Cd68 (CD68 antigen) - Rat Genome Database

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Gene: Cd68 (CD68 antigen) Mus musculus
Analyze
Symbol: Cd68
Name: CD68 antigen
RGD ID: 1314317
MGI Page MGI
Description: Involved in several processes, including cellular response to lipopolysaccharide; cellular response to oxidised low-density lipoprotein particle stimulus; and negative regulation of dendritic cell antigen processing and presentation. Acts upstream of or within cellular response to organic substance. Located in lysosome and plasma membrane. Is expressed in several structures, including central nervous system; heart blood vessel; liver; spleen; and tooth. Orthologous to human CD68 (CD68 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gp11; gp110; La; Lamp4; ma; macrosialin; Sca; Scard1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,555,039 - 69,556,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,555,039 - 69,556,979 (-)EnsemblGRCm39 Ensembl
GRCm381169,664,213 - 69,666,170 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,664,213 - 69,666,153 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,477,873 - 69,479,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,248,478 - 70,250,169 (-)NCBIMGSCv36mm8
MGSCv361169,480,566 - 69,482,257 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetamide  (ISO)
adenine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alternariol  (ISO)
amitrole  (ISO)
amlexanox  (EXP)
antimycin A  (EXP)
antirheumatic drug  (ISO)
argatroban  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
asbestos  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromodichloromethane  (EXP)
buspirone  (ISO)
butanal  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium dichloride  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
chromium atom  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
cobalt dichloride  (ISO)
conjugated linoleic acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP)
Cuprizon  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diethylstilbestrol  (EXP)
dimethyl fumarate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (EXP)
fenamidone  (EXP)
fenitrothion  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fragrance  (ISO)
fructose  (EXP,ISO)
gadolinium trichloride  (EXP,ISO)
genistein  (EXP)
gentamycin  (ISO)
Gingerenone A  (EXP)
GW 4064  (EXP)
hexadecanoic acid  (EXP)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
iron dichloride  (ISO)
kainic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (EXP)
mechlorethamine  (ISO)
mercaptopurine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
N(4)-hydroxycytidine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nifuroxazide  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
nonanedioic acid  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perindopril  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propionic acid  (ISO)
propofol  (ISO)
prostaglandin E2  (EXP)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
retinoic acid receptor antagonist  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trans-caffeic acid  (EXP)
tributylstannane  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valsartan  (ISO)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma. Azambuja D, etal., Ann Oncol. 2012 Mar;23(3):736-742. doi: 10.1093/annonc/mdr157. Epub 2011 May 20.
2. Comparative quantitative analysis of macrophage populations defined by CD68 and carbohydrate antigens in normal and pathologically altered human liver tissue. Baldus SE, etal., Anal Cell Pathol. 1998;16(3):141-50. doi: 10.1155/1998/192975.
3. Impact of opiate addiction on neuroinflammation in HIV. Byrd D, etal., J Neurovirol. 2012 Oct;18(5):364-73. doi: 10.1007/s13365-012-0118-x. Epub 2012 Jul 14.
4. HIV-1 expression protects macrophages and microglia from apoptotic death. Cosenza MA, etal., Neuropathol Appl Neurobiol. 2004 Oct;30(5):478-90. doi: 10.1111/j.1365-2990.2004.00563.x.
5. Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome. Greaves P, etal., J Clin Oncol. 2013 Jan 10;31(2):256-62. doi: 10.1200/JCO.2011.39.9881. Epub 2012 Oct 8.
6. All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling. Hong K, etal., Immunol Lett. 2014 Nov;162(1 Pt A):34-40. doi: 10.1016/j.imlet.2014.06.011. Epub 2014 Jul 6.
7. Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma. Kamper P, etal., Haematologica. 2011 Feb;96(2):269-76. doi: 10.3324/haematol.2010.031542. Epub 2010 Nov 11.
8. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma. Komohara Y, etal., Cancer Sci. 2013 Jul;104(7):945-51. doi: 10.1111/cas.12167. Epub 2013 May 9.
10. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Intratumoral and peritumoral expression of CD68 and CD206 in hepatocellular carcinoma and their prognostic value. Ren CX, etal., Oncol Rep. 2017 Aug;38(2):886-898. doi: 10.3892/or.2017.5738. Epub 2017 Jun 21.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Gene expression of cell surface antigens in the early phase of murine influenza pneumonia determined by a cDNA expression array technique. Sakai S, etal., Mediators Inflamm. 2002 Dec;11(6):359-61. doi: 10.1080/0962935021000051557.
17. Macrophages and nerve fibres in peritoneal endometriosis. Tran LV, etal., Hum Reprod. 2009 Apr;24(4):835-41. doi: 10.1093/humrep/den483. Epub 2009 Jan 9.
18. Association of steroid use with complicated sigmoid diverticulitis: potential role of activated CD68+/CD163+ macrophages. von Rahden BH, etal., Langenbecks Arch Surg. 2011 Aug;396(6):759-68. doi: 10.1007/s00423-011-0797-4. Epub 2011 May 7.
19. Merkel cell carcinoma induces lymphatic microvessel formation. Werchau S, etal., J Am Acad Dermatol. 2012 Aug;67(2):215-25. doi: 10.1016/j.jaad.2011.09.002. Epub 2011 Nov 3.
20. Orchitis: a complication of severe acute respiratory syndrome (SARS). Xu J, etal., Biol Reprod. 2006 Feb;74(2):410-6. doi: 10.1095/biolreprod.105.044776. Epub 2005 Oct 19.
Additional References at PubMed
PMID:8486654   PMID:8889548   PMID:8962141   PMID:9479000   PMID:9653646   PMID:9790779   PMID:10349636   PMID:10524236   PMID:10577503   PMID:10862717   PMID:11005868   PMID:11042159  
PMID:11076861   PMID:12477932   PMID:12562841   PMID:14610273   PMID:15489334   PMID:15580571   PMID:15582152   PMID:15755524   PMID:15950722   PMID:16141072   PMID:16141073   PMID:16157452  
PMID:16344855   PMID:16428780   PMID:17062627   PMID:18480170   PMID:18497889   PMID:20208058   PMID:20431028   PMID:20805985   PMID:21267068   PMID:21308776   PMID:21339485   PMID:21572087  
PMID:21677750   PMID:21775686   PMID:21873635   PMID:21922246   PMID:21991369   PMID:22046273   PMID:22163030   PMID:22354871   PMID:22536403   PMID:22753134   PMID:22915101   PMID:23132945  
PMID:23518926   PMID:23843525   PMID:24912173   PMID:24952082   PMID:25352454   PMID:25395457   PMID:25753484   PMID:26216124   PMID:26438362   PMID:26549461   PMID:26745185   PMID:26988120  
PMID:27009605   PMID:27464987   PMID:27551151   PMID:27746173   PMID:27820699   PMID:27869795   PMID:28007893   PMID:28173622   PMID:28218627   PMID:28580280   PMID:28923684   PMID:29176738  
PMID:29285798   PMID:29804196   PMID:30252950   PMID:30409884   PMID:30647151   PMID:30799229   PMID:30818997   PMID:31235857   PMID:31404815   PMID:31695671   PMID:31712428   PMID:31924792  
PMID:32553121   PMID:33130914   PMID:33406432   PMID:33887203   PMID:34428430   PMID:35250464   PMID:35338195   PMID:35372333   PMID:35749158   PMID:35798848   PMID:35933009   PMID:36103829  
PMID:36139418   PMID:36207400   PMID:36451006   PMID:36473461   PMID:36718792   PMID:36965676   PMID:37118836   PMID:37610874   PMID:37669937   PMID:37883229   PMID:38101413  


Genomics

Comparative Map Data
Cd68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,555,039 - 69,556,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,555,039 - 69,556,979 (-)EnsemblGRCm39 Ensembl
GRCm381169,664,213 - 69,666,170 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,664,213 - 69,666,153 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,477,873 - 69,479,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,248,478 - 70,250,169 (-)NCBIMGSCv36mm8
MGSCv361169,480,566 - 69,482,257 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
CD68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,579,638 - 7,582,111 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,579,491 - 7,582,111 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,482,956 - 7,485,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,423,529 - 7,426,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,423,707 - 7,426,150NCBI
Celera177,509,128 - 7,511,752 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,376,970 - 7,379,593 (+)NCBIHuRef
CHM1_1177,491,734 - 7,494,362 (+)NCBICHM1_1
T2T-CHM13v2.0177,483,886 - 7,486,361 (+)NCBIT2T-CHM13v2.0
Cd68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,880,562 - 54,882,441 (-)NCBIGRCr8
mRatBN7.21054,381,814 - 54,383,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,381,815 - 54,383,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,044,451 - 59,046,330 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,533,003 - 58,534,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,040,608 - 54,042,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,268,726 - 56,270,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,268,720 - 56,270,640 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,014,364 - 56,016,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,481,701 - 56,483,580 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,495,323 - 56,497,228 (-)NCBI
Celera1053,536,351 - 53,538,212 (-)NCBICelera
Cytogenetic Map10q24NCBI
Cd68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,341,364 - 9,343,836 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,340,490 - 9,343,912 (-)NCBIChiLan1.0ChiLan1.0
CD68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,174,231 - 15,176,798 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,140,359 - 17,142,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,610,725 - 7,613,696 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,596,995 - 7,599,981 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,596,947 - 7,599,981 (+)Ensemblpanpan1.1panPan2
CD68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,500,899 - 32,503,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,501,380 - 32,503,183 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,640,582 - 32,642,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,606,269 - 32,608,583 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,606,541 - 32,608,348 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,573,887 - 32,576,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,530,349 - 32,532,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,709,456 - 32,711,701 (+)NCBIUU_Cfam_GSD_1.0
Cd68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,384,190 - 47,386,943 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936595858,289 - 861,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,874,785 - 52,877,695 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,874,754 - 52,877,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,296,987 - 55,299,491 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,956,633 - 6,959,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,957,212 - 6,959,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,448,764 - 14,451,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,195,337 - 10,197,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd68
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:176
Interacting mature miRNAs:200
Transcripts:ENSMUST00000018918, ENSMUST00000108654, ENSMUST00000154124
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse

