Ifitm3 (interferon induced transmembrane protein 3) - Rat Genome Database

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Gene: Ifitm3 (interferon induced transmembrane protein 3) Mus musculus
Analyze
Symbol: Ifitm3
Name: interferon induced transmembrane protein 3
RGD ID: 1557912
MGI Page MGI
Description: Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to symbiont; negative regulation of cell population proliferation; and receptor-mediated endocytosis. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including egg cylinder; embryo ectoderm; genitourinary system; gut; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM3 (interferon induced transmembrane protein 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1110004C05Rik; Cd225; Cdw217; dispanin subfamily A member 2b; DSPA2b; Fg; Fgls; fr; fragilis; ifitm-like protein 1; interferon-induced transmembrane protein 3; interferon-inducible protein 15; IP; IP15; mil; mil-1
RGD Orthologs
Human
Rat
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,589,503 - 140,590,657 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,589,499 - 140,590,683 (-)EnsemblGRCm39 Ensembl
GRCm387141,009,590 - 141,010,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,009,586 - 141,010,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,195,489 - 148,196,643 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,860,910 - 140,862,064 (-)NCBIMGSCv36mm8
Celera7140,802,289 - 140,803,443 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
Cuprizon  (ISO)
cypermethrin  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
dieldrin  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
fenthion  (EXP)
finasteride  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
genistein  (EXP,ISO)
glafenine  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
metformin  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
prothioconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
7. Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019. Zhang Y, etal., J Infect Dis. 2020 Jun 16;222(1):34-37. doi: 10.1093/infdis/jiaa224.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12124616   PMID:12477932   PMID:12659663   PMID:14511483   PMID:14516695   PMID:14610273   PMID:15184081  
PMID:15254899   PMID:15289457   PMID:15666347   PMID:15937476   PMID:16141072   PMID:16141073   PMID:16326387   PMID:16395393   PMID:16602821   PMID:16887830   PMID:16950123   PMID:17035243  
PMID:17369397   PMID:18184919   PMID:18287559   PMID:18505827   PMID:18799693   PMID:19371732   PMID:20016822   PMID:20064371   PMID:20845430   PMID:21056461   PMID:21253575   PMID:21267068  
PMID:21531817   PMID:21731673   PMID:21873635   PMID:22446628   PMID:22467717   PMID:22511783   PMID:22960234   PMID:22969429   PMID:22993855   PMID:23354485   PMID:23382131   PMID:23469192  
PMID:23639725   PMID:24067232   PMID:24212590   PMID:24268777   PMID:24278312   PMID:24627473   PMID:25265877   PMID:25738301   PMID:25810472   PMID:26256211   PMID:26792178   PMID:27113764  
PMID:27268505   PMID:27384652   PMID:27435625   PMID:27440901   PMID:28240600   PMID:28246125   PMID:28535371   PMID:28594571   PMID:28612841   PMID:28880886   PMID:29281729   PMID:29356071  
PMID:30348171   PMID:30365177   PMID:30416070   PMID:30550785   PMID:30650117   PMID:30973865   PMID:31242426   PMID:31451661   PMID:31731106   PMID:32321380   PMID:32553073   PMID:32554809  
PMID:32879487   PMID:33149299   PMID:33706013   PMID:33882122   PMID:34404769   PMID:36108743   PMID:36194487   PMID:36880581   PMID:37162420   PMID:37196079   PMID:38167862   PMID:38226173  
PMID:38355793   PMID:39477971  


Genomics

Comparative Map Data
Ifitm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,589,503 - 140,590,657 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,589,499 - 140,590,683 (-)EnsemblGRCm39 Ensembl
GRCm387141,009,590 - 141,010,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,009,586 - 141,010,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,195,489 - 148,196,643 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,860,910 - 140,862,064 (-)NCBIMGSCv36mm8
Celera7140,802,289 - 140,803,443 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.25NCBI
IFITM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811319,676 - 320,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11319,676 - 329,475 (-)EnsemblGRCh38hg38GRCh38
GRCh3711319,676 - 320,860 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611309,673 - 310,914 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411309,668 - 311,050NCBI
Cytogenetic Map11p15.5NCBI
HuRef11137,979 - 139,220 (-)NCBIHuRef
CHM1_111318,636 - 319,877 (-)NCBICHM1_1
T2T-CHM13v2.011360,910 - 362,094 (-)NCBIT2T-CHM13v2.0
Ifitm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,540,649 - 205,541,758 (-)NCBIGRCr8
mRatBN7.21196,111,026 - 196,112,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,111,043 - 196,112,203 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,456,782 - 204,457,903 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,583,367 - 211,584,488 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,257,495 - 204,258,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,810,712 - 213,811,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,810,696 - 213,811,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,730,715 - 220,731,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,198,659 - 201,199,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1193,745,524 - 193,746,633 (-)NCBICelera
Cytogenetic Map1q41NCBI
LOC103238550
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,228 - 148,078 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,176,566 - 97,188,322 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:205
Interacting mature miRNAs:210
Transcripts:ENSMUST00000026565
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
Fgls-pending  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,009,696 - 141,010,682UniSTSGRCm38
MGSCv377148,195,595 - 148,196,581UniSTSGRCm37
Celera7140,802,395 - 140,803,381UniSTS
Cytogenetic Map7F5UniSTS
cM Map7 UniSTS
PMC208779P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,009,687 - 141,010,662UniSTSGRCm38
MGSCv377148,195,586 - 148,196,561UniSTSGRCm37
Celera7140,802,386 - 140,803,361UniSTS
Cytogenetic Map7F5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000026565   ⟹   ENSMUSP00000026565
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,589,499 - 140,590,683 (-)Ensembl
GRCm38.p6 Ensembl7141,009,586 - 141,010,770 (-)Ensembl
RefSeq Acc Id: NM_025378   ⟹   NP_079654
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,589,503 - 140,590,657 (-)NCBI
GRCm387141,009,590 - 141,010,744 (-)ENTREZGENE
MGSCv377148,195,489 - 148,196,643 (-)RGD
Celera7140,802,289 - 140,803,443 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079654   ⟸   NM_025378
- UniProtKB: Q9D8L6 (UniProtKB/Swiss-Prot),   Q9CQW9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000026565   ⟸   ENSMUST00000026565

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQW9-F1-model_v2 AlphaFold Q9CQW9 1-137 view protein structure

Promoters
RGD ID:8666053
Promoter ID:EPDNEW_M11058
Type:initiation region
Name:Ifitm3_1
Description:Mus musculus interferon induced transmembrane protein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,010,699 - 141,010,759EPDNEW
RGD ID:6841316
Promoter ID:MM_KWN:53208
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_025378
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,196,446 - 148,197,437 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913391 AgrOrtholog
Ensembl Genes ENSMUSG00000025492 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026565 ENTREZGENE
  ENSMUST00000026565.7 UniProtKB/Swiss-Prot
InterPro CD225/Dispanin_fam UniProtKB/Swiss-Prot
  IFITM_antiviral_protein UniProtKB/Swiss-Prot
KEGG Report mmu:66141 UniProtKB/Swiss-Prot
MGD MGI:1913391 ENTREZGENE
NCBI Gene 66141 ENTREZGENE
PANTHER INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN UniProtKB/Swiss-Prot
  INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3 UniProtKB/Swiss-Prot
Pfam CD225 UniProtKB/Swiss-Prot
PhenoGen Ifitm3 PhenoGen
UniProt IFM3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9D8L6 ENTREZGENE
UniProt Secondary Q9D8L6 UniProtKB/Swiss-Prot