Pcyox1 (prenylcysteine oxidase 1) - Rat Genome Database
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Gene: Pcyox1 (prenylcysteine oxidase 1) Mus musculus
Analyze
Symbol: Pcyox1
Name: prenylcysteine oxidase 1
RGD ID: 733109
MGI Page MGI
Description: Exhibits prenylcysteine oxidase activity. Involved in prenylcysteine catabolic process. Localizes to lysosome. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and respiratory system. Orthologous to human PCYOX1 (prenylcysteine oxidase 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200015P13Rik; AI115532; AI448340; PC; PCL1; Pcly; prenylcysteine lyase; prenylcysteine oxidase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,362,988 - 86,374,132 (-)NCBIGRCm39mm39
GRCm38686,386,006 - 86,397,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,386,006 - 86,397,154 (-)EnsemblGRCm38mm10GRCm38
MGSCv37686,336,000 - 86,347,144 (-)NCBIGRCm37mm9NCBIm37
MGSCv36686,352,491 - 86,362,754 (-)NCBImm8
Celera688,323,385 - 88,334,467 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12151402   PMID:12477932   PMID:12904583   PMID:14681479   PMID:15368895   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16944957   PMID:18287559   PMID:21267068   PMID:21873635   PMID:29514215   PMID:32325033  


Genomics

Comparative Map Data
Pcyox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,362,988 - 86,374,132 (-)NCBIGRCm39mm39
GRCm38686,386,006 - 86,397,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,386,006 - 86,397,154 (-)EnsemblGRCm38mm10GRCm38
MGSCv37686,336,000 - 86,347,144 (-)NCBIGRCm37mm9NCBIm37
MGSCv36686,352,491 - 86,362,754 (-)NCBImm8
Celera688,323,385 - 88,334,467 (-)NCBICelera
Cytogenetic Map6D1NCBI
PCYOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl270,257,386 - 70,281,185 (+)EnsemblGRCh38hg38GRCh38
GRCh38270,258,137 - 70,281,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37270,485,269 - 70,508,317 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37270,485,231 - 70,508,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,338,797 - 70,360,731 (+)NCBINCBI36hg18NCBI36
Build 34270,396,943 - 70,418,866NCBI
Celera270,335,922 - 70,359,008 (+)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,222,037 - 70,245,162 (+)NCBIHuRef
CHM1_1270,414,817 - 70,437,898 (+)NCBICHM1_1
Pcyox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,832,114 - 118,842,951 (-)NCBI
Rnor_6.0 Ensembl4118,187,134 - 118,198,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04118,187,133 - 118,198,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,758,383 - 182,769,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,569,436 - 120,580,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,812,433 - 120,824,736 (-)NCBI
Celera4107,803,829 - 107,814,666 (-)NCBICelera
Cytogenetic Map4q34NCBI
Pcyox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,855,106 - 14,865,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,854,755 - 14,865,920 (-)NCBIChiLan1.0ChiLan1.0
PCYOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A71,429,520 - 71,449,292 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,429,514 - 71,449,292 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A70,313,204 - 70,335,361 (+)NCBIMhudiblu_PPA_v0panPan3
PCYOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1068,806,572 - 68,823,291 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11068,806,611 - 68,825,941 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pcyox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649114,422,683 - 14,439,599 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCYOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,204,815 - 72,223,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1372,207,406 - 72,223,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,478,452 - 75,494,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCYOX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,840,056 - 36,859,114 (-)NCBI
ChlSab1.1 Ensembl1436,841,327 - 36,859,079 (-)Ensembl
Pcyox1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247623,164,320 - 3,175,760 (-)NCBI

Position Markers
AI448340  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38686,386,849 - 86,387,030UniSTSGRCm38
MGSCv37686,336,843 - 86,337,024UniSTSGRCm37
Celera688,324,230 - 88,324,411UniSTS
Cytogenetic Map6D1UniSTS
Whitehead/MRC_RH6892.87UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1418
Count of miRNA genes:684
Interacting mature miRNAs:856
Transcripts:ENSMUST00000032065, ENSMUST00000129650, ENSMUST00000131500, ENSMUST00000153723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_025823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC155947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032065   ⟹   ENSMUSP00000032065
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,386,006 - 86,397,154 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129650
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,394,518 - 86,396,626 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131500   ⟹   ENSMUSP00000122602
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,388,989 - 86,392,343 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153723   ⟹   ENSMUSP00000119449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,391,684 - 86,397,143 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203960
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,395,783 - 86,397,119 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204116   ⟹   ENSMUSP00000145474
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,388,671 - 86,397,141 (-)Ensembl
RefSeq Acc Id: NM_001355687   ⟹   NP_001342616
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39686,362,988 - 86,374,132 (-)NCBI
GRCm38686,386,006 - 86,397,150 (-)NCBI
Sequence:
RefSeq Acc Id: NM_025823   ⟹   NP_080099
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39686,362,988 - 86,374,132 (-)NCBI
GRCm38686,386,006 - 86,397,150 (-)NCBI
MGSCv37686,336,000 - 86,347,144 (-)RGD
Celera688,323,385 - 88,334,467 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080099   ⟸   NM_025823
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9CQF9 (UniProtKB/Swiss-Prot),   Q3UYP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342616   ⟸   NM_001355687
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: ENSMUSP00000145474   ⟸   ENSMUST00000204116
RefSeq Acc Id: ENSMUSP00000032065   ⟸   ENSMUST00000032065
RefSeq Acc Id: ENSMUSP00000122602   ⟸   ENSMUST00000131500
RefSeq Acc Id: ENSMUSP00000119449   ⟸   ENSMUST00000153723
Protein Domains
Prenylcys_lyase

Promoters
RGD ID:6839732
Promoter ID:MM_KWN:46730
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_025823,   OTTMUST00000056867,   OTTMUST00000056868
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36686,346,046 - 86,347,147 (-)MPROMDB
RGD ID:6890276
Promoter ID:EPDNEW_M8589
Type:initiation region
Name:Pcyox1_1
Description:Mus musculus prenylcysteine oxidase 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38686,397,105 - 86,397,165EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914131 AgrOrtholog
Ensembl Genes ENSMUSG00000029998 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032065 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000119449 UniProtKB/TrEMBL
  ENSMUSP00000122602 UniProtKB/TrEMBL
  ENSMUSP00000145474 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032065 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131500 UniProtKB/TrEMBL
  ENSMUST00000153723 UniProtKB/TrEMBL
  ENSMUST00000204116 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prenylcys_lyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prenylcysteine_Oxase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66881 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1914131 ENTREZGENE
NCBI Gene 66881 ENTREZGENE
PANTHER PTHR15944 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prenylcys_lyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcyox1 PhenoGen
PIRSF Prenylcysteine_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SWD3_MOUSE UniProtKB/TrEMBL
  D3Z275_MOUSE UniProtKB/TrEMBL
  F7CIP8_MOUSE UniProtKB/TrEMBL
  PCYOX_MOUSE UniProtKB/Swiss-Prot
  Q3TVT6_MOUSE UniProtKB/TrEMBL
  Q3UYP2 ENTREZGENE, UniProtKB/TrEMBL
  Q99JK4_MOUSE UniProtKB/TrEMBL
  Q9CQF9 ENTREZGENE
UniProt Secondary Q3UHV6 UniProtKB/Swiss-Prot
  Q69ZW0 UniProtKB/Swiss-Prot
  Q8BZX1 UniProtKB/Swiss-Prot