Cebpb (CCAAT/enhancer binding protein (C/EBP), beta) - Rat Genome Database

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Gene: Cebpb (CCAAT/enhancer binding protein (C/EBP), beta) Mus musculus
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Symbol: Cebpb
Name: CCAAT/enhancer binding protein (C/EBP), beta
RGD ID: 10326
MGI Page MGI
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver development; regulation of leukocyte differentiation; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of DNA-templated transcription. Located in chromosome; cytoplasm; and nuclear matrix. Part of C/EBP complex. Is expressed in several structures, including adrenal gland; connective tissue; extraembryonic component; genitourinary system; and integumental system. Used to study osteochondrodysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AGP/EBP; C/EBP BETA; C/EBPbe; C/EBPbeta; CCAAT/enhancer-binding protein beta; CR; CRP2; IL-6; IL-6DBP; interleukin-6-dependent-binding protein; LAP; LIP; liver-enriched transcriptional activator; Nf; NF-; NF-IL6; NF-M; Nfil6; nuclear protein Il6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)EnsemblGRCm39 Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBIMGSCv36mm8
MGSCv362168,673,393 - 168,674,898 (+)NCBIMGSCv36mm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(R)-adrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cGMP  (EXP)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
apigenin  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
astemizole  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
baicalein  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
betulinic acid  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
boric acid  (EXP)
bortezomib  (EXP,ISO)
bucladesine  (EXP)
butylated hydroxyanisole  (EXP)
C60 fullerene  (ISO)
caffeine  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboxy-PTIO  (EXP,ISO)
carmustine  (ISO)
ceruletide  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
choline  (EXP,ISO)
Chorionic gonadotropin  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
endrin  (EXP)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (EXP)
fenpyroximate  (ISO)
flavone  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
gallic acid  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
geraniol  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycidol  (ISO)
glycyrrhizinic acid  (EXP)
GW 4064  (EXP)
herbimycin  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (EXP)
indometacin  (EXP,ISO)
Iodine aqueous  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoniazide  (EXP)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
L-serine  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Muraglitazar  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitroprusside  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oltipraz  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pentane  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
picene  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
prostaglandin J2  (ISO)
pyrazinecarboxamide  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
riboflavin  (ISO)
rifampicin  (EXP)
rolipram  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sincalide  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
stavudine  (ISO)
streptozocin  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (EXP)
tebufenpyrad  (ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
Tetramethylthiourea  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torin 1  (EXP,ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP,ISO)
tunicamycin  (EXP,ISO)
undecane  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brown fat cell differentiation  (IMP)
cell differentiation  (IEA)
cellular response to amino acid stimulus  (IDA)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
defense response to bacterium  (IMP)
DNA-templated transcription  (IEA)
embryonic placenta development  (IGI)
fat cell differentiation  (IDA,IGI)
granuloma formation  (IMP)
hepatocyte proliferation  (IDA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
liver development  (ISO)
liver regeneration  (IMP)
mammary gland epithelial cell differentiation  (IMP)
mammary gland epithelial cell proliferation  (IMP)
memory  (ISO)
myeloid cell development  (NAS)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of T cell proliferation  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
neuron differentiation  (IDA)
ovarian follicle development  (IMP)
positive regulation of biomineral tissue development  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of fat cell differentiation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (IGI)
positive regulation of interleukin-4 production  (IDA)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of sodium-dependent phosphate transport  (ISO)
positive regulation of transcription by RNA polymerase II  (EXP,IDA,IGI,IMP,ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
regulation of cell differentiation  (IBA)
regulation of dendritic cell differentiation  (IGI)
