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Gene: Scn5a (sodium channel, voltage-gated, type V, alpha) Mus musculus
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Symbol: Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Description: Exhibits scaffold protein binding activity and voltage-gated sodium channel activity involved in SA node cell action potential. Involved in several processes, including calcium ion homeostasis; cardiac ventricle development; and regulation of heart contraction. Localizes to several cellular components, including T-tubule; intercalated disc; and lateral plasma membrane. Is expressed in several structures, including cranial ganglion; epidermis; heart; sensory organ; and skeleton. Used to study Brugada syndrome 1; dilated cardiomyopathy 1E; long QT syndrome 3; progressive familial heart block type IA; and sick sinus syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and sudden infant death syndrome. Orthologous to human SCN5A (sodium voltage-gated channel alpha subunit 5); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mH1; Nav1.5; Nav1.5c; SkM1; SkM2; sodium channel protein cardiac muscle subunit alpha; sodium channel protein type 5 subunit alpha; sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage-gated, type V, alpha polypeptide; voltage-gated sodium channel Nav1.5 variant a; voltage-gated sodium channel Nav1.5 variant b; voltage-gated sodium channel subunit alpha Nav1.5
Orthologs:
Homo sapiens (human) : SCN5A (sodium voltage-gated channel alpha subunit 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Scn5a (sodium voltage-gated channel alpha subunit 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn5a (sodium voltage-gated channel alpha subunit 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN5A (sodium voltage-gated channel alpha subunit 5)
Canis lupus familiaris (dog) : SCN5A (sodium voltage-gated channel alpha subunit 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn5a (sodium voltage-gated channel alpha subunit 5)
Sus scrofa (pig) : SCN5A (sodium voltage-gated channel alpha subunit 5)
Chlorocebus sabaeus (African green monkey) : SCN5A (sodium voltage-gated channel alpha subunit 5)
Heterocephalus glaber (naked mole-rat) : Scn5a (sodium voltage-gated channel alpha subunit 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl9119,483,408 - 119,579,016 (-)EnsemblGRCm38mm10GRCm38
GRCm389119,483,404 - 119,579,030 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379119,392,529 - 119,488,134 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,332,109 - 119,427,714 (-)NCBImm8
Celera9119,954,231 - 120,036,580 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model