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Gene: Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2) Mus musculus
Symbol: Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Description: Exhibits hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Localizes to the mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; facial bone primordium; nervous system; and reproductive system. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-dexrazoxane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300002P16; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, mitochondrial; mHS
Homo sapiens (human) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Canis lupus familiaris (dog) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Sus scrofa (pig) : LOC110260333 (hydroxymethylglutaryl-CoA synthase, mitochondrial-like)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl398,280,435 - 98,310,738 (+)Ensembl
GRCm38398,280,431 - 98,310,738 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37398,084,354 - 98,114,661 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,365,840 - 98,396,137 (+)NCBImm8
Celera399,679,562 - 99,709,869 (+)NCBICelera
Cytogenetic Map3 F2.2NCBI
cM Map342.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hmgcs2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10713
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.