regulation of DNA-templated transcription  (ISO)
regulation of interleukin-6 production  (IDA)
regulation of odontoblast differentiation  (ISO,ISS)
regulation of osteoclast differentiation  (IDA)
regulation of transcription by RNA polymerase II  (IBA,IMP,ISO)
response to endoplasmic reticulum stress  (ISO)
response to lipopolysaccharide  (IMP)
T-helper 1 cell activation  (IMP)
transcription by RNA polymerase II  (IDA,IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue physiology  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal brown adipose tissue physiology  (IAGP)
abnormal brown adipose tissue thermogenesis  (IAGP)
abnormal brown fat cell morphology  (IAGP)
abnormal brown fat lipid droplet number  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal circulating free fatty acids level  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal epidermis stratum spinosum morphology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hair follicle infundibulum morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal innate immunity  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal lactation  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymph node cortex morphology  (IAGP)
abnormal lymph node medulla morphology  (IAGP)
abnormal lymph node medullary cord morphology  (IAGP)
abnormal lymph node secondary follicle morphology  (IAGP)
abnormal lymph node T cell domain morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal male preputial gland morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mammary gland epithelium physiology  (IAGP)
abnormal Meibomian gland morphology  (IAGP)
abnormal mucosa-associated lymphoid tissue morphology  (IAGP)
abnormal myeloid cell number  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pancreatic beta cell mass  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal plasma cell morphology  (IAGP)
abnormal sebaceous gland morphology  (IAGP)
abnormal sebaceous lipid secretion  (IAGP)
abnormal sebocyte differentiation  (IAGP)
abnormal sebocyte morphology  (IAGP)
abnormal skeletal muscle mass  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal spleen secondary B follicle morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
absent corpus luteum  (IAGP)
absent epidermis stratum corneum  (IAGP)
absent epidermis stratum granulosum  (IAGP)
absent estrous cycle  (IAGP)
calcified muscle  (IAGP)
decreased body weight  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-10 level  (IAGP)
decreased circulating interleukin-12 level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased glycogen catabolism rate  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased incidence of induced tumors  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased insulin secretion  (IAGP)
decreased lipoprotein lipase activity  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased superovulation rate  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased transforming growth factor beta level  (IAGP)
decreased triglyceride level  (IAGP)
decreased tumor growth/size  (IAGP)
decreased uterine fat pad weight  (IAGP)
decreased white adipose tissue amount  (IAGP)
dry eyes  (IAGP)
enhanced osteoblast differentiation  (IAGP)
enlarged axillary lymph nodes  (IAGP)
enlarged inguinal lymph nodes  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged submandibular lymph nodes  (IAGP)
epidermal hyperplasia  (IAGP)
expanded mesangial matrix  (IAGP)
extramedullary hematopoiesis  (IAGP)
eyelids open at birth  (IAGP)
female infertility  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
hair follicle outer root sheath hyperplasia  (IAGP)
hemosiderosis  (IAGP)
hyperglycemia  (IAGP)
hyperkeratosis  (IAGP)
hypoglycemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired granulosa cell differentiation  (IAGP)
impaired lipolysis  (IAGP)
impaired liver regeneration  (IAGP)
impaired luteinization  (IAGP)
impaired macrophage phagocytosis  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
increased bone marrow cell number  (IAGP)
increased bone mineralization  (IAGP)
increased bone ossification  (IAGP)
increased bone resorption  (IAGP)
increased bone trabecula number  (IAGP)
increased bone volume  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased IgG level  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-12 secretion  (IAGP)
increased keratinocyte apoptosis  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased mesangial cell number  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to fungal infection  (IAGP)
increased trabecular bone thickness  (IAGP)
Meibomian gland atrophy  (IAGP)
myositis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
parakeratosis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
renal glomerulus hypertrophy  (IAGP)
shiny skin  (IAGP)
skeletal muscle fibrosis  (IAGP)
skin lesions  (IAGP)
thick epidermis  (IAGP)
tight skin  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. Cain DW, etal., J Immunol. 2013 Nov 1;191(9):4665-75. doi: 10.4049/jimmunol.1300581. Epub 2013 Sep 27.
2. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. Colangelo V, etal., J Neurosci Res. 2002 Nov 1;70(3):462-73.
3. Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection. Foldenauer ME, etal., J Immunol. 2013 Jun 1;190(11):5649-58. doi: 10.4049/jimmunol.1203094. Epub 2013 Apr 26.
4. Identification of a molecular signature of sarcopenia. Giresi PG, etal., Physiol Genomics. 2005 Apr 14;21(2):253-63. Epub 2005 Feb 1.
5. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Gong B, etal., Mol Immunol. 2013 Dec;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.
6. CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. Greenbaum LE, etal., J Clin Invest 1998 Sep 1;102(5):996-1007.
7. CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis. Hayashida M, etal., Arthritis Rheum. 2009 Mar;60(3):708-16. doi: 10.1002/art.24332.
8. C/EBPbeta and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2alpha as the inducer in chondrocytes. Hirata M, etal., Hum Mol Genet. 2012 Mar 1;21(5):1111-23. doi: 10.1093/hmg/ddr540. Epub 2011 Nov 17.
9. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
10. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. CRE-mediated transcription is increased in Huntington's disease transgenic mice. Obrietan K and Hoyt KR, J Neurosci. 2004 Jan 28;24(4):791-6.
15. C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Penner G, etal., Am J Physiol Regul Integr Comp Physiol 2002 Feb;282(2):R439-44.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity. Pope RM, etal., Clin Immunol. 1999 Jun;91(3):271-82.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. Sahu SK, etal., PLoS Pathog. 2017 May 30;13(5):e1006410. doi: 10.1371/journal.ppat.1006410. eCollection 2017 May.
22. Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis. Saito H, etal., Mech Ageing Dev. 2003 Dec;124(10-12):1047-58. doi: 10.1016/j.mad.2003.08.002.
23. Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice. Sandhir R and Berman NE, Neurochem Int. 2010 Jan;56(1):188-93. doi: 10.1016/j.neuint.2009.10.002. Epub 2009 Oct 13.
24. Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration. Shi X, etal., Infect Immun. 2017 Oct 18;85(11). pii: IAI.00369-17. doi: 10.1128/IAI.00369-17. Print 2017 Nov.
25. C/EBPbeta Promotes Immunity to Oral Candidiasis through Regulation of beta-Defensins. Simpson-Abelson MR, etal., PLoS One. 2015 Aug 28;10(8):e0136538. doi: 10.1371/journal.pone.0136538. eCollection 2015.
26. Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia. Sun R, etal., Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C101-15. doi: 10.1152/ajpcell.00344.2015. Epub 2016 Apr 27.
27. The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. Uematsu S, etal., J Immunol. 2007 Oct 15;179(8):5378-86. doi: 10.4049/jimmunol.179.8.5378.
28. Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta. Wang L, etal., J Biol Chem 2000 May 12;275(19):14173-81.
29. Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPbeta and NFkappaB cleavage. Wu SM, etal., J Pineal Res. 2016 Mar;60(2):142-54. doi: 10.1111/jpi.12295. Epub 2015 Dec 16.
30. Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Xiong L, etal., Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z.
