Eomes (eomesodermin) - Rat Genome Database

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Gene: Eomes (eomesodermin) Mus musculus
Analyze
Symbol: Eomes
Name: eomesodermin
RGD ID: 1552408
MGI Page MGI
Description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and chromatin DNA binding activity. Involved in several processes, including gastrulation; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including endodermal cell fate specification; nervous system development; and trophectodermal cell differentiation. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; gonad; limb; and limb bud. Orthologous to human EOMES (eomesodermin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C77258; eomesodermin homolog; T-box brain protein 2; T-brain-2; Tbr; TBR-2; Tbr2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,307,259 - 118,315,176 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,307,280 - 118,315,200 (+)EnsemblGRCm39 Ensembl
GRCm389118,478,186 - 118,486,132 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9118,478,212 - 118,486,132 (+)EnsemblGRCm38mm10GRCm38
MGSCv379118,387,307 - 118,395,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369118,327,042 - 118,334,830 (+)NCBIMGSCv36mm8
Celera9118,948,428 - 118,956,371 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map970.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
acetic acid  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromochloroacetic acid  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
Citreoviridin  (EXP)
Cuprizon  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (ISO)
hexachlorophene  (EXP)
iron dichloride  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
Monobutylphthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
staurosporine  (ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (ISO)
tributylstannane  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IDA)
nucleoplasm  (TAS)
nucleus  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amniotic cavity morphology  (IAGP)
abnormal anterior primitive streak morphology  (IAGP)
abnormal anterior visceral endoderm cell migration  (IAGP)
abnormal axon guidance  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal germ layer development  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interleukin level  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal NK cell differentiation  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent anterior commissure  (IAGP)
absent mesoderm  (IAGP)
absent primitive node  (IAGP)
absent trophectoderm  (IAGP)
absent trophoblast giant cells  (IAGP)
decreased bone mineral content  (IEA)
decreased brain size  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating creatinine level  (IEA)
decreased grip strength  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased lean body mass  (IEA)
decreased memory T cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased retina ganglion cell number  (IAGP)
disorganized embryonic tissue  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality between implantation and placentation  (IAGP)
embryonic lethality between implantation and placentation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic-extraembryonic boundary constriction  (IAGP)
enlarged floor plate  (IAGP)
failure of embryo implantation  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
increased aggression towards humans  (IAGP)
increased aggression towards mice  (IAGP)
increased exploration in new environment  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased neutrophil cell number  (IAGP)
increased retina apoptosis  (IAGP)
increased somite number  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased total body fat amount  (IEA)
increased tumor incidence  (IAGP)
no abnormal phenotype detected  (IAGP)
prenatal lethality  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rostral body truncation  (IAGP)
rostral-caudal axis duplication  (IAGP)
small olfactory bulb  (IAGP)
thin cerebral cortex  (IAGP)
thin retina ganglion layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Nodal signalling in the epiblast patterns the early mouse embryo. Brennan J, etal., Nature 2001 Jun 21;411(6840):965-9.
2. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Kimura N, etal., Brain Res Dev Brain Res 1999 Jun 2;115(2):183-93.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Russ AP, etal., Nature 2000 Mar 2;404(6773):95-9.
12. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. Saba-El-Leil MK, etal., EMBO Rep 2003 Oct;4(10):964-8. Epub 2003 Sep 19.
13. Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells. Shier P, etal., Immunogenetics 2000 Aug;51(10):771-8.
14. Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. Ueno M, etal., Gene 2000 Aug 22;254(1-2):29-35.
