Cdkn2b (cyclin dependent kinase inhibitor 2B) - Rat Genome Database

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Gene: Cdkn2b (cyclin dependent kinase inhibitor 2B) Mus musculus
Symbol: Cdkn2b
Name: cyclin dependent kinase inhibitor 2B
RGD ID: 731792
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; lung; and retina. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; small cell lung carcinoma pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV083695; cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; INK4b; MTS; MTS2; p1; p14-INK4b; p15; p15(INK4b); p15-INK4b; p15IN; p15INK4b
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39489,224,526 - 89,229,269 (-)NCBIGRCm39mm39
GRCm39 Ensembl489,224,536 - 89,229,276 (-)Ensembl
GRCm38489,306,289 - 89,311,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl489,306,299 - 89,311,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,952,198 - 88,956,941 (-)NCBIGRCm37mm9NCBIm37
MGSCv36488,777,556 - 88,782,190 (-)NCBImm8
Celera487,792,244 - 87,797,039 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
antimonite  (ISO)
aristolochic acid  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
auraptene  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
daunorubicin  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fenbendazole  (ISO)
flavonoids  (ISO)
fluoxetine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
GW 3965  (ISO)
GW 4064  (ISO)
harmine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (EXP)
indole-3-methanol  (ISO)
lead diacetate  (ISO)
linalool  (ISO)
lithium chloride  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monoethyl phthalate  (EXP)
monosodium L-glutamate  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
prednisone  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sorafenib  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

References - curated
1. Adamovic T, etal., Cancer Genet Cytogenet. 2008 Jul;184(1):9-21.
2. Arcellana-Panlilio MY, etal., Genes Chromosomes Cancer. 2002 Oct;35(2):176-81.
3. Cleary HJ, etal., Leukemia. 1999 Dec;13(12):2049-52.
4. Dimasi DP, etal., Am J Ophthalmol. 2012 Nov;154(5):833-842.e2. doi: 10.1016/j.ajo.2012.04.023. Epub 2012 Jul 27.
5. Eissa S, etal., IUBMB Life. 2004 Sep;56(9):557-64.
6. Faderl S, etal., Cancer. 2000 Nov 1;89(9):1976-82.
7. Feng W, etal., Mod Pathol. 2007 Sep;20(9):961-6. Epub 2007 Jul 13.
8. Gu F, etal., Br J Cancer. 2013 Apr 2;108(6):1378-86. doi: 10.1038/bjc.2013.7. Epub 2013 Jan 29.
9. Hong Q, etal., Exp Ther Med. 2016 May;11(5):1901-1907. Epub 2016 Feb 19.
10. Hu Q, etal., Lab Invest. 2010 Mar;90(3):360-73. doi: 10.1038/labinvest.2009.140. Epub 2010 Jan 11.
11. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
12. Kurakawa E, etal., Int J Oncol. 2001 Aug;19(2):277-81.
13. Laharanne E, etal., Mod Pathol. 2010 Apr;23(4):547-58. doi: 10.1038/modpathol.2009.196. Epub 2010 Jan 29.
14. Le Frere-Belda MA, etal., Br J Cancer. 2001 Nov 16;85(10):1515-21.
15. Liu Z, etal., Clin Cancer Res. 2005 Jul 1;11(13):4968-76.
16. MGD data from the GO Consortium
18. Moad AI, etal., J Cutan Pathol. 2009 Feb;36(2):183-9. doi: 10.1111/j.1600-0560.2008.00989.x. Epub 2008 Jun 17.
19. Ogawa K, etal., Oral Oncol. 2006 Mar 7;.
20. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Raj K, etal., Leukemia. 2007 Sep;21(9):1937-44. Epub 2007 Jul 5.
