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Gene: Xbp1 (X-box binding protein 1) Mus musculus
Symbol: Xbp1
Name: X-box binding protein 1
Description: Exhibits several functions, including RNA polymerase II transcription factor binding activity; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including gland development; lipid homeostasis; and positive regulation of secretion. Localizes to the cytoplasm and nucleus. Used to study inflammatory bowel disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human XBP1 (X-box binding protein 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; forkhead class A signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (-)-anisomycin; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D11Ertd39e; tax-responsive element-binding protein 5 homolog; TREB-5; TREB5; X-box-binding protein 1; XBP-1
Homo sapiens (human) : XBP1 (X-box binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xbp1 (X-box binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xbp1 (X-box binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XBP1 (X-box binding protein 1)
Canis lupus familiaris (dog) : XBP1 (X-box binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xbp1 (X-box binding protein 1)
Sus scrofa (pig) : XBP1 (X-box binding protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38115,520,641 - 5,525,993 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37115,420,970 - 5,425,875 (+)NCBIGRCm37mm9NCBIm37
MGSCv36115,420,970 - 5,425,875 (+)NCBImm8
Celera116,013,628 - 6,018,986 (+)NCBICelera
Cytogenetic Map11 A1NCBI
cM Map113.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Xbp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332312
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.