Additional References at PubMed
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PMID:26802325   PMID:26814967   PMID:26830346   PMID:26856890   PMID:26903504   PMID:26921468   PMID:26939553   PMID:26961948   PMID:26962139   PMID:27005988   PMID:27037025   PMID:27067865  
PMID:27111087   PMID:27117402   PMID:27142930   PMID:27144456   PMID:27156386   PMID:27171262   PMID:27178193   PMID:27183623   PMID:27210758   PMID:27214567   PMID:27217206   PMID:27256596  
PMID:27282384   PMID:27307230   PMID:27320921   PMID:27385014   PMID:27390776   PMID:27392482   PMID:27425845   PMID:27445154   PMID:27452274   PMID:27476503   PMID:27496734   PMID:27504805  
PMID:27510895   PMID:27523618   PMID:27562601   PMID:27565344   PMID:27581449   PMID:27586544   PMID:27599295   PMID:27600842   PMID:27618312   PMID:27620979   PMID:27626380   PMID:27664421  
PMID:27705792   PMID:27707753   PMID:27717094   PMID:27742544   PMID:27760115   PMID:27760310   PMID:27780844   PMID:27789627   PMID:27791111   PMID:27798144   PMID:27798843   PMID:27806305  
PMID:27845622   PMID:27848932   PMID:27871306   PMID:27955690   PMID:27965054   PMID:27965439   PMID:27974163   PMID:27982126   PMID:27993979   PMID:27993981   PMID:28041877   PMID:28049832  
PMID:28069738   PMID:28123024   PMID:28174238   PMID:28232627   PMID:28272472   PMID:28276603   PMID:28288114   PMID:28299779   PMID:28322231   PMID:28386934   PMID:28401892   PMID:28450263  
PMID:28462915   PMID:28467430   PMID:28475893   PMID:28482867   PMID:28494873   PMID:28506990   PMID:28514662   PMID:28550044   PMID:28552558   PMID:28584103   PMID:28595361   PMID:28619992  
PMID:28646547   PMID:28655839   PMID:28663132   PMID:28670268   PMID:28671691   PMID:28674667   PMID:28698286   PMID:28728023   PMID:28737488   PMID:28738016   PMID:28759001   PMID:28768199  
PMID:28781964   PMID:28790015   PMID:28790189   PMID:28794184   PMID:28805812   PMID:28808228   PMID:28814327   PMID:28816361   PMID:28839193   PMID:28874785   PMID:28892064   PMID:28914974  
PMID:28916710   PMID:28924369   PMID:28935707   PMID:28939666   PMID:28945921   PMID:28965759   PMID:28981589   PMID:28994651   PMID:29021239   PMID:29045729   PMID:29053761   PMID:29056343  
PMID:29078390   PMID:29082311   PMID:29086765   PMID:29088697   PMID:29132503   PMID:29168693   PMID:29180410   PMID:29241535   PMID:29271784   PMID:29294103   PMID:29305158   PMID:29311744  
PMID:29317485   PMID:29335608   PMID:29351579   PMID:29420689   PMID:29424438   PMID:29436413   PMID:29440505   PMID:29462287   PMID:29474907   PMID:29507213   PMID:29526762   PMID:29530878  
PMID:29537098   PMID:29551674   PMID:29570951   PMID:29587143   PMID:29659809   PMID:29698519   PMID:29748916   PMID:29751817   PMID:29779941   PMID:29855337   PMID:29867343   PMID:29868845  
PMID:29869132   PMID:29884675   PMID:29894691   PMID:29899142   PMID:29900695   PMID:29901792   PMID:29915126   PMID:29939162   PMID:29961574   PMID:30006548   PMID:30037926   PMID:30044992  
PMID:30065628   PMID:30084950   PMID:30093551   PMID:30093555   PMID:30134160   PMID:30143575   PMID:30144030   PMID:30174314   PMID:30186101   PMID:30201687   PMID:30208054   PMID:30210296  
PMID:30217810   PMID:30224493   PMID:30240734   PMID:30260951   PMID:30264295   PMID:30266827   PMID:30304535   PMID:30315415   PMID:30329130   PMID:30332643   PMID:30344048   PMID:30361413  
PMID:30374017   PMID:30392794   PMID:30449657   PMID:30521606   PMID:30523785   PMID:30529950   PMID:30560934   PMID:30566428   PMID:30578296   PMID:30597194   PMID:30619337   PMID:30626697  
PMID:30635555   PMID:30659230   PMID:30668728   PMID:30677129   PMID:30692224   PMID:30705426   PMID:30709655   PMID:30796806   PMID:30842446   PMID:30843579   PMID:30858607   PMID:30864157  
