Cebpb (CCAAT/enhancer binding protein beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cebpb (CCAAT/enhancer binding protein beta) Mus musculus
Analyze
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
RGD ID: 10326
MGI Page MGI
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver development; positive regulation of metabolic process; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of C/EBP complex. Is expressed in several structures, including adrenal gland; connective tissue; extraembryonic component; genitourinary system; and integumental system. Used to study osteochondrodysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AGP/EBP; C/EBP BETA; C/EBPbe; C/EBPbeta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; CR; CRP2; IL-6; IL-6DBP; interleukin-6-dependent-binding protein; LAP; LIP; liver-enriched transcriptional activator; Nf; NF-; NF-IL6; NF-M; Nfil6; nuclear protein Il6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)EnsemblGRCm39 Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBIMGSCv36mm8
MGSCv362168,673,393 - 168,674,898 (+)NCBIMGSCv36mm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMouseAlzheimer's disease  ISOCEBPB (Homo sapiens)10401229mRNA:increased expression:hippocampus CA1 (human)RGD 
CebpbMouseAlzheimer's disease treatmentIDA 10401268 RGD 
CebpbMouseBacteremia  IEP 40903040associated with alcohol use disorder and mRNA:increased expression:bone marrow (mouse)RGD 
CebpbMouseBrain Injuries  IEP 10401206mRNA and protein:increased expression:cerebral cortex (mouse)RGD 
CebpbMouseCachexia treatmentIEP 40903021 RGD 
CebpbMouseEndotoxemia treatmentISOCebpb (Rattus norvegicus)1625687 RGD 
CebpbMouseEndotoxemia  IDA 40903034 RGD 
CebpbMouseEosinophilia  IMP 40903041 RGD 
CebpbMousehepatocellular carcinoma  ISOCEBPB (Homo sapiens)40903042mRNA: increased expression:liver (human)RGD 
CebpbMouseHuntington's disease  IEP 10401227protein:increased expression:brain (mouse)RGD 
CebpbMouseInflammation  ISOCEBPB (Homo sapiens)10401215associated with Arthritis more ...RGD 
CebpbMouselisteriosis severityIMP 40903039 RGD 
CebpbMouseneurodegenerative disease  ISOCebpb (Rattus norvegicus)408418724protein:increased expression:neuronRGD 
CebpbMouseoral candidiasis susceptibilityIMP 11079756 RGD 
CebpbMouseosteoarthritis susceptibilityIMP 10401214 RGD 
CebpbMouseperitoneum cancer severityIMP 11556383associated with stomach cancerRGD 
CebpbMousePseudomonas Aeruginosa Keratitis treatmentIEP 40903020mRNA and protein:increased expression:cornea (mouse)RGD 
CebpbMouserheumatoid arthritis  ISOCEBPB (Homo sapiens)10401213protein:increased expression:knee and articular cartilage (human)RGD 
CebpbMouseSarcopenia  ISOCEBPB (Homo sapiens)10401226mRNA:increased expression:vastus lateralis muscle (human)RGD 
CebpbMouseSepsis  ISOCebpb (Rattus norvegicus)625506protein:increased expression:skeletal muscleRGD 
1 to 20 of 21 rows
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMouseadenocarcinoma  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34973135
CebpbMouseBrain Injuries  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21549006
CebpbMousebrain ischemia  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17394460
CebpbMouseCardiomegaly  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:29266779
CebpbMouseDisease Progression  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34973135
CebpbMouseFemale Infertility  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21177758
CebpbMouseFibrosis  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:29266779
CebpbMousehepatocellular carcinoma  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14563831
CebpbMousepulmonary fibrosis  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17177178
CebpbMousesteatotic liver disease  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24469900
CebpbMouseStomach Neoplasms  ISOCEBPB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34973135
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMouseosteochondrodysplasia  IAGP 13592920 MouseDO 
CebpbMouseviral infectious disease  IAGP 13592920 MouseDO 

1 to 20 of 565 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMouse(-)-cotinine multiple interactionsISOCebpb (Rattus norvegicus)6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNACTDPMID:29617909
CebpbMouse(R)-adrenaline decreases expressionEXP 6480464Epinephrine results in decreased expression of CEBPB proteinCTDPMID:31520687
CebpbMouse(S)-amphetamine increases expressionEXP 6480464Dextroamphetamine results in increased expression of CEBPB mRNACTDPMID:12558987
CebpbMouse(S)-nicotine increases expressionISOCEBPB (Homo sapiens)6480464Nicotine results in increased expression of CEBPB mRNACTDPMID:18805435
CebpbMouse(S)-nicotine multiple interactionsISOCebpb (Rattus norvegicus)6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNACTDPMID:29617909
CebpbMouse1,1-dichloroethene increases expressionEXP 6480464vinylidene chloride results in increased expression of CEBPB mRNACTDPMID:26682919
CebpbMouse1,2,4-trimethylbenzene increases expressionISOCebpb (Rattus norvegicus)6480464pseudocumene results in increased expression of CEBPB proteinCTDPMID:17337753
CebpbMouse1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of CEBPB mRNACTDPMID:22206623
CebpbMouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CEBPB mRNACTDPMID:22206623
CebpbMouse1-naphthyl isothiocyanate multiple interactionsISOCEBPB (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CEBPB mRNACTDPMID:27344345
CebpbMouse1-nitropyrene increases expressionISOCEBPB (Homo sapiens)64804641-nitropyrene results in increased expression of CEBPB mRNACTDPMID:19428942
CebpbMouse14-Deoxy-11,12-didehydroandrographolide multiple interactionsEXP 648046414-deoxy-11 more ...CTDPMID:30248417
CebpbMouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of CEBPB mRNACTDPMID:17942748
CebpbMouse17alpha-ethynylestradiol increases expressionISOCebpb (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of CEBPB mRNACTDPMID:17351261
CebpbMouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CEBPB mRNACTDPMID:17942748
CebpbMouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of CEBPB mRNACTDPMID:15289156 more ...
CebpbMouse17beta-estradiol increases expressionISOCebpb (Rattus norvegicus)6480464Estradiol results in increased expression of CEBPB mRNACTDPMID:32145629
CebpbMouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of CEBPB mRNACTDPMID:19484750
CebpbMouse17beta-estradiol increases expressionISOCEBPB (Homo sapiens)6480464Estradiol results in increased expression of CEBPB mRNACTDPMID:23373633
CebpbMouse17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of CEBPB mRNACTDPMID:15598610

1 to 20 of 565 rows

Biological Process
1 to 20 of 68 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMousebrown fat cell differentiation involved_inIMP 2290270 PMID:19641492UniProtPMID:19641492
CebpbMousecellular response to amino acid stimulus acts_upstream_of_or_withinIDA 2290270 PMID:20548288MGIPMID:20548288
CebpbMousecellular response to interleukin-1  ISOCebpb (Rattus norvegicus)9068941 RGDPMID:18405661 and REF_RGD_ID:10401220
CebpbMousecellular response to interleukin-1 involved_inISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMousecellular response to lipopolysaccharide  ISOCebpb (Rattus norvegicus)9068941 RGDPMID:18405661 and REF_RGD_ID:10401220
CebpbMousecellular response to lipopolysaccharide involved_inISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMousedefense response to bacterium involved_inIMP 2290270 PMID:17911624UniProtPMID:17911624
CebpbMouseembryonic placenta development acts_upstream_of_or_withinIGIMGI:994802290270 PMID:15509779MGIPMID:15509779
CebpbMousefat cell differentiation acts_upstream_of_or_withinIGIMGI:989562290270 PMID:17888405MGIPMID:17888405
CebpbMousefat cell differentiation acts_upstream_of_or_withinIDA 2290270 PMID:15509789 and PMID:17888405MGIPMID:15509789 and PMID:17888405
CebpbMousefat cell differentiation acts_upstream_of_or_withinIGI 2290270 PMID:23643813MGIPMID:23643813
CebpbMousegranuloma formation involved_inIMP 2290270 PMID:17911624UniProtPMID:17911624
CebpbMousehepatocyte proliferation involved_inISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMousehepatocyte proliferation involved_inIDA 2290270 PMID:10635333UniProtPMID:10635333
CebpbMouseintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress involved_inIMP 2290270 PMID:9531536ParkinsonsUK-UCLPMID:9531536
CebpbMouseliver development  ISOCebpb (Rattus norvegicus)9068941 RGDPMID:1377818 and REF_RGD_ID:69946
CebpbMouseliver regeneration involved_inIMP 2290270 PMID:9727068UniProtPMID:9727068
CebpbMousemammary gland epithelial cell differentiation acts_upstream_of_or_withinIMPMGI:21493292290270 PMID:10707954MGIPMID:10707954
CebpbMousemammary gland epithelial cell proliferation acts_upstream_of_or_withinIMPMGI:21493292290270 PMID:10683373MGIPMID:10683373
CebpbMousememory  ISOCebpb (Rattus norvegicus)9068941 RGDPMID:17512093 and REF_RGD_ID:2299897
1 to 20 of 68 rows

Cellular Component
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMouseC/EBP complex part_ofISOUniProtKB:P176762290270 GO_CentralGO_REF:0000119
CebpbMouseC/EBP complex part_ofIPI 2290270 PMID:17264204ComplexPortalPMID:17264204
CebpbMouseCHOP-C/EBP complex part_ofISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMouseCHOP-C/EBP complex part_ofISOUniProtKB:P176762290270 GO_CentralGO_REF:0000119
CebpbMouseCHOP-C/EBP complex part_ofISOComplexPortal:CPX-622290270 ComplexPortalGO_REF:0000114
CebpbMousechromatin located_inIDA 2290270 PMID:15187136BHF-UCLPMID:15187136
CebpbMousecondensed chromosome, centromeric region located_inIDA 2290270 PMID:21122806MGIPMID:21122806
CebpbMousecytoplasm located_inIDA 2290270 PMID:11684016 and PMID:15870285MGIPMID:11684016 and PMID:15870285
CebpbMousenuclear matrix  ISOCebpb (Rattus norvegicus)9068941 RGDPMID:12095231 more ...
CebpbMousenuclear matrix located_inIDA 2290270 PMID:21122806MGIPMID:21122806
CebpbMousenuclear matrix located_inISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMousenucleoplasm located_inISOUniProtKB:P176762290270 GO_CentralGO_REF:0000119
CebpbMousenucleoplasm located_inTAS 2290270 ReactomeReactome:R-MMU-442516 more ...
CebpbMousenucleus located_inISOUniProtKB:P176762290270 GO_CentralGO_REF:0000119
CebpbMousenucleus located_inNAS 2290270 PMID:20829347 and PMID:8657121ComplexPortalPMID:20829347 and PMID:8657121
CebpbMousenucleus located_inIDA 2290270 PMID:10588870 more ...MGIPMID:10588870 more ...
CebpbMousenucleus located_inISOComplexPortal:CPX-33612290270 ComplexPortalGO_REF:0000114
CebpbMousenucleus located_inISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMouseRNA polymerase II transcription regulator complex part_ofISOUniProtKB:P176762290270 GO_CentralGO_REF:0000119
CebpbMouseRNA polymerase II transcription regulator complex part_ofIDA 2290270 PMID:27812542MGIPMID:27812542
1 to 20 of 21 rows

Molecular Function
1 to 20 of 58 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMousechromatin binding enablesIDA 2290270 PMID:21122806 and PMID:24216764MGIPMID:21122806 and PMID:24216764
CebpbMousechromatin DNA binding enablesIDA 2290270 PMID:25921091MGIPMID:25921091
CebpbMouseDNA binding  ISOCebpb (Rattus norvegicus)9068941 RGDPMID:11792653 and REF_RGD_ID:625506
CebpbMouseDNA binding enablesIDA 2290270 PMID:10510303 more ...MGIPMID:10510303 more ...
CebpbMouseDNA binding enablesISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMouseDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 2290270 PMID:10588870MGIPMID:10588870
CebpbMouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN001515662 more ...2290270 GO_CentralGO_REF:0000033
CebpbMouseDNA-binding transcription factor activity, RNA polymerase II-specific contributes_toIDA 2290270 PMID:27812542MGIPMID:27812542
CebpbMouseDNA-binding transcription factor activity, RNA polymerase II-specific enablesIDA 2290270 PMID:19641492 and PMID:25472717BHF-UCLPMID:19641492 and PMID:25472717
CebpbMouseDNA-binding transcription factor binding  ISOPpara (Rattus norvegicus)9068941 RGDPMID:15661831 and REF_RGD_ID:152995267
CebpbMouseDNA-binding transcription factor binding enablesISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMouseDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
CebpbMouseDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISSUniProtKB:P212722290270 PMID:15308669UniProtPMID:15308669
CebpbMousehistone acetyltransferase binding enablesIPIUniProtKB:B2RWS62290270 PMID:18486321UniProtPMID:18486321
CebpbMousehistone acetyltransferase binding enablesIPIUniProtKB:Q92830 more ...2290270 PMID:17301242UniProtPMID:17301242
CebpbMousehistone deacetylase binding enablesIPIUniProtKB:O091062290270 PMID:18486321UniProtPMID:18486321
CebpbMouseidentical protein binding enablesIPIUniProtKB:P280332290270 PMID:12177065UniProtPMID:12177065
CebpbMousekinase binding enablesIPIUniProtKB:P186532290270 PMID:10635333UniProtPMID:10635333
CebpbMousenuclear glucocorticoid receptor binding enablesISOCebpb (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
1 to 20 of 58 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMousetuberculosis pathway  IEA 6907045 KEGGmmu:05152

Imported Annotations - PID (archival)

1 to 20 of 207 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CebpbMouseabnormal adipose tissue physiology  IAGP 5509061 MGIPMID:9916132
CebpbMouseabnormal bone trabecula morphology  IAGP 5509061 MGIPMID:19440205
CebpbMouseabnormal branching of the mammary ductal tree  IAGP 5509061 MGIPMID:9637691
CebpbMouseabnormal branching of the mammary ductal tree  IAGP 5509061 MGIPMID:9637692
CebpbMouseabnormal brown adipose tissue morphology  IAGP 5509061 MGIPMID:9405372
CebpbMouseabnormal brown adipose tissue physiology  IAGP 5509061 MGIPMID:15762841
CebpbMouseabnormal brown adipose tissue thermogenesis  IAGP 5509061 MGIPMID:9405372
CebpbMouseabnormal brown fat cell morphology  IAGP 5509061 MGIPMID:9405372
CebpbMouseabnormal brown fat lipid droplet number  IAGP 5509061 MGIPMID:9405372
CebpbMouseabnormal cell differentiation  IAGP 5509061 MGIPMID:9405372
CebpbMouseabnormal cell-mediated immunity  IAGP 5509061 MGIPMID:7744000
CebpbMouseabnormal circulating free fatty acids level  IAGP 5509061 MGIPMID:9916132
CebpbMouseabnormal clavicle morphology  IAGP 5509061 MGIPMID:24885110
CebpbMouseabnormal definitive hematopoiesis  IAGP 5509061 MGIPMID:7744000
CebpbMouseabnormal enzyme/coenzyme level  IAGP 5509061 MGIPMID:9916132
CebpbMouseabnormal epidermal layer morphology  IAGP 5509061 MGIPMID:19749746
CebpbMouseabnormal epidermal layer morphology  IAGP 5509061 MGIPMID:20352127
CebpbMouseabnormal epidermis stratum basale morphology  IAGP 5509061 MGIPMID:20352127
CebpbMouseabnormal epidermis stratum corneum morphology  IAGP 5509061 MGIPMID:19749746
CebpbMouseabnormal epidermis stratum granulosum morphology  IAGP 5509061 MGIPMID:19749746
1 to 20 of 207 rows

1 to 20 of 31 rows
#
Reference Title
Reference Citation
1. Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. Cain DW, etal., J Immunol. 2013 Nov 1;191(9):4665-75. doi: 10.4049/jimmunol.1300581. Epub 2013 Sep 27.
2. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. Colangelo V, etal., J Neurosci Res. 2002 Nov 1;70(3):462-73.
3. Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection. Foldenauer ME, etal., J Immunol. 2013 Jun 1;190(11):5649-58. doi: 10.4049/jimmunol.1203094. Epub 2013 Apr 26.
4. Identification of a molecular signature of sarcopenia. Giresi PG, etal., Physiol Genomics. 2005 Apr 14;21(2):253-63. Epub 2005 Feb 1.
5. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Gong B, etal., Mol Immunol. 2013 Dec;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.
6. CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. Greenbaum LE, etal., J Clin Invest 1998 Sep 1;102(5):996-1007.
7. CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis. Hayashida M, etal., Arthritis Rheum. 2009 Mar;60(3):708-16. doi: 10.1002/art.24332.
8. Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ. Hernandez-Encinas E, etal., J Neuroinflammation. 2016 Oct 21;13(1):276. doi: 10.1186/s12974-016-0742-0.
9. C/EBPbeta and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2alpha as the inducer in chondrocytes. Hirata M, etal., Hum Mol Genet. 2012 Mar 1;21(5):1111-23. doi: 10.1093/hmg/ddr540. Epub 2011 Nov 17.
10. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
11. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. CRE-mediated transcription is increased in Huntington's disease transgenic mice. Obrietan K and Hoyt KR, J Neurosci. 2004 Jan 28;24(4):791-6.
16. C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Penner G, etal., Am J Physiol Regul Integr Comp Physiol 2002 Feb;282(2):R439-44.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity. Pope RM, etal., Clin Immunol. 1999 Jun;91(3):271-82.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
1 to 20 of 31 rows
1 to 10 of 49 rows
PMID:1371974   PMID:1371993   PMID:1701020   PMID:1840554   PMID:7530603   PMID:7557387   PMID:7598808   PMID:7622488   PMID:7684005   PMID:7744000   PMID:7760844   PMID:7781998  
PMID:7959007   PMID:8211130   PMID:8297376   PMID:8336793   PMID:8530045   PMID:8563027   PMID:8628296   PMID:8657121   PMID:8754811   PMID:8754826   PMID:8879230   PMID:8946919  
PMID:8973343   PMID:9001238   PMID:9049631   PMID:9271672   PMID:9303532   PMID:9334201   PMID:9405372   PMID:9428809   PMID:9434955   PMID:9494081   PMID:9531536   PMID:9545285  
PMID:9545506   PMID:9616220   PMID:9637691   PMID:9637692   PMID:9693973   PMID:9742105   PMID:9813043   PMID:9916132   PMID:9918941   PMID:10082561   PMID:10092809   PMID:10224054  
PMID:10319019   PMID:10349636   PMID:10455174   PMID:10490653   PMID:10510303   PMID:10528209   PMID:10536163   PMID:10588870   PMID:10600708   PMID:10635333   PMID:10683373   PMID:10707954  
PMID:10859308   PMID:10921906   PMID:10982846   PMID:11018027   PMID:11024029   PMID:11042159   PMID:11076861   PMID:11151091   PMID:11159172   PMID:11196172   PMID:11278638   PMID:11684016  
PMID:11726507   PMID:11726661   PMID:11733516   PMID:11756662   PMID:11792321   PMID:11877276   PMID:11940593   PMID:11976687   PMID:12048207   PMID:12048245   PMID:12071851   PMID:12072435  
PMID:12095417   PMID:12177065   PMID:12184911   PMID:12213825   PMID:12215258   PMID:12355443   PMID:12379662   PMID:12456789   PMID:12466851   PMID:12524424   PMID:12525691   PMID:12556485  
PMID:12558604   PMID:12821655   PMID:12832471   PMID:12837957   PMID:12847250   PMID:12871593   PMID:14576085   PMID:14593102   PMID:14670999   PMID:14681479   PMID:14688407   PMID:14697236  
PMID:14736879   PMID:14981542   PMID:15005571   PMID:15051496   PMID:15060147   PMID:15130516   PMID:15143161   PMID:15158467   PMID:15175325   PMID:15187136   PMID:15289464   PMID:15308669  
1 to 10 of 49 rows



Cebpb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)EnsemblGRCm39 Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBIMGSCv36mm8
MGSCv362168,673,393 - 168,674,898 (+)NCBIMGSCv36mm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
CEBPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,190,583 - 50,192,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2050,190,734 - 50,192,690 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,807,120 - 48,809,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,240,783 - 48,242,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 342048,240,782 - 48,242,619NCBI
Celera2045,511,633 - 45,513,469 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBIHuRef
CHM1_12048,711,778 - 48,713,885 (+)NCBICHM1_1
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBIT2T-CHM13v2.0
Cebpb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,817,005 - 176,818,436 (+)NCBIGRCr8
mRatBN7.23156,398,035 - 156,399,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,397,052 - 156,399,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,193,187 - 160,194,618 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,692,267 - 168,693,698 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,433,973 - 166,435,404 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
Cebpb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554458,060,432 - 8,061,289 (-)NCBIChiLan1.0ChiLan1.0
CEBPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,937,048 - 55,939,152 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,930,154 - 55,932,278 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02046,533,163 - 46,535,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CEBPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,661,294 - 36,663,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,661,616 - 36,662,656 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,905,196 - 35,907,045 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,368,136 - 37,369,976 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,368,234 - 37,369,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,608,936 - 36,610,792 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,742,145 - 36,743,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,285,911 - 37,287,750 (+)NCBIUU_Cfam_GSD_1.0
CEBPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,722,426 - 51,724,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,722,633 - 51,723,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,041,640 - 58,042,680 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEBPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,780,538 - 13,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,781,160 - 13,782,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,211,871 - 62,213,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cebpb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,368,349 - 5,369,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,367,808 - 5,369,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Cebpb
33 total Variants

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:148
Interacting mature miRNAs:167
Transcripts:ENSMUST00000070642
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 41 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse

1 to 10 of 41 rows
Cebpb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,690,109 - 167,690,205UniSTSGRCm38
MGSCv372167,515,653 - 167,515,742UniSTSGRCm37
Celera2173,630,233 - 173,630,322UniSTS
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC114562P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,689,309 - 167,689,783UniSTSGRCm38
MGSCv372167,514,809 - 167,515,283UniSTSGRCm37
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC21741P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,689,676 - 167,690,117UniSTSGRCm38
MGSCv372167,515,176 - 167,515,617UniSTSGRCm37
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC316377P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,689,260 - 167,689,406UniSTSGRCm38
MGSCv372167,514,760 - 167,514,906UniSTSGRCm37
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC55812P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,688,999 - 167,689,112UniSTSGRCm38
MGSCv372167,514,499 - 167,514,612UniSTSGRCm37
Celera2173,629,196 - 173,629,309UniSTS
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
PMC55812P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,688,996 - 167,689,112UniSTSGRCm38
MGSCv372167,514,496 - 167,514,612UniSTSGRCm37
Celera2173,629,193 - 173,629,309UniSTS
Cytogenetic Map2H3UniSTS
cM Map295.5UniSTS
Cebpb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,690,153 - 167,690,242UniSTSGRCm38
MGSCv372167,515,653 - 167,515,742UniSTSGRCm37
Celera2173,630,233 - 173,630,322UniSTS
Cytogenetic Map2H3UniSTS
Cebpb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H3UniSTS







Ensembl Acc Id: ENSMUST00000070642   ⟹   ENSMUSP00000069850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)Ensembl
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)Ensembl
RefSeq Acc Id: NM_001287738   ⟹   NP_001274667
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,530,835 - 167,532,352 (+)NCBI
GRCm382167,688,915 - 167,690,432 (+)NCBI
Celera2173,629,112 - 173,630,512 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287739   ⟹   NP_001274668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,530,835 - 167,532,352 (+)NCBI
GRCm382167,688,915 - 167,690,432 (+)NCBI
Celera2173,629,112 - 173,630,512 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009883   ⟹   NP_034013
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,530,835 - 167,532,352 (+)NCBI
GRCm382167,688,915 - 167,690,432 (+)NCBI
MGSCv372167,514,415 - 167,515,918 (+)RGD
Celera2173,629,112 - 173,630,512 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_001274667 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274668 (Get FASTA)   NCBI Sequence Viewer  
  NP_034013 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37192 (Get FASTA)   NCBI Sequence Viewer  
  AAP32012 (Get FASTA)   NCBI Sequence Viewer  
  BAA25315 (Get FASTA)   NCBI Sequence Viewer  
  BAE25356 (Get FASTA)   NCBI Sequence Viewer  
  CAA44484 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000069850
  ENSMUSP00000069850.4
GenBank Protein P28033 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_034013   ⟸   NM_009883
- Peptide Label: isoform a
- UniProtKB: P28033 (UniProtKB/Swiss-Prot),   Q3UPN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274667   ⟸   NM_001287738
- Peptide Label: isoform b
- UniProtKB: P28033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001274668   ⟸   NM_001287739
- Peptide Label: isoform c
- UniProtKB: P28033 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000069850   ⟸   ENSMUST00000070642
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-P28033-F1-model_v2 AlphaFold P28033 1-296 view protein structure

RGD ID:6830699
Promoter ID:MM_KWN:33124
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000021742,   NM_009883,   UC008OAG.1,   UC008OAH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,513,626 - 167,516,717 (+)MPROMDB
RGD ID:6879814
Promoter ID:EPDNEW_M3358
Type:multiple initiation site
Name:Cebpb_1
Description:Mus musculus CCAAT/enhancer binding protein (C/EBP), beta , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,688,967 - 167,689,027EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000056501 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070642 ENTREZGENE
  ENSMUST00000070642.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  C/EBP UniProtKB/Swiss-Prot
  C/EBP_chordates UniProtKB/Swiss-Prot
KEGG Report mmu:12608 UniProtKB/Swiss-Prot
MGD MGI:88373 ENTREZGENE
NCBI Gene 12608 ENTREZGENE
PANTHER CCAAT/ENHANCER BINDING PROTEIN UniProtKB/Swiss-Prot
  CCAAT/ENHANCER-BINDING PROTEIN BETA UniProtKB/Swiss-Prot
Pfam bZIP_2 UniProtKB/Swiss-Prot
PhenoGen Cebpb PhenoGen
PIRSF CCAAT/enhancer-binding UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt CEBPB_MOUSE UniProtKB/Swiss-Prot
  O70192_MOUSE UniProtKB/TrEMBL
  P28033 ENTREZGENE
  Q3UPN9 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Cebpb  CCAAT/enhancer binding protein beta  Cebpb  CCAAT/enhancer binding protein (C/EBP), beta  Symbol and/or name change 5135510 APPROVED