H2ax (H2A.X variant histone) - Rat Genome Database
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Gene: H2ax (H2A.X variant histone) Mus musculus
Analyze
Symbol: H2ax
Name: H2A.X variant histone
RGD ID: 1558155
MGI Page MGI
Description: Exhibits damaged DNA binding activity. Involved in double-strand break repair via homologous recombination and spermatogenesis. Localizes to chromosome and male germ cell nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including blastocyst; central nervous system; early embryo; eye; and gonad. Orthologous to human H2AX (H2A.X variant histone).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AW228881; gammaH; gammaH2ax; H2A histone family, member X; H2A.; H2A.X; H2a/x; H2af; H2afx; Hist5-; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; histone H2AX
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,246,012 - 44,247,374 (+)NCBIGRCm39mm39
GRCm38944,334,715 - 44,336,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,334,694 - 44,336,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37944,142,798 - 44,144,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv36944,085,710 - 44,087,072 (+)NCBImm8
Celera941,589,440 - 41,590,802 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-benzoquinone  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (EXP)
2,2'-bipyridine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitroanisole  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
680C91  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
9-aminoacridine  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
all-trans-retinoic acid  (ISO)
alternariol  (ISO)
alvocidib  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aphidicolin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
benzo[e]pyrene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (ISO)
busulfan  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (EXP,ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
carmustine  (ISO)
celecoxib  (ISO)
chlorambucil  (ISO)
chlordecone  (EXP)
chlorite  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
chromone  (ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cyprodinil  (ISO)
cytarabine  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
diepoxybutane  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
epothilone A  (ISO)
erdosteine  (EXP)
erlotinib hydrochloride  (ISO)
Estragole  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP,ISO)
ferric oxide  (ISO)
flavanones  (ISO)
fludioxonil  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fomepizole  (ISO)
fotemustine  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
genistein  (ISO)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glutathione  (EXP)
glycerol 2-phosphate  (ISO)
glyphosate  (EXP)
hexachlorobenzene  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP,ISO)
imiquimod  (EXP)
iprodione  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isocyanates  (EXP,ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
kaempferol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
Longikaurin A  (ISO)
lovastatin  (EXP,ISO)
Manumycin A  (ISO)
mechlorethamine  (EXP)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (ISO)
menaquinone  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
miconazole  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
n-propyl gallate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nimustine  (ISO)
nitrogen mustard  (ISO)
nocodazole  (ISO)
norethisterone  (ISO)
NS-398  (ISO)
NSC 23766  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
olaparib  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (EXP)
pentamidine  (ISO)
phenanthridone  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
PhIP  (ISO)
phosphoramide mustard  (EXP,ISO)
phthalic acid  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium bromate  (EXP,ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
promethazine  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
pyrimethamine  (ISO)
quercetin  (EXP,ISO)
rac-1,2-dichloropropane  (EXP,ISO)
razoxane  (ISO)
reactive oxygen species  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
romidepsin  (ISO)
rotenone  (EXP)
Satratoxin H  (ISO)
selenium atom  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
Sodium salicylate  (ISO)
sterigmatocystin  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (EXP,ISO)
TEMPO  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (EXP,ISO)
toxaphene  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triciribine  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
veliparib  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
zearalenone  (EXP)
zebularine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Baban B, etal., Hypertension. 2013 Jan;61(1):95-104. doi: 10.1161/HYPERTENSIONAHA.111.00028. Epub 2012 Oct 29.
2. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
3. Chen YT, etal., Stem Cell Res Ther. 2013 May 31;4(3):62.
4. Cho BO, etal., Food Chem. 2013 May 1;138(1):107-15. doi: 10.1016/j.foodchem.2012.10.026. Epub 2012 Nov 6.
5. Crowe SL, etal., J Neurosci. 2011 May 25;31(21):7648-56. doi: 10.1523/JNEUROSCI.0092-11.2011.
6. Hori T, etal., Ann Transplant. 2013 Jun 17;18:299-313. doi: 10.12659/AOT.883955.
7. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Kimura M, etal., Exp Toxicol Pathol. 2013 Nov;65(7-8):979-88. doi: 10.1016/j.etp.2013.01.012. Epub 2013 Mar 7.
