Birc3 (baculoviral IAP repeat-containing 3) - Rat Genome Database

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Gene: Birc3 (baculoviral IAP repeat-containing 3) Mus musculus
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Symbol: Birc3
Name: baculoviral IAP repeat-containing 3
RGD ID: 733266
MGI Page MGI
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus adenocarcinoma; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; Api1; Api2; apoptosis inhibitor 1; AW107670; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 3; Birc2; C-IAP2; cellular inhibitor of apoptosis 2; cI; cIA; cIAP-1; cIAP-2; cIAP1; cIAP2; HI; HIAP2; I; IAP-1; IAP1; IAP2; inhibitor of apoptosis protein 1; MI; mIAP-1; MIAP1; MIAP2; MIH; MIHB; MIHC; RING-type E3 ubiquitin transferase BIRC3; RNF; RNF49
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm7019  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,848,698 - 7,873,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,848,700 - 7,873,187 (-)EnsemblGRCm39 Ensembl
GRCm3897,847,468 - 7,873,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,848,699 - 7,873,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,848,699 - 7,873,170 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,849,220 - 7,873,545 (-)NCBIMGSCv36mm8
Celera95,240,413 - 5,264,652 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(aminomethyl)phosphonic acid  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene  (ISO)
2-butoxyethanol  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5Z-7-oxozeaenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aprepitant  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bryostatin 1  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
chrysazin  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cryptolepine  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fluoranthene  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gastrin-17  (ISO)
gemcitabine  (EXP,ISO)
Genipin  (EXP)
gentamycin  (ISO)
gliotoxin  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
guggulsterone  (ISO)
homocysteine  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibrutinib  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
L-ascorbic acid  (ISO)
LCL161  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lobaplatin  (ISO)
lonafarnib  (ISO)
LY294002  (ISO)
lysophosphatidylethanolamine  (ISO)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
Mitotane  (ISO)
morin  (ISO)
N,N'-(hexane-1,6-diyl)bis(1-\{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl\}-L-prolyl-beta-phenyl-L-phenylalaninamide)  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric oxide  (EXP,ISO)
o-xylene  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
PD 0325901  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium atom  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
succimer  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tephrosin  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cytokine secretion  (IAGP)
abnormal gut-associated lymphoid tissue morphology  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal interleukin-1 beta secretion  (IAGP)
abnormal interleukin-12 secretion  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal tumor necrosis factor secretion  (IAGP)
congestive heart failure  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased follicular B cell number  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgG1 level  (IAGP)
decreased immature B cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged pericardium  (IAGP)
enlarged spleen  (IAGP)
hemopericardium  (IAGP)
hemorrhage  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased follicular B cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased marginal zone B cell number  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lymph node hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. An MJ, etal., Cancer Lett. 2009 Jun 28;279(1):93-100. doi: 10.1016/j.canlet.2009.01.026. Epub 2009 Feb 18.
2. [Association of cellular inhibitor of apoptosis protein-2 expression with clinical outcomes of hepatocellular carcinoma]. Bi M, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(7):1020-5, 1030.
3. Identification of microRNA-124 in regulation of Hepatocellular carcinoma through BIRC3 and the NF-κB pathway. Cao J, etal., J Cancer. 2018 Jul 30;9(17):3006-3015. doi: 10.7150/jca.25956. eCollection 2018.
4. Cytoplasmic HuR expression: correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells. Cha JD, etal., Head Neck. 2014 Aug;36(8):1168-75. doi: 10.1002/hed.23431. Epub 2014 Jan 16.
5. Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. Chen JY, etal., Life Sci. 2010 Sep 11;87(11-12):350-7. doi: 10.1016/j.lfs.2010.06.017. Epub 2010 Jul 17.
6. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
7. Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma. Chen Z, etal., Biochem Pharmacol. 2020 Jul;177:114023. doi: 10.1016/j.bcp.2020.114023. Epub 2020 May 13.
8. Tumor necrosis factor. Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
9. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Dagenais M, etal., Mucosal Immunol. 2016 Jan;9(1):146-58. doi: 10.1038/mi.2015.46. Epub 2015 Jun 3.
10. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
11. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Ebert G, etal., Proc Natl Acad Sci U S A. 2015 May 5;112(18):5797-802. doi: 10.1073/pnas.1502390112. Epub 2015 Apr 20.
12. New insight into BIRC3: A novel prognostic indicator and a potential therapeutic target for liver cancer. Fu PY, etal., J Cell Biochem. 2019 Apr;120(4):6035-6045. doi: 10.1002/jcb.27890. Epub 2018 Oct 28.
13. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
14. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. Hu Y, etal., Biochem Pharmacol. 2013 Apr 1;85(7):1007-17. doi: 10.1016/j.bcp.2013.01.023. Epub 2013 Feb 8.
15. cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-κB pathway. Jiang X, etal., Cancer Sci. 2017 Jun;108(6):1144-1156. doi: 10.1111/cas.13236. Epub 2017 May 31.
16. cIAP2 via NF-κB signalling affects cell proliferation and invasion in hepatocellular carcinoma. Jiang XJ, etal., Life Sci. 2021 Feb 1;266:118867. doi: 10.1016/j.lfs.2020.118867. Epub 2020 Dec 10.
17. Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. Kempkensteffen C, etal., Int J Cancer. 2007 Mar 1;120(5):1081-6.
18. t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement. Kuo SH, etal., Cancer Chemother Pharmacol. 2011 Dec;68(6):1387-95. doi: 10.1007/s00280-011-1631-y. Epub 2011 Apr 5.
19. Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis. Li MY, etal., Eur Respir J. 2008 Oct;32(4):911-23. doi: 10.1183/09031936.00064508. Epub 2008 May 28.
20. Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways. Liu YD, etal., Int Immunopharmacol. 2018 Jun;59:375-383. doi: 10.1016/j.intimp.2018.04.033. Epub 2018 Apr 24.
21. Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family. Mahdavi M, etal., Biomed Pharmacother. 2011 Jun;65(3):175-82. doi: 10.1016/j.biopha.2011.03.001. Epub 2011 Apr 8.
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. Mitsuishi T, etal., BMC Cancer. 2010 Mar 27;10:118. doi: 10.1186/1471-2407-10-118.
25. Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma. Nagata M, etal., Br J Cancer. 2011 Oct 25;105(9):1322-30. doi: 10.1038/bjc.2011.387. Epub 2011 Sep 27.
26. Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. Nguyen L, etal., Exp Mol Pathol. 2018 Feb;104(1):45-49. doi: 10.1016/j.yexmp.2017.12.007. Epub 2018 Jan 4.
27. Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions. Pekow J, etal., Inflamm Bowel Dis. 2013 Mar;19(3):461-70. doi: 10.1097/MIB.0b013e3182802bac.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients. Piro G, etal., Br J Cancer. 2015 Sep 15;113(6):878-85. doi: 10.1038/bjc.2015.283. Epub 2015 Aug 20.
31. An apoptosis-independent role of SMAC in tumor suppression. Qiu W, etal., Oncogene. 2013 May 9;32(19):2380-9. doi: 10.1038/onc.2012.265. Epub 2012 Jul 2.
32. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. API2-MALT1 chimeric transcript is a predictive marker for the responsiveness of H. pylori eradication treatment in low-grade gastric MALT lymphoma. Sugiyama T, etal., Gastroenterology. 2001 Jun;120(7):1884-5. doi: 10.1053/gast.2001.25305.
36. Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival. Tang D, etal., Am J Cancer Res. 2020 Aug 1;10(8):2582-2595. eCollection 2020.
37. Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells. Tian A, etal., Cancer Lett. 2014 Sep 1;351(2):232-41. doi: 10.1016/j.canlet.2014.06.006. Epub 2014 Jun 27.
38. Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Tomicic MT, etal., Arch Toxicol. 2019 Aug;93(8):2265-2277. doi: 10.1007/s00204-019-02513-7. Epub 2019 Jul 9.
39. CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC. Wang L, etal., Oncol Rep. 2018 Mar;39(3):951-966. doi: 10.3892/or.2017.6174. Epub 2017 Dec 28.
40. Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection. Weng L, etal., Mol Cancer. 2012 Jun 8;11:39. doi: 10.1186/1476-4598-11-39.
41. cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer. Wu HH, etal., Clin Cancer Res. 2010 Nov 1;16(21):5200-10. doi: 10.1158/1078-0432.CCR-10-0020. Epub 2010 Oct 19.
42. The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Wu P, etal., Cell Death Dis. 2014 Feb 27;5:e1085. doi: 10.1038/cddis.2014.13.
43. LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC. Yang C, etal., J Exp Clin Cancer Res. 2016 Sep 30;35(1):158. doi: 10.1186/s13046-016-0435-7.
44. Helicobacter pylori Eradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis. Yoon H, etal., Gut Liver. 2017 Jan 15;11(1):79-86. doi: 10.5009/gnl15585.
45. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. Zhang S, etal., J Exp Clin Cancer Res. 2019 Jan 10;38(1):14. doi: 10.1186/s13046-018-0985-y.
46. Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer. Zhang W, etal., Medicine (Baltimore). 2019 Jan;98(3):e14069. doi: 10.1097/MD.0000000000014069.
47. Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence. Zhang Z, etal., Oncol Rep. 2019 Feb;41(2):981-988. doi: 10.3892/or.2018.6856. Epub 2018 Nov 9.
Additional References at PubMed
PMID:8548810   PMID:9441758   PMID:9916987   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12153481   PMID:12466851   PMID:12477932  
PMID:12679106   PMID:12815069   PMID:14610273   PMID:14623868   PMID:14634619   PMID:15102471   PMID:15608679   PMID:15798218   PMID:16116448   PMID:16141072   PMID:16141073   PMID:16382159  
PMID:16699955   PMID:17321613   PMID:17476283   PMID:18287559   PMID:18621737   PMID:18635759   PMID:18684108   PMID:18697935   PMID:18708583   PMID:18784070   PMID:19029953   PMID:19276372  
PMID:19421137   PMID:19464198   PMID:19644667   PMID:19815541   PMID:19898473   PMID:20080598   PMID:20356846   PMID:20676140   PMID:21048983   PMID:21052097   PMID:21267068   PMID:21300983  
PMID:21331077   PMID:21339290   PMID:21393245   PMID:21593423   PMID:21653699   PMID:21677750   PMID:21695558   PMID:21765415   PMID:21873635   PMID:21954216   PMID:22195745   PMID:22327219  
PMID:22332634   PMID:22365665   PMID:22576661   PMID:23074266   PMID:23109427   PMID:23126497   PMID:23184147   PMID:23248260   PMID:23250032   PMID:23334419   PMID:23384561   PMID:23799077  
PMID:23815148   PMID:23837962   PMID:24276241   PMID:24439895   PMID:24497535   PMID:24633224   PMID:25501826   PMID:25693118   PMID:26096449   PMID:27074575   PMID:27129149   PMID:27377744  
PMID:28055006   PMID:28190767   PMID:28542143   PMID:28647349   PMID:28723569   PMID:29191979   PMID:29452637   PMID:29743550   PMID:31126323   PMID:31141691   PMID:31624230   PMID:32234472  
PMID:32325033   PMID:32554809   PMID:33608556   PMID:34914932   PMID:35008722   PMID:35718775   PMID:36440627   PMID:37209886   PMID:37789765  


Genomics

Comparative Map Data
Birc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,848,698 - 7,873,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,848,700 - 7,873,187 (-)EnsemblGRCm39 Ensembl
GRCm3897,847,468 - 7,873,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,848,699 - 7,873,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,848,699 - 7,873,170 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,849,220 - 7,873,545 (-)NCBIMGSCv36mm8
Celera95,240,413 - 5,264,652 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
BIRC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,317,484 - 102,339,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,317,484 - 102,339,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,188,215 - 102,210,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,693,404 - 101,713,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,693,403 - 101,713,674NCBI
Celera1199,349,739 - 99,370,012 (+)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,114,738 - 98,136,703 (+)NCBIHuRef
CHM1_111102,071,142 - 102,093,097 (+)NCBICHM1_1
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBIT2T-CHM13v2.0
Birc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,285,702 - 13,313,329 (-)NCBIGRCr8
mRatBN7.285,000,844 - 5,028,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,960,993 - 8,975,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,258,675 - 7,273,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,260,542 - 5,275,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,048,590 - 6,076,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,047,454 - 6,075,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,682,202 - 4,696,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,682,202 - 4,696,856 (-)NCBI
Celera86,558,921 - 6,573,882 (-)NCBICelera
Cytogenetic Map8q11NCBI
Birc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,628,973 - 5,643,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,624,865 - 5,643,520 (+)NCBIChiLan1.0ChiLan1.0
