Dhrs9 (dehydrogenase/reductase 9)

Advanced Search (OLGA)

Gene: Dhrs9 (dehydrogenase/reductase 9) Mus musculus

Analyze

Symbol:

Dhrs9

Name:

dehydrogenase/reductase 9

RGD ID:

733519

MGI Page

MGI

Description:

Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in androgen metabolic process; progesterone metabolic process; and retinoid metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human DHRS9 (dehydrogenase/reductase 9).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; 3alpha-HSD; C730025I08Rik; dehydrogenase/reductase (SDR family) member 9; dehydrogenase/reductase SDR family member 9; epithelial retinol dehydrogenase; Rdh1; Rdh15; retinol dehydrogenase; short-chain dehydrogenase/reductase retSDR8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DHRS9 (dehydrogenase/reductase 9)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Rattus norvegicus (Norway rat):	Dhrs9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dhrs9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DHRS9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DHRS9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dhrs9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DHRS9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DHRS9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dhrs9 (dehydrogenase/reductase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Dhrs9 (dehydrogenase/reductase 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DHRS9 (dehydrogenase/reductase 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dhrs9 (dehydrogenase/reductase (SDR family) member 9)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	AYR1	Alliance	DIOPT (Hieranoid\|InParanoid)
Drosophila melanogaster (fruit fly):	CG8888	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	dhs-16	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dhs-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	dhs-20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	drd-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	dhrs9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	69,210,806 - 69,233,430 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	69,210,789 - 69,234,877 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	69,380,462 - 69,403,086 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	69,380,445 - 69,404,533 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	69,218,519 - 69,241,143 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	69,181,301 - 69,203,925 (+)	NCBI		MGSCv36	mm8
Celera	2	71,045,992 - 71,068,496 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	40.59	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bardet-Biedl syndrome (ISO)

Birth Weight (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (EXP)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3,7-dihydropurine-6-thione (ISO)

5-aza-2'-deoxycytidine (ISO)

9-cis-retinoic acid (ISO)

acetamide (ISO)

afimoxifene (EXP)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

all-trans-retinol (ISO)

alpha-Zearalanol (ISO)

ammonium chloride (ISO)

antimonite (ISO)

arotinoid acid (ISO)

arsane (EXP,ISO)

arsenic atom (EXP,ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

avobenzone (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

butanal (ISO)

butane-2,3-dione (ISO)

carbon nanotube (EXP)

CHIR 99021 (ISO)

chlorpyrifos (EXP)

choline (EXP)

copper atom (ISO)

copper(0) (ISO)

cortisol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cypermethrin (EXP)

D-glucose (EXP)

DDE (ISO)

dextran sulfate (EXP)

diarsenic trioxide (ISO)

dimethylarsinic acid (EXP)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

disodium selenite (EXP)

doxorubicin (ISO)

epoxiconazole (EXP)

fluoranthene (EXP)

folic acid (EXP)

formaldehyde (ISO)

fructose (EXP)

glucose (EXP)

Heliotrine (ISO)

hexanal (ISO)

isotretinoin (ISO)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (EXP)

lipopolysaccharide (ISO)

mercaptopurine (ISO)

methylarsonic acid (EXP)

methylisothiazolinone (ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

O-methyleugenol (ISO)

octanal (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

pentanal (ISO)

pentane-2,3-dione (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP)

propanal (ISO)

purine-6-thiol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

senecionine (ISO)

Senkirkine (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (EXP,ISO)

sodium arsenite (EXP,ISO)

streptozocin (EXP)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (ISO)

toluene (ISO)

tributylstannane (EXP)

triclosan (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

vorinostat (ISO)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

9-cis-retinoic acid biosynthetic process (ISO)

androgen metabolic process (ISO)

lipid metabolic process (IEA)

progesterone metabolic process (ISO)

retinoic acid biosynthetic process (ISO)

retinol metabolic process (IBA)

steroid metabolic process (IBA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (ISO)

intracellular membrane-bounded organelle (IBA)

membrane (IEA)

Molecular Function

alcohol dehydrogenase (NAD+) activity (ISO)

all-trans-retinol dehydrogenase (NAD+) activity (IBA,ISO)

androstan-3-alpha,17-beta-diol dehydrogenase activity (ISO)

androsterone dehydrogenase activity (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

testosterone dehydrogenase (NAD+) activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

retinoic acid metabolic pathway (ISO)

retinol metabolic pathway (IEA,ISO)

vitamin A deficiency pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal enzyme/coenzyme activity (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat.	Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
2.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	Physiological insights into all-trans-retinoic acid biosynthesis.	Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes.	Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.