PMID:30894800   PMID:30914320   PMID:31018127   PMID:31043608   PMID:31044175   PMID:31064784   PMID:31080058   PMID:31086189   PMID:31097699   PMID:31116980   PMID:31149899   PMID:31175212  
PMID:31197172   PMID:31202705   PMID:31255486   PMID:31260508   PMID:31273213   PMID:31277925   PMID:31315048   PMID:31317506   PMID:31318893   PMID:31319858   PMID:31340148   PMID:31371378  
PMID:31386652   PMID:31393266   PMID:31396962   PMID:31399471   PMID:31415124   PMID:31421080   PMID:31462248   PMID:31477701   PMID:31488566   PMID:31504280   PMID:31515109   PMID:31569049  
PMID:31570595   PMID:31606264   PMID:31653921   PMID:31655624   PMID:31665628   PMID:31680852   PMID:31699896   PMID:31712428   PMID:31729356   PMID:31736464   PMID:31740755   PMID:31761722  
PMID:31792383   PMID:31794381   PMID:31794431   PMID:31794640   PMID:31801076   PMID:31806049   PMID:31810881   PMID:31816041   PMID:31816056   PMID:31845732   PMID:31845734   PMID:31871317  
PMID:31911949   PMID:31914388   PMID:31919497   PMID:31980168   PMID:32001437   PMID:32008040   PMID:32024956   PMID:32037591   PMID:32041791   PMID:32049024   PMID:32094111   PMID:32097653  
PMID:32098764   PMID:32103003   PMID:32103006   PMID:32115408   PMID:32140099   PMID:32170161   PMID:32182234   PMID:32186707   PMID:32228681   PMID:32234482   PMID:32238574   PMID:32238932  
PMID:32242005   PMID:32244352   PMID:32245946   PMID:32249816   PMID:32267063   PMID:32284593   PMID:32294449   PMID:32321712   PMID:32386572   PMID:32393787   PMID:32404061   PMID:32415109  
PMID:32424367   PMID:32433954   PMID:32439762   PMID:32474139   PMID:32484994   PMID:32492428   PMID:32493987   PMID:32499648   PMID:32541003   PMID:32708917   PMID:32734619   PMID:32737167  
PMID:32737294   PMID:32817053   PMID:32840212   PMID:32868797   PMID:32888487   PMID:32985705   PMID:32986815   PMID:32991634   PMID:32991667   PMID:33002559   PMID:33020269   PMID:33042990  
PMID:33053331   PMID:33073849   PMID:33116204   PMID:33116259   PMID:33127892   PMID:33199445   PMID:33200984   PMID:33203851   PMID:33220177   PMID:33304758   PMID:33309869   PMID:33324410  
PMID:33326788   PMID:33335032   PMID:33361812   PMID:33390832   PMID:33393905   PMID:33420489   PMID:33462115   PMID:33488348   PMID:33510165   PMID:33523829   PMID:33542216   PMID:33553191  
PMID:33579706   PMID:33591268   PMID:33594090   PMID:33597191   PMID:33602870   PMID:33622776   PMID:33626347   PMID:33627187   PMID:33649223   PMID:33711282   PMID:33723434   PMID:33731848  
PMID:33739968   PMID:33774122   PMID:33786818   PMID:33790322   PMID:33798452   PMID:33854232   PMID:33899739   PMID:33907211   PMID:33938018   PMID:33946570   PMID:33972181   PMID:33976153  
PMID:34013328   PMID:34031387   PMID:34046991   PMID:34059773   PMID:34107259   PMID:34133916   PMID:34163074   PMID:34170322   PMID:34183415   PMID:34184027   PMID:34235142   PMID:34237032  
PMID:34245014   PMID:34262022   PMID:34287339   PMID:34321664   PMID:34321999   PMID:34345913   PMID:34351428   PMID:34381067   PMID:34407390   PMID:34417257   PMID:34419458   PMID:34427181  
PMID:34431536   PMID:34437840   PMID:34462601   PMID:34469723   PMID:34518365   PMID:34521844   PMID:34524839   PMID:34550336   PMID:34587386   PMID:34614421   PMID:34616069   PMID:34616075  
PMID:34679163   PMID:34686326   PMID:34710087   PMID:34741805   PMID:34769078   PMID:34815315   PMID:34850819   PMID:34879283   PMID:34931379   PMID:34935271   PMID:34943873   PMID:34963132  
PMID:34986510   PMID:34996870   PMID:35013230   PMID:35020876   PMID:35089129   PMID:35090564   PMID:35110543   PMID:35132236   PMID:35135854   PMID:35159260   PMID:35171666   PMID:35245119  
PMID:35245678   PMID:35296538   PMID:35338093   PMID:35342336   PMID:35354032   PMID:35361248   PMID:35361962   PMID:35365601   PMID:35367368   PMID:35379703   PMID:35388219   PMID:35401124  