BIRC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,122,394 - 103,144,359 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,210,806 - 104,232,727 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,269,778 - 97,290,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,763,274 - 100,785,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,763,274 - 100,785,194 (+)Ensemblpanpan1.1panPan2
BIRC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,324,893 - 29,343,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,325,331 - 29,337,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,274,261 - 29,286,176 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,377,538 - 29,396,454 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,377,570 - 29,395,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,434,557 - 29,446,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,292,001 - 29,303,913 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,466,940 - 29,478,850 (-)NCBIUU_Cfam_GSD_1.0
Birc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,977,221 - 85,992,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,544,065 - 5,556,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,544,047 - 5,556,550 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,003,276 - 33,020,242 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,003,570 - 33,020,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,951,995 - 36,969,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BIRC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,692,239 - 93,711,905 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,150,453 - 32,171,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878523,300 - 536,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878516,750 - 541,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Birc3
825 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1125
Count of miRNA genes:616
Interacting mature miRNAs:742
Transcripts:ENSMUST00000013949, ENSMUST00000115672, ENSMUST00000115673, ENSMUST00000159323, ENSMUST00000159672, ENSMUST00000161099, ENSMUST00000161642
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse

Markers in Region
AW107670  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,849,045 - 7,849,180UniSTSGRCm38
MGSCv3797,849,045 - 7,849,180UniSTSGRCm37
Celera95,240,759 - 5,240,894UniSTS
Cytogenetic Map9A2UniSTS
Whitehead/MRC_RH990.59UniSTS
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
UniSTS:236051  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,848,832 - 7,849,065UniSTSGRCm38
MGSCv3797,848,832 - 7,849,065UniSTSGRCm37
Celera95,240,546 - 5,240,779UniSTS
Cytogenetic Map9A2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK154721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA556605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U88908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000013949   ⟹   ENSMUSP00000013949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,848,700 - 7,873,025 (-)Ensembl
GRCm38.p6 Ensembl97,848,699 - 7,873,024 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115672   ⟹   ENSMUSP00000111336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,855,816 - 7,872,984 (-)Ensembl
GRCm38.p6 Ensembl97,855,815 - 7,872,983 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115673   ⟹   ENSMUSP00000111337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,860,811 - 7,873,187 (-)Ensembl
GRCm38.p6 Ensembl97,860,810 - 7,873,186 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159323   ⟹   ENSMUSP00000125652
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,860,792 - 7,873,171 (-)Ensembl
GRCm38.p6 Ensembl97,860,791 - 7,873,170 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,868,649 - 7,872,898 (-)Ensembl
GRCm38.p6 Ensembl97,868,648 - 7,872,897 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161099
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,866,194 - 7,872,858 (-)Ensembl
GRCm38.p6 Ensembl97,866,193 - 7,872,857 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161642   ⟹   ENSMUSP00000125512
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,849,695 - 7,860,327 (-)Ensembl
GRCm38.p6 Ensembl97,849,694 - 7,860,326 (-)Ensembl
RefSeq Acc Id: NM_007464   ⟹   NP_031490
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,700 - 7,873,171 (-)NCBI
GRCm3897,848,699 - 7,873,170 (-)NCBI
MGSCv3797,848,699 - 7,873,170 (-)RGD
Celera95,240,413 - 5,264,652 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509828   ⟹   XP_006509891
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,873,199 (-)NCBI
GRCm3897,847,468 - 7,873,205 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509829   ⟹   XP_006509892
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,873,199 (-)NCBI
GRCm3897,848,699 - 7,873,205 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509830   ⟹   XP_006509893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,867,186 (-)NCBI
GRCm3897,848,699 - 7,866,150 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509831   ⟹   XP_006509894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,872,797 (-)NCBI
GRCm3897,848,699 - 7,873,049 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242352   ⟹   XP_011240654
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,867,186 (-)NCBI
GRCm3897,848,699 - 7,866,150 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242353   ⟹   XP_011240655
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,867,959 (-)NCBI
GRCm3897,848,699 - 7,867,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154571   ⟹   XP_036010464
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,848,698 - 7,867,803 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031490   ⟸   NM_007464
- UniProtKB: E9QLX3 (UniProtKB/Swiss-Prot),   O08863 (UniProtKB/Swiss-Prot),   A2CGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509891   ⟸   XM_006509828
- Peptide Label: isoform X1
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509892   ⟸   XM_006509829
- Peptide Label: isoform X2
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509894   ⟸   XM_006509831
- Peptide Label: isoform X3
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot),   A2CGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509893   ⟸   XM_006509830
- Peptide Label: isoform X3
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot),   A2CGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240655   ⟸   XM_011242353
- Peptide Label: isoform X3
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot),   A2CGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240654   ⟸   XM_011242352
- Peptide Label: isoform X3
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot),   A2CGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000125652   ⟸   ENSMUST00000159323
RefSeq Acc Id: ENSMUSP00000013949   ⟸   ENSMUST00000013949
RefSeq Acc Id: ENSMUSP00000111337   ⟸   ENSMUST00000115673
RefSeq Acc Id: ENSMUSP00000111336   ⟸   ENSMUST00000115672
RefSeq Acc Id: ENSMUSP00000125512   ⟸   ENSMUST00000161642
RefSeq Acc Id: XP_036010464   ⟸   XM_036154571
- Peptide Label: isoform X3
- UniProtKB: O08863 (UniProtKB/Swiss-Prot),   E9QLX3 (UniProtKB/Swiss-Prot),   A2CGA5 (UniProtKB/TrEMBL)
Protein Domains
BIRC2/3-like UBA   CARD   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08863-F1-model_v2 AlphaFold O08863 1-600 view protein structure

Promoters
RGD ID:6844249
Promoter ID:MM_KWN:56337
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC009ODA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3697,851,166 - 7,852,317 (-)MPROMDB
RGD ID:6848382
Promoter ID:MM_ACW:49500
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:BIRC3.HSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3697,863,766 - 7,864,266 (-)MPROMDB
RGD ID:6844250
Promoter ID:MM_KWN:56338
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000048783,   UC009ODC.1,   UC009ODD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3697,872,724 - 7,873,224 (-)MPROMDB
RGD ID:8668766
Promoter ID:EPDNEW_M12414
Type:initiation region
Name:Birc3_1
Description:Mus musculus baculoviral IAP repeat-containing 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12415  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3897,873,024 - 7,873,084EPDNEW
RGD ID:8668768
Promoter ID:EPDNEW_M12415
Type:multiple initiation site
Name:Birc3_2
Description:Mus musculus baculoviral IAP repeat-containing 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12414  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3897,873,186 - 7,873,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1197007 AgrOrtholog
Ensembl Genes ENSMUSG00000032000 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000013949 ENTREZGENE
  ENSMUST00000013949.15 UniProtKB/TrEMBL
  ENSMUST00000115672.2 UniProtKB/TrEMBL
  ENSMUST00000115673.3 UniProtKB/TrEMBL
  ENSMUST00000159323.2 UniProtKB/TrEMBL
  ENSMUST00000161642.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIRC2/BIRC3_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report mmu:11796 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1197007 ENTREZGENE
NCBI Gene 11796 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Birc3 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2CGA3_MOUSE UniProtKB/TrEMBL
  A2CGA5 ENTREZGENE, UniProtKB/TrEMBL
  BIRC3_MOUSE UniProtKB/Swiss-Prot
  E0CZ20_MOUSE UniProtKB/TrEMBL
  E0CZ68_MOUSE UniProtKB/TrEMBL
  E9QLX3 ENTREZGENE
  F7BQL8_MOUSE UniProtKB/TrEMBL
  O08863 ENTREZGENE
  Q3T9B6_MOUSE UniProtKB/TrEMBL
  Q3TSE5_MOUSE UniProtKB/TrEMBL
  Q921N0_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QLX3 UniProtKB/Swiss-Prot