Additional References at PubMed

PMID:10349636	PMID:10800688	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932	PMID:14611944	PMID:14681479	PMID:16141072	PMID:16141073	PMID:17270348	PMID:21267068
PMID:21677750	PMID:21873635	PMID:28167773	PMID:31562240	PMID:32554809	PMID:34953854

Genomics

Comparative Map Data

Dhrs9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	69,210,806 - 69,233,430 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	69,210,789 - 69,234,877 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	69,380,462 - 69,403,086 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	69,380,445 - 69,404,533 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	69,218,519 - 69,241,143 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	69,181,301 - 69,203,925 (+)	NCBI		MGSCv36	mm8
Celera	2	71,045,992 - 71,068,496 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	40.59	NCBI

DHRS9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	169,067,077 - 169,096,167 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	169,064,789 - 169,096,167 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	169,923,587 - 169,952,677 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	169,629,545 - 169,660,923 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	169,749,051 - 169,778,184	NCBI
Celera	2	163,546,627 - 163,578,019 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	161,818,234 - 161,849,556 (+)	NCBI		HuRef
CHM1_1	2	169,927,309 - 169,958,689 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	169,542,807 - 169,571,856 (+)	NCBI		T2T-CHM13v2.0

Dhrs9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	74,553,357 - 74,579,535 (+)	NCBI		GRCr8
mRatBN7.2	3	54,147,834 - 54,170,052 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	54,147,803 - 54,220,241 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	57,547,988 - 57,569,938 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	66,131,554 - 66,153,514 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	63,894,233 - 63,916,194 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	55,623,671 - 55,645,883 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	55,623,634 - 55,648,325 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	62,230,676 - 62,252,887 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	51,521,343 - 51,543,552 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	51,417,714 - 51,439,924 (+)	NCBI
Celera	3	53,710,208 - 53,732,381 (+)	NCBI		Celera
Cytogenetic Map	3	q21	NCBI

Dhrs9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	5,359,617 - 5,380,267 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	5,360,486 - 5,380,279 (-)	NCBI	ChiLan1.0	ChiLan1.0

DHRS9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	71,732,933 - 71,761,526 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	71,747,905 - 71,774,747 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	56,347,489 - 56,376,463 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	173,814,354 - 173,840,879 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	173,811,932 - 173,842,816 (+)	Ensembl	panpan1.1		panPan2

DHRS9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	13,859,935 - 13,881,432 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	13,866,959 - 13,880,179 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	13,872,769 - 13,897,292 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	13,978,257 - 14,002,826 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	13,987,853 - 13,996,566 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	14,062,759 - 14,087,288 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	14,050,712 - 14,075,307 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	14,163,864 - 14,188,389 (+)	NCBI		UU_Cfam_GSD_1.0