Additional References at PubMed
PMID:1371974   PMID:1371993   PMID:1701020   PMID:1840554   PMID:7530603   PMID:7557387   PMID:7598808   PMID:7622488   PMID:7684005   PMID:7744000   PMID:7760844   PMID:7781998  
PMID:7959007   PMID:8211130   PMID:8297376   PMID:8336793   PMID:8530045   PMID:8563027   PMID:8628296   PMID:8657121   PMID:8754811   PMID:8754826   PMID:8879230   PMID:8946919  
PMID:8973343   PMID:9001238   PMID:9049631   PMID:9271672   PMID:9303532   PMID:9334201   PMID:9405372   PMID:9428809   PMID:9434955   PMID:9494081   PMID:9531536   PMID:9545285  
PMID:9545506   PMID:9616220   PMID:9637691   PMID:9637692   PMID:9693973   PMID:9742105   PMID:9813043   PMID:9916132   PMID:9918941   PMID:10082561   PMID:10092809   PMID:10224054  
PMID:10319019   PMID:10349636   PMID:10455174   PMID:10490653   PMID:10510303   PMID:10528209   PMID:10536163   PMID:10588870   PMID:10600708   PMID:10635333   PMID:10683373   PMID:10707954  
PMID:10859308   PMID:10921906   PMID:10982846   PMID:11018027   PMID:11024029   PMID:11042159   PMID:11076861   PMID:11151091   PMID:11159172   PMID:11196172   PMID:11278638   PMID:11684016  
PMID:11726507   PMID:11726661   PMID:11733516   PMID:11756662   PMID:11792321   PMID:11877276   PMID:11940593   PMID:11976687   PMID:12048207   PMID:12048245   PMID:12071851   PMID:12072435  
PMID:12095417   PMID:12177065   PMID:12184911   PMID:12213825   PMID:12215258   PMID:12355443   PMID:12379662   PMID:12456789   PMID:12466851   PMID:12524424   PMID:12525691   PMID:12556485  
PMID:12558604   PMID:12821655   PMID:12832471   PMID:12837957   PMID:12847250   PMID:12871593   PMID:14576085   PMID:14593102   PMID:14670999   PMID:14681479   PMID:14688407   PMID:14697236  
PMID:14736879   PMID:14981542   PMID:15005571   PMID:15051496   PMID:15060147   PMID:15130516   PMID:15143161   PMID:15158467   PMID:15175325   PMID:15187136   PMID:15289464   PMID:15308669  
PMID:15383601   PMID:15504955   PMID:15509779   PMID:15509789   PMID:15519652   PMID:15598659   PMID:15601867   PMID:15613028   PMID:15618518   PMID:15632071   PMID:15644333   PMID:15659391  
PMID:15665733   PMID:15713650   PMID:15721291   PMID:15737626   PMID:15747579   PMID:15762841   PMID:15775988   PMID:15788409   PMID:15809228   PMID:15850785   PMID:15863502   PMID:15870285  
PMID:15878863   PMID:15879117   PMID:15936952   PMID:15985551   PMID:16014896   PMID:16046404   PMID:16054042   PMID:16054051   PMID:16107878   PMID:16120603   PMID:16141072   PMID:16141073  
PMID:16150866   PMID:16166081   PMID:16205634   PMID:16288022   PMID:16318580   PMID:16431920   PMID:16439483   PMID:16492136   PMID:16585579   PMID:16632469   PMID:16682266   PMID:16698852  
PMID:16751774   PMID:16784777   PMID:16837772   PMID:16850160   PMID:16892179   PMID:16899075   PMID:16959612   PMID:17064678   PMID:17078024   PMID:17110376   PMID:17177178   PMID:17192478  
PMID:17210130   PMID:17244625   PMID:17254333   PMID:17264204   PMID:17288991   PMID:17301242   PMID:17387171   PMID:17433708   PMID:17464987   PMID:17504763   PMID:17510195   PMID:17524357  
PMID:17525287   PMID:17576771   PMID:17584738   PMID:17599912   PMID:17601773   PMID:17646392   PMID:17702848   PMID:17724128   PMID:17855774   PMID:17888405   PMID:17913887   PMID:17975479  
PMID:17982082   PMID:18056834   PMID:18092000   PMID:18159255   PMID:18174271   PMID:18195020   PMID:18250155   PMID:18287559   PMID:18339625   PMID:18346930   PMID:18388310   PMID:18392683  
PMID:18439838   PMID:18448564   PMID:18467525   PMID:18478268   PMID:18486321   PMID:18550528   PMID:18596980   PMID:18622014   PMID:18636078   PMID:18678862   PMID:18703634   PMID:18760339  
PMID:18761321   PMID:18824566   PMID:18843047   PMID:18981473   PMID:18996961   PMID:19026986   PMID:19029947   PMID:19056928   PMID:19103292   PMID:19126543   PMID:19164449   PMID:19169276  
PMID:19218285   PMID:19228596   PMID:19229324   PMID:19297554   PMID:19324970   PMID:19344698   PMID:19353522   PMID:19398579   PMID:19440205   PMID:19443782   PMID:19454718   PMID:19478079  
PMID:19520806   PMID:19563810   PMID:19581927   PMID:19628693   PMID:19641492   PMID:19652026   PMID:19749746   PMID:19805133   PMID:19811452   PMID:19875812   PMID:19885945   PMID:19940121  
PMID:19955657   PMID:20047998   PMID:20048163   PMID:20052801   PMID:20054865   PMID:20086097   PMID:20111005   PMID:20194724   PMID:20209087   PMID:20351173   PMID:20352127   PMID:20371871  
PMID:20410440   PMID:20446924   PMID:20479126   PMID:20498378   PMID:20501671   PMID:20529561   PMID:20548288   PMID:20605485   PMID:20686481   PMID:20726009   PMID:20829347   PMID:20876575  
PMID:20960217   PMID:20962249   PMID:20966351   PMID:20979051   PMID:21047912   PMID:21072215   PMID:21122806   PMID:21148742   PMID:21167261   PMID:21177758   PMID:21183071   PMID:21185356  
PMID:21267068   PMID:21268070   PMID:21292824   PMID:21303932   PMID:21308778   PMID:21346244   PMID:21353395   PMID:21455770   PMID:21464964   PMID:21471197   PMID:21487015   PMID:21521687  
PMID:21558273   PMID:21562127   PMID:21562223   PMID:21563299   PMID:21606199   PMID:21621583   PMID:21847090   PMID:21873635   PMID:21897364   PMID:21899882   PMID:21933012   PMID:21982742  
PMID:21998664   PMID:22003384   PMID:22011580   PMID:22044243   PMID:22068055   PMID:22074460   PMID:22078933   PMID:22082962   PMID:22138520   PMID:22147692   PMID:22172035   PMID:22260630  
PMID:22306325   PMID:22355693   PMID:22369944   PMID:22411169   PMID:22503555   PMID:22521691   PMID:22556424   PMID:22573614   PMID:22581863   PMID:22610404   PMID:22634316   PMID:22662254  
PMID:22722334   PMID:22732594   PMID:22737085   PMID:22742194   PMID:22751693   PMID:22859371   PMID:22865229   PMID:22902781   PMID:22948537   PMID:22977257   PMID:23024276   PMID:23034923  
PMID:23065276   PMID:23159614   PMID:23160954   PMID:23177475   PMID:23251594   PMID:23266643   PMID:23375831   PMID:23382991   PMID:23456364   PMID:23472114   PMID:23475960   PMID:23512806  
PMID:23515163   PMID:23524343   PMID:23541989   PMID:23547050   PMID:23564453   PMID:23564995   PMID:23568773   PMID:23585399   PMID:23643813   PMID:23665916   PMID:23754749   PMID:23755188  
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PMID:25802132   PMID:25804385   PMID:25813145   PMID:25848030   PMID:25921091   PMID:26017382   PMID:26065429   PMID:26066982   PMID:26113365   PMID:26147683   PMID:26168729   PMID:26217013  
PMID:26220403   PMID:26243869   PMID:26271478   PMID:26372225   PMID:26476039   PMID:26526992   PMID:26566865   PMID:26646662   PMID:26667036   PMID:26709824   PMID:26740594   PMID:26913600  
PMID:26934381   PMID:26941360   PMID:26963625   PMID:26966068   PMID:26984772   PMID:27072340   PMID:27135215   PMID:27147263   PMID:27297958   PMID:27382175   PMID:27430527   PMID:27522676  
PMID:27586877   PMID:27593484   PMID:27731369   PMID:27746211   PMID:27803164   PMID:27812542   PMID:27819350   PMID:27923061   PMID:27923399   PMID:27974211   PMID:28002407   PMID:28088614  
PMID:28107648   PMID:28383550   PMID:28476751   PMID:28482072   PMID:28514690   PMID:28604636   PMID:28636830   PMID:28646352   PMID:28657144   PMID:28668397   PMID:28698219   PMID:28807982  
PMID:28854265   PMID:28934717   PMID:28965824   PMID:28972158   PMID:29030964   PMID:29138456   PMID:29266779   PMID:29324844   PMID:29448105   PMID:29563610   PMID:29581460   PMID:29688375  
PMID:29708496   PMID:29725016   PMID:29768199   PMID:29849099   PMID:29870755   PMID:30010083   PMID:30026232   PMID:30081710   PMID:30273359   PMID:30323292   PMID:30443252   PMID:30530690  
PMID:30698678   PMID:30711544   PMID:31061100   PMID:31067460   PMID:31101736   PMID:31209363   PMID:31240246   PMID:31371025   PMID:31433978   PMID:31686316   PMID:31791580   PMID:31953319  
PMID:32094117   PMID:32098917   PMID:32358019   PMID:32795415   PMID:32892421   PMID:32971400   PMID:33017390   PMID:33238123   PMID:33339957   PMID:33486744   PMID:33684156   PMID:33744198  
PMID:33866588   PMID:34215724   PMID:34697411   PMID:34792688   PMID:34794427   PMID:34958873   PMID:35179324   PMID:35181694   PMID:35196497   PMID:35451956   PMID:35863637   PMID:36111785  
