Fat4 (FAT atypical cadherin 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fat4 (FAT atypical cadherin 4) Mus musculus
Analyze
Symbol: Fat4
Name: FAT atypical cadherin 4
RGD ID: 1617975
MGI Page MGI
Description: Predicted to enable calcium ion binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and nervous system development. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and condensed mesenchymal cell proliferation. Located in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; lung; and metanephros. Human ortholog(s) of this gene implicated in Hennekam syndrome and Van Maldergem syndrome 2. Orthologous to human FAT4 (FAT atypical cadherin 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6030410K14Rik; 9430004M15; FAT tumor suppressor homolog 4; fat-like cadherin protein FAT-J; protocadherin Fat 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39338,940,045 - 39,066,136 (+)NCBIGRCm39mm39
GRCm39 Ensembl338,941,089 - 39,066,134 (+)Ensembl
GRCm38338,884,667 - 39,011,992 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl338,886,940 - 39,011,985 (+)EnsemblGRCm38mm10GRCm38
MGSCv37338,785,862 - 38,910,907 (+)NCBIGRCm37mm9NCBIm37
MGSCv36339,078,489 - 39,203,530 (+)NCBImm8
Celera338,729,877 - 38,854,312 (+)NCBICelera
Cytogenetic Map3BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16059920   PMID:16141072   PMID:16141073   PMID:18604206   PMID:19048595  
PMID:19506035   PMID:21303848   PMID:21677750   PMID:21764761   PMID:21873635   PMID:22153077   PMID:22510986   PMID:23342162   PMID:23563179   PMID:23974041   PMID:24056717   PMID:24998526  
PMID:25355906   PMID:26114487   PMID:26116661   PMID:26116666   PMID:26209645   PMID:26511275   PMID:27145737   PMID:27381226   PMID:27568557   PMID:28239148   PMID:28705793   PMID:30853441  
PMID:30862798   PMID:31358536   PMID:31747096   PMID:32155439   PMID:32182215   PMID:32541007   PMID:32715478  


Genomics

Comparative Map Data
Fat4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39338,940,045 - 39,066,136 (+)NCBIGRCm39mm39
GRCm39 Ensembl338,941,089 - 39,066,134 (+)Ensembl
GRCm38338,884,667 - 39,011,992 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl338,886,940 - 39,011,985 (+)EnsemblGRCm38mm10GRCm38
MGSCv37338,785,862 - 38,910,907 (+)NCBIGRCm37mm9NCBIm37
MGSCv36339,078,489 - 39,203,530 (+)NCBImm8
Celera338,729,877 - 38,854,312 (+)NCBICelera
Cytogenetic Map3BNCBI
FAT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4125,314,918 - 125,492,932 (+)EnsemblGRCh38hg38GRCh38
GRCh384125,314,918 - 125,492,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374126,236,110 - 126,414,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364126,457,017 - 126,632,373 (+)NCBINCBI36hg18NCBI36
Build 344126,672,695 - 126,770,528NCBI
Celera4123,617,849 - 123,794,372 (+)NCBI
Cytogenetic Map4q28.1NCBI
HuRef4121,965,923 - 122,142,399 (+)NCBIHuRef
CHM1_14126,214,142 - 126,390,638 (+)NCBICHM1_1
Fat4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22121,928,188 - 122,056,711 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl2125,752,130 - 125,879,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2126,267,658 - 126,284,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02125,751,818 - 125,879,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02145,864,192 - 145,880,594 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02145,349,239 - 145,477,455 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42125,847,465 - 125,975,620 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2116,853,380 - 116,981,485 (+)NCBICelera
Cytogenetic Map2q25NCBI
Fat4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542815,622,498 - 15,810,896 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542815,621,333 - 15,812,167 (-)NCBIChiLan1.0ChiLan1.0
FAT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14128,637,516 - 128,814,413 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4128,637,516 - 128,814,407 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04117,494,842 - 117,674,382 (+)NCBIMhudiblu_PPA_v0panPan3
FAT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11915,157,595 - 15,332,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1915,158,922 - 15,332,045 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1915,363,356 - 15,537,231 (-)NCBI
ROS_Cfam_1.01915,259,451 - 15,431,654 (-)NCBI
UMICH_Zoey_3.11915,223,649 - 15,398,514 (-)NCBI
UNSW_CanFamBas_1.01915,500,460 - 15,675,303 (-)NCBI
UU_Cfam_GSD_1.01915,965,180 - 16,139,594 (-)NCBI
Fat4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530163,414,526 - 63,583,319 (-)NCBI
SpeTri2.0NW_0049366623,537,917 - 3,704,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1899,141,967 - 99,312,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28105,998,766 - 106,018,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1772,498,182 - 72,686,607 (+)NCBI
ChlSab1.1 Ensembl772,500,264 - 72,685,546 (+)Ensembl
Vero_WHO_p1.0NW_02366603751,514,689 - 51,708,405 (+)NCBI
Fat4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247776,095,166 - 6,293,142 (+)NCBI