PMID:35440748   PMID:35470378   PMID:35538503   PMID:35575074   PMID:35585091   PMID:35604347   PMID:35613048   PMID:35613274   PMID:35649377   PMID:35666215   PMID:35690356   PMID:35700169  
PMID:35711069   PMID:35726782   PMID:35762573   PMID:35864088   PMID:35903551   PMID:35906071   PMID:35915089   PMID:35917186   PMID:35931079   PMID:35977029   PMID:35979738   PMID:35988542  
PMID:35998584   PMID:36017733   PMID:36029179   PMID:36039295   PMID:36051443   PMID:36067211   PMID:36078123   PMID:36095192   PMID:36103829   PMID:36127134   PMID:36131014   PMID:36131015  
PMID:36133924   PMID:36153792   PMID:36196585   PMID:36197846   PMID:36218069   PMID:36343267   PMID:36399562   PMID:36412518   PMID:36440275   PMID:36440598   PMID:36517595   PMID:36580919  
PMID:36596698   PMID:36604424   PMID:36756120   PMID:36764294   PMID:36768434   PMID:36796357   PMID:36806938   PMID:36843845   PMID:36917980   PMID:36933672   PMID:36989113   PMID:36993956  
PMID:37012455   PMID:37054704   PMID:37071993   PMID:37085665   PMID:37126314   PMID:37139782   PMID:37172586   PMID:37256750   PMID:37272771   PMID:37291945   PMID:37300483   PMID:37307441  
PMID:37321213   PMID:37348506   PMID:37360696   PMID:37416774   PMID:37524711   PMID:37540708   PMID:37543948   PMID:37553330   PMID:37553426   PMID:37590085   PMID:37612280   PMID:37633271  
PMID:37665322   PMID:37725078   PMID:37738575   PMID:37838801   PMID:37871215   PMID:37900274   PMID:38019816   PMID:38019906   PMID:38025769   PMID:38086370   PMID:38103552   PMID:38113263  
PMID:38157853   PMID:38197653   PMID:38199563   PMID:38288355   PMID:38306425   PMID:38321029   PMID:38324473   PMID:38355793   PMID:38374152   PMID:38383780   PMID:38386557   PMID:38402586  
PMID:38411929   PMID:38429579   PMID:38487272   PMID:38489388   PMID:38498715   PMID:38512724   PMID:38514807   PMID:38574132   PMID:38600346   PMID:38636614   PMID:38658571   PMID:38697111  
PMID:38713624   PMID:38772376   PMID:38781073   PMID:38808662   PMID:38912572   PMID:38960088   PMID:38961108   PMID:38971831   PMID:39010274   PMID:39037895   PMID:39047740   PMID:39095712  
PMID:39106860   PMID:39198421   PMID:39250533   PMID:39268037   PMID:39271675  


Genomics

Comparative Map Data
Eomes
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,307,259 - 118,315,176 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,307,280 - 118,315,200 (+)EnsemblGRCm39 Ensembl
GRCm389118,478,186 - 118,486,132 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9118,478,212 - 118,486,132 (+)EnsemblGRCm38mm10GRCm38
MGSCv379118,387,307 - 118,395,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369118,327,042 - 118,334,830 (+)NCBIMGSCv36mm8
Celera9118,948,428 - 118,956,371 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map970.21NCBI
EOMES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38327,715,953 - 27,722,713 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl327,715,949 - 27,722,711 (-)EnsemblGRCh38hg38GRCh38
GRCh37327,757,444 - 27,764,204 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36327,732,872 - 27,738,789 (-)NCBINCBI36Build 36hg18NCBI36
Build 34327,732,890 - 27,738,789NCBI
Celera327,694,279 - 27,700,196 (-)NCBICelera
Cytogenetic Map3p24.1NCBI
HuRef327,699,819 - 27,706,575 (-)NCBIHuRef
CHM1_1327,707,433 - 27,714,192 (-)NCBICHM1_1
T2T-CHM13v2.0327,718,036 - 27,724,801 (-)NCBIT2T-CHM13v2.0
Eomes
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,059,215 - 127,067,070 (+)NCBIGRCr8
mRatBN7.28118,181,340 - 118,189,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,181,777 - 118,188,316 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08127,144,367 - 127,152,618 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,144,903 - 127,151,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,369,713 - 126,375,233 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48123,376,689 - 123,383,451 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18123,398,873 - 123,402,528 (+)NCBI