PMID:36301029   PMID:36578534   PMID:36624847  


Genomics

Comparative Map Data
Cebpb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)EnsemblGRCm39 Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBIMGSCv36mm8
MGSCv362168,673,393 - 168,674,898 (+)NCBIMGSCv36mm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
CEBPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,190,583 - 50,192,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2050,190,830 - 50,192,668 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,807,120 - 48,809,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,240,783 - 48,242,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 342048,240,782 - 48,242,619NCBI
Celera2045,511,633 - 45,513,469 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBIHuRef
CHM1_12048,711,778 - 48,713,885 (+)NCBICHM1_1
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBIT2T-CHM13v2.0
Cebpb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,398,035 - 156,399,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,397,052 - 156,399,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,193,187 - 160,194,618 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03168,692,267 - 168,693,698 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03166,433,973 - 166,435,404 (+)NCBIRnor_WKY
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
Cebpb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554458,060,432 - 8,061,289 (-)NCBIChiLan1.0ChiLan1.0
CEBPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02046,533,163 - 46,535,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CEBPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,661,294 - 36,663,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,661,616 - 36,662,656 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,905,196 - 35,907,045 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,368,136 - 37,369,976 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,368,234 - 37,369,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,608,936 - 36,610,792 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,742,145 - 36,743,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,285,911 - 37,287,750 (+)NCBIUU_Cfam_GSD_1.0
CEBPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,722,426 - 51,724,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,722,633 - 51,723,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,041,640 - 58,042,680 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEBPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,780,538 - 13,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,781,160 - 13,782,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,211,871 - 62,213,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cebpb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,368,349 - 5,369,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,367,808 - 5,369,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir155mmu-miR-155-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI19520806
Mir155mmu-miR-155-5pOncomiRDBexternal_infoNANA19711427

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:148
Interacting mature miRNAs:167
Transcripts:ENSMUST00000070642
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160611165169794802Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160611165169794802Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
1301378Hpdty_mhindlimb polydactyly (mouse)Not determined2165664893168623678Mouse

Markers in Region
Cebpb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,690,109 - 167,690,205UniSTSGRCm38
MGSCv372167,515,653 - 167,515,742UniSTSGRCm37
Celera2173,630,233 - 173,630,322UniSTS
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC114562P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,689,309 - 167,689,783UniSTSGRCm38
MGSCv372167,514,809 - 167,515,283UniSTSGRCm37
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC21741P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,689,676 - 167,690,117UniSTSGRCm38
MGSCv372167,515,176 - 167,515,617UniSTSGRCm37
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC316377P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,689,260 - 167,689,406UniSTSGRCm38
MGSCv372167,514,760 - 167,514,906UniSTSGRCm37
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC55812P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,688,999 - 167,689,112UniSTSGRCm38
MGSCv372167,514,499 - 167,514,612UniSTSGRCm37
Celera2173,629,196 - 173,629,309UniSTS
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC55812P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,688,996 - 167,689,112UniSTSGRCm38
MGSCv372167,514,496 - 167,514,612UniSTSGRCm37
Celera2173,629,193 - 173,629,309UniSTS
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
Cebpb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,690,153 - 167,690,242UniSTSGRCm38
MGSCv372167,515,653 - 167,515,742UniSTSGRCm37
Celera2173,630,233 - 173,630,322UniSTS
Cytogenetic Map2H3UniSTS
Cebpb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070642   ⟹   ENSMUSP00000069850
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)Ensembl
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)Ensembl
RefSeq Acc Id: NM_001287738   ⟹   NP_001274667
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,530,835 - 167,532,352 (+)NCBI
GRCm382167,688,915 - 167,690,432 (+)NCBI
Celera2173,629,112 - 173,630,512 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287739   ⟹   NP_001274668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,530,835 - 167,532,352 (+)NCBI
GRCm382167,688,915 - 167,690,432 (+)NCBI
Celera2173,629,112 - 173,630,512 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009883   ⟹   NP_034013
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,530,835 - 167,532,352 (+)NCBI
GRCm382167,688,915 - 167,690,432 (+)NCBI
MGSCv372167,514,415 - 167,515,918 (+)RGD
Celera2173,629,112 - 173,630,512 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034013   ⟸   NM_009883
- Peptide Label: isoform a
- UniProtKB: P28033 (UniProtKB/Swiss-Prot),   Q3UPN9 (UniProtKB/TrEMBL),   A0A6P5PDV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274667   ⟸   NM_001287738
- Peptide Label: isoform b
- UniProtKB: P28033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001274668   ⟸   NM_001287739
- Peptide Label: isoform c
- UniProtKB: P28033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069850   ⟸   ENSMUST00000070642
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28033-F1-model_v2 AlphaFold P28033 1-296 view protein structure

Promoters
RGD ID:6830699
Promoter ID:MM_KWN:33124
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000021742,   NM_009883,   UC008OAG.1,   UC008OAH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,513,626 - 167,516,717 (+)MPROMDB
RGD ID:6879814
Promoter ID:EPDNEW_M3358
Type:multiple initiation site
Name:Cebpb_1
Description:Mus musculus CCAAT/enhancer binding protein (C/EBP), beta , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,688,967 - 167,689,027EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88373 AgrOrtholog
Ensembl Genes ENSMUSG00000056501 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000069850 ENTREZGENE
  ENSMUSP00000069850.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070642 ENTREZGENE
  ENSMUST00000070642.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C/EBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C/EBP_chordates UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12608 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88373 ENTREZGENE
NCBI Gene 12608 ENTREZGENE
PANTHER CCAAT/ENHANCER BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CCAAT/ENHANCER-BINDING PROTEIN BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cebpb PhenoGen
PIRSF CCAAT/enhancer-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6P5PDV6 ENTREZGENE
  CEBPB_MOUSE UniProtKB/Swiss-Prot
  O70192_MOUSE UniProtKB/TrEMBL
  P28033 ENTREZGENE
  Q3UPN9 ENTREZGENE, UniProtKB/TrEMBL