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Gene: Keap1 (kelch-like ECH-associated protein 1) Mus musculus
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Symbol: Keap1
Name: kelch-like ECH-associated protein 1
Description: Exhibits disordered domain specific binding activity and protein homodimerization activity. Involved in several processes, including cellular protein metabolic process; cellular response to interleukin-4; and regulation of epidermal cell differentiation. Localizes to several cellular components, including the Cul3-RING ubiquitin ligase complex; actin filament; and inclusion body. Human ortholog(s) of this gene implicated in gallbladder cancer. Is expressed in eye and limb mesenchyme. Orthologous to human KEAP1 (kelch like ECH associated protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,2-Naphthoquinone; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytosolic inhibitor of Nrf2; INRF2; mKIAA0132; NRF2 cytosolic inhibitor; ring canal protein
Orthologs:
Homo sapiens (human) : KEAP1 (kelch like ECH associated protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Keap1 (Kelch-like ECH-associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Keap1 (kelch like ECH associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KEAP1 (kelch like ECH associated protein 1)
Canis lupus familiaris (dog) : KEAP1 (kelch like ECH associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Keap1 (kelch like ECH associated protein 1)
Sus scrofa (pig) : KEAP1 (kelch like ECH associated protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38921,229,730 - 21,239,332 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37921,034,174 - 21,043,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36920,980,469 - 20,989,215 (-)NCBImm8
Celera918,498,845 - 18,508,447 (-)NCBICelera
Cytogenetic Map9 A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Keap1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733529
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.