Vav3 (vav 3 oncogene) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Vav3 (vav 3 oncogene) Mus musculus
Analyze
Symbol: Vav3
Name: vav 3 oncogene
RGD ID: 1558102
MGI Page MGI
Description: Enables epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb segment; metanephros; and sensory organ. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A530094I06Rik; AA986410; guanine nucleotide exchange factor VAV3; Idd18.; Idd18.1; MGC27838; VAV-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393109,247,757 - 109,593,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3109,247,969 - 109,593,014 (+)EnsemblGRCm39 Ensembl
GRCm383109,340,465 - 109,685,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3109,340,653 - 109,685,698 (+)EnsemblGRCm38mm10GRCm38
MGSCv373109,143,601 - 109,488,612 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363109,468,739 - 109,813,750 (+)NCBIMGSCv36mm8
Celera3111,676,271 - 112,018,586 (+)NCBICelera
Cytogenetic Map3F3NCBI
cM Map348.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
fipronil  (ISO)
genistein  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
luteolin  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
Pf-06840003  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
immunological synapse  (IEA,ISO)
plasma membrane  (IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal aorta tunica media morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal B cell calcium ion homeostasis  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal bradykinin level  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal sympathetic nervous system physiology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal urination  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal vascular endothelial cell migration  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
anterior iris synechia  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
buphthalmos  (IAGP)
cardiac fibrosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased B cell proliferation  (IAGP)
decreased creatinine clearance  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased follicular B cell number  (IAGP)
decreased heart ventricle muscle contractility  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased transitional stage T2 B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased urine potassium level  (IAGP)
decreased urine sodium level  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hypertension  (IAGP)
impaired wound healing  (IAGP)
increased angiotensin I-converting enzyme activity  (IAGP)
increased circulating adrenaline level  (IAGP)
increased circulating aldosterone level  (IAGP)
increased circulating angiotensin II level  (IAGP)
increased circulating antidiuretic hormone level  (IAGP)
increased circulating noradrenaline level  (IAGP)
increased circulating renin level  (IAGP)
increased dopamine level  (IAGP)
increased heart rate  (IAGP)
increased immature B cell number  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased renin activity  (IAGP)
increased transitional stage T1 B cell number  (IAGP)
intestinal ulcer  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertension  (IAGP)
optic nerve cupping  (IAGP)
renal fibrosis  (IAGP)
retina ganglion cell degeneration  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. Cella M, etal., J Exp Med 2004 Sep 20;200(6):817-23. Epub 2004 Sep 13.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10713454   PMID:10938113   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14623913   PMID:15249579   PMID:15456756   PMID:15489334   PMID:15711558  
PMID:15728722   PMID:15848800   PMID:15941910   PMID:16015370   PMID:16141072   PMID:16141073   PMID:16546099   PMID:16767097   PMID:16782872   PMID:17015685   PMID:17054426   PMID:17056570  
PMID:17142761   PMID:17158234   PMID:17202406   PMID:17932569   PMID:17984307   PMID:18424751   PMID:18676865   PMID:19088377   PMID:19139088   PMID:19141316   PMID:19147786   PMID:19158396  
PMID:19435813   PMID:19586920   PMID:19592646   PMID:19715691   PMID:19906978   PMID:20011522   PMID:20038798   PMID:20089829   PMID:20140222   PMID:20308364   PMID:20363978   PMID:20634378  
PMID:20926682   PMID:21115475   PMID:21178006   PMID:21209086   PMID:21257963   PMID:21267068   PMID:21427288   PMID:21873635   PMID:21880903   PMID:21930962   PMID:21979919   PMID:22177564  
PMID:22596354   PMID:22683124   PMID:22692505   PMID:22718904   PMID:22884313   PMID:23931752   PMID:23935450   PMID:24091327   PMID:24155889   PMID:24659802   PMID:25288640   PMID:25501893  
PMID:25538043   PMID:26147533   PMID:26240279   PMID:26438525   PMID:26876204   PMID:27507811   PMID:27926862   PMID:28930674   PMID:29136506   PMID:29858212   PMID:30087437   PMID:30333137  
PMID:30450647   PMID:30703063   PMID:32013053   PMID:32528129   PMID:32963234   PMID:33221374   PMID:34374463   PMID:34711926   PMID:35534539   PMID:36531963  


Genomics

Comparative Map Data
Vav3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393109,247,757 - 109,593,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3109,247,969 - 109,593,014 (+)EnsemblGRCm39 Ensembl
GRCm383109,340,465 - 109,685,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3109,340,653 - 109,685,698 (+)EnsemblGRCm38mm10GRCm38
MGSCv373109,143,601 - 109,488,612 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363109,468,739 - 109,813,750 (+)NCBIMGSCv36mm8
Celera3111,676,271 - 112,018,586 (+)NCBICelera
Cytogenetic Map3F3NCBI
cM Map348.13NCBI