Position Markers
Fat4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3BUniSTS
cM Map3 UniSTS
D3Mit295  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38338,928,541 - 38,928,642UniSTSGRCm38
MGSCv37338,827,463 - 38,827,564UniSTSGRCm37
Celera338,771,310 - 38,771,412UniSTS
Cytogenetic Map3BUniSTS
cM Map320.6UniSTS
Whitehead Genetic315.3UniSTS
Whitehead_YAC3 UniSTS
D13S289  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38338,885,178 - 38,886,530UniSTSGRCm38
MGSCv37338,784,100 - 38,785,452UniSTSGRCm37
Celera1725,564,159 - 25,565,676UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map3BUniSTS
Fat4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3BUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3752111468809613Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31157630445576442Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1823401952234019Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32012071354125954Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33188340565883548Mouse
12910778Pwgrq13_mpost-weaning growth rate QTL 13 (mouse)33258161158109942Mouse
12910781Pwgrq12_mpost-weaning growth rate QTL 12 (mouse)33258161158109942Mouse
1357689Mdmsc1_mmodifier of muscularity 1 (mouse)Not determined33327305245962044Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33358101667581166Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33384462467844807Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33384462467844807Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33426332068263320Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33466868268668682Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33550000069500000Mouse
14746977Manh53_mmandible shape 53 (mouse)33601785970017859Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33712559368809613Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:481
Count of miRNA genes:345
Interacting mature miRNAs:398
Transcripts:ENSMUST00000061260, ENSMUST00000129182
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061260   ⟹   ENSMUSP00000061836
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl338,886,940 - 39,011,985 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129182
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl338,890,942 - 38,952,429 (+)Ensembl
RefSeq Acc Id: NM_183221   ⟹   NP_899044
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39338,941,089 - 39,066,134 (+)NCBI
GRCm38338,886,940 - 39,011,985 (+)NCBI
MGSCv37338,785,862 - 38,910,907 (+)RGD
Celera338,729,877 - 38,854,312 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006535484   ⟹   XP_006535547
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39338,940,045 - 39,066,136 (+)NCBI
GRCm38338,884,667 - 39,011,992 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_899044   ⟸   NM_183221
- Peptide Label: precursor
- UniProtKB: Q2PZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006535547   ⟸   XM_006535484
- Peptide Label: isoform X1
- UniProtKB: Q2PZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000061836   ⟸   ENSMUST00000061260
Protein Domains
Cadherin   EGF-like   Laminin G-like

Promoters
RGD ID:6833765
Promoter ID:MM_KWN:34170
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4,   MEF_B6
Transcripts:OTTMUST00000060734,   UC008PBE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36338,786,346 - 38,790,342 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045256 AgrOrtholog
Ensembl Genes ENSMUSG00000046743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000061836 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061260 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
KEGG Report mmu:329628 UniProtKB/Swiss-Prot
MGD MGI:3045256 ENTREZGENE
NCBI Gene 329628 ENTREZGENE
Pfam Cadherin UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
PhenoGen Fat4 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt FAT4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E9QMR9 UniProtKB/Swiss-Prot
  Q68FE0 UniProtKB/Swiss-Prot
  Q8BM82 UniProtKB/Swiss-Prot
  Q8CD68 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Fat4  FAT atypical cadherin 4    FAT tumor suppressor homolog 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED