Tfrc (transferrin receptor) - Rat Genome Database

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Gene: Tfrc (transferrin receptor) Mus musculus
Symbol: Tfrc
Name: transferrin receptor
RGD ID: 70503
Description: Predicted to have several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to leukemia inhibitory factor; positive regulation of bone resorption; and positive regulation of lymphocyte proliferation. Localizes to several cellular components, including HFE-transferrin receptor complex; endosome; and extracellular exosome. Is expressed in several structures, including alimentary system; extraembryonic component; liver; lung; and meninges. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; mammary tumor virus receptor 1; Mtv; Mtvr; Mtvr-1; Mtvr1; p9; p90; TFR; TFR1; TR; transferrin receptor protein 1; Trfr
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391632,427,714 - 32,451,612 (+)NCBIGRCm39mm39
GRCm39 Ensembl1632,427,738 - 32,451,612 (+)Ensembl
GRCm381632,608,896 - 32,632,794 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,608,920 - 32,632,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,608,982 - 32,632,880 (+)NCBIGRCm37mm9NCBIm37
MGSCv361632,528,768 - 32,552,537 (+)NCBImm8
Celera1633,088,313 - 33,112,331 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-methoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
Actein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (EXP)
alachlor  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium(0)  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthracene-1,8,9-triol  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bucladesine  (ISO)
busulfan  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (EXP)
catechol  (ISO)
cefaloridine  (ISO)
chloropicrin  (ISO)
cholic acid  (EXP)
choline  (EXP)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
D-penicillamine  (ISO)
deferiprone  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
diiodine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (EXP,ISO)
ferric ammonium citrate  (EXP,ISO)
ferric oxide  (EXP)
ferric pyrophosphate  (ISO)
fipronil  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (EXP,ISO)
gallium atom  (ISO)
genistein  (EXP,ISO)
ginkgetin  (EXP,ISO)
ginkgolide B  (EXP,ISO)
glafenine  (ISO)
glycerol  (ISO)
hemin  (ISO)
heparin  (ISO)
heroin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
LY294002  (ISO)
malathion  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
Mezerein  (EXP)
mithramycin  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
okadaic acid  (EXP)
oleic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
palytoxin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propane-1,2-diol  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
ranitidine  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
Ro 41-5253  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
saccharin  (EXP)
sarin  (ISO)
SB 431542  (ISO)
sepiapterin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tin(II) chloride (anhydrous)  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
torcetrapib  (ISO)
tributylstannane  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
Yessotoxin  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
aging  (ISO)
cellular iron ion homeostasis  (IBA,IMP)
cellular response to drug  (ISO)
cellular response to extracellular stimulus  (TAS)
cellular response to iron ion  (TAS)
cellular response to leukemia inhibitory factor  (IEP)
endocytosis  (IEA)
intracellular signal transduction  (ISO)
iron ion transport  (IBA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of mitochondrial fusion  (ISO)
osteoclast differentiation  (IMP)
positive regulation of B cell proliferation  (IDA,ISO)
positive regulation of bone resorption  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of isotype switching  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of T cell proliferation  (IDA,ISO)
receptor internalization  (ISO)
receptor-mediated endocytosis  (IEA)
regulation of cell growth  (ISO)
regulation of cell population proliferation  (ISO)
response to copper ion  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to iron ion  (ISO)
response to manganese ion  (ISO)
response to nutrient  (ISO)
response to organic substance  (ISO)
response to retinoic acid  (ISO)
transferrin transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal colon morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal embryonic erythrocyte morphology  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal gait  (IEA)
abnormal intestinal mineral absorption  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal iron homeostasis  (IAGP)
abnormal iron level  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal vocalization  (IEA)
anemia  (IAGP)
blunted small intestinal villi  (IAGP)
decreased body size  (IAGP)
decreased circulating iron level  (IAGP)
decreased colon length  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased hemoglobin content  (IEA)
decreased liver iron level  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased spleen iron level  (IAGP)
diarrhea  (IAGP)
distended stomach  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
hydrops fetalis  (IAGP)
hypochromic microcytic anemia  (IAGP)
hypoxia  (IAGP)
increased apoptosis  (IAGP)
increased circulating phosphate level  (IEA)
increased erythrocyte cell number  (IAGP)
increased liver iron level  (IAGP)
increased red blood cell distribution width  (IEA)
kinked neural tube  (IAGP)
melena  (IAGP)
microcytosis  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
pericardial effusion  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
weight loss  (IAGP)

References - curated
1. Aleo Lujan E, etal., An Pediatr (Barc). 2004 May;60(5):428-35.
2. Barisani D, etal., Physiol Genomics. 2004 May 19;17(3):316-25.
3. Bruckner K, etal., Neuron 1999 Mar;22(3):511-24.
4. Cortes-Barberena E, etal., Clin Exp Immunol. 2008 Mar 28;.
5. Daniels TR, etal., J Immunother. 2011 Jul-Aug;34(6):500-8. doi: 10.1097/CJI.0b013e318222ffc8.
6. Daniels-Wells TR, etal., J Immunother. 2015 Oct;38(8):307-10. doi: 10.1097/CJI.0000000000000092.
7. Farley J, etal., Anal Quant Cytol Histol. 1998 Aug;20(4):238-49.
8. FitzGerald DJ, etal., Cancer Res. 1987 Mar 1;47(5):1407-10.
9. Hofer T, etal., Exp Gerontol. 2008 Feb 29;.
10. Hogemann-Savellano D, etal., Neoplasia. 2003 Nov-Dec;5(6):495-506.
11. Holmstrom P, etal., Liver Int. 2006 Oct;26(8):976-85.
12. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Khomenko T, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. doi: 10.1152/ajpgi.90257.2008. Epub 2009 Apr 2.
14. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
15. Kudoh S, etal., Int J Cancer. 1994 Aug 1;58(3):369-75.
16. Kuvibidila S, etal., J Lab Clin Med. 2004 Oct;144(4):176-82.
17. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
18. Lelliott PM, etal., Infect Immun. 2015 Nov;83(11):4322-34. doi: 10.1128/IAI.00926-15. Epub 2015 Aug 24.
19. Li Y, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):242-8. doi: 10.1007/s12011-012-9455-0. Epub 2012 May 26.
20. Liu CY, etal., Zhonghua Xue Ye Xue Za Zhi. 2007 Apr;28(4):255-8.
21. Martin FM, etal., PLoS One. 2011 Feb 4;6(2):e16894. doi: 10.1371/journal.pone.0016894.
22. Mechtersheimer G, etal., Pathol Res Pract. 1990 Aug;186(4):427-38.
23. Meli R, etal., PLoS One. 2013 Jun 21;8(6):e66570. doi: 10.1371/journal.pone.0066570. Print 2013.
24. MGD and Homologene mouse data transfer
25. MGD data from the GO Consortium
27. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. OMIM Disease Annotation Pipeline
29. Pipeline to import KEGG annotations from KEGG into RGD
30. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Rahman SA, etal., Urol Res. 1997;25(5):325-9.
32. RGD automated import pipeline
33. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. RGD automated import pipeline for gene-chemical interactions
35. Richardson SC, etal., Mol Biol Cell 2004 Mar;15(3):1197-210. Epub 2003 Dec 10.
36. Shabtai M, etal., J Urol. 2002 Nov;168(5):2216-9.
37. Sheikh N, etal., Lab Invest. 2007 Apr 9;.
38. Sheikh N, etal., Lab Invest. 2007 Jul;87(7):713-25. Epub 2007 Apr 9.
39. Weizer-Stern O, etal., Am J Hematol. 2006 Jul;81(7):479-83.
40. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
41. Yang DC, etal., Anticancer Res. 2001 Jan-Feb;21(1B):541-9.
42. Yang DC, etal., Anticancer Res. 2001 May-Jun;21(3B):1777-87.
43. Zhu BM, etal., Blood. 2008 Sep 1;112(5):2071-80. doi: 10.1182/blood-2007-12-127480. Epub 2008 Jun 13.
Additional References at PubMed
PMID:1397688   PMID:1734036   PMID:2984291   PMID:6092468   PMID:6290505   PMID:6296428   PMID:6641714   PMID:7567998   PMID:7994765   PMID:8875074   PMID:8889548   PMID:8930792  
PMID:9525630   PMID:9665270   PMID:10192390   PMID:10349636   PMID:10364163   PMID:10444069   PMID:10562540   PMID:10791995   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11092755  
PMID:11266470   PMID:12218182   PMID:12477932   PMID:12589962   PMID:12881306   PMID:12904583   PMID:14610273   PMID:14694089   PMID:15229288   PMID:15358563   PMID:15469906   PMID:15489334  
PMID:15716025   PMID:15782199   PMID:16092918   PMID:16141072   PMID:16141073   PMID:16227996   PMID:16254249   PMID:16424878   PMID:16481319   PMID:16602821   PMID:16787915   PMID:16799992  
PMID:16893896   PMID:17087999   PMID:17119325   PMID:17121833   PMID:17374603   PMID:17434485   PMID:17716972   PMID:17961511   PMID:18003730   PMID:18029550   PMID:18287559   PMID:18316026  
PMID:18321981   PMID:18354138   PMID:18434600   PMID:18519569   PMID:18547789   PMID:18607772   PMID:18621680   PMID:18694996   PMID:18696076   PMID:18799693   PMID:18829060   PMID:19066835  
PMID:19144828   PMID:19154717   PMID:19252502   PMID:19339555   PMID:19387073   PMID:19538749   PMID:19596281   PMID:19724054   PMID:19884258   PMID:20004763   PMID:20080761   PMID:20424607  
PMID:20439489   PMID:20631077   PMID:20711497   PMID:21078691   PMID:21252237   PMID:21266579   PMID:21267068   PMID:21483770   PMID:21553221   PMID:21565611   PMID:21700773   PMID:21718402  
PMID:21873635   PMID:21903580   PMID:21907140   PMID:22019713   PMID:22028793   PMID:22330344   PMID:22556427   PMID:22566683   PMID:22937132   PMID:23016877   PMID:23102618   PMID:23269685  
PMID:23303939   PMID:23357852   PMID:23395379   PMID:23416069   PMID:23650374   PMID:23958061   PMID:24045836   PMID:24470444   PMID:24515870   PMID:24752778   PMID:25044020   PMID:25758223  
PMID:25782630   PMID:25860887   PMID:26166573   PMID:26201991   PMID:26275132   PMID:26287972   PMID:26324903   PMID:26419445   PMID:26432893   PMID:26456827   PMID:26551679   PMID:26637351  
PMID:26642240   PMID:26792178   PMID:26870796   PMID:26880306   PMID:26929359   PMID:26952984   PMID:27100851   PMID:27362800   PMID:27695001   PMID:27732846   PMID:28069738   PMID:28151426  
PMID:28378742   PMID:28538180   PMID:28694332   PMID:29054881   PMID:29459677   PMID:29654211   PMID:29958803   PMID:30093529   PMID:30409884   PMID:30457570   PMID:30538134   PMID:30550785  
PMID:30701202   PMID:30713523   PMID:30976085   PMID:31339576   PMID:31366551   PMID:31541184   PMID:31601687   PMID:31676601   PMID:31838906   PMID:32324134   PMID:32325033   PMID:32374849  
PMID:32405996   PMID:32968282  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391632,427,714 - 32,451,612 (+)NCBIGRCm39mm39
GRCm39 Ensembl1632,427,738 - 32,451,612 (+)Ensembl
GRCm381632,608,896 - 32,632,794 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,608,920 - 32,632,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,608,982 - 32,632,880 (+)NCBIGRCm37mm9NCBIm37
MGSCv361632,528,768 - 32,552,537 (+)NCBImm8
Celera1633,088,313 - 33,112,331 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.06NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3196,027,183 - 196,082,096 (-)EnsemblGRCh38hg38GRCh38
GRCh383196,018,694 - 196,082,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,776,155 - 195,808,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,260,744 - 197,293,338 (-)NCBINCBI36hg18NCBI36
Build 343197,264,659 - 197,297,251NCBI
Celera3194,360,605 - 194,393,477 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,076,917 - 193,109,375 (-)NCBIHuRef
CHM1_13195,747,516 - 195,780,405 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21168,163,413 - 68,185,257 (-)NCBI
Rnor_6.0 Ensembl1171,397,383 - 71,419,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01171,397,423 - 71,419,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01174,479,841 - 74,502,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,976,258 - 69,998,098 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,034,788 - 70,049,347 (-)NCBI
Celera1167,596,761 - 67,618,555 (-)NCBICelera
Cytogenetic Map11q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542012,348,821 - 12,372,691 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,348,392 - 12,372,714 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.13203,333,953 - 203,365,586 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,333,953 - 203,373,998 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03193,384,817 - 193,417,532 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13329,206,024 - 29,237,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,208,609 - 29,238,242 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,234,803 - 29,256,627 (-)NCBI
ROS_Cfam_1.03329,440,415 - 29,471,780 (-)NCBI
UMICH_Zoey_3.13329,229,617 - 29,251,398 (-)NCBI
UNSW_CanFamBas_1.03329,284,382 - 29,306,157 (-)NCBI
UU_Cfam_GSD_1.03329,905,548 - 29,927,547 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405602125,156,856 - 125,188,523 (+)NCBI
SpeTri2.0NW_004936784696,738 - 728,385 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13133,970,594 - 134,000,278 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,976,765 - 133,997,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,414,634 - 143,435,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11591,102,153 - 91,134,994 (+)NCBI
ChlSab1.1 Ensembl1591,102,817 - 91,135,584 (+)Ensembl
Vero_WHO_p1.0NW_02366604164,945,566 - 64,977,969 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462473061,282,650 - 61,313,487 (-)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,632,568 - 32,632,778UniSTSGRCm38
MGSCv371632,632,654 - 32,632,864UniSTSGRCm37
Celera1633,112,105 - 33,112,315UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,630,148 - 32,630,295UniSTSGRCm38
MGSCv371632,630,234 - 32,630,381UniSTSGRCm37
Celera1633,109,685 - 33,109,832UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,632,244 - 32,632,438UniSTSGRCm38
MGSCv371632,632,330 - 32,632,524UniSTSGRCm37
Celera1633,111,781 - 33,111,975UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,620,687 - 32,620,792UniSTSGRCm38
MGSCv371632,620,773 - 32,620,878UniSTSGRCm37
Celera1633,100,175 - 33,100,280UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,632,414 - 32,632,538UniSTSGRCm38
MGSCv371632,632,500 - 32,632,624UniSTSGRCm37
Celera1633,111,951 - 33,112,075UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,614,719 - 32,615,215UniSTSGRCm38
MGSCv371632,614,805 - 32,615,301UniSTSGRCm37
Celera1633,094,207 - 33,094,703UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,607,357 - 32,607,542UniSTSGRCm38
MGSCv371632,607,443 - 32,607,628UniSTSGRCm37
Celera1633,086,775 - 33,086,960UniSTS
Cytogenetic Map16B3UniSTS
cM Map1621.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,630,164 - 32,630,316UniSTSGRCm38
MGSCv371632,630,250 - 32,630,402UniSTSGRCm37
Celera1633,109,701 - 33,109,853UniSTS
Cytogenetic Map16B3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16665914535200846Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162020057985803938Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162211802156118212Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2295650257773713Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162897245062972589Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162897245062972589Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162897245062972589Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162897245062972589Mouse
25394537Skmw83_mskeletal muscle weight 83, soleus (mouse)163148564733369337Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163158368336719911Mouse
1300935Aod1_mautoimmune ovarian dysgenesis 1 (mouse)Not determined163231202232704294Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163249243266492570Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1091
Count of miRNA genes:602
Interacting mature miRNAs:773
Transcripts:ENSMUST00000023486, ENSMUST00000120680, ENSMUST00000124243, ENSMUST00000128285, ENSMUST00000137901, ENSMUST00000155929
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_001357298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ426432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF714992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY101284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X57349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000023486   ⟹   ENSMUSP00000023486
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,608,920 - 32,632,794 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120680   ⟹   ENSMUSP00000113028
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,608,983 - 32,623,741 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124243   ⟹   ENSMUSP00000123423
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,609,250 - 32,613,226 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128285
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,624,442 - 32,632,790 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137901
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,615,232 - 32,617,156 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155929
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,618,279 - 32,620,881 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231912
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1632,620,389 - 32,623,741 (+)Ensembl
RefSeq Acc Id: NM_001357298   ⟹   NP_001344227
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391632,427,940 - 32,451,612 (+)NCBI
GRCm381632,609,122 - 32,632,794 (+)NCBI
RefSeq Acc Id: NM_011638   ⟹   NP_035768
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391632,427,714 - 32,451,612 (+)NCBI
GRCm381632,608,896 - 32,632,794 (+)ENTREZGENE
MGSCv371632,608,982 - 32,632,880 (+)RGD
Celera1633,088,313 - 33,112,331 (+)RGD
RefSeq Acc Id: XM_036159875   ⟹   XP_036015768
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391632,427,783 - 32,451,065 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_035768   ⟸   NM_011638
- UniProtKB: Q62351 (UniProtKB/Swiss-Prot),   Q542D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001344227   ⟸   NM_001357298
RefSeq Acc Id: ENSMUSP00000123423   ⟸   ENSMUST00000124243
RefSeq Acc Id: ENSMUSP00000113028   ⟸   ENSMUST00000120680
RefSeq Acc Id: ENSMUSP00000023486   ⟸   ENSMUST00000023486
RefSeq Acc Id: XP_036015768   ⟸   XM_036159875
- Peptide Label: isoform X1
Protein Domains
PA   Peptidase_M28   TFR_dimer

RGD ID:6827555
Promoter ID:MM_KWN:20769
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000120680,   OTTMUST00000066569,   OTTMUST00000066571
Mouse AssemblyChrPosition (strand)Source
MGSCv361632,608,861 - 32,609,361 (+)MPROMDB
RGD ID:8685998
Promoter ID:EPDNEW_M21030
Type:multiple initiation site
Description:Mus musculus transferrin receptor , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381632,608,983 - 32,609,043EPDNEW
RGD ID:6827556
Promoter ID:MM_KWN:20770
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv361632,614,156 - 32,614,656 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98822 AgrOrtholog
Ensembl Genes ENSMUSG00000022797 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023486 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113028 UniProtKB/TrEMBL
  ENSMUSP00000123423 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023486 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000120680 UniProtKB/TrEMBL
  ENSMUST00000124243 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M28B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TfR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR-like_dimer_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR-like_dimer_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TfR1/2_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22042 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10404 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10404:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF02225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tfrc PhenoGen
Superfamily-SCOP SSF47672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q61560 UniProtKB/Swiss-Prot