VAV3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381107,571,161 - 107,965,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1107,571,161 - 107,965,180 (-)EnsemblGRCh38hg38GRCh38
GRCh371108,113,783 - 108,507,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361107,915,305 - 108,309,068 (-)NCBINCBI36Build 36hg18NCBI36
Build 341107,825,831 - 108,219,580NCBI
Celera1106,288,518 - 106,682,258 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1106,059,691 - 106,453,322 (-)NCBIHuRef
CHM1_11108,228,649 - 108,622,362 (-)NCBICHM1_1
T2T-CHM13v2.01107,608,692 - 108,002,653 (-)NCBIT2T-CHM13v2.0
Vav3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82199,699,861 - 200,042,344 (+)NCBIGRCr8
mRatBN7.22197,011,901 - 197,354,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2204,649,909 - 204,985,041 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02202,536,978 - 202,872,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02197,354,079 - 197,689,388 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02212,247,061 - 212,585,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02231,716,228 - 232,053,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42204,982,222 - 205,326,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2189,650,820 - 189,990,562 (+)NCBICelera
Cytogenetic Map2q41NCBI
Vav3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543511,326,910 - 11,599,043 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543511,326,910 - 11,599,043 (-)NCBIChiLan1.0ChiLan1.0
VAV3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21119,178,596 - 119,579,566 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11118,341,662 - 118,742,435 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,101,651 - 110,531,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11109,216,867 - 109,617,658 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1109,210,813 - 109,617,658 (-)Ensemblpanpan1.1panPan2
VAV3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1643,663,787 - 44,002,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl643,559,985 - 44,000,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha646,430,623 - 46,782,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0643,923,858 - 44,276,352 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl643,923,610 - 44,276,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1643,658,033 - 44,009,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0643,628,551 - 43,981,239 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0644,059,178 - 44,411,293 (+)NCBIUU_Cfam_GSD_1.0
Vav3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058116,810,838 - 117,160,637 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936731417,322 - 767,429 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936731417,610 - 767,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAV3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4111,824,896 - 112,202,825 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14111,825,071 - 112,202,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24122,945,014 - 122,967,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VAV3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12025,631,104 - 26,023,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2025,631,171 - 26,023,849 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603832,217,599 - 32,613,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vav3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247723,604,165 - 4,022,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247723,604,553 - 4,022,986 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vav3
17464 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3055
Count of miRNA genes:699
Interacting mature miRNAs:913
Transcripts:ENSMUST00000046864, ENSMUST00000106576, ENSMUST00000126179, ENSMUST00000128033, ENSMUST00000137871, ENSMUST00000148866
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1357599msrvh1_mmodifier of susceptibility to renal vascular hypertrophy/hyperplasia 1 (mouse)Not determined3107376936115624197Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse

Markers in Region
D3Mit158  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383109,344,217 - 109,344,334UniSTSGRCm38
MGSCv373109,147,135 - 109,147,252UniSTSGRCm37
Celera3111,679,570 - 111,679,687UniSTS
Cytogenetic Map3G1UniSTS
cM Map352.5UniSTS
Whitehead Genetic339.3UniSTS
Whitehead_YAC3 UniSTS
AU048068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383109,387,315 - 109,387,446UniSTSGRCm38
MGSCv373109,190,233 - 109,190,364UniSTSGRCm37
Celera3111,722,628 - 111,722,759UniSTS
Cytogenetic Map3G1UniSTS
AA986410  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383109,685,283 - 109,685,411UniSTSGRCm38
MGSCv373109,488,201 - 109,488,329UniSTSGRCm37
Celera3112,018,175 - 112,018,303UniSTS
Cytogenetic Map3G1UniSTS
Whitehead/MRC_RH31251.89UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001378987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_146139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF067816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF140280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY965019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR938729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000046864   ⟹   ENSMUSP00000036270
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3109,247,969 - 109,593,014 (+)Ensembl
GRCm38.p6 Ensembl3109,340,653 - 109,685,698 (+)Ensembl