23. RGD automated import pipeline
24. RGD automated import pipeline for gene-chemical interactions
25. Rodrigues EF, etal., Leuk Lymphoma. 2010 Oct;51(10):1887-94. doi: 10.3109/10428194.2010.505820.
26. Schwaller J, etal., Leukemia. 1997 Jan;11(1):54-63.
27. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
28. Shimamoto T, etal., Leuk Res. 2005 Jun;29(6):653-9. Epub 2005 Jan 19.
29. Tanaka T, etal., Oncogene. 1999 Jun 24;18(25):3793-7.
30. Teofili L, etal., Leukemia. 2003 May;17(5):919-24.
31. Tessema M, etal., Leukemia. 2003 May;17(5):910-8.
32. Wolff L, etal., Oncogene. 2003 Dec 18;22(58):9265-74.
33. Yalcin A, etal., Int J Lab Hematol. 2009 Aug;31(4):407-19. doi: 10.1111/j.1751-553X.2008.01052.x. Epub 2008 Apr 1.
34. Yurakh AO, etal., Eur Urol. 2006 Sep;50(3):506-15; discussion 515. Epub 2006 Mar 31.
35. Zhang L, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jan;17(1):6-10.
36. Zhang Y, etal., Zhonghua Xue Ye Xue Za Zhi. 2013 Mar;34(3):237-41. doi: 10.3760/cma.j.issn.0253-2727.2013.03.013.
37. Zhang Z, etal., Mod Pathol. 2006 Oct;19(10):1339-43. Epub 2006 Jun 23.
Additional References at PubMed
PMID:7585567   PMID:7651726   PMID:8078588   PMID:8587124   PMID:8934534   PMID:9040936   PMID:9061010   PMID:9094671   PMID:9178896   PMID:9244355   PMID:9372237   PMID:9482902  
PMID:9488045   PMID:9501299   PMID:9659582   PMID:9927195   PMID:10344755   PMID:10349636   PMID:10435599   PMID:10498883   PMID:10556039   PMID:10753221   PMID:10773440   PMID:10828598  
PMID:10880462   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11606789   PMID:11707341   PMID:11813303   PMID:12381668   PMID:12477932   PMID:12642863   PMID:14560010   PMID:14757439  
PMID:14976051   PMID:15260977   PMID:15322169   PMID:15342385   PMID:15345747   PMID:15370242   PMID:15459098   PMID:15489334   PMID:15562441   PMID:15730892   PMID:15735755   PMID:15833857  
PMID:16141072   PMID:16141073   PMID:16183747   PMID:16602821   PMID:17123792   PMID:17309820   PMID:17713536   PMID:18037485   PMID:18185590   PMID:18192284   PMID:18625706   PMID:18836456  
PMID:19854167   PMID:19864318   PMID:20007774   PMID:20059953   PMID:20068150   PMID:20103622   PMID:20457873   PMID:20498273   PMID:20685850   PMID:20696760   PMID:21040902   PMID:21220025  
PMID:21619792   PMID:21674058   PMID:21778144   PMID:21873635   PMID:22154697   PMID:22158708   PMID:22226369   PMID:22227036   PMID:22461492   PMID:22560297   PMID:22682244   PMID:22952318  
PMID:23034635   PMID:23045274   PMID:23071090   PMID:23154982   PMID:23162013   PMID:23349189   PMID:23497137   PMID:23674600   PMID:23699408   PMID:23831572   PMID:24013501   PMID:24142690  
PMID:24238961   PMID:24238962   PMID:24449168   PMID:24531546   PMID:24618618   PMID:24632607   PMID:24958854   PMID:25157181   PMID:25550505   PMID:25773539   PMID:25882552   PMID:26418719  
PMID:26596284   PMID:27179789   PMID:27214556   PMID:27318131   PMID:27608041   PMID:27728803   PMID:28049658   PMID:28074012   PMID:28118982   PMID:28346462   PMID:28512107   PMID:28791750  
PMID:28892048   PMID:29420051   PMID:29632206   PMID:30785991   PMID:30926782   PMID:31634485   PMID:31748650   PMID:32271879   PMID:33197428   PMID:33824349   PMID:33846290  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39489,224,526 - 89,229,269 (-)NCBIGRCm39mm39
GRCm39 Ensembl489,224,536 - 89,229,276 (-)Ensembl
GRCm38489,306,289 - 89,311,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl489,306,299 - 89,311,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,952,198 - 88,956,941 (-)NCBIGRCm37mm9NCBIm37
MGSCv36488,777,556 - 88,782,190 (-)NCBImm8
Celera487,792,244 - 87,797,039 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl922,002,903 - 22,009,305 (-)EnsemblGRCh38hg38GRCh38
GRCh38922,002,903 - 22,009,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37922,002,902 - 22,009,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,992,902 - 21,999,312 (-)NCBINCBI36hg18NCBI36
Build 34921,992,902 - 21,999,312NCBI
Celera921,941,270 - 21,947,682 (-)NCBI
Cytogenetic Map9p21.3NCBI
HuRef921,966,171 - 21,972,582 (-)NCBIHuRef
CHM1_1922,002,731 - 22,009,141 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25104,009,839 - 104,019,082 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5104,010,680 - 104,019,050 (-)Ensembl
Rnor_6.05107,834,353 - 107,857,428 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5107,845,951 - 107,858,104 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05111,817,188 - 111,826,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45108,939,669 - 108,945,293 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15108,946,492 - 108,950,551 (-)NCBI