Dhrs9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	131,131,376 - 131,152,420 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	10,465,701 - 10,487,534 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	10,465,701 - 10,487,534 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DHRS9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	75,507,588 - 75,534,481 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	75,507,538 - 75,533,942 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	84,800,183 - 84,823,204 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DHRS9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	54,611,792 - 54,641,037 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	54,614,559 - 54,641,877 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	144,893,959 - 144,920,547 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dhrs9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	6,758,478 - 6,776,238 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	6,751,787 - 6,776,181 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dhrs9
742 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1062
Count of miRNA genes:	556
Interacting mature miRNAs:	676
Transcripts:	ENSMUST00000063690
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13464141	Hbbcq3_m	hemoglobin concentration QTL 3 (mouse)					2	52448019	86448136	Mouse
13824983	Vclq1_m	curvilinear velocity QTL 1 (mouse)					2	61830344	136841920	Mouse
1301402	Ap2q_m	alcohol preference 2 QTL (mouse)			Not determined		2	43520612	77520756	Mouse
4142133	Pbwg1.6_m	postnatal body weight growth 1.6 (mouse)			Not determined			35797324	69797406	Mouse
1300761	Lgth1_m	body length 1 (mouse)			Not determined		2	51703276	85703425	Mouse
4141236	Hbnr5_m	Heligmosomoides bakeri nematode resistance 5 (mouse)			Not determined			31214567	105143570	Mouse
1302174	Dssc2_m	dextran sodium sulfate induced colitis QTL2 (mouse)			Not determined		2	24224632	148700377	Mouse
1301405	Etohr_m	ethanol response acute (mouse)			Not determined		2	63005954	97006113	Mouse
1301660	Iba1_m	induction of brown adipocytes 1 (mouse)			Not determined		2	67647887	101648142	Mouse
1558915	W3q1_m	weight 3 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1300875	Taste1_m	taste-saccharin preference 1 (mouse)			Not determined		2	50923175	84923278	Mouse
1301769	Orgwq2_m	organ weight QTL 2 (mouse)			Not determined		2	3887126	93421651	Mouse
1357454	Kidq1_m	kidney weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357577	Trmq3_m	T cell ratio modifier QTL 3 (mouse)			Not determined		2	60520612	119355518	Mouse
1558966	W10q9_m	weight 10 weeks QTL 9 (mouse)			Not determined		2	20897778	118894840	Mouse
4141854	T2dm2sa_m	type 2 diabetes mellitus 2 in SMXA RI mice (mouse)			Not determined		2	29307947	148374934	Mouse
13432174	Actres5_m	activity response to ethanol/saline 5 (mouse)					2	59892287	69792287	Mouse
1300662	Etohila_m	ethanol induced locomotor activity (mouse)			Not determined		2	63005954	97006113	Mouse
1300788	Cia2_m	collagen induced arthritis QTL 2 (mouse)			Not determined		2	43520612	77520756	Mouse
10053681	Lith24_m	lithogenic gene 24 (mouse)			Not determined		2	63005954	97006113	Mouse
1301048	Actre2_m	activity response to ethanol 2 (mouse)			Not determined		2	63005954	97006113	Mouse
1300671	Cia4_m	collagen induced arthritis QTL 4 (mouse)			Not determined		2	43520612	77520756	Mouse
