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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Mus musculus
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
Description: Predicted to have co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including embryonic morphogenesis; negative regulation of signal transduction; and regulation of nervous system development. Predicted to localize to extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dickkopf homolog 1; dickkopf-1; dickkopf-like protein 1; dickkopf-related protein 1; dkk-1; mdkk-1
Homo sapiens (human) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Canis lupus familiaris (dog) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Sus scrofa (pig) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Chlorocebus sabaeus (African green monkey) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Heterocephalus glaber (naked mole-rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)EnsemblGRCm38mm10GRCm38
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIGRCm37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBImm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dkk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316436
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.