Markers in Region
PMC228408P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,665,257 - 69,665,331UniSTSGRCm38
MGSCv371169,478,759 - 69,478,833UniSTSGRCm37
Cytogenetic Map11B3UniSTS
cM Map1139.0UniSTS
PMC27130P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,665,039 - 69,665,275UniSTSGRCm38
MGSCv371169,478,541 - 69,478,777UniSTSGRCm37
Cytogenetic Map11B3UniSTS
cM Map1139.0UniSTS
PMC136595P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,664,456 - 69,665,340UniSTSGRCm38
MGSCv371169,477,958 - 69,478,842UniSTSGRCm37
Cytogenetic Map11B3UniSTS
cM Map1139.0UniSTS
PMC296995P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,664,459 - 69,665,079UniSTSGRCm38
MGSCv371169,477,961 - 69,478,581UniSTSGRCm37
Cytogenetic Map11B3UniSTS
cM Map1139.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000018918   ⟹   ENSMUSP00000018918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,555,039 - 69,556,979 (-)Ensembl
GRCm38.p6 Ensembl1169,664,213 - 69,666,153 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108654   ⟹   ENSMUSP00000104294
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,555,197 - 69,556,888 (-)Ensembl
GRCm38.p6 Ensembl1169,664,371 - 69,666,062 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154124
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,555,132 - 69,556,888 (-)Ensembl
GRCm38.p6 Ensembl1169,664,306 - 69,666,062 (-)Ensembl
RefSeq Acc Id: NM_001291058   ⟹   NP_001277987
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,555,039 - 69,556,996 (-)NCBI
GRCm381169,664,213 - 69,666,170 (-)NCBI
Sequence:
RefSeq Acc Id: NR_110993
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,555,039 - 69,556,996 (-)NCBI
GRCm381169,664,213 - 69,666,170 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001277987   ⟸   NM_001291058
- Peptide Label: precursor
- UniProtKB: Q5F2A8 (UniProtKB/Swiss-Prot),   Q3S4A9 (UniProtKB/Swiss-Prot),   O70321 (UniProtKB/Swiss-Prot),   O54688 (UniProtKB/Swiss-Prot),   Q9DD15 (UniProtKB/Swiss-Prot),   P31996 (UniProtKB/Swiss-Prot),   A0A0R4J1C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000104294   ⟸   ENSMUST00000108654
RefSeq Acc Id: ENSMUSP00000018918   ⟸   ENSMUST00000018918
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31996-F1-model_v2 AlphaFold P31996 1-326 view protein structure

Promoters
RGD ID:6820596
Promoter ID:MM_KWN:8098
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000018918,   ENSMUST00000108654,   OTTMUST00000013439
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,479,196 - 69,480,477 (-)MPROMDB
RGD ID:8675198
Promoter ID:EPDNEW_M15630
Type:initiation region
Name:Cd68_1
Description:Mus musculus CD68 antigen , transcript variant 2, non-codingRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,666,091 - 69,666,151EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88342 AgrOrtholog
Ensembl Genes ENSMUSG00000018774 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018918 ENTREZGENE
  ENSMUST00000018918.12 UniProtKB/Swiss-Prot
  ENSMUST00000108654.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Lamp2-like_luminal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lysosome-assoc_membr_glycop UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12514 UniProtKB/Swiss-Prot
MGD MGI:88342 ENTREZGENE
NCBI Gene 12514 ENTREZGENE
PANTHER MACROSIALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lamp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd68 PhenoGen
PRINTS LYSASSOCTDMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LAMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1C8 ENTREZGENE, UniProtKB/TrEMBL
  CD68_MOUSE UniProtKB/Swiss-Prot
  O54688 ENTREZGENE
  O70321 ENTREZGENE
  P31996 ENTREZGENE
  Q3S4A9 ENTREZGENE
  Q5F2A8 ENTREZGENE
  Q9DD15 ENTREZGENE
UniProt Secondary O54688 UniProtKB/Swiss-Prot
  O70321 UniProtKB/Swiss-Prot
  Q3S4A9 UniProtKB/Swiss-Prot
  Q5F2A8 UniProtKB/Swiss-Prot
  Q9DD15 UniProtKB/Swiss-Prot