Celera5102,728,741 - 102,734,427 (-)NCBICelera
Cytogenetic Map5q32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495547212,275,544 - 12,280,528 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547212,275,613 - 12,280,141 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1922,455,662 - 22,462,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl922,455,662 - 22,462,156 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0921,838,902 - 21,845,355 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11141,259,627 - 41,264,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1139,895,530 - 39,924,805 (-)NCBI
Dog10K_Boxer_Tasha1139,933,406 - 39,936,568 (-)NCBI
ROS_Cfam_1.01142,165,720 - 42,207,150 (-)NCBI
UMICH_Zoey_3.11140,873,681 - 40,876,835 (-)NCBI
UNSW_CanFamBas_1.01140,761,542 - 40,764,705 (-)NCBI
UNSW_CanFamBas_1.01140,723,758 - 40,752,953 (-)NCBI
UU_Cfam_GSD_1.01141,374,892 - 41,378,057 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947155,907,481 - 155,911,659 (-)NCBI
SpeTri2.0NW_0049366523,576,975 - 3,582,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1200,761,004 - 200,766,056 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11200,666,250 - 200,770,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,955,554 - 223,960,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462473625,929,314 - 25,933,318 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38489,306,444 - 89,306,587UniSTSGRCm38
MGSCv37488,952,353 - 88,952,496UniSTSGRCm37
Celera487,792,399 - 87,792,542UniSTS
Cytogenetic Map4C3-C6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38489,306,625 - 89,306,764UniSTSGRCm38
MGSCv37488,952,534 - 88,952,673UniSTSGRCm37
Cytogenetic Map4C3-C6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38489,307,078 - 89,307,316UniSTSGRCm38
MGSCv37488,952,987 - 88,953,225UniSTSGRCm37
Celera487,793,071 - 87,793,309UniSTS
Cytogenetic Map4C3-C6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38489,307,096 - 89,307,282UniSTSGRCm38
MGSCv37488,953,005 - 88,953,191UniSTSGRCm37
Celera487,793,089 - 87,793,275UniSTS
Cytogenetic Map4C3-C6UniSTS
cM Map442.7UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C3-C6UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108500000Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105299798Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105944663Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123233418Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993875068Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124161387Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103400000Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000129100000Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094900000Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
10043964Obq26_mobesity QTL 26 (mouse)Not determined45912901493129014Mouse
1301190Cd4ts2_mCD4 T cell subset 2 (mouse)Not determined46022704094227187Mouse
1357507Synch2_msynechia 2 (mouse)Not determined46022704094227187Mouse
1357870Pfat1_mpredicted fat percentage 1 (mouse)Not determined46370128997701448Mouse
12879903Berr8_mberghei resistance locus 8 (mouse)46430422398304223Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465400000119000000Mouse
13506251Cytrq1_mcytokine response QTL 1 (mouse)46579984999799849Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
27095938Ulnl6_mulna length 6, 10 week (mouse)46680000098700000Mouse
1301757Tlsr4_mthymic lymphoma suppressor region 4 (mouse)Not determined466838893100839021Mouse
1357561Mbsyd_mmetabolic syndrome (mouse)Not determined466970208100970351Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468100000107300000Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468100000130500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469200000131000000Mouse
1302057Pgia27_mproteoglycan induced arthritis 27 (mouse)Not determined470148990104149227Mouse
1301739Pitm2_mprion incubation time 2 (mouse)Not determined472063832106063979Mouse
1302044Nss1_mNOD Sjogren's syndrome 1 (mouse)Not determined472063832106063979Mouse
12879897Berr4_mberghei resistance locus 4 (mouse)472063832106063979Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474145650108145792Mouse