9. Lovren F, etal., J Thorac Cardiovasc Surg. 2014 Jun;147(6):1946-55, 1955.e1. doi: 10.1016/j.jtcvs.2013.09.060. Epub 2013 Nov 13.
10. Maze I, etal., Nat Rev Genet. 2014 Apr;15(4):259-71. doi: 10.1038/nrg3673. Epub 2014 Mar 11.
11. MGD data from the GO Consortium
12. MGD IEA
13. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Raz L, etal., PLoS One. 2010 Sep 7;5(9):e12606. doi: 10.1371/journal.pone.0012606.
17. RGD automated import pipeline
18. RGD automated import pipeline for gene-chemical interactions
19. Tarasenko N, etal., PLoS One. 2012;7(2):e31393. doi: 10.1371/journal.pone.0031393. Epub 2012 Feb 23.
Additional References at PubMed
PMID:2041781   PMID:7217105   PMID:7407044   PMID:7642525   PMID:7774939   PMID:9488723   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11242108   PMID:11331621   PMID:11571274  
PMID:11740565   PMID:11803372   PMID:11893489   PMID:11934988   PMID:12034884   PMID:12140190   PMID:12360237   PMID:12447390   PMID:12477932   PMID:12533428   PMID:12660252   PMID:12689589  
PMID:12697768   PMID:12792649   PMID:12810694   PMID:12841599   PMID:12897845   PMID:12914700   PMID:12914701   PMID:14530383   PMID:14561636   PMID:14611631   PMID:14736746   PMID:14999024  
PMID:15059890   PMID:15115728   PMID:15226823   PMID:15322096   PMID:15326357   PMID:15364958   PMID:15456874   PMID:15489334   PMID:15520243   PMID:15574327   PMID:15580272   PMID:15589157  
PMID:15604234   PMID:15610743   PMID:15632067   PMID:15657431   PMID:15707990   PMID:15782199   PMID:15944199   PMID:16030261   PMID:16141072   PMID:16141073   PMID:16199867   PMID:16292313  
PMID:16400328   PMID:16427009   PMID:16427010   PMID:16540514   PMID:16857171   PMID:16927366   PMID:17115059   PMID:17301228   PMID:17304220   PMID:17344431   PMID:17369397   PMID:17475928  
PMID:17498656   PMID:17599069   PMID:17635934   PMID:17668632   PMID:17696610   PMID:17855626   PMID:17912366   PMID:17923115   PMID:17923680   PMID:18070917   PMID:18185516   PMID:18283110  
PMID:18316482   PMID:18413980   PMID:18542054   PMID:18599436   PMID:18617533   PMID:18619440   PMID:18633137   PMID:18663141   PMID:18694567   PMID:18695893   PMID:18755145   PMID:18852295  
PMID:18927154   PMID:18981061   PMID:19014927   PMID:19064695   PMID:19074312   PMID:19074348   PMID:19092802   PMID:19124014   PMID:19154734   PMID:19171781   PMID:19176879   PMID:19223465  
PMID:19234442   PMID:19273588   PMID:19321613   PMID:19377486   PMID:19432895   PMID:19450528   PMID:19463809   PMID:19531582   PMID:19570515   PMID:19598117   PMID:19620979   PMID:19633665  
PMID:19667071   PMID:19716796   PMID:19735653   PMID:19876815   PMID:19887394   PMID:19887628   PMID:19910469   PMID:20059948   PMID:20096683   PMID:20106871   PMID:20118229   PMID:20231360  
PMID:20356835   PMID:20360685   PMID:20364144   PMID:20448412   PMID:20448641   PMID:20479123   PMID:20484573   PMID:20508641   PMID:20516196   PMID:20551173   PMID:20557919   PMID:20577743  
PMID:20657840   PMID:20693977   PMID:20703100   PMID:20707993   PMID:20833365   PMID:20943707   PMID:20947684   PMID:21160472   PMID:21160476   PMID:21185283   PMID:21267068   PMID:21355037  
PMID:21383063   PMID:21383078   PMID:21385577   PMID:21436033   PMID:21444690   PMID:21451147   PMID:21478856   PMID:21482717   PMID:21498842   PMID:21525980   PMID:21539824   PMID:21555580  
PMID:21613325   PMID:21621532   PMID:21655083   PMID:21660050   PMID:21676867   PMID:21690091   PMID:21690297   PMID:21791604   PMID:21849621   PMID:21852425   PMID:21858116   PMID:21862448  
