Dspp (dentin sialophosphoprotein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dspp (dentin sialophosphoprotein) Mus musculus
Analyze
Symbol: Dspp
Name: dentin sialophosphoprotein
RGD ID: 10493
MGI Page MGI
Description: Predicted to enable collagen binding activity. Acts upstream of or within several processes, including animal organ morphogenesis; epithelial cell differentiation; and negative regulation of cell population proliferation. Located in extracellular matrix; extracellular space; and nucleus. Is expressed in alimentary system; central nervous system; lung; male reproductive gland or organ; and metanephros. Used to study dentinogenesis imperfecta and periodontal disease. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D; dentin matrix protein 3; Dmp; DMP-3; Dmp2; Dmp3; Dpp; Dsp; MGC124498
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,318,569 - 104,327,993 (+)NCBIGRCm39mm39
GRCm39 Ensembl5104,318,578 - 104,327,993 (+)Ensembl
GRCm385104,170,703 - 104,180,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,170,712 - 104,180,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,599,731 - 104,609,146 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,411,005 - 104,420,429 (+)NCBImm8
Celera5101,476,457 - 101,494,758 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
collagen binding  (IBA,ISO)
protein binding  (IPI,ISO)

References

Additional References at PubMed
PMID:8937648   PMID:8995371   PMID:9395101   PMID:9421236   PMID:9541234   PMID:9545272   PMID:9786327   PMID:10357935   PMID:11042175   PMID:11044393   PMID:11566357   PMID:12403705  
PMID:12466851   PMID:12477932   PMID:12489180   PMID:12721295   PMID:14688224   PMID:14960276   PMID:14966118   PMID:15261838   PMID:15292199   PMID:15308669   PMID:15525533   PMID:15980071  
PMID:16014627   PMID:16937369   PMID:17286598   PMID:17449229   PMID:17957093   PMID:18022614   PMID:18156176   PMID:18424784   PMID:18572160   PMID:18789408   PMID:19001636   PMID:19348940  
PMID:19379665   PMID:19450697   PMID:19783797   PMID:20059976   PMID:20079836   PMID:20484882   PMID:20803598   PMID:21034733   PMID:21122108   PMID:21246660   PMID:21267068   PMID:21490069  
PMID:21873635   PMID:22042093   PMID:22043023   PMID:22088564   PMID:22175728   PMID:22234613   PMID:22351753   PMID:22351765   PMID:22508542   PMID:22572386   PMID:22581382   PMID:22753148  
PMID:22798071   PMID:22934831   PMID:23319349   PMID:23349460   PMID:23489896   PMID:23525114   PMID:23589294   PMID:23603361   PMID:23776616   PMID:23900597   PMID:23975681   PMID:24112131  
PMID:24194600   PMID:24352500   PMID:25027178   PMID:25158189   PMID:25369078   PMID:25386098   PMID:25568170   PMID:26310138   PMID:26487719   PMID:26503913   PMID:26686820   PMID:26763578  
PMID:26780724   PMID:26927967   PMID:26972716   PMID:27430624   PMID:27626380   PMID:27628095   PMID:27680507   PMID:28195206   PMID:28331230   PMID:28527696   PMID:28892649   PMID:29138798  
PMID:29155305   PMID:29672573   PMID:30570432   PMID:30963569   PMID:31173534   PMID:31218856   PMID:31374250   PMID:32243674   PMID:32866472   PMID:32921220  