1357881	Estoq1_m	embryo survival total QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
5491197	Mobq5_m	multigenic obesity QTL 5 (mouse)			Not determined		2	65269746	162518926	Mouse
1301948	Elsgp3_m	elevated serum gp70 3 (mouse)			Not determined		2	68724269	102724407	Mouse
1301411	Pitm1_m	prion incubation time 1 (mouse)			Not determined		2	43520612	77520756	Mouse
4141069	Pbwg1.5_m	postnatal body weight growth 1.5 (mouse)			Not determined			43520612	77520756	Mouse
1558820	Moo1_m	modifier of Odc1 (mouse)			Not determined		17	48269746	82269934	Mouse
13432184	Actdes1_m	activity chamber total difference ethanol/saline 1 (mouse)					2	59392287	69292287	Mouse
4141186	Pbwg1.8_m	postnatal body weight growth 1.8 (mouse)			Not determined			35797324	69797406	Mouse
13432178	Actres2_m	activity response to ethanol/saline 2 (mouse)					2	60692287	74092287	Mouse
12738429	Lfibq18_m	liver fibrosis QTL 18 (mouse)					2	57919991	91919991	Mouse
39128209	Lwq14_m	liver weight QTL 14 (mouse)					2	20897778	118894840	Mouse
1558738	W6q1_m	weight 6 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
11038703	Ltpr1_m	Leishmania tropica response 1 (mouse)					2	39971665	73971811	Mouse
1300568	Hdl1_m	high density lipoprotein (HDL) level 1 (mouse)			Not determined		2	48269746	82269934	Mouse
1559001	Eae33_m	experimental allergic encephalomyelitis susceptibility 33 (mouse)			Not determined		2	35991679	71609412	Mouse
4142447	Pbwg1.7_m	postnatal body weight growth 1.7 (mouse)			Not determined			35797324	69797406	Mouse
1301059	Hrtfm1_m	heart failure modifier 1 (mouse)			Not determined		2	67591940	74964933	Mouse
1301703	Bomd3_m	bone mineral density 3 (mouse)			Not determined		2	63005954	97006113	Mouse
1301747	Eae21_m	experimental allergic encephalomyelitis 21 (mouse)			Not determined		2	48269746	82269934	Mouse
1301235	Alcw4_m	alcohol withdrawal 4 (mouse)			Not determined		2	48269746	82269934	Mouse
4141406	Alpq2_m	alcohol preference QTL 2 (mouse)			Not determined		2	57524117	91524288	Mouse
10755526	Lymph1_m	lymphocyte differential 1 (mouse)					2	50819314	84819314	Mouse
13463471	Hctq6_m	hematocrit QTL 6 (mouse)					2	52448019	86448136	Mouse
1301873	Hsl1_m	hyperoxia susceptibility locus 1 (mouse)			Not determined		2	63570154	97570301	Mouse
1558899	Egq1_m	early growth QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357681	Hrtq1_m	heart weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1301109	Dntcs2_m	dental caries susceptibility 2 (mouse)			Not determined		2	40885493	114910165	Mouse
1357436	Splq1_m	spleen weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
10755532	Lymph5_m	lymphocyte differential 5 (mouse)					2	44199017	78199017	Mouse
1301882	Etohc2_m	ethanol consumption 2 (mouse)			Not determined		2	68724269	102724407	Mouse
11532740	Pbwg1.10_m	postnatal body weight growth 1.10 (mouse)					2	48132412	82132495	Mouse
1300577	Capsq1_m	capsaicin sensitivity related QTL 1 (mouse)			Not determined		2	27602060	84013384	Mouse
1301344	Lith1_m	lithogenic gene 1 (mouse)			Not determined		2	45347635	145312647	Mouse
13463482	Mchq17_m	mean corpuscular hemoglobin QTL 17 (mouse)					2	67647887	101648142	Mouse
1301480	Pbwg1_m	postnatal body weight growth 1 (mouse)			Not determined		2	41820719	75820843	Mouse
10044002	Hdl7_m	HDL level 7 (mouse)			Not determined		2	63005954	97006113	Mouse