PMID:21873635   PMID:21911473   PMID:21943826   PMID:21947081   PMID:21991325   PMID:22071108   PMID:22154935   PMID:22164254   PMID:22206758   PMID:22266795   PMID:22297488   PMID:22344029  
PMID:22360967   PMID:22370720   PMID:22402492   PMID:22508511   PMID:22522401   PMID:22530760   PMID:22579044   PMID:22580959   PMID:22628289   PMID:22699483   PMID:22711701   PMID:22730535  
PMID:22763785   PMID:22854038   PMID:22908299   PMID:22922362   PMID:22940690   PMID:22946062   PMID:23039116   PMID:23090997   PMID:23133398   PMID:23151479   PMID:23254285   PMID:23269666  
PMID:23271346   PMID:23300469   PMID:23355489   PMID:23382223   PMID:23384561   PMID:23396135   PMID:23401851   PMID:23431372   PMID:23463509   PMID:23492809   PMID:23518926   PMID:23536184  
PMID:23553930   PMID:23555294   PMID:23563309   PMID:23683352   PMID:23754376   PMID:23759310   PMID:23798389   PMID:23810942   PMID:23824453   PMID:23824539   PMID:23892236   PMID:23897892  
PMID:23935957   PMID:23964092   PMID:23966158   PMID:24009519   PMID:24067652   PMID:24068956   PMID:24238961   PMID:24238962   PMID:24301314   PMID:24301385   PMID:24315958   PMID:24440154  
PMID:24463367   PMID:24483844   PMID:24496623   PMID:24503550   PMID:24553289   PMID:24576537   PMID:24671879   PMID:24706806   PMID:24713393   PMID:24725274   PMID:24759790   PMID:24784881  
PMID:24793032   PMID:24797475   PMID:24829461   PMID:24837676   PMID:24859845   PMID:24899573   PMID:24899707   PMID:24912678   PMID:25010009   PMID:25079315   PMID:25102060   PMID:25155611  
PMID:25158167   PMID:25192463   PMID:25264618   PMID:25288669   PMID:25344072   PMID:25352572   PMID:25458011   PMID:25515659   PMID:25605334   PMID:25609427   PMID:25611385   PMID:25634095  
PMID:25650421   PMID:25668066   PMID:25668206   PMID:25675407   PMID:25694116   PMID:25703348   PMID:25727968   PMID:25731851   PMID:25738897   PMID:25758227   PMID:25773539   PMID:25810472  
PMID:25951169   PMID:26023099   PMID:26028220   PMID:26045162   PMID:26116663   PMID:26123487   PMID:26158450   PMID:26232259   PMID:26234156   PMID:26251404   PMID:26290337   PMID:26292757  
PMID:26302789   PMID:26308889   PMID:26358182   PMID:26362256   PMID:26383973   PMID:26427872   PMID:26428007   PMID:26456157   PMID:26489649   PMID:26490168   PMID:26509888   PMID:26694365  
PMID:26711500   PMID:26712235   PMID:26717153   PMID:26742488   PMID:26745185   PMID:26751069   PMID:26791933   PMID:26876348   PMID:26917450   PMID:26917764   PMID:26941327   PMID:27006338  
PMID:27065194   PMID:27073218   PMID:27090237   PMID:27125672   PMID:27130279   PMID:27160905   PMID:27172884   PMID:27173733   PMID:27179789   PMID:27251002   PMID:27260000   PMID:27320916  
PMID:27373144   PMID:27389782   PMID:27609454   PMID:27618282   PMID:27760146   PMID:27798842   PMID:27869164   PMID:27918549   PMID:28057860   PMID:28123024   PMID:28128212   PMID:28199840  
PMID:28240985   PMID:28254491   PMID:28276606   PMID:28292424   PMID:28380054   PMID:28389581   PMID:28552778   PMID:28619823   PMID:28633017   PMID:28708136   PMID:28716713   PMID:28724724  
PMID:28768199   PMID:28768200   PMID:28777373   PMID:28818995   PMID:28827401   PMID:28893945   PMID:28977657   PMID:29087293   PMID:29114052   PMID:29180744   PMID:29311308   PMID:29321668  
PMID:29329290   PMID:29352998   PMID:29386106   PMID:29391475   PMID:29437857   PMID:29447390   PMID:29617656   PMID:29670103   PMID:29698519   PMID:29718910   PMID:29742439   PMID:29754823  
PMID:29795555   PMID:30059908   PMID:30061411   PMID:30093551   PMID:30102701   PMID:30196744   PMID:30232008   PMID:30239864   PMID:30272023   PMID:30289439   PMID:30302025   PMID:30304535  
PMID:30333137   PMID:30335684   PMID:30344095   PMID:30348983   PMID:30393076   PMID:30398394   PMID:30457570   PMID:30462294   PMID:30518625   PMID:30523785   PMID:30538199   PMID:30562941  
PMID:30569039   PMID:30590785   PMID:30595499   PMID:30659795   PMID:30668728   PMID:30704900   PMID:30713523   PMID:30746471   PMID:30760716   PMID:30885981   PMID:30910969   PMID:30912742  
PMID:30938680   PMID:30949703   PMID:30995416   PMID:31059511   PMID:31084574   PMID:31123184   PMID:31197172   PMID:31216312   PMID:31256246   PMID:31299635   PMID:31358751   PMID:31453335  
PMID:31624230   PMID:31680852   PMID:31715134   PMID:31794431   PMID:31949138   PMID:32032549   PMID:32054698   PMID:32094118   PMID:32103583   PMID:32123907   PMID:32232159   PMID:32294451  
PMID:32321712   PMID:32452519   PMID:32572033   PMID:32674113   PMID:32719317   PMID:32994318  


Genomics

Comparative Map Data
H2ax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,246,012 - 44,247,374 (+)NCBIGRCm39mm39
GRCm38944,334,715 - 44,336,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,334,694 - 44,336,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37944,142,798 - 44,144,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv36944,085,710 - 44,087,072 (+)NCBImm8
Celera941,589,440 - 41,590,802 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
H2AX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11119,093,854 - 119,095,467 (-)EnsemblGRCh38hg38GRCh38
GRCh3811119,093,874 - 119,095,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,964,580 - 118,966,177 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,469,794 - 118,471,387 (-)NCBINCBI36hg18NCBI36
Build 3411118,469,796 - 118,471,387NCBI
Celera11116,121,998 - 116,123,592 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,904,032 - 114,905,625 (-)NCBIHuRef
CHM1_111118,850,886 - 118,852,479 (-)NCBICHM1_1
H2ax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0848,665,652 - 48,666,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,665,652 - 48,666,981 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,284,623 - 47,285,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,312,609 - 47,313,938 (+)NCBIRGSC3.4rn4RGSC3.4
Celera844,258,161 - 44,259,490 (+)NCBICelera
Cytogenetic Map8q22NCBI
LOC102025775
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,203,772 - 20,204,203 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,203,173 - 20,204,714 (-)NCBIChiLan1.0ChiLan1.0
LOC100994157
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111117,862,383 - 117,862,841 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011113,932,078 - 113,933,679 (-)NCBIMhudiblu_PPA_v0panPan3
H2AX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl514,766,126 - 14,766,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1514,765,625 - 14,766,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101966907
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365424,046,930 - 4,049,017 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100522201
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,309,653 - 46,310,084 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,308,824 - 46,310,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,343,962 - 51,345,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
H2AFX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,466,692 - 110,468,776 (-)NCBI
ChlSab1.1 Ensembl1110,467,775 - 110,468,206 (-)Ensembl
LOC101701891
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478414,475,813 - 14,477,269 (-)NCBI

Position Markers
