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Gene: Vdr (vitamin D (1,25-dihydroxyvitamin D3) receptor) Mus musculus
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Symbol: Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Description: Exhibits DNA binding activity and nuclear receptor activity. Predicted to contribute to DNA-binding transcription factor activity and vitamin D response element binding activity. Involved in several processes, including mammary gland development; positive regulation of apoptotic process involved in mammary gland involution; and regulation of cellular biosynthetic process. Predicted to colocalize with the caveola. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bone disease (multiple); liver disease (multiple); melanoma (multiple); and tuberculosis (multiple). Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Orthologous to human VDR (vitamin D receptor); PARTICIPATES IN altered p53 signaling pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 24,25-Dihydroxyvitamin D; 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1,25-dihydroxyvitamin D3 receptor; Nr1i1; nuclear receptor subfamily 1 group I member 1; vitamin D receptor; vitamin D3 receptor
Orthologs:
Homo sapiens (human) : VDR (vitamin D receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vdr (vitamin D receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vdr (vitamin D receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : VDR (vitamin D receptor)
Canis lupus familiaris (dog) : VDR (vitamin D receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vdr (vitamin D receptor)
Sus scrofa (pig) : VDR (vitamin D receptor)
Chlorocebus sabaeus (African green monkey) : VDR (vitamin D receptor)
Heterocephalus glaber (naked mole-rat) : Vdr (vitamin D receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1597,854,425 - 97,910,630 (-)Ensembl
GRCm381597,854,427 - 97,908,296 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371597,684,858 - 97,738,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv361597,682,461 - 97,736,330 (-)NCBImm8
Celera1599,981,938 - 100,035,599 (-)NCBICelera
Cytogenetic Map15F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Vdr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11484
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.