Celera8117,369,438 - 117,374,985 (+)NCBICelera
Cytogenetic Map8q32NCBI
Eomes
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543019,281,602 - 19,286,867 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543019,280,460 - 19,287,060 (-)NCBIChiLan1.0ChiLan1.0
EOMES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2227,660,108 - 27,667,051 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1327,664,874 - 27,671,819 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0327,601,829 - 27,608,701 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1327,923,970 - 27,930,687 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl327,925,086 - 27,930,274 (-)Ensemblpanpan1.1panPan2
EOMES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12316,476,498 - 16,512,406 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2316,506,032 - 16,511,527 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2316,470,654 - 16,506,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02316,772,614 - 16,808,585 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2316,801,788 - 16,808,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12316,596,607 - 16,632,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02316,709,336 - 16,745,304 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02316,774,662 - 16,810,661 (+)NCBIUU_Cfam_GSD_1.0
Eomes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118185,687,397 - 185,694,575 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647318,825,942 - 18,833,179 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647318,825,969 - 18,833,179 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EOMES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1314,209,736 - 14,215,797 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11314,209,590 - 14,216,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21315,846,197 - 15,852,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EOMES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11572,257,626 - 72,264,563 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604145,447,831 - 45,454,607 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eomes
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247885,550,445 - 5,557,321 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247885,550,569 - 5,557,342 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eomes
290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:621
Count of miRNA genes:372
Interacting mature miRNAs:428
Transcripts:ENSMUST00000035020, ENSMUST00000111763, ENSMUST00000150633
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse

Markers in Region
Eomes  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv379118,390,426 - 118,391,205UniSTSGRCm37
Celera9118,951,547 - 118,952,326UniSTS
Cytogenetic Map9F3UniSTS
cM Map967.0UniSTS
cM Map967.0UniSTS
UniSTS:236277  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389118,485,323 - 118,485,549UniSTSGRCm38
MGSCv379118,394,441 - 118,394,667UniSTSGRCm37
Celera9118,955,562 - 118,955,788UniSTS
Cytogenetic Map9F3UniSTS
cM Map967.0UniSTS
RH126131  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389118,485,865 - 118,486,066UniSTSGRCm38
MGSCv379118,394,983 - 118,395,184UniSTSGRCm37
Celera9118,956,104 - 118,956,305UniSTS
Cytogenetic Map9F3UniSTS
cM Map967.0UniSTS
Whitehead/MRC_RH91163.94UniSTS
Eomes  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
Eomes  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
Eomes  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389118,481,308 - 118,482,087UniSTSGRCm38
MGSCv379118,390,426 - 118,391,205UniSTSGRCm37
Celera9118,951,547 - 118,952,326UniSTS
Cytogenetic Map9F3UniSTS