BB138393  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,333,693 - 44,333,777UniSTSGRCm38
MGSCv37944,141,776 - 44,141,860UniSTSGRCm37
Celera941,588,418 - 41,588,502UniSTS
Cytogenetic Map9A5.2UniSTS
Whitehead/MRC_RH9490.11UniSTS
RH136449  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,333,270 - 44,333,474UniSTSGRCm38
MGSCv37944,141,353 - 44,141,557UniSTSGRCm37
Celera941,587,995 - 41,588,199UniSTS
Cytogenetic Map9A5.2UniSTS
AW228881  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,335,701 - 44,335,822UniSTSGRCm38
MGSCv37944,143,784 - 44,143,905UniSTSGRCm37
Celera941,590,426 - 41,590,547UniSTS
Cytogenetic Map9A5.2UniSTS
UniSTS:225267  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38944,335,542 - 44,335,721UniSTSGRCm38
MGSCv37944,143,625 - 44,143,804UniSTSGRCm37
Celera941,590,267 - 41,590,446UniSTS
Cytogenetic Map9A5.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93682494749509211Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93703211050199840Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93724206644340026Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94050829851897370Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94073407848440176Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94149086645432445Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir138-1mmu-miR-138-5pOncomiRDBexternal_infoNANA21693595
Mir138-2mmu-miR-138-5pOncomiRDBexternal_infoNANA21693595

Predicted Target Of
Summary Value
Count of predictions:327
Count of miRNA genes:234
Interacting mature miRNAs:260
Transcripts:ENSMUST00000052686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000052686   ⟹   ENSMUSP00000051432
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl944,334,694 - 44,336,077 (+)Ensembl
RefSeq Acc Id: NM_010436   ⟹   NP_034566
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39944,246,012 - 44,247,374 (+)NCBI
GRCm38944,334,715 - 44,336,077 (+)ENTREZGENE
MGSCv37944,142,798 - 44,144,160 (+)RGD
Celera941,589,440 - 41,590,802 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034566   ⟸   NM_010436
- UniProtKB: P27661 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000051432   ⟸   ENSMUST00000052686

Promoters
RGD ID:6844645
Promoter ID:MM_KWN:57108
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_010436
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36944,142,746 - 44,143,967 (+)MPROMDB
RGD ID:8669370
Promoter ID:EPDNEW_M12716
Type:multiple initiation site
Name:H2afx_1
Description:Mus musculus H2A histone family, member X , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38944,334,695 - 44,334,755EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102688 AgrOrtholog
Ensembl Genes ENSMUSG00000049932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000051432 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052686 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
InterPro Histone-fold UniProtKB/Swiss-Prot
  Histone_H2A UniProtKB/Swiss-Prot
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot
  Histone_H2A_CS UniProtKB/Swiss-Prot
KEGG Report mmu:15270 UniProtKB/Swiss-Prot
MGD MGI:102688 ENTREZGENE
NCBI Gene 15270 ENTREZGENE
Pfam Histone UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot
PhenoGen H2ax PhenoGen
PRINTS HISTONEH2A UniProtKB/Swiss-Prot
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot
SMART H2A UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
UniProt H2AX_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-01 H2ax  H2A.X variant histone  H2afx  H2A histone family, member X  Symbol and/or name change 5135510 APPROVED