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Gene: Keap1 (kelch-like ECH-associated protein 1) Mus musculus
Symbol: Keap1
Name: kelch-like ECH-associated protein 1
Description: Exhibits disordered domain specific binding activity and protein homodimerization activity. Involved in several processes, including cellular protein metabolic process; cellular response to interleukin-4; and regulation of epidermal cell differentiation. Localizes to several cellular components, including the Cul3-RING ubiquitin ligase complex; actin filament; and inclusion body. Human ortholog(s) of this gene implicated in gallbladder cancer. Is expressed in eye and limb mesenchyme. Orthologous to human KEAP1 (kelch like ECH associated protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,2-Naphthoquinone; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytosolic inhibitor of Nrf2; INRF2; mKIAA0132; NRF2 cytosolic inhibitor; ring canal protein
Homo sapiens (human) : KEAP1 (kelch like ECH associated protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Keap1 (Kelch-like ECH-associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Keap1 (kelch like ECH associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KEAP1 (kelch like ECH associated protein 1)
Canis lupus familiaris (dog) : KEAP1 (kelch like ECH associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Keap1 (kelch like ECH associated protein 1)
Sus scrofa (pig) : KEAP1 (kelch like ECH associated protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38921,229,730 - 21,239,332 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37921,034,174 - 21,043,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36920,980,469 - 20,989,215 (-)NCBImm8
Celera918,498,845 - 18,508,447 (-)NCBICelera
Cytogenetic Map9 A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Keap1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733529
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.