Tmprss4 (transmembrane protease, serine 4) - Rat Genome Database

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Gene: Tmprss4 (transmembrane protease, serine 4) Mus musculus
Analyze
Symbol: Tmprss4
Name: transmembrane protease, serine 4
RGD ID: 1312822
MGI Page MGI
Description: Predicted to have serine-type peptidase activity. Involved in response to wounding. Localizes to secretory granule. Is expressed in alimentary system; olfactory epithelium; and urinary system. Orthologous to human TMPRSS4 (transmembrane serine protease 4); PARTICIPATES IN influenza A pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAP2; channel-activating protease 2; channel-activating protease 4; mCAP2; membrane-type serine protease 2; MGC29209; transmembrane protease serine 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,084,024 - 45,115,417 (-)NCBIGRCm39mm39
GRCm39 Ensembl945,084,024 - 45,115,390 (-)Ensembl
GRCm38945,172,726 - 45,204,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,172,726 - 45,204,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,980,809 - 45,012,158 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,923,721 - 44,955,070 (-)NCBImm8
Celera942,448,298 - 42,479,621 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12149280   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16428450   PMID:16524950   PMID:18287559  
PMID:19592578   PMID:20562862   PMID:21267068   PMID:21677750   PMID:21993886   PMID:22944691   PMID:26309024   PMID:26889029   PMID:29529050   PMID:32303635   PMID:32325033   PMID:32379417  


Genomics

Comparative Map Data
Tmprss4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,084,024 - 45,115,417 (-)NCBIGRCm39mm39
GRCm39 Ensembl945,084,024 - 45,115,390 (-)Ensembl
GRCm38945,172,726 - 45,204,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,172,726 - 45,204,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,980,809 - 45,012,158 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,923,721 - 44,955,070 (-)NCBImm8
Celera942,448,298 - 42,479,621 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
TMPRSS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11118,077,012 - 118,121,890 (+)EnsemblGRCh38hg38GRCh38
GRCh3811118,077,016 - 118,125,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711117,947,793 - 117,992,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,452,937 - 117,495,768 (+)NCBINCBI36hg18NCBI36
Build 3411117,452,975 - 117,494,380NCBI
Celera11115,105,578 - 115,148,408 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11113,881,375 - 113,924,217 (+)NCBIHuRef
CHM1_111117,833,208 - 117,876,364 (+)NCBICHM1_1
Tmprss4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2845,475,819 - 45,508,409 (-)NCBI
Rnor_6.0 Ensembl849,469,503 - 49,502,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0849,469,804 - 49,503,304 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0848,096,253 - 48,129,105 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,120,501 - 48,154,809 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1848,129,873 - 48,192,563 (-)NCBI
Celera845,060,426 - 45,092,778 (-)NCBICelera
Cytogenetic Map8q22NCBI
Tmprss4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,258,949 - 19,292,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541219,258,955 - 19,292,766 (+)NCBIChiLan1.0ChiLan1.0
TMPRSS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111116,843,287 - 116,884,767 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,843,287 - 116,884,767 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011112,910,223 - 112,953,677 (+)NCBIMhudiblu_PPA_v0panPan3
TMPRSS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,575,068 - 15,609,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,575,338 - 15,610,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,625,320 - 15,660,603 (-)NCBI
ROS_Cfam_1.0515,516,982 - 15,552,268 (-)NCBI
UMICH_Zoey_3.1515,654,797 - 15,690,088 (-)NCBI
UNSW_CanFamBas_1.0515,558,508 - 15,593,779 (-)NCBI
UU_Cfam_GSD_1.0515,600,003 - 15,635,286 (-)NCBI
Tmprss4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,258,799 - 100,294,556 (+)NCBI
SpeTri2.0NW_0049365423,180,260 - 3,216,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,400,464 - 45,435,916 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1945,400,263 - 45,436,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,441,507 - 50,476,053 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103248572
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,449,920 - 109,497,169 (+)NCBI
ChlSab1.1 Ensembl1109,470,496 - 109,495,224 (+)Ensembl
Vero_WHO_p1.0NW_02366604316,558,383 - 16,604,301 (-)NCBI
Tmprss4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478413,495,196 - 13,531,670 (+)NCBI

Position Markers
Tmprss4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38945,173,117 - 45,173,225UniSTSGRCm38
MGSCv37944,981,200 - 44,981,308UniSTSGRCm37
Celera942,448,689 - 42,448,797UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93682494749509211Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93703211050199840Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94050829851897370Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94073407848440176Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94149086645432445Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1447
Count of miRNA genes:547
Interacting mature miRNAs:671
Transcripts:ENSMUST00000034599, ENSMUST00000163237, ENSMUST00000163945, ENSMUST00000165263, ENSMUST00000170069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034599   ⟹   ENSMUSP00000034599
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl945,172,726 - 45,204,092 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163237
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl945,173,305 - 45,204,060 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163945
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl945,174,797 - 45,180,653 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165263   ⟹   ENSMUSP00000131890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl945,173,305 - 45,203,986 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170069   ⟹   ENSMUSP00000131933
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl945,172,727 - 45,204,090 (-)Ensembl
RefSeq Acc Id: NM_001364528   ⟹   NP_001351457
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,084,024 - 45,115,333 (-)NCBI
GRCm38945,172,726 - 45,204,035 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145403   ⟹   NP_663378
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,084,024 - 45,115,333 (-)NCBI
GRCm38945,172,726 - 45,204,035 (-)NCBI
MGSCv37944,980,809 - 45,012,158 (-)RGD
Celera942,448,298 - 42,479,621 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313272   ⟹   XP_017168761
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,084,188 - 45,115,417 (-)NCBI
GRCm38945,172,890 - 45,204,119 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_663378   ⟸   NM_145403
- Peptide Label: isoform 1
- UniProtKB: Q8VCA5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168761   ⟸   XM_017313272
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001351457   ⟸   NM_001364528
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000131933   ⟸   ENSMUST00000170069
RefSeq Acc Id: ENSMUSP00000034599   ⟸   ENSMUST00000034599
RefSeq Acc Id: ENSMUSP00000131890   ⟸   ENSMUST00000165263
Protein Domains
LDL-receptor class A   Peptidase S1   SRCR

Promoters
RGD ID:6845267
Promoter ID:MM_KWN:57178
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_145403,   UC009PFJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36945,012,106 - 45,012,606 (-)MPROMDB
RGD ID:8669440
Promoter ID:EPDNEW_M12751
Type:multiple initiation site
Name:Tmprss4_1
Description:Mus musculus transmembrane protease, serine 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38945,204,035 - 45,204,095EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384877 AgrOrtholog
Ensembl Genes ENSMUSG00000032091 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034599 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000131890 UniProtKB/TrEMBL
  ENSMUSP00000131933 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034599 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000165263 UniProtKB/TrEMBL
  ENSMUST00000170069 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:214523 UniProtKB/Swiss-Prot
MGD MGI:2384877 ENTREZGENE
NCBI Gene 214523 ENTREZGENE
Pfam SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmprss4 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q4A7_MOUSE UniProtKB/TrEMBL
  E9Q4T9_MOUSE UniProtKB/TrEMBL
  Q8VCA5 ENTREZGENE, UniProtKB/Swiss-Prot