Ensembl Acc Id: ENSMUST00000106576   ⟹   ENSMUSP00000102186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3109,481,223 - 109,593,010 (+)Ensembl
GRCm38.p6 Ensembl3109,573,907 - 109,685,694 (+)Ensembl
Ensembl Acc Id: ENSMUST00000126179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3109,247,999 - 109,470,857 (+)Ensembl
GRCm38.p6 Ensembl3109,340,683 - 109,563,541 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3109,402,100 - 109,411,012 (+)Ensembl
GRCm38.p6 Ensembl3109,494,784 - 109,503,696 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3109,248,422 - 109,349,528 (+)Ensembl
GRCm38.p6 Ensembl3109,341,106 - 109,442,212 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148866
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3109,554,840 - 109,590,219 (+)Ensembl
GRCm38.p6 Ensembl3109,647,524 - 109,682,903 (+)Ensembl
RefSeq Acc Id: NM_001378987   ⟹   NP_001365916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393109,248,077 - 109,593,010 (+)NCBI
GRCm383109,340,761 - 109,685,694 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020505   ⟹   NP_065251
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393109,247,999 - 109,593,010 (+)NCBI
GRCm383109,340,683 - 109,685,694 (+)NCBI
MGSCv373109,143,601 - 109,488,612 (+)RGD
Celera3111,676,271 - 112,018,586 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_146139   ⟹   NP_666251
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393109,481,323 - 109,593,010 (+)NCBI
GRCm383109,574,007 - 109,685,694 (+)NCBI
MGSCv373109,143,601 - 109,488,612 (+)RGD
Celera3111,676,271 - 112,018,586 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501820   ⟹   XP_006501883
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393109,247,757 - 109,593,010 (+)NCBI
GRCm383109,340,465 - 109,685,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163196   ⟹   XP_036019089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393109,247,757 - 109,593,010 (+)NCBI
Sequence:
RefSeq Acc Id: NP_065251   ⟸   NM_020505
- Peptide Label: isoform 1
- UniProtKB: Q8R076 (UniProtKB/Swiss-Prot),   Q8CCF5 (UniProtKB/Swiss-Prot),   Q8BRV2 (UniProtKB/Swiss-Prot),   Q7TS85 (UniProtKB/Swiss-Prot),   A2CFD7 (UniProtKB/Swiss-Prot),   Q9JLS6 (UniProtKB/Swiss-Prot),   Q9R0C8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_666251   ⟸   NM_146139
- Peptide Label: isoform 2
- UniProtKB: Q9R0C8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501883   ⟸   XM_006501820
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001365916   ⟸   NM_001378987
- Peptide Label: isoform 3
Ensembl Acc Id: ENSMUSP00000036270   ⟸   ENSMUST00000046864
Ensembl Acc Id: ENSMUSP00000102186   ⟸   ENSMUST00000106576
RefSeq Acc Id: XP_036019089   ⟸   XM_036163196
- Peptide Label: isoform X2
Protein Domains
Calponin-homology (CH)   DH   PH   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0C8-F1-model_v2 AlphaFold Q9R0C8 1-847 view protein structure

Promoters
RGD ID:6834610
Promoter ID:MM_KWN:35829
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B6
Transcripts:OTTMUST00000017035,   OTTMUST00000017036,   OTTMUST00000035161
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363109,143,086 - 109,143,802 (+)MPROMDB
RGD ID:6882120
Promoter ID:EPDNEW_M4511
Type:initiation region
Name:Vav3_1
Description:Mus musculus vav 3 oncogene , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4512  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383109,340,761 - 109,340,821EPDNEW
RGD ID:6834609
Promoter ID:MM_KWN:35832
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000106576,   NM_146139
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363109,375,726 - 109,376,226 (+)MPROMDB
RGD ID:6882122
Promoter ID:EPDNEW_M4512
Type:initiation region
Name:Vav3_2
Description:Mus musculus vav 3 oncogene , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4511  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383109,574,011 - 109,574,071EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1888518 AgrOrtholog
Ensembl Genes ENSMUSG00000033721 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000046864 ENTREZGENE
  ENSMUST00000046864.14 UniProtKB/Swiss-Prot
  ENSMUST00000106576 ENTREZGENE
  ENSMUST00000106576.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro CAMSAP_CH UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_Vav UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  SM22_calponin UniProtKB/Swiss-Prot
  SOS1_NGEF_PH UniProtKB/Swiss-Prot
  VAV3_SH2 UniProtKB/Swiss-Prot
  VAV3_SH3_1 UniProtKB/Swiss-Prot
  VAV3_SH3_2 UniProtKB/Swiss-Prot
KEGG Report mmu:57257 UniProtKB/Swiss-Prot
MGD MGI:1888518 ENTREZGENE
NCBI Gene 57257 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3 UniProtKB/Swiss-Prot
  PROTEIN VAV UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  CAMSAP_CH UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
  SOS1_NGEF_PH UniProtKB/Swiss-Prot
PhenoGen Vav3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
  SM22CALPONIN UniProtKB/Swiss-Prot
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
SMART RhoGEF UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47576 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A2CFD7 ENTREZGENE
  Q7TS85 ENTREZGENE
  Q8BRV2 ENTREZGENE
  Q8CCF5 ENTREZGENE
  Q8R076 ENTREZGENE
  Q9JLS6 ENTREZGENE
  Q9R0C8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2CFD7 UniProtKB/Swiss-Prot
  Q7TS85 UniProtKB/Swiss-Prot
  Q8BRV2 UniProtKB/Swiss-Prot
  Q8CCF5 UniProtKB/Swiss-Prot
  Q8R076 UniProtKB/Swiss-Prot
  Q9JLS6 UniProtKB/Swiss-Prot