Gcgr (glucagon receptor) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gcgr (glucagon receptor) Mus musculus
Analyze
Symbol: Gcgr
Name: glucagon receptor
RGD ID: 1332263
MGI Page MGI
Description: Enables glucagon receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Is active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Used to study Mahvash Disease. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G; GL-R; GR
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,420,011 - 120,429,815 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,421,525 - 120,429,812 (+)EnsemblGRCm39 Ensembl
GRCm3811120,529,185 - 120,538,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,530,699 - 120,538,986 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,392,041 - 120,400,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,345,362 - 120,355,178 (+)NCBIMGSCv36mm8
Celera11132,266,137 - 132,274,394 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chrysene  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
disulfiram  (ISO)
endosulfan  (ISO)
fenthion  (EXP)
gatifloxacin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucagon  (EXP)
graphite  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenylhydrazine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP,ISO)
temozolomide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endosome  (IEA,ISO)
plasma membrane  (IBA,IDA,ISO,ISS)

Molecular Function
glucagon receptor activity  (IBA,IDA,IMP,ISO)
peptide hormone binding  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone structure  (IEA)
abnormal circulating amino acid level  (IAGP)
abnormal exocrine gland morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal kidney morphology  (IEA)
abnormal liver physiology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic alpha cell differentiation  (IAGP)
abnormal pancreatic alpha cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
decreased abdominal adipose tissue amount  (IAGP)
decreased body fat mass  (IAGP)
decreased body weight  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased carbon dioxide production  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased fasting circulating glucose level  (IAGP)
decreased food intake  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased interscapular fat pad weight  (IAGP)
decreased litter size  (IAGP)
decreased liver weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased oxygen consumption  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to age-related hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced non-insulin dependent diabetes  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased total body fat amount  (IAGP)
decreased triglyceride level  (IAGP)
enlarged kidney  (IEA)
enlarged pancreas  (IAGP)
enlarged pancreatic islets  (IAGP)
female infertility  (IEA)
hypoglycemia  (IAGP)
improved glucose tolerance  (IAGP)
increased bile salt level  (IAGP)
increased blood urea nitrogen level  (IEA)
increased body mass index  (IAGP)
increased bone mineral content  (IEA)
increased circulating calcium level  (IEA)
increased circulating cholesterol level  (IEA)
increased circulating glucagon level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased glucagon secretion  (IAGP)
increased glucagonoma incidence  (IAGP)
increased insulin sensitivity  (IAGP)
increased kidney weight  (IEA)
increased lean body mass  (IEA)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased mean corpuscular volume  (IEA)
increased pancreas tumor incidence  (IAGP)
increased pancreas weight  (IAGP)
increased pancreatic alpha cell mass  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic alpha cell proliferation  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased startle reflex  (IEA)
male infertility  (IEA)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
pancreatic islet hyperplasia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise. Charbonneau A, etal., Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E8-14. Epub 2005 Feb 1.
2. Structural and functional characterizations of the 5'-flanking region of the mouse glucagon receptor gene: comparison with the rat gene. Geiger A, etal., Biochem Biophys Res Commun 2000 Jun 16;272(3):912-21.
3. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Hager J, etal., Nat Genet. 1995 Mar;9(3):299-304.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7590348   PMID:7613039   PMID:8156917   PMID:9105899   PMID:9525910   PMID:10349636   PMID:10621976   PMID:11042159   PMID:11076861   PMID:11785978   PMID:12477932   PMID:12552113  
PMID:15300587   PMID:15459251   PMID:15746257   PMID:16141072   PMID:16141073   PMID:16627579   PMID:17130493   PMID:17131145   PMID:17159157   PMID:17366624   PMID:17479245   PMID:18809404  
PMID:19046568   PMID:19051206   PMID:19602537   PMID:19602585   PMID:19647035   PMID:19662685   PMID:20547661   PMID:21267068   PMID:21270251   PMID:21540554   PMID:21631939   PMID:21695571  
PMID:21853126   PMID:21873635   PMID:22167521   PMID:22198437   PMID:22232430   PMID:22318544   PMID:22438981   PMID:22457490   PMID:22569789   PMID:22621866   PMID:22863277   PMID:22891336  
PMID:22933116   PMID:22951296   PMID:22967998   PMID:23070814   PMID:23160527   PMID:23185367   PMID:23203689   PMID:23209793   PMID:23305646   PMID:23828778   PMID:24062250   PMID:24194600  
PMID:24303183   PMID:24326371   PMID:24703698   PMID:24939431   PMID:25157166   PMID:25485909   PMID:25660260   PMID:25685700   PMID:25738454   PMID:26166562   PMID:26261055   PMID:26621734  
PMID:27092792   PMID:27402918   PMID:27626380   PMID:27656411   PMID:27720451   PMID:28115707   PMID:28487437   PMID:28591637   PMID:28591638   PMID:28680878   PMID:28727763   PMID:28978545  
PMID:29107282   PMID:29925501   PMID:30150304   PMID:30170980   PMID:30380405   PMID:30615494   PMID:30720465   PMID:30772257   PMID:30807215   PMID:31230984   PMID:31673703   PMID:32174131  
PMID:32554468   PMID:32561493   PMID:32677665   PMID:32726606   PMID:32785645   PMID:32937194   PMID:33043402   PMID:33619103   PMID:33641163   PMID:34002801   PMID:34108943   PMID:34799628  
PMID:36002172   PMID:36243006   PMID:36325048   PMID:36383639   PMID:36400402   PMID:36596263   PMID:37589053   PMID:37848446   PMID:38237602   PMID:38355793  


Genomics

Comparative Map Data
Gcgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,420,011 - 120,429,815 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,421,525 - 120,429,812 (+)EnsemblGRCm39 Ensembl
GRCm3811120,529,185 - 120,538,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,530,699 - 120,538,986 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,392,041 - 120,400,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,345,362 - 120,355,178 (+)NCBIMGSCv36mm8
Celera11132,266,137 - 132,274,394 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.24NCBI
GCGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,804,150 - 81,814,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,804,132 - 81,814,008 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,762,026 - 79,771,884 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 34171,860,193 - 1,870,113NCBI
Celera1776,365,499 - 76,375,377 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,168,495 - 75,173,668 (+)NCBIHuRef
CHM1_11779,848,214 - 79,858,084 (+)NCBICHM1_1
T2T-CHM13v2.01782,671,316 - 82,681,173 (+)NCBIT2T-CHM13v2.0
Gcgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,306,803 - 106,314,970 (+)NCBIGRCr8
mRatBN7.210105,808,474 - 105,816,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,912,618 - 110,920,789 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,375,645 - 110,383,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,728,922 - 105,737,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,707,863 - 109,716,253 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,301,000 - 109,309,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,921,411 - 109,929,577 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,935,913 - 109,944,081 (+)NCBI
Celera10104,352,017 - 104,360,184 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Gcgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,340,689 - 1,344,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,340,410 - 1,348,028 (-)NCBIChiLan1.0ChiLan1.0
GCGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,339,489 - 98,350,188 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,240,205 - 103,250,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,205,023 - 76,220,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,911,915 - 81,922,906 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,912,135 - 81,922,906 (+)Ensemblpanpan1.1panPan2
GCGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19455,744 - 463,070 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9344,438 - 459,925 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,057,897 - 1,065,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,048,891 - 1,056,220 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.191,074,261 - 1,081,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,200,838 - 1,208,113 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,279,553 - 1,286,873 (-)NCBIUU_Cfam_GSD_1.0
Gcgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,060,107 - 1,068,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,343,740 - 5,351,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,347,789 - 5,351,852 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,146,069 - 1,157,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,149,589 - 1,157,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GCGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,672,490 - 73,693,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,681,571 - 73,693,299 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,089,536 - 45,141,103 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gcgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,678,944 - 10,682,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,674,854 - 10,682,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gcgr
195 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:698
Count of miRNA genes:382
Interacting mature miRNAs:426
