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Gene: Afp (alpha fetoprotein) Mus musculus
Symbol: Afp
Name: alpha fetoprotein
RGD ID: 10116
Description: Predicted to have fatty acid binding activity and zinc ion binding activity. Involved in SMAD protein signal transduction; ovulation from ovarian follicle; and progesterone metabolic process. Localizes to cytoplasm and extracellular space. Is expressed in several structures, including amniotic fluid; egg cylinder; gut; liver and biliary system; and metanephros. Orthologous to human AFP (alpha fetoprotein); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein; alpha-foetoprotein
Homo sapiens (human) : AFP (alpha fetoprotein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Afp (alpha-fetoprotein)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AFP (alpha fetoprotein)
Canis lupus familiaris (dog) : AFP (alpha fetoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afp (alpha fetoprotein)
Sus scrofa (pig) : AFP (alpha fetoprotein)
Chlorocebus sabaeus (African green monkey) : AFP (alpha fetoprotein)
Heterocephalus glaber (naked mole-rat) : Afp (alpha fetoprotein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39590,638,573 - 90,656,766 (+)NCBI
GRCm38590,490,714 - 90,508,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,490,737 - 90,508,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,919,740 - 90,937,933 (+)NCBIGRCm37mm9NCBIm37
MGSCv36591,565,937 - 91,584,106 (+)NCBImm8
Celera588,652,007 - 88,670,199 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Afp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10116
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.