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_175512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF361479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK050180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK080914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK089247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY936479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC118029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX649336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000063690 ⟹ ENSMUSP00000069631

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	69,210,789 - 69,234,877 (+)	Ensembl
GRCm38.p6 Ensembl	2	69,380,445 - 69,404,533 (+)	Ensembl

RefSeq Acc Id:

NM_175512 ⟹ NP_780721

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	69,210,806 - 69,233,430 (+)	NCBI
GRCm38	2	69,380,462 - 69,403,086 (+)	ENTREZGENE
MGSCv37	2	69,218,519 - 69,241,143 (+)	RGD
Celera	2	71,045,992 - 71,068,496 (+)	RGD
cM Map	2		ENTREZGENE

Sequence:

show sequence

GGAAGTCTTCACACATGCAGGTCTCAGAGCTCCGCAGACCGCAGGCACCTTGAGAGGATCAGCT
TGACGGAGCTGCACTTCCTTCCCCTGGACCACAGCAGGAAGGTGACAATCTGCAGCAGCGGAGC
AAGTCGCCCTCAGCTTCTGCACTGCGAGTCATCTTCAGCGAGGACATGATCTTTTATTGTACGT
GAAATAAGTATCCCTGTCACACAGAGAAAAAGGAAGATGCTGTTTTGGTTGTTGGCTCTCCTGT
TCCTCTGTGCTTTTCTGTGGAATTATAAAGGGCAGTTGAAGATAGCAGACATTGCTGACAAGTA
TGTCTTCATCACCGGATGTGACACGGGCTTTGGAAACTTAGCAGCCAGAACTTTTGATAAAAAA
GGCTTCCGTGTCATTGCTGCCTGCCTGACTGAGTCAGGATCAGCTGCTTTGAAGGCCAAAACCT
CAGAGAGACTCCACACCGTGCTTCTGGATGTCACTGACCCAGAGAATGTCAAGAAGACGGCCCA
GTGGGTGAAGAGCCATGTAGGAGAAAAGGGTCTCTGGGGTCTGATCAATAATGCTGGTGTTCTT
GGCGTGTTGGCTCCCACTGACTGGTTGACAGTGGACGACTACAGAGAACCCATTGAAGTTAACC
TGTTTGGACTCATCAACGTGACACTGAATATGCTTCCACTGGTCAAAAAAGCTCGAGGGCGTGT
TATCAATGTCTCCAGCATTGGAGGCCGGCTTGCATTTGGTGGAGGGGGCTATACTCCATCCAAA
TACGCAGTGGAGGGTTTCAATGACAGCCTAAGGCGGGATATGAAAGCTTTTGGTGTGCATGTCT
CATGCATTGAACCAGGGCTGTTCAAAACAGAGCTGGCAGATCCAATCAAGACAACTGAAAAAAA
ACTGGCCATTTGGAAACATCTGTCTCCAGATATCAAACAACAATATGGAGAGGGCTACATTGAA
AAAAGTCTACACAGACTGAAAAGCAATACCTCCTCGGTGAACTTGGACCTCTCTCTAGTGGTAG
GGTGCATGGACCACGCTCTAACAAGTCTCTTCCCCAAGACTCGGTACATTGCTGGGAAAGATGC
CAAGACATTCTGGATACCTCTGTCTCACATGCCAGCAGTTTTACAAGACTTTTTATTGCTGAAA
CAGAAAGTAGAGCTGGCAAATCCCAAAGCTGTGTGACTCAACTAACCACAAATGCCTGCCCCCA
GCTTCGAGATTGGCTGATTTCAGAGACTTGGCACCTCAATCTCATTCTTTACCAGACCCAACTC
GGACTCACTTAGACCAGGTTTCCGTTTTTAAAAGAAGATAGTCCATAGTCTCTTCTTAAGTCTT
CTGTGAAAATAAGGACAGAGAAGGCCTATCTCATAAGCCAGTCTTGCCAGATACTGAAGCTTTA
CCTGATTGGTAAGATGAAAGAGAAATGGAAAGACTTCTCCATCCAAAATAGGTGTGCTGCTACC
TGCCCCTGACTGGTTCAGTAATCCAGATTGCTAAGCATTGTCGCTTATTGAAATGTTAAGTGAT
AAGAAGTCTTTAATAAGTGGATCCAATGGCTCTGTTATCTGGCAGAGAAGAAGACTCAATACAT
TCTGATAAGCTTTGATAAGAACAAGAAAGAGATAAAAGGTGTTACCACGCAGAGCACTGGTATG
AACTGAGAGGCGGTTAGAAACAGGGAAGAAATAGAAGGGCAGAAAAAGACAAGGAATGAAAGGT
GGGGACACGCCAATACAAGCCTCATACTCCAGAGGGACACAGAGGACACACTACTGCTGTTACC
GTGAAGTCACTGCATCTGGTCCTAGCCCTAGAGGTACCTCACCAGTACCTTCATCAGTCAGCTG
CATCACAGCGGAAGCACACCAGTTCTGTTGGCTACAGCTGCTCCTCATTACAAGGCCAGGTTCT
TGGCTCCATCTCATGGCTTCAGACTCTGTGGCTTGCTTACTGCCCTTTGACTTTCCCGATGTCC
AAAGACTACCAAGATTTGCAGAATCCCAAGGGAATTCCTTTATTGATCTTCCAATCATGCTAAT
CCAATCGCTCAACCTTCTAATTCTGTCTCTGTTTTGCCTCATCCTGAGATGCTTTCTATTATTC
TTATCCCTTTAAGTAGCTACAATTCGCTTACTCTTTCTTCCCATCAAAAACTAAGTGTCATGCA
GTCTACCATTGAGCGCAAGCTTGCCAGCTGCAGCATCTGTGTTAGCAGTGTGCCAGCTGCACTT
CTGTTAAGCTCTGAGTACTTCCTTCTTAGCTGTAGCTCCGCCATCAGCCTTCCCACAGAGAAGG
CTCGCTCAGCAGAACAAGGTGGCTGCTCTTCACTTGTTGGTTCGGAGATACTGTGAAGGAGCCT
GCTGCATATGTAAACTGTCCAGACGAAAGAGAATCTCTTCCATTTAAACTATCTTCAAGACCCT
AAACCATCTGTGGGTAGCTCAGCCTAGTACATAATGAAGAAAATTCCCAAGAAGCTGCTAAGAA
AAATGTTCAAGTTTTGCCTTTCTCTACAGTATTCATCCCAGTAGTTCTCGGGGGTATAAGACAC
CACAGGCTCATTTATGTAGAAATGGCCAAACATTCGCAAAATGAAAAACTCTGCTACCTACAGG
TGATTTCTATCGATTTTACTCTAAGCGATGGCCTCCTGAATCCTTGCCAAAGGAGACAGTTCTG
TTACACTTGCCCCTAACTCTGGTTTCTTTCACCCTTCTTTTTGTCATGGAGGCTCAAATCCAGA
ATCTCGGGCATGGGCCCATGCTACACCACTGAGCTACACCACACCCCAGTTCAGGATTTATTTT
T

