Crlf1 (cytokine receptor-like factor 1) - Rat Genome Database
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Gene: Crlf1 (cytokine receptor-like factor 1) Mus musculus
Analyze
Symbol: Crlf1
Name: cytokine receptor-like factor 1
RGD ID: 1322795
MGI Page MGI
Description: Predicted to contribute to ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in negative regulation of motor neuron apoptotic process and ureteric bud development. Localizes to extracellular space. Is expressed in several structures, including genitourinary system; jaw; limb; respiratory system; and tongue. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Orthologous to human CRLF1 (cytokine receptor like factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLF-; CLF-1; CRL; CRLM-3; CRLM3; cytokine receptor like molecule 3; cytokine receptor-like molecule 3; cytokine-like factor 1; novel cytokine receptor 6; NR6; NR6.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,945,736 - 70,956,728 (+)NCBIGRCm39mm39
GRCm38870,493,097 - 70,504,078 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,493,158 - 70,504,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,017,055 - 73,027,980 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,422,145 - 73,433,070 (+)NCBImm8
Celera873,049,567 - 73,060,492 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:9686600   PMID:10349636   PMID:10359701   PMID:11042159   PMID:11076861   PMID:12090754   PMID:12477932   PMID:14523086   PMID:14610273   PMID:15142957   PMID:15378723  
PMID:15683542   PMID:16141072   PMID:16141073   PMID:16545622   PMID:16602821   PMID:18287559   PMID:19898483   PMID:19933857   PMID:21035938   PMID:21267068   PMID:21873635   PMID:21924257  
PMID:22429962   PMID:24006456   PMID:24952961   PMID:25804736   PMID:26243870   PMID:27113764   PMID:27480037   PMID:28705898   PMID:29240767   PMID:30853441  


Genomics

Comparative Map Data
Crlf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,945,736 - 70,956,728 (+)NCBIGRCm39mm39
GRCm38870,493,097 - 70,504,078 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,493,158 - 70,504,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,017,055 - 73,027,980 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,422,145 - 73,433,070 (+)NCBImm8
Celera873,049,567 - 73,060,492 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
CRLF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,572,220 - 18,607,741 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,593,237 - 18,606,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,704,035 - 18,717,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,565,047 - 18,578,660 (-)NCBINCBI36hg18NCBI36
Build 341918,565,046 - 18,578,660NCBI
Celera1918,606,237 - 18,619,858 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,266,624 - 18,309,213 (-)NCBIHuRef
CHM1_11918,704,266 - 18,717,662 (-)NCBICHM1_1
Crlf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,675,042 - 20,686,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,675,042 - 20,686,317 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,530,521 - 20,541,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,431,472 - 19,442,747 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,431,472 - 19,442,745 (-)NCBI
Celera1619,116,098 - 19,127,373 (-)NCBICelera
Cytogenetic Map16p14NCBI
Crlf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,998,260 - 3,003,283 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,998,258 - 3,003,553 (+)NCBIChiLan1.0ChiLan1.0
CRLF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,040,355 - 19,048,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,040,682 - 19,046,584 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,070,465 - 18,083,701 (-)NCBIMhudiblu_PPA_v0panPan3
CRLF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,466,810 - 44,472,637 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,466,812 - 44,476,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Crlf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,693,881 - 2,702,443 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRLF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,222,566 - 59,233,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,222,551 - 59,233,723 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,069,084 - 59,075,048 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRLF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,061,289 - 17,074,930 (-)NCBI
ChlSab1.1 Ensembl617,061,621 - 17,074,794 (-)Ensembl
Crlf1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,752,773 - 1,762,272 (-)NCBI

