Pls1 (plastin 1 (I-isoform)) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pls1 (plastin 1 (I-isoform)) Mus musculus
Analyze
Symbol: Pls1
Name: plastin 1 (I-isoform)
RGD ID: 1316160
MGI Page MGI
Description: Predicted to have actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and terminal web assembly. Localizes to brush border; stereocilium; and terminal web. Is expressed in intestine epithelium; thymus primordium; and yolk sac endoderm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PLS1 (plastin 1); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 1-benzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI427122; I-fi; I-fimbrin; plastin 1, I; plastin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39995,634,695 - 95,727,359 (-)NCBIGRCm39mm39
GRCm38995,752,642 - 95,845,306 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl995,752,642 - 95,845,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37995,653,061 - 95,745,698 (-)NCBIGRCm37mm9NCBIm37
MGSCv36995,563,391 - 95,654,612 (-)NCBImm8
Celera995,319,770 - 95,411,700 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2686960   PMID:7655078   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14756805  
PMID:16141072   PMID:16141073   PMID:19321664   PMID:20551175   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22114352   PMID:24595139   PMID:24923387   PMID:25124451   PMID:27614263  
PMID:27811163   PMID:32325033  


Genomics

Comparative Map Data
Pls1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39995,634,695 - 95,727,359 (-)NCBIGRCm39mm39
GRCm38995,752,642 - 95,845,306 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl995,752,642 - 95,845,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37995,653,061 - 95,745,698 (-)NCBIGRCm37mm9NCBIm37
MGSCv36995,563,391 - 95,654,612 (-)NCBImm8
Celera995,319,770 - 95,411,700 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
PLS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3142,596,393 - 142,713,664 (+)EnsemblGRCh38hg38GRCh38
GRCh383142,596,393 - 142,713,664 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373142,315,229 - 142,432,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,825,034 - 143,915,191 (+)NCBINCBI36hg18NCBI36
Build 343143,825,041 - 143,915,199NCBI
Celera3140,738,741 - 140,856,000 (+)NCBI
Cytogenetic Map3q23NCBI
HuRef3139,687,922 - 139,805,221 (+)NCBIHuRef
CHM1_13142,278,265 - 142,395,516 (+)NCBICHM1_1
Pls1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08103,557,361 - 103,659,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,557,364 - 103,608,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,008,357 - 103,110,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48100,825,543 - 100,858,153 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18100,845,099 - 100,913,858 (-)NCBI
Celera895,763,631 - 95,795,453 (-)NCBICelera
Cytogenetic Map8q31NCBI
Pls1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,213,646 - 3,260,554 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555083,215,304 - 3,324,240 (-)NCBIChiLan1.0ChiLan1.0
PLS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13147,221,909 - 147,338,600 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3147,289,205 - 147,338,600 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03139,629,825 - 139,747,080 (+)NCBIMhudiblu_PPA_v0panPan3
PLS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2338,243,024 - 38,347,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12338,243,631 - 38,347,195 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pls1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365404,205,871 - 4,323,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1383,308,007 - 83,434,128 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11383,307,692 - 83,434,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11547,919,807 - 48,031,158 (-)NCBI
ChlSab1.1 Ensembl1547,919,823 - 48,003,805 (-)Ensembl
Pls1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473019,164,360 - 19,302,369 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:729
Count of miRNA genes:514
Interacting mature miRNAs:584
Transcripts:ENSMUST00000093800, ENSMUST00000119760, ENSMUST00000135816
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093800   ⟹   ENSMUSP00000091317
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl995,752,642 - 95,845,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119760   ⟹   ENSMUSP00000113200
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl995,784,181 - 95,815,406 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135816
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl995,785,554 - 95,845,311 (-)Ensembl
RefSeq Acc Id: NM_001033210   ⟹   NP_001028382
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39995,634,695 - 95,727,332 (-)NCBI
GRCm38995,752,642 - 95,845,279 (-)NCBI
Celera995,319,770 - 95,411,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510746   ⟹   XP_006510809
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39995,634,695 - 95,699,922 (-)NCBI
GRCm38995,752,642 - 95,815,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510748   ⟹   XP_006510811
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39995,634,695 - 95,727,359 (-)NCBI
GRCm38995,752,642 - 95,845,306 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001028382   ⟸   NM_001033210
- UniProtKB: Q3V0K9 (UniProtKB/Swiss-Prot),   Q3V3X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510811   ⟸   XM_006510748
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006510809   ⟸   XM_006510746
- Peptide Label: isoform X1
- UniProtKB: Q3V0K9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113200   ⟸   ENSMUST00000119760
RefSeq Acc Id: ENSMUSP00000091317   ⟸   ENSMUST00000093800
Protein Domains
Calponin-homology (CH)   EF-hand

Promoters
RGD ID:8670470
Promoter ID:EPDNEW_M13266
Type:initiation region
Name:Pls1_2
Description:Mus musculus plastin 1 (I-isoform) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13267  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38995,815,366 - 95,815,426EPDNEW
RGD ID:8670472
Promoter ID:EPDNEW_M13267
Type:initiation region
Name:Pls1_1
Description:Mus musculus plastin 1 (I-isoform) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13266  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38995,845,280 - 95,845,340EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104809 AgrOrtholog
Ensembl Genes ENSMUSG00000049493 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000091317 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113200 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093800 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000119760 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fimbrin/Plastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:102502 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104809 ENTREZGENE
NCBI Gene 102502 ENTREZGENE
PANTHER PTHR19961 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19961:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PLS1 RGD
PhenoGen Pls1 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.11869 ENTREZGENE
UniProt D3Z6J7_MOUSE UniProtKB/TrEMBL
  PLSI_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V3X1 ENTREZGENE, UniProtKB/TrEMBL
  Q8R0U6_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-17 Pls1  plastin 1 (I-isoform)  AI427122  expressed sequence AI427122  Symbol and/or name change 5135510 APPROVED