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Gene: Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2) Mus musculus
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Symbol: Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Description: Exhibits hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Localizes to the mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; facial bone primordium; nervous system; and reproductive system. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-dexrazoxane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300002P16; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, mitochondrial; mHS
Orthologs:
Homo sapiens (human) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Canis lupus familiaris (dog) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Sus scrofa (pig) : LOC110260333 (hydroxymethylglutaryl-CoA synthase, mitochondrial-like)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl398,280,435 - 98,310,738 (+)Ensembl
GRCm38398,280,431 - 98,310,738 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37398,084,354 - 98,114,661 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,365,840 - 98,396,137 (+)NCBImm8
Celera399,679,562 - 99,709,869 (+)NCBICelera
Cytogenetic Map3 F2.2NCBI
cM Map342.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hmgcs2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10713
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.