Position Markers
Crlf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,498,806 - 70,499,152UniSTSGRCm38
MGSCv37873,022,705 - 73,023,051UniSTSGRCm37
Celera873,055,217 - 73,055,563UniSTS
Cytogenetic Map8C1UniSTS
cM Map8 UniSTS
Crlf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:506
Count of miRNA genes:291
Interacting mature miRNAs:327
Transcripts:ENSMUST00000008032, ENSMUST00000127983, ENSMUST00000132648
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001378799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB040038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC157774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000008032   ⟹   ENSMUSP00000008032
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,493,158 - 70,504,081 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127983   ⟹   ENSMUSP00000115614
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,501,133 - 70,504,030 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132648   ⟹   ENSMUSP00000119545
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,493,361 - 70,500,930 (+)Ensembl
RefSeq Acc Id: NM_001378799   ⟹   NP_001365728
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,798 - 70,956,728 (+)NCBI
GRCm38870,493,148 - 70,504,078 (+)NCBI
RefSeq Acc Id: NM_001378800   ⟹   NP_001365729
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,798 - 70,956,728 (+)NCBI
GRCm38870,493,148 - 70,504,078 (+)NCBI
RefSeq Acc Id: NM_001378801   ⟹   NP_001365730
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,798 - 70,956,728 (+)NCBI
GRCm38870,493,148 - 70,504,078 (+)NCBI
RefSeq Acc Id: NM_001378802   ⟹   NP_001365731
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,798 - 70,956,728 (+)NCBI
GRCm38870,493,148 - 70,504,078 (+)NCBI
RefSeq Acc Id: NM_001378803   ⟹   NP_001365732
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,798 - 70,956,728 (+)NCBI
GRCm38870,493,148 - 70,504,078 (+)NCBI
RefSeq Acc Id: NM_018827   ⟹   NP_061297
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,798 - 70,956,728 (+)NCBI
GRCm38870,493,148 - 70,504,078 (+)NCBI
MGSCv37873,017,055 - 73,027,980 (+)RGD
Celera873,049,567 - 73,060,492 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509541   ⟹   XP_006509604
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,736 - 70,956,728 (+)NCBI
GRCm38870,493,097 - 70,504,078 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153743   ⟹   XP_036009636
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,968 - 70,956,728 (+)NCBI
RefSeq Acc Id: XR_004934756
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,945,736 - 70,956,728 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_061297   ⟸   NM_018827
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9JM58 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509604   ⟸   XM_006509541
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001365729   ⟸   NM_001378800
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001365728   ⟸   NM_001378799
- Peptide Label: isoform 1 precursor
RefSeq Acc Id: NP_001365730   ⟸   NM_001378801
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001365731   ⟸   NM_001378802
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001365732   ⟸   NM_001378803
- Peptide Label: isoform 6
RefSeq Acc Id: ENSMUSP00000115614   ⟸   ENSMUST00000127983
RefSeq Acc Id: ENSMUSP00000119545   ⟸   ENSMUST00000132648
RefSeq Acc Id: ENSMUSP00000008032   ⟸   ENSMUST00000008032
RefSeq Acc Id: XP_036009636   ⟸   XM_036153743
- Peptide Label: isoform X2
Promoters
RGD ID:8667313
Promoter ID:EPDNEW_M11687
Type:initiation region
Name:Crlf1_1
Description:Mus musculus cytokine receptor-like factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,493,148 - 70,493,208EPDNEW
RGD ID:6842971
Promoter ID:MM_KWN:54708
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4
Transcripts:ENSMUST00000110112,   NM_018827,   OTTMUST00000084077,   OTTMUST00000084078,   OTTMUST00000084079
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,016,356 - 73,016,856 (+)MPROMDB
RGD ID:6842972
Promoter ID:MM_KWN:54709
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:OTTMUST00000084080
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,023,931 - 73,024,431 (+)MPROMDB
RGD ID:6842983
Promoter ID:MM_KWN:54710
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Kidney,   MEF_B4,   MEF_B6
Transcripts:UC009MAK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,026,206 - 73,027,482 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1340030 AgrOrtholog
Ensembl Genes ENSMUSG00000007888 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000008032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000115614 UniProtKB/TrEMBL
  ENSMUSP00000119545 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000008032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000127983 UniProtKB/TrEMBL
  ENSMUST00000132648 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12931 UniProtKB/Swiss-Prot
MGD MGI:1340030 ENTREZGENE
NCBI Gene 12931 ENTREZGENE
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot
PhenoGen Crlf1 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.335584 ENTREZGENE
UniProt CRLF1_MOUSE UniProtKB/Swiss-Prot
  F6RP70_MOUSE UniProtKB/TrEMBL
  F6T1W4_MOUSE UniProtKB/TrEMBL
  Q3B7Y2_MOUSE UniProtKB/TrEMBL
  Q3B7Y3_MOUSE UniProtKB/TrEMBL
  Q9D2R5_MOUSE UniProtKB/TrEMBL
  Q9JM58 ENTREZGENE