Transcripts:ENSMUST00000026119, ENSMUST00000128827, ENSMUST00000143063, ENSMUST00000147877
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF229079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV354937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB869050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000026119   ⟹   ENSMUSP00000026119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,421,525 - 120,429,810 (+)Ensembl
GRCm38.p6 Ensembl11120,530,699 - 120,538,984 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128827
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,421,600 - 120,429,809 (+)Ensembl
GRCm38.p6 Ensembl11120,530,774 - 120,538,983 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,425,506 - 120,427,535 (+)Ensembl
GRCm38.p6 Ensembl11120,534,680 - 120,536,709 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,421,570 - 120,429,812 (+)Ensembl
GRCm38.p6 Ensembl11120,530,744 - 120,538,986 (+)Ensembl
RefSeq Acc Id: NM_008101   ⟹   NP_032127
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,421,553 - 120,429,810 (+)NCBI
GRCm3811120,530,727 - 120,538,984 (+)NCBI
MGSCv3711120,392,041 - 120,400,298 (+)RGD
Celera11132,266,137 - 132,274,394 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532216   ⟹   XP_006532279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,421,510 - 120,429,815 (+)NCBI
GRCm3811120,530,684 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532217   ⟹   XP_006532280
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,427,302 - 120,429,815 (+)NCBI
GRCm3811120,536,476 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314263   ⟹   XP_017169752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,012 - 120,429,815 (+)NCBI
GRCm3811120,529,186 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314265   ⟹   XP_017169754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,012 - 120,429,815 (+)NCBI
GRCm3811120,529,186 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314266   ⟹   XP_017169755
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,017 - 120,429,813 (+)NCBI
GRCm3811120,529,191 - 120,538,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314267   ⟹   XP_017169756
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,011 - 120,429,280 (+)NCBI
GRCm3811120,529,185 - 120,538,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314268   ⟹   XP_017169757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,013 - 120,429,815 (+)NCBI
GRCm3811120,529,187 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314269   ⟹   XP_017169758
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,011 - 120,429,815 (+)NCBI
GRCm3811120,529,185 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245567   ⟹   XP_030101427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,421,510 - 120,429,815 (+)NCBI
GRCm3811120,530,684 - 120,538,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156335   ⟹   XP_036012228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,420,015 - 120,429,815 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032127   ⟸   NM_008101
- Peptide Label: precursor
- UniProtKB: Q63960 (UniProtKB/Swiss-Prot),   Q8K0B5 (UniProtKB/Swiss-Prot),   Q61606 (UniProtKB/Swiss-Prot),   Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532279   ⟸   XM_006532216
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006532280   ⟸   XM_006532217
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017169758   ⟸   XM_017314269
- Peptide Label: isoform X5
- UniProtKB: Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169756   ⟸   XM_017314267
- Peptide Label: isoform X3
- UniProtKB: Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169752   ⟸   XM_017314263
- Peptide Label: isoform X1
- UniProtKB: Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169754   ⟸   XM_017314265
- Peptide Label: isoform X1
- UniProtKB: Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169757   ⟸   XM_017314268
- Peptide Label: isoform X4
- UniProtKB: Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169755   ⟸   XM_017314266
- Peptide Label: isoform X2
- UniProtKB: Q63960 (UniProtKB/Swiss-Prot),   Q8K0B5 (UniProtKB/Swiss-Prot),   Q61606 (UniProtKB/Swiss-Prot),   Q3UN81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030101427   ⟸   XM_030245567
- Peptide Label: isoform X6
Ensembl Acc Id: ENSMUSP00000026119   ⟸   ENSMUST00000026119
RefSeq Acc Id: XP_036012228   ⟸   XM_036156335
- Peptide Label: isoform X6
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61606-F1-model_v2 AlphaFold Q61606 1-485 view protein structure

Promoters
RGD ID:6821966
Promoter ID:MM_KWN:10928
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000009674,   OTTMUST00000009687,   UC007MTC.1,   UC007MTD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611120,391,631 - 120,392,232 (-)MPROMDB
RGD ID:6820926
Promoter ID:MM_KWN:10930
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Spleen
Transcripts:OTTMUST00000009676,   UC007MTE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611120,395,731 - 120,396,482 (+)MPROMDB
RGD ID:8677686
Promoter ID:EPDNEW_M16873
Type:initiation region
Name:Gcgr_1
Description:Mus musculus glucagon receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811120,530,774 - 120,530,834EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99572 AgrOrtholog
Ensembl Genes ENSMUSG00000025127 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026119 ENTREZGENE
  ENSMUST00000026119.8 UniProtKB/Swiss-Prot
  ENSMUST00000147877 ENTREZGENE
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99572 ENTREZGENE
NCBI Gene 14527 ENTREZGENE
PANTHER GLUCAGON RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gcgr PhenoGen
PRINTS GLUCAGNFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCAGONR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GLR_MOUSE UniProtKB/Swiss-Prot
  Q3UN81 ENTREZGENE, UniProtKB/TrEMBL
  Q61606 ENTREZGENE
  Q63960 ENTREZGENE
  Q8K0B5 ENTREZGENE
UniProt Secondary Q63960 UniProtKB/Swiss-Prot
  Q8K0B5 UniProtKB/Swiss-Prot