Neu3 (neuraminidase 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Neu3 (neuraminidase 3) Mus musculus
Analyze
Symbol: Neu3
Name: neuraminidase 3
RGD ID: 734190
MGI Page MGI
Description: Exhibits exo-alpha-(2->3)-sialidase activity. Involved in ganglioside catabolic process. Localizes to early endosome membrane; external side of plasma membrane; and recycling endosome membrane. Is expressed in brain. Orthologous to human NEU3 (neuraminidase 3); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-diaminodiphenylmethane; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ganglioside sialidase; membrane sialidase; N-acetyl-alpha-neuraminidase 3; Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3); sialidase-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,460,641 - 99,477,660 (-)NCBIGRCm39mm39
GRCm39 Ensembl799,460,646 - 99,477,624 (-)Ensembl
GRCm38799,811,434 - 99,828,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,811,439 - 99,828,417 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,959,949 - 106,976,927 (-)NCBIGRCm37mm9NCBIm37
MGSCv36799,685,522 - 99,702,500 (-)NCBImm8
Celera7100,136,642 - 100,153,663 (-)NCBICelera
Cytogenetic Map7E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10713120   PMID:11042159   PMID:11076861   PMID:11696012   PMID:12477932   PMID:12730204   PMID:14970224   PMID:16141072   PMID:16141073   PMID:16618389   PMID:16765317  
PMID:17176265   PMID:17382908   PMID:17708748   PMID:17883393   PMID:18155174   PMID:18799693   PMID:18945680   PMID:19215228   PMID:19506080   PMID:21089368   PMID:21677750   PMID:21873635  
PMID:22552967   PMID:22815940   PMID:22989879   PMID:23209287   PMID:24925219   PMID:26022181   PMID:28442549   PMID:28974375   PMID:29039925   PMID:29271120   PMID:29357434   PMID:30308156  
PMID:30359429   PMID:31617733   PMID:32251344   PMID:33039353  


Genomics

Comparative Map Data
Neu3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,460,641 - 99,477,660 (-)NCBIGRCm39mm39
GRCm39 Ensembl799,460,646 - 99,477,624 (-)Ensembl
GRCm38799,811,434 - 99,828,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,811,439 - 99,828,417 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,959,949 - 106,976,927 (-)NCBIGRCm37mm9NCBIm37
MGSCv36799,685,522 - 99,702,500 (-)NCBImm8
Celera7100,136,642 - 100,153,663 (-)NCBICelera
Cytogenetic Map7E1NCBI
NEU3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1174,988,279 - 75,018,893 (+)EnsemblGRCh38hg38GRCh38
GRCh381174,988,644 - 75,010,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371174,699,689 - 74,721,952 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,377,598 - 74,396,391 (+)NCBINCBI36hg18NCBI36
Build 341174,376,826 - 74,396,389NCBI
Celera1172,006,517 - 72,025,314 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1170,996,749 - 71,016,487 (+)NCBIHuRef
CHM1_11174,583,347 - 74,602,139 (+)NCBICHM1_1
Neu3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21154,137,732 - 154,148,879 (-)NCBI
Rnor_6.0 Ensembl1164,803,574 - 164,814,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01164,803,574 - 164,814,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01171,006,216 - 171,017,255 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,172,027 - 157,183,064 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11157,250,432 - 157,261,470 (-)NCBI
Celera1152,223,019 - 152,234,091 (-)NCBICelera
Cytogenetic Map1q32NCBI
Neu3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,788,171 - 16,798,535 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,783,996 - 16,798,368 (-)NCBIChiLan1.0ChiLan1.0
NEU3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11173,353,332 - 73,373,270 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1173,353,332 - 73,373,270 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01170,047,878 - 70,070,303 (+)NCBIMhudiblu_PPA_v0panPan3
NEU3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,456,424 - 23,484,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2123,213,985 - 23,250,034 (-)NCBI
ROS_Cfam_1.02123,651,315 - 23,687,393 (-)NCBI
UMICH_Zoey_3.12123,449,567 - 23,485,563 (-)NCBI
UNSW_CanFamBas_1.02123,646,010 - 23,682,029 (-)NCBI
UU_Cfam_GSD_1.02123,563,652 - 23,599,693 (-)NCBI
Neu3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,297,867 - 62,315,348 (+)NCBI
SpeTri2.0NW_0049364983,897,511 - 3,915,013 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEU3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,315,301 - 9,334,918 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,315,263 - 9,333,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,407,329 - 10,423,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEU3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,220,472 - 66,243,163 (+)NCBI
Neu3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248172,107,893 - 2,133,626 (-)NCBI

Position Markers
Neu3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,813,869 - 99,814,290UniSTSGRCm38
MGSCv377106,962,379 - 106,962,800UniSTSGRCm37
Celera7100,139,072 - 100,139,493UniSTS
Cytogenetic Map7F1UniSTS
cM Map7 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)766139778100139778Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)766139778100139778Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767640886101641032Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767640886101641032Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767640886101641032Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768716387102716494Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:616
Count of miRNA genes:393
Interacting mature miRNAs:462
Transcripts:ENSMUST00000036331
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036331   ⟹   ENSMUSP00000045222
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl799,811,439 - 99,828,417 (-)Ensembl
RefSeq Acc Id: NM_016720   ⟹   NP_057929
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39799,460,646 - 99,477,624 (-)NCBI
GRCm38799,811,439 - 99,828,417 (-)NCBI
MGSCv377106,959,949 - 106,976,927 (-)RGD
Celera7100,136,642 - 100,153,663 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030242761   ⟹   XP_030098621
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39799,460,641 - 99,477,660 (-)NCBI
GRCm38799,811,434 - 99,828,457 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057929   ⟸   NM_016720
- UniProtKB: Q9JMH7 (UniProtKB/Swiss-Prot),   Q543I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030098621   ⟸   XM_030242761
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000045222   ⟸   ENSMUST00000036331
Protein Domains
Sialidase

Promoters
RGD ID:8664893
Promoter ID:EPDNEW_M10478
Type:initiation region
Name:Neu3_1
Description:Mus musculus neuraminidase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38799,828,358 - 99,828,418EPDNEW
RGD ID:6841630
Promoter ID:MM_KWN:51688
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_016720
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367106,976,559 - 106,977,059 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1355305 AgrOrtholog
Ensembl Genes ENSMUSG00000035239 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000045222 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036331 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Sialidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialidase-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialidase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1355305 ENTREZGENE
NCBI Gene 50877 ENTREZGENE
PANTHER PTHR10628 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10628:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BNR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Neu3 PhenoGen
Superfamily-SCOP SSF50939 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NEUR3_MOUSE UniProtKB/Swiss-Prot
  Q543I9 ENTREZGENE, UniProtKB/TrEMBL
  Q9JMH7 ENTREZGENE