Eomes  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map967.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000035020   ⟹   ENSMUSP00000035020
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,307,412 - 118,315,200 (+)Ensembl
GRCm38.p6 Ensembl9118,478,344 - 118,486,132 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111763   ⟹   ENSMUSP00000107393
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,307,280 - 118,314,434 (+)Ensembl
GRCm38.p6 Ensembl9118,478,212 - 118,485,366 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150633   ⟹   ENSMUSP00000118079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,307,929 - 118,311,825 (+)Ensembl
GRCm38.p6 Ensembl9118,478,861 - 118,482,757 (+)Ensembl
RefSeq Acc Id: NM_001164789   ⟹   NP_001158261
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,307,259 - 118,315,176 (+)NCBI
GRCm389118,478,189 - 118,486,132 (+)NCBI
MGSCv379118,387,307 - 118,395,250 (+)RGD
Celera9118,948,428 - 118,956,371 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001411153   ⟹   NP_001398082
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,307,259 - 118,315,176 (+)NCBI
RefSeq Acc Id: NM_010136   ⟹   NP_034266
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,307,259 - 118,315,176 (+)NCBI
GRCm389118,478,189 - 118,486,132 (+)NCBI
MGSCv379118,387,307 - 118,395,250 (+)RGD
Celera9118,948,428 - 118,956,371 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034266   ⟸   NM_010136
- Peptide Label: isoform 1
- UniProtKB: Q9JJL1 (UniProtKB/Swiss-Prot),   Q8BN22 (UniProtKB/Swiss-Prot),   Q52KJ1 (UniProtKB/Swiss-Prot),   Q3UPL1 (UniProtKB/Swiss-Prot),   Q9QYG7 (UniProtKB/Swiss-Prot),   O54839 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001158261   ⟸   NM_001164789
- Peptide Label: isoform 2
- UniProtKB: O54839 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000118079   ⟸   ENSMUST00000150633
Ensembl Acc Id: ENSMUSP00000107393   ⟸   ENSMUST00000111763
Ensembl Acc Id: ENSMUSP00000035020   ⟸   ENSMUST00000035020
RefSeq Acc Id: NP_001398082   ⟸   NM_001411153
- Peptide Label: isoform 3
Protein Domains
T-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54839-F1-model_v2 AlphaFold O54839 1-707 view protein structure

Promoters
RGD ID:6844502
Promoter ID:MM_KWN:59091
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Lung
Transcripts:NM_001164789,   OTTMUST00000049812,   UC009RZO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369118,387,596 - 118,388,387 (+)MPROMDB
RGD ID:8671162
Promoter ID:EPDNEW_M13612
Type:single initiation site
Name:Eomes_1
Description:Mus musculus eomesodermin , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389118,478,191 - 118,478,251EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201683 AgrOrtholog
Ensembl Genes ENSMUSG00000032446 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035020 ENTREZGENE
  ENSMUST00000035020.15 UniProtKB/Swiss-Prot
  ENSMUST00000111763 ENTREZGENE
  ENSMUST00000111763.8 UniProtKB/Swiss-Prot
  ENSMUST00000150633 ENTREZGENE
  ENSMUST00000150633.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13813 UniProtKB/Swiss-Prot
MGD MGI:1201683 ENTREZGENE
NCBI Gene 13813 ENTREZGENE
PANTHER EOMESODERMIN HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eomes PhenoGen
PRINTS TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EOMES_MOUSE UniProtKB/Swiss-Prot
  F6VSW9_MOUSE UniProtKB/TrEMBL
  O54839 ENTREZGENE
  Q3UPL1 ENTREZGENE
  Q52KJ1 ENTREZGENE
  Q5PSA9_MOUSE UniProtKB/TrEMBL
  Q8BN22 ENTREZGENE
  Q9JJL1 ENTREZGENE
  Q9QYG7 ENTREZGENE
UniProt Secondary Q3UPL1 UniProtKB/Swiss-Prot
  Q52KJ1 UniProtKB/Swiss-Prot
  Q8BN22 UniProtKB/Swiss-Prot
  Q9JJL1 UniProtKB/Swiss-Prot
  Q9QYG7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Eomes  eomesodermin    eomesodermin homolog (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED