Calr3 (calreticulin 3) - Rat Genome Database
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Gene: Calr3 (calreticulin 3) Mus musculus
Analyze
Symbol: Calr3
Name: calreticulin 3
RGD ID: 1319476
MGI Page MGI
Description: Exhibits protein folding chaperone. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein folding. Predicted to localize to endoplasmic reticulum lumen; endoplasmic reticulum membrane; and nuclear envelope. Is expressed in cerebral cortex and telencephalon. Orthologous to human CALR3 (calreticulin 3); INTERACTS WITH 17alpha-ethynylestradiol; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700031L01Rik; 6330586I20Rik; ca; calreticulin-2; calreticulin-3; calspeculin; calsperin; Crt; Crt2; cspn
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,178,020 - 73,197,638 (-)NCBIGRCm39mm39
GRCm38872,424,176 - 72,443,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,424,176 - 72,443,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,948,082 - 74,967,677 (-)NCBIGRCm37mm9NCBIm37
MGSCv36875,353,172 - 75,372,767 (-)NCBImm8
Celera876,763,438 - 76,782,291 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12384296   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21131354   PMID:21677750   PMID:21873635   PMID:22357757  
PMID:24501175   PMID:32325033  


Genomics

Comparative Map Data
Calr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,178,020 - 73,197,638 (-)NCBIGRCm39mm39
GRCm38872,424,176 - 72,443,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,424,176 - 72,443,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,948,082 - 74,967,677 (-)NCBIGRCm37mm9NCBIm37
MGSCv36875,353,172 - 75,372,767 (-)NCBImm8
Celera876,763,438 - 76,782,291 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
CALR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,479,057 - 16,496,192 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1916,479,061 - 16,496,167 (-)EnsemblGRCh38hg38GRCh38
GRCh381916,479,061 - 16,496,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,589,767 - 16,607,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,450,887 - 16,468,003 (-)NCBINCBI36hg18NCBI36
Build 341916,450,887 - 16,468,003NCBI
Celera1916,491,740 - 16,508,840 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,158,784 - 16,175,504 (-)NCBIHuRef
CHM1_11916,589,388 - 16,606,484 (-)NCBICHM1_1
Calr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,097,391 - 19,124,062 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,097,391 - 19,124,062 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,960,142 - 18,985,150 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,814,237 - 17,842,744 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,814,234 - 17,842,742 (+)NCBI
Celera1617,615,842 - 17,640,280 (+)NCBICelera
Cytogenetic Map16p14NCBI
Calr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,245,708 - 1,256,478 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,245,607 - 1,256,528 (+)NCBIChiLan1.0ChiLan1.0
CALR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,948,431 - 16,965,232 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,948,499 - 16,965,161 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01915,969,684 - 15,986,858 (-)NCBIMhudiblu_PPA_v0panPan3
CALR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,039,115 - 46,060,814 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,039,115 - 46,060,834 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Calr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365964,120,292 - 4,140,432 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,105,303 - 61,134,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,105,307 - 61,136,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,738,182 - 60,767,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,987,761 - 15,007,145 (-)NCBI
ChlSab1.1 Ensembl614,987,230 - 15,006,857 (-)Ensembl
Calr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908949,709 - 962,114 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:122
Interacting mature miRNAs:140
Transcripts:ENSMUST00000019876, ENSMUST00000109974
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019876   ⟹   ENSMUSP00000019876
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,424,176 - 72,443,870 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109974   ⟹   ENSMUSP00000105601
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,424,183 - 72,435,156 (-)Ensembl
RefSeq Acc Id: NM_028500   ⟹   NP_082776
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,178,027 - 73,197,622 (-)NCBI
GRCm38872,424,183 - 72,443,778 (-)NCBI
MGSCv37874,948,082 - 74,967,677 (-)RGD
Celera876,763,438 - 76,782,291 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029782   ⟹   NP_084058
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,178,027 - 73,189,000 (-)NCBI
GRCm38872,424,183 - 72,435,156 (-)NCBI
MGSCv37874,948,082 - 74,967,677 (-)RGD
Celera876,763,438 - 76,782,291 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509761   ⟹   XP_006509824
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,178,020 - 73,197,638 (-)NCBI
GRCm38872,424,176 - 72,443,819 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243800   ⟹   XP_030099660
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,178,020 - 73,188,937 (-)NCBI
GRCm38872,424,176 - 72,435,093 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_084058   ⟸   NM_029782
- Peptide Label: isoform 2
- UniProtKB: Q8BL82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_082776   ⟸   NM_028500
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9D9Q6 (UniProtKB/Swiss-Prot),   Q8BL82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509824   ⟸   XM_006509761
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030099660   ⟸   XM_030243800
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000105601   ⟸   ENSMUST00000109974
RefSeq Acc Id: ENSMUSP00000019876   ⟸   ENSMUST00000019876

Promoters
RGD ID:8667469
Promoter ID:EPDNEW_M11766
Type:initiation region
Name:Calr3_1
Description:Mus musculus calreticulin 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,443,735 - 72,443,795EPDNEW
RGD ID:6842613
Promoter ID:MM_KWN:54870
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000121902,   OTTMUST00000078711,   OTTMUST00000078727
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,967,434 - 74,967,934 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920566 AgrOrtholog
Ensembl Genes ENSMUSG00000019732 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000019876 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105601 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019876 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000109974 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calret/calnex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calret/calnex_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calreticulin/calnexin_P_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73316 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1920566 ENTREZGENE
NCBI Gene 73316 ENTREZGENE
PANTHER PTHR11073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Calr3 PhenoGen
PIRSF Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CALRETICULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALRETICULIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALRETICULIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.196315 ENTREZGENE
UniProt B1Q2L7_MOUSE UniProtKB/TrEMBL
  CALR3_MOUSE UniProtKB/Swiss-Prot
  Q8BL82 ENTREZGENE, UniProtKB/TrEMBL
  Q9D373_MOUSE UniProtKB/TrEMBL
  Q9D9Q6 ENTREZGENE
UniProt Secondary G5E827 UniProtKB/Swiss-Prot