - 50,698,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,492,911 - 50,698,400 (+)EnsemblGRCm39 Ensembl
GRCm381150,602,085 - 50,807,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,602,084 - 50,807,573 (+)EnsemblGRCm38mm10GRCm38
MGSCv371150,415,587 - 50,617,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,445,508 - 50,647,472 (+)NCBIMGSCv36mm8
Celera1155,162,823 - 55,366,156 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.78NCBI
ADAMTS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,110,853 - 179,345,461 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,110,853 - 179,345,461 (-)EnsemblGRCh38hg38GRCh38
GRCh375178,537,854 - 178,772,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,473,456 - 178,704,935 (-)NCBINCBI36Build 36hg18NCBI36
Build 345178,510,735 - 178,704,935NCBI
Celera5174,165,082 - 174,399,060 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,265,383 - 173,499,085 (-)NCBIHuRef
CHM1_15177,971,059 - 178,205,092 (-)NCBICHM1_1
T2T-CHM13v2.05179,664,045 - 179,898,855 (-)NCBIT2T-CHM13v2.0
Adamts2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,422,030 - 35,627,483 (+)NCBIGRCr8
mRatBN7.21034,920,992 - 35,126,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,921,049 - 35,123,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,593,339 - 39,808,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,132,574 - 8,348,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,587,008 - 34,802,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,098,051 - 36,304,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,098,051 - 36,304,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,868,666 - 36,075,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,168,655 - 36,377,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1034,268,635 - 34,483,095 (+)NCBICelera
Cytogenetic Map10q22NCBI
Adamts2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554081,157,740 - 1,367,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554081,157,826 - 1,367,146 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,047,680 - 174,289,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,182,352 - 172,428,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,264,811 - 174,502,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,554,934 - 181,785,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,557,928 - 181,786,175 (-)Ensemblpanpan1.1panPan2
ADAMTS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,279,983 - 2,504,630 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,280,108 - 2,502,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,405,139 - 2,628,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,257,166 - 2,480,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,256,096 - 2,478,201 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,228,645 - 2,452,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,306,958 - 2,530,502 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,547,778 - 2,771,332 (+)NCBIUU_Cfam_GSD_1.0
Adamts2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213120,182,091 - 120,431,360 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,394,119 - 1,641,130 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,394,119 - 1,643,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl279,182,943 - 79,406,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1279,182,901 - 79,406,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,866,167 - 81,010,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,852,588 - 81,081,593 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,852,331 - 81,080,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,207,935 - 12,439,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,070,087 - 42,264,849 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,070,069 - 42,264,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts2
6697 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1645
Count of miRNA genes:731
Interacting mature miRNAs:972
Transcripts:ENSMUST00000040523, ENSMUST00000125988, ENSMUST00000127534, ENSMUST00000142118
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse

Markers in Region
D11Sac17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,670,125 - 50,670,276UniSTSGRCm38
MGSCv371150,483,627 - 50,483,778UniSTSGRCm37
Celera1155,231,256 - 55,231,407UniSTS
Cytogenetic Map11B1.3UniSTS
18.MMHAP75FRF9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,682,283 - 50,682,445UniSTSGRCm38
MGSCv371150,495,785 - 50,495,947UniSTSGRCm37
Celera1155,243,413 - 55,243,575UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11693.13UniSTS
D11Sac18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,740,370 - 50,740,486UniSTSGRCm38
MGSCv371150,553,872 - 50,553,988UniSTSGRCm37
Celera1155,301,857 - 55,301,973UniSTS
Cytogenetic Map11B1.3UniSTS
D11Sac19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,655,480 - 50,655,730UniSTSGRCm38
MGSCv371150,468,982 - 50,469,232UniSTSGRCm37
Celera1155,216,566 - 55,216,816UniSTS
Cytogenetic Map11B1.3UniSTS
D11Sac9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,672,419 - 50,672,589UniSTSGRCm38
MGSCv371150,485,921 - 50,486,091UniSTSGRCm37
Celera1155,233,550 - 55,233,720UniSTS
Cytogenetic Map11B1.3UniSTS
Adamts2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,603,305 - 50,603,602UniSTSGRCm38
Celera1155,164,043 - 55,164,340UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1130.78UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000040523   ⟹   ENSMUSP00000040171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,492,911 - 50,698,400 (+)Ensembl
GRCm38.p6 Ensembl1150,602,084 - 50,807,573 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,667,006 - 50,667,842 (+)Ensembl
GRCm38.p6 Ensembl1150,776,179 - 50,777,015 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127534
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,672,597 - 50,673,625 (+)Ensembl
GRCm38.p6 Ensembl1150,781,770 - 50,782,798 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142118   ⟹   ENSMUSP00000159176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,492,911 - 50,689,173 (+)Ensembl
GRCm38.p6 Ensembl1150,602,084 - 50,798,346 (+)Ensembl
RefSeq Acc Id: NM_175643   ⟹   NP_783574
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,492,912 - 50,698,400 (+)NCBI
GRCm381150,602,085 - 50,807,573 (+)NCBI
MGSCv371150,415,587 - 50,617,551 (+)RGD
Celera1155,162,823 - 55,369,680 (+)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_783574   ⟸   NM_175643
- Peptide Label: preproprotein
- UniProtKB: Q8C9W3 (UniProtKB/Swiss-Prot),   A0A5F8MPY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040171   ⟸   ENSMUST00000040523
RefSeq Acc Id: ENSMUSP00000159176   ⟸   ENSMUST00000142118
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C9W3-F1-model_v2 AlphaFold Q8C9W3 1-1213 view protein structure

Promoters
RGD ID:6820288
Promoter ID:MM_KWN:7254
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000012439
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,415,481 - 50,415,981 (+)MPROMDB
RGD ID:8674516
Promoter ID:EPDNEW_M15289
Type:initiation region
Name:Adamts2_1
Description:Mus musculus a disintegrin-like and metallopeptidase with thrombospondintype 1 motif, 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15290  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381150,602,088 - 50,602,148EPDNEW
RGD ID:8674518
Promoter ID:EPDNEW_M15290
Type:multiple initiation site
Name:Adamts2_2
Description:Mus musculus a disintegrin-like and metallopeptidase with thrombospondintype 1 motif, 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15289  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381150,603,398 - 50,603,458EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347356 AgrOrtholog
Ensembl Genes ENSMUSG00000036545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040523 ENTREZGENE
  ENSMUST00000040523.9 UniProtKB/Swiss-Prot
  ENSMUST00000142118.3 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAC UniProtKB/Swiss-Prot
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:216725 UniProtKB/Swiss-Prot
MGD MGI:1347356 ENTREZGENE
NCBI Gene 216725 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adamts2 PhenoGen
PRINTS ADAMTS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAC UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F8MPY1 ENTREZGENE, UniProtKB/TrEMBL
  ATS2_MOUSE UniProtKB/Swiss-Prot
  Q1LZL1_MOUSE UniProtKB/TrEMBL
  Q5DTQ6_MOUSE UniProtKB/TrEMBL
  Q8C9W3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Adamts2  ADAM metallopeptidase with thrombospondin type 1 motif 2  Adamts2  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2  Symbol and/or name change 5135510 APPROVED