Genomics

Comparative Map Data
Dspp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,318,569 - 104,327,993 (+)NCBIGRCm39mm39
GRCm39 Ensembl5104,318,578 - 104,327,993 (+)Ensembl
GRCm385104,170,703 - 104,180,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,170,712 - 104,180,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,599,731 - 104,609,146 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,411,005 - 104,420,429 (+)NCBImm8
Celera5101,476,457 - 101,494,758 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.59NCBI
DSPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl487,608,529 - 87,616,873 (+)EnsemblGRCh38hg38GRCh38
GRCh38487,608,529 - 87,616,873 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37488,529,681 - 88,538,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,748,705 - 88,757,049 (+)NCBINCBI36hg18NCBI36
Build 34488,886,859 - 88,895,204NCBI
Celera485,818,035 - 85,826,406 (+)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,275,661 - 84,283,858 (+)NCBIHuRef
CHM1_1488,506,445 - 88,514,787 (+)NCBICHM1_1
Dspp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2145,565,562 - 5,571,669 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl145,565,629 - 5,571,672 (-)Ensembl
Rnor_6.0146,926,972 - 6,933,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,914,385 - 6,920,492 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,674,662 - 6,680,769 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1146,674,663 - 6,680,769 (-)NCBI
Celera145,704,631 - 5,710,738 (-)NCBICelera
Cytogenetic Map14p22NCBI
Dspp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554742,254,842 - 2,259,303 (-)NCBIChiLan1.0ChiLan1.0
DSPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1490,630,300 - 90,635,681 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0479,903,923 - 79,909,836 (+)NCBIMhudiblu_PPA_v0panPan3
DSPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,017,440 - 11,022,780 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,932,307 - 30,937,641 (-)NCBI
ROS_Cfam_1.03211,069,800 - 11,075,135 (+)NCBI
UMICH_Zoey_3.13211,152,952 - 11,158,287 (+)NCBI
UNSW_CanFamBas_1.03210,978,595 - 10,983,939 (+)NCBI
UU_Cfam_GSD_1.03228,970,188 - 28,976,515 (-)NCBI
LOC101955952
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052852,036,925 - 2,043,572 (-)NCBI
SpeTri2.0NW_004936905458,062 - 463,359 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,319,983 - 131,472,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,318,187 - 131,444,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,512,001 - 140,540,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235939
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,993,669 - 35,999,443 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603714,694,483 - 14,700,534 (+)NCBIVero_WHO_p1.0
Dspp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248724,096,001 - 4,102,392 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537424144112317856Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552537120107173175Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552537120107173175Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55230992108614761Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563548099104239199Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572271017106271152Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575154687119880564Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576042404110042620Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576132927110133058Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576132927110133058Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576132927110133058Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576297205110297366Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576297205110297366Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576297205110297366Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576297205110297366Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579391781113391927Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580701400114701400Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined580871790114871944Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582690609116690738Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582690609116690738Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587239005121239199Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587239005121239199Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587239005121239199Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587239005121239199Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587239005121239199Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589271017118725963Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589271017124100176Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590173096124173175Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590413140124413285Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590413140124413285Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592682300126682419Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595085348129085464Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595286714129286920Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595317683129317856Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595317683129317856Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595317683129317856Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596172519130172667Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined596883692130883925Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined596883692130883925Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined597871790113883925Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined597871790116738565Mouse
1301877Bbaa3_mB.burgdorferi-associated arthritis 3 (mouse)Not determined599307426112317856Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99801563126805880Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100527900134527900Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100527900134527900Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101194514135194514Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101725767135725963Mouse
14746986Manh58_mmandible shape 58 (mouse)5102308218136308218Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102806972136807131Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5102900000115400000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:333
Interacting mature miRNAs:360
Transcripts:ENSMUST00000112771
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000112771   ⟹   ENSMUSP00000108391
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5104,318,578 - 104,327,993 (+)Ensembl
GRCm38.p6 Ensembl5104,170,712 - 104,180,127 (+)Ensembl
RefSeq Acc Id: NM_010080   ⟹   NP_034210
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395104,318,569 - 104,327,993 (+)NCBI
GRCm385104,170,703 - 104,180,127 (+)NCBI
MGSCv375104,599,731 - 104,609,146 (+)RGD
Celera5101,476,457 - 101,494,758 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034210   ⟸   NM_010080
- Peptide Label: preproprotein
- UniProtKB: E9Q9Z9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000108391   ⟸   ENSMUST00000112771

Promoters
RGD ID:6887348
Promoter ID:EPDNEW_M7125
Type:multiple initiation site
Name:Dspp_1
Description:Mus musculus dentin sialophosphoprotein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385104,170,678 - 104,170,738EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109172 AgrOrtholog
Ensembl Genes ENSMUSG00000053268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000108391 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112771 ENTREZGENE, UniProtKB/TrEMBL
KEGG Report mmu:666279 UniProtKB/TrEMBL
MGD MGI:109172 ENTREZGENE
NCBI Gene 666279 ENTREZGENE
PhenoGen Dspp PhenoGen
UniProt A1L2Z1_MOUSE UniProtKB/TrEMBL
  DSPP_MOUSE UniProtKB/Swiss-Prot
  E9Q9Z9 ENTREZGENE, UniProtKB/TrEMBL
  P97399 ENTREZGENE
  Q1JQ89_MOUSE UniProtKB/TrEMBL
UniProt Secondary O70567 UniProtKB/Swiss-Prot