hide sequence

Protein Sequences


Protein RefSeqs	NP_780721	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI18030	(Get FASTA)	NCBI Sequence Viewer
	AAN75755	(Get FASTA)	NCBI Sequence Viewer
	AAX33670	(Get FASTA)	NCBI Sequence Viewer
	BAC34110	(Get FASTA)	NCBI Sequence Viewer
	BAC38075	(Get FASTA)	NCBI Sequence Viewer
	EDL27033	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000069631
	ENSMUSP00000069631.4
GenBank Protein	Q58NB6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_780721 ⟸ NM_175512
- Peptide Label:	precursor
- UniProtKB:	Q8BGC7 (UniProtKB/Swiss-Prot), Q58NB6 (UniProtKB/Swiss-Prot), Q148Q4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLFWLLALLFLCAFLWNYKGQLKIADIADKYVFITGCDTGFGNLAARTFDKKGFRVIAACLTES GSAALKAKTSERLHTVLLDVTDPENVKKTAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVD DYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRR DMKAFGVHVSCIEPGLFKTELADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSNTSS VNLDLSLVVGCMDHALTSLFPKTRYIAGKDAKTFWIPLSHMPAVLQDFLLLKQKVELANPKAV hide sequence

Ensembl Acc Id:

ENSMUSP00000069631 ⟸ ENSMUST00000063690

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q58NB6-F1-model_v2	AlphaFold	Q58NB6	1-319	view protein structure

Promoters

RGD ID:

6831159

Promoter ID:

MM_KWN:29539

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, MEF_B4

Transcripts:

OTTMUST00000031297

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	69,218,356 - 69,218,856 (+)	MPROMDB

RGD ID:

6877496

Promoter ID:

EPDNEW_M2198

Type:

initiation region

Name:

Dhrs9_1

Description:

Mus musculus dehydrogenase/reductase member 9 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	69,380,497 - 69,380,557	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2442798	AgrOrtholog
Ensembl Genes	ENSMUSG00000027068	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000063690	ENTREZGENE
	ENSMUST00000063690.4	UniProtKB/Swiss-Prot
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:241452	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2442798	ENTREZGENE
NCBI Gene	241452	ENTREZGENE
PANTHER	DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dhrs9	PhenoGen
PRINTS	GDHRDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	DHRS9_MOUSE	UniProtKB/Swiss-Prot
	Q148Q4	ENTREZGENE, UniProtKB/TrEMBL
	Q58NB6	ENTREZGENE
	Q8BGC7	ENTREZGENE
UniProt Secondary	Q8BGC7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-07-04	Dhrs9	dehydrogenase/reductase 9	Dhrs9	dehydrogenase/reductase (SDR family) member 9	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype