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Gene: Cdkn2b (cyclin dependent kinase inhibitor 2B) Mus musculus
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Symbol: Cdkn2b
Name: cyclin dependent kinase inhibitor 2B
Description: Predicted to have cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and spleen. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; small cell lung carcinoma pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV083695; cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; INK4b; MTS2; p14-INK4b; p15; p15(INK4b); p15-INK4b; p15INK4b
Orthologs:
Homo sapiens (human) : CDKN2B (cyclin dependent kinase inhibitor 2B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdkn2b (cyclin-dependent kinase inhibitor 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn2b (cyclin dependent kinase inhibitor 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN2B (cyclin dependent kinase inhibitor 2B)
Canis lupus familiaris (dog) : CDKN2B (cyclin dependent kinase inhibitor 2B)
Sus scrofa (pig) : CDKN2B (cyclin dependent kinase inhibitor 2B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38489,306,289 - 89,311,032 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37488,952,198 - 88,956,941 (-)NCBIGRCm37mm9NCBIm37
MGSCv36488,777,556 - 88,782,190 (-)NCBImm8
Celera487,792,244 - 87,797,039 (-)NCBICelera
Cytogenetic Map4 C4NCBI
cM Map442.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Cdkn2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731792
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.