Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) - Rat Genome Database
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Gene: Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) Mus musculus
Analyze
Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
RGD ID: 1552032
MGI Page MGI
Description: Predicted to have 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to localize to cytosol. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4); PARTICIPATES IN glycolysis pathway; fructose and mannose metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; C230090D14; PFK/FBPase 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,817,336 - 108,861,302 (+)NCBIGRCm39mm39
GRCm389108,988,272 - 109,032,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,991,778 - 109,032,228 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,893,947 - 108,934,739 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,848,901 - 108,889,603 (+)NCBImm8
Celera9108,549,891 - 108,591,002 (+)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
genistein  (ISO)
hydralazine  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
quercetin  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14623077   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16311927   PMID:16602821  
PMID:21074528   PMID:21677750   PMID:21873635   PMID:24194600   PMID:26221874   PMID:27626380  


Genomics

Comparative Map Data
Pfkfb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,817,336 - 108,861,302 (+)NCBIGRCm39mm39
GRCm389108,988,272 - 109,032,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,991,778 - 109,032,228 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,893,947 - 108,934,739 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,848,901 - 108,889,603 (+)NCBImm8
Celera9108,549,891 - 108,591,002 (+)NCBICelera
Cytogenetic Map9F2NCBI
PFKFB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,517,684 - 48,562,015 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,517,684 - 48,562,383 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,555,117 - 48,598,607 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,530,121 - 48,569,231 (-)NCBINCBI36hg18NCBI36
Build 34348,530,122 - 48,569,231NCBI
Celera348,510,977 - 48,550,079 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,613,565 - 48,652,666 (-)NCBIHuRef
CHM1_1348,507,387 - 48,550,920 (-)NCBICHM1_1
Pfkfb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,733,347 - 117,776,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,737,117 - 117,775,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,085,098 - 117,128,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,012,543 - 114,050,534 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18114,031,997 - 114,069,989 (+)NCBI
Celera8108,939,193 - 108,977,086 (+)NCBICelera
Cytogenetic Map8q32NCBI
Pfkfb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532606,643 - 644,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532606,597 - 644,238 (-)NCBIChiLan1.0ChiLan1.0
PFKFB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,521,541 - 49,560,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,521,550 - 49,560,711 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,439,542 - 48,479,501 (-)NCBIMhudiblu_PPA_v0panPan3
PFKFB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2040,556,790 - 40,585,652 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12040,556,548 - 40,587,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pfkfb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936529304,090 - 346,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,212,550 - 31,259,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,212,553 - 31,259,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,457,005 - 34,504,235 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl229,919,764 - 9,957,543 (-)Ensembl
ChlSab1.1229,920,252 - 9,962,243 (-)NCBI
Pfkfb4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247302,519,661 - 2,566,664 (-)NCBI

Position Markers
BE136572  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389109,031,933 - 109,032,079UniSTSGRCm38
MGSCv379108,934,447 - 108,934,593UniSTSGRCm37
Celera9108,590,710 - 108,590,856UniSTS
Cytogenetic Map9F2UniSTS
Whitehead/MRC_RH91112.12UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2280
Count of miRNA genes:810
Interacting mature miRNAs:1028
Transcripts:ENSMUST00000051873, ENSMUST00000125336, ENSMUST00000129526, ENSMUST00000131344, ENSMUST00000136534, ENSMUST00000137818, ENSMUST00000147989, ENSMUST00000152220, ENSMUST00000154190
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC174646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY646092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY707862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA316033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ350638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU571215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU571216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU571217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000051873   ⟹   ENSMUSP00000057197
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,991,902 - 109,032,228 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196249   ⟹   ENSMUSP00000143249
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,992,016 - 109,030,712 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198140   ⟹   ENSMUSP00000142378
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,991,778 - 109,032,228 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198277
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,991,948 - 108,999,269 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198763
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,017,380 - 109,032,197 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199184
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,992,016 - 109,030,712 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199591   ⟹   ENSMUSP00000142992
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,992,016 - 109,030,712 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,991,992 - 108,992,901 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200015   ⟹   ENSMUSP00000142339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,011,186 - 109,028,904 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200229
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,998,888 - 109,010,656 (+)Ensembl
RefSeq Acc Id: NM_173019   ⟹   NP_766607
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,820,970 - 108,861,293 (+)NCBI
GRCm389108,991,902 - 109,032,225 (+)NCBI
MGSCv379108,893,947 - 108,934,739 (+)RGD
Celera9108,549,891 - 108,591,002 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153429
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,820,970 - 108,861,293 (+)NCBI
GRCm389108,991,902 - 109,032,225 (+)NCBI
Sequence:
RefSeq Acc Id: NR_153430
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,820,970 - 108,861,293 (+)NCBI
GRCm389108,991,902 - 109,032,225 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512133   ⟹   XP_006512196
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,820,821 - 108,861,302 (+)NCBI
GRCm389108,991,753 - 109,032,236 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017313402   ⟹   XP_017168891
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,826,993 - 108,861,302 (+)NCBI
GRCm389108,992,133 - 109,032,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017313403   ⟹   XP_017168892
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,827,956 - 108,861,302 (+)NCBI
GRCm389108,998,888 - 109,032,236 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017313404   ⟹   XP_017168893
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,827,927 - 108,861,302 (+)NCBI
GRCm389108,998,859 - 109,032,236 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244404   ⟹   XP_030100264
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,821,047 - 108,861,302 (+)NCBI
GRCm389108,991,979 - 109,032,236 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155034   ⟹   XP_036010927
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,820,851 - 108,861,302 (+)NCBI
RefSeq Acc Id: XM_036155035   ⟹   XP_036010928
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,817,348 - 108,861,302 (+)NCBI
RefSeq Acc Id: XM_036155036   ⟹   XP_036010929
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,820,851 - 108,861,302 (+)NCBI
RefSeq Acc Id: XM_036155037   ⟹   XP_036010930
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,817,336 - 108,861,302 (+)NCBI
RefSeq Acc Id: XM_036155038   ⟹   XP_036010931
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,818,888 - 108,861,302 (+)NCBI
RefSeq Acc Id: XM_036155039   ⟹   XP_036010932
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,827,927 - 108,861,302 (+)NCBI
Protein Sequences
Protein RefSeqs NP_766607 (Get FASTA)   NCBI Sequence Viewer  
  XP_006512196 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168891 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168892 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168893 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100264 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010927 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010928 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010929 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010930 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010931 (Get FASTA)   NCBI Sequence Viewer  
  XP_036010932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH57594 (Get FASTA)   NCBI Sequence Viewer  
  AAT72897 (Get FASTA)   NCBI Sequence Viewer  
  AAU88258 (Get FASTA)   NCBI Sequence Viewer  
  AAV32501 (Get FASTA)   NCBI Sequence Viewer  
  AAV32502 (Get FASTA)   NCBI Sequence Viewer  
  AAV32503 (Get FASTA)   NCBI Sequence Viewer  
  ABC71307 (Get FASTA)   NCBI Sequence Viewer  
  ACC61773 (Get FASTA)   NCBI Sequence Viewer  
  ACC61774 (Get FASTA)   NCBI Sequence Viewer  
  ACC61775 (Get FASTA)   NCBI Sequence Viewer  
  BAC33508 (Get FASTA)   NCBI Sequence Viewer  
  BAE33093 (Get FASTA)   NCBI Sequence Viewer  
  EDL21327 (Get FASTA)   NCBI Sequence Viewer  
  EDL21328 (Get FASTA)   NCBI Sequence Viewer  
  Q6DTY7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_766607   ⟸   NM_173019
- UniProtKB: Q6DTY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512196   ⟸   XM_006512133
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017168891   ⟸   XM_017313402
- Peptide Label: isoform X8
- UniProtKB: Q6DTY7 (UniProtKB/Swiss-Prot),   C9VZF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168893   ⟸   XM_017313404
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017168892   ⟸   XM_017313403
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_030100264   ⟸   XM_030244404
- Peptide Label: isoform X7
RefSeq Acc Id: ENSMUSP00000142378   ⟸   ENSMUST00000198140
RefSeq Acc Id: ENSMUSP00000057197   ⟸   ENSMUST00000051873
RefSeq Acc Id: ENSMUSP00000142992   ⟸   ENSMUST00000199591
RefSeq Acc Id: ENSMUSP00000143249   ⟸   ENSMUST00000196249
RefSeq Acc Id: ENSMUSP00000142339   ⟸   ENSMUST00000200015
RefSeq Acc Id: XP_036010930   ⟸   XM_036155037
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036010928   ⟸   XM_036155035
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036010931   ⟸   XM_036155038
- Peptide Label: isoform X5
RefSeq Acc Id: XP_036010929   ⟸   XM_036155036
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036010927   ⟸   XM_036155034
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036010932   ⟸   XM_036155039
- Peptide Label: isoform X11
Protein Domains
6PF2K

Promoters
RGD ID:6844927
Promoter ID:MM_KWN:58839
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000098369,   NM_173019,   OTTMUST00000067929,   OTTMUST00000067931,   OTTMUST00000067934,   OTTMUST00000067935,   UC009RRJ.1,   UC009RRK.1,   UC009RRL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,893,531 - 108,894,357 (+)MPROMDB
RGD ID:6844930
Promoter ID:MM_KWN:58840
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000067942
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,901,121 - 108,901,621 (+)MPROMDB
RGD ID:6844934
Promoter ID:MM_KWN:58841
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000067943
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,912,116 - 108,912,616 (+)MPROMDB
RGD ID:6844931
Promoter ID:MM_KWN:58842
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000067933
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,919,121 - 108,919,621 (+)MPROMDB
RGD ID:8670944
Promoter ID:EPDNEW_M13503
Type:initiation region
Name:Pfkfb4_1
Description:Mus musculus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,991,990 - 108,992,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687284 AgrOrtholog
Ensembl Genes ENSMUSG00000025648 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000057197 UniProtKB/Swiss-Prot
  ENSMUSP00000142339 UniProtKB/TrEMBL
  ENSMUSP00000142378 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142992 UniProtKB/Swiss-Prot
  ENSMUSP00000143249 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000051873 UniProtKB/Swiss-Prot
  ENSMUST00000196249 UniProtKB/TrEMBL
  ENSMUST00000198140 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000199591 UniProtKB/Swiss-Prot
  ENSMUST00000200015 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:270198 UniProtKB/Swiss-Prot
MGD MGI:2687284 ENTREZGENE
NCBI Gene 270198 ENTREZGENE
PANTHER PTHR10606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfkfb4 PhenoGen
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PGAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.132391 ENTREZGENE
UniProt A0A0G2JDE6_MOUSE UniProtKB/TrEMBL
  A0A0G2JFP0_MOUSE UniProtKB/TrEMBL
  C9VZF1_MOUSE UniProtKB/TrEMBL
  C9VZF2 ENTREZGENE, UniProtKB/TrEMBL
  C9VZF3_MOUSE UniProtKB/TrEMBL
  F264_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BX50_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q5UD55 UniProtKB/Swiss-Prot
  Q5UD56 UniProtKB/Swiss-Prot
  Q5UD57 UniProtKB/Swiss-Prot
  Q5Y296 UniProtKB/Swiss-Prot
  Q6PFE8 UniProtKB/Swiss-Prot