1301597Anxty_manxiety (mouse)Not determined474219337128115487Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474556462108556746Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474556462108556746Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474556462108556746Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474556462108556746Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474556462108556746Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474556462108556746Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474556462108556746Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474556462108556746Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474556462108556746Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474556462108556746Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474800000108500000Mouse
26884406Huml3_mhumerus length 3, 10 week (mouse)475700000100300000Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476874870110875068Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined478069342112069538Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479477514113477630Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479477514113477630Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479477514113477630Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479477514113477630Mouse
12904738Idohtq_miris defect with ocular hypertension QTL (mouse)48083423093224754Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481325754115325754Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482356158116356345Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483200000108500000Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483747673117747809Mouse
10412176Habiir3_mhyperoxic acute lung injury imprinted region 3 (mouse)Not determined48383889394405503Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)485000000107300000Mouse
26884435Zlq4_mzygomatic length QTL 4, 10 week (mouse)485200000105100000Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485571641119571840Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485571641119571840Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485923970119924082Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485923970119924082Mouse
27226801Feml6_mfemur length 6, 5 week (mouse)487600000103400000Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487600000107300000Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487600000108500000Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488200000108500000Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488200000118700000Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488600000108500000Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488600000108600000Mouse
1300601Tlsr1_mthymic lymphoma suppressor region 1 (mouse)Not determined48868292195069538Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)489063832116413923Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:193
Interacting mature miRNAs:199
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_007670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF015460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01036593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DT919921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000097981   ⟹   ENSMUSP00000095595
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl489,224,536 - 89,229,276 (-)Ensembl
GRCm38.p6 Ensembl489,306,299 - 89,311,039 (-)Ensembl
RefSeq Acc Id: NM_007670   ⟹   NP_031696
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39489,224,526 - 89,229,269 (-)NCBI
GRCm38489,306,289 - 89,311,032 (-)ENTREZGENE
MGSCv37488,952,198 - 88,956,941 (-)RGD
Celera487,792,244 - 87,797,039 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_031696   ⟸   NM_007670
- UniProtKB: P55271 (UniProtKB/Swiss-Prot),   Q549R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000095595   ⟸   ENSMUST00000097981
Protein Domains

RGD ID:6835046
Promoter ID:MM_KWN:38378
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Mouse AssemblyChrPosition (strand)Source
MGSCv36488,956,671 - 88,957,171 (-)MPROMDB
RGD ID:6883830
Promoter ID:EPDNEW_M5366
Type:initiation region
Description:Mus musculus cyclin-dependent kinase inhibitor 2B (p15, inhibitsCDK4) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38489,310,992 - 89,311,052EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104737 AgrOrtholog
Ensembl Genes ENSMUSG00000073802 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000095595 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000097981 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12579 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdkn2b PhenoGen
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CDN2B_MOUSE UniProtKB/Swiss-Prot
  O54846_MOUSE UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Cdkn2b  cyclin dependent kinase inhibitor 2B    cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)  Symbol and/or name change 5135510 APPROVED