3-methylcholanthrene - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	3-methylcholanthrene	go back to main search page
Accession:	CHEBI:34342	browse the term
Definition:	A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Synonyms:	exact_synonym:	3-methyl-1,2-dihydrocyclopenta[ij]tetraphene
	related_synonym:	1,2-Dihydro-3-methylbenz(j)aceanthrylene; 20-MC; 20-Methylcholanthrene; 3-MC; 3-MCA; 3-methyl-1,2-dihydrobenzo[j]aceanthrylene; Formula=C21H16; InChI=1S/C21H16/c1-13-6-7-15-12-20-17-5-3-2-4-14(17)8-9-18(20)19-11-10-16(13)21(15)19/h2-9,12H,10-11H2,1H3; InChIKey=PPQNQXQZIWHJRB-UHFFFAOYSA-N; MC; MCA; Methylcholanthrene; SMILES=Cc1ccc2cc3c(ccc4ccccc34)c3CCc1c23
	xref:	Beilstein:1913890; CAS:56-49-5; KEGG:C14470; LINCS:LSM-5711
	xref_mesh:	MESH:D008748
	xref:	PMID:11922910; PMID:16359657; PMID:24658119; PMID:26076008; PMID:7561049; Reaxys:1913890; Wikipedia:Methylcholanthrene

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Genes (999)

3-methylcholanthrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 0610040J01 gene

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF19 promoter]

NCBI chr 5:63,969,833...64,056,968
Ensembl chr 5:63,969,706...64,056,968

G

RIKEN cDNA 1190005I06 gene

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to C16ORF74 promoter]

NCBI chr 8:121,335,341...121,361,129
Ensembl chr 8:121,335,341...121,374,371

G

RIKEN cDNA 1700016H13 gene

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF36 promoter]

NCBI chr 5:103,796,449...103,803,898
Ensembl chr 5:103,795,905...103,803,876

G

RIKEN cDNA 4921524L21 gene

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CCDC144NL promoter]

NCBI chr18:6,603,629...6,638,970
Ensembl chr18:6,603,629...6,638,970

G

ATP-binding cassette, sub-family A member 1

decreases expression

Methylcholanthrene results in decreased expression of ABCA1 mRNA

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 1A

increases expression

Methylcholanthrene results in increased expression of ABCB1 mRNA; Methylcholanthrene results in increased expression of ABCB1A mRNA

PMID:11096091 PMID:27160211

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 1B

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [TRP53 protein binds to ABCB1B promoter]
Methylcholanthrene results in increased expression of ABCB1B mRNA

PMID:11096091 PMID:20713471

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

ATP-binding cassette, sub-family B member 4

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of ABCB4 mRNA

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

ATP-binding cassette, sub-family B member 6

increases expression

Methylcholanthrene results in increased expression of ABCB6 mRNA

NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036

G

ATP-binding cassette, sub-family C member 3

increases expression

Methylcholanthrene results in increased expression of ABCC3 mRNA

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP-binding cassette, sub-family C member 4

increases expression

Methylcholanthrene results in increased expression of ABCC4 mRNA; Methylcholanthrene results in increased expression of ABCC4 protein

NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631

G

ATP binding cassette subfamily G member 2 (Junior blood group)

multiple interactions
affects response to substance
increases expression

AHR protein affects the reaction [Methylcholanthrene results in increased expression of ABCG2 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ABCG2 5' UTR]
ABCG2 5' UTR affects the susceptibility to Methylcholanthrene
Methylcholanthrene results in increased expression of ABCG2; Methylcholanthrene results in increased expression of ABCG2 mRNA; Methylcholanthrene results in increased expression of ABCG2 mRNA alternative form; Methylcholanthrene results in increased expression of ABCG2 protein

PMID:20804740 PMID:23081912

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

ABI family member 3 binding protein

decreases expression

Methylcholanthrene results in decreased expression of ABI3BP mRNA

NCBI chr16:56,298,179...56,510,498
Ensembl chr16:56,298,241...56,510,498

G

acyl-Coenzyme A oxidase 2, branched chain

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ACOX2 promoter]

NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ACSL4 promoter]

NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531

G

actin alpha 1, skeletal muscle

decreases expression

Methylcholanthrene results in decreased expression of ACTA1 mRNA

NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490

G

actin alpha 2, smooth muscle, aorta

decreases expression

Methylcholanthrene results in decreased expression of ACTA2 mRNA

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

a disintegrin and metallopeptidase domain 8

increases expression

Methylcholanthrene results in increased expression of ADAM8 mRNA

NCBI chr 7:139,558,845...139,573,016
Ensembl chr 7:139,558,845...139,572,475

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

decreases acetylation
multiple interactions
increases expression
increases methylation

Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of ADAMTS1 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ADAMTS1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of ADAMTS1 promoter]
Methylcholanthrene results in increased expression of ADAMTS1 mRNA

NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001

G

ADAM metallopeptidase with thrombospondin type 1 motif 12

decreases expression

Methylcholanthrene results in decreased expression of ADAMTS12 mRNA

NCBI chr15:11,064,781...11,349,321
Ensembl chr15:11,064,876...11,349,317

G

ADAM metallopeptidase with thrombospondin type 1 motif 2

decreases expression

Methylcholanthrene results in decreased expression of ADAMTS2 mRNA

NCBI chr11:50,492,912...50,698,400
Ensembl chr11:50,492,911...50,698,400

G

ADAM metallopeptidase with thrombospondin type 1 motif 4

increases expression

Methylcholanthrene results in increased expression of ADAMTS4 mRNA

NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206

G

adenylate cyclase 7

increases expression

Methylcholanthrene results in increased expression of ADCY7 mRNA

PMID:20713471 PMID:29554273

NCBI chr 8:88,998,818...89,056,593
Ensembl chr 8:88,999,031...89,056,590

G

adhesion G protein-coupled receptor F1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ADGRF1 promoter]

NCBI chr17:43,581,174...43,636,767
Ensembl chr17:43,581,220...43,635,628

G

adhesion G protein-coupled receptor G5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of ADGRG5 mRNA; [Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of ADGRG5 mRNA

NCBI chr 8:95,648,439...95,669,921
Ensembl chr 8:95,650,322...95,669,908

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Methylcholanthrene results in decreased expression of ADH4 mRNA

NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653

G

alcohol dehydrogenase 6B (class V)

decreases expression

Methylcholanthrene results in decreased expression of ADH6 mRNA

NCBI chr 3:138,047,176...138,064,621
Ensembl chr 3:138,047,536...138,064,622

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases expression

Methylcholanthrene results in increased expression of ADH7 mRNA

NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143

G

adenosine A2a receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA2A mRNA

NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618

G

adenosine A3 receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA3 mRNA

NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242

G

adrenergic receptor, alpha 2a

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ADRA2A promoter]
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADRA2A mRNA

PMID:20348232 PMID:23519560

NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413

G

anterior gradient 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to AGR2 promoter]

NCBI chr12:36,042,924...36,054,080
Ensembl chr12:36,042,906...36,054,086

G

aryl-hydrocarbon receptor

increases response to substance
affects localization
multiple interactions
increases expression
increases degradation
decreases expression
increases activity
increases localization
affects response to substance
affects binding

AHR protein results in increased susceptibility to Methylcholanthrene; AHR results in increased susceptibility to Methylcholanthrene
Methylcholanthrene affects the localization of AHR protein
[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Methylcholanthrene; [chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [Genistein co-treated with Methylcholanthrene] affects the activity of AHR protein; [Methylcholanthrene co-treated with Oxygen deficiency] results in increased expression of AHR mRNA; [Methylcholanthrene co-treated with pirinixic acid] results in increased expression of AHR protein; [Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of IL1B mRNA; [Quercetin co-treated with Methylcholanthrene] affects the activity of AHR protein; AHR gene mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of ABCG2 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP3A5 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; Methylcholanthrene binds to and results in increased activity of AHR protein; Methylcholanthrene binds to and results in increased activity of AHR protein polymorphism; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ABCG2 5' UTR]; Methylcholanthrene promotes the reaction [AHR protein binds to ACOX2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ACSL4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ADGRF1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ADRA2A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to AGR2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to AKAP13 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ANGPTL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ANKRD13C promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ANKRD30B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP22 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP35 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP44 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARL3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARMC12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BAMBI promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BBX promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BCL6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BPIFA2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein]; Methylcholanthrene promotes the reaction [AHR protein binds to BRWD1-AS2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to C16ORF74 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF19 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF36 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CA12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CA8 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CACNA1B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CALB2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CAST promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCDC144NL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCDC57 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCDC6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCN5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CD55 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CEACAM3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CENPL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CEP70 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CFAP61 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CHPT1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CHRDL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CILK1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CISD1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CLDN17 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CLK3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CLPSL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to COLCA1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to COX4I1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CRKL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CTNNA1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CUEDC1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYB5B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP2A7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DEGS1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DIAPH1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DTNA promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DUSP14 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to EHD3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to EPS15 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ERCC6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to EXOSC9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to FOXN1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to FREM2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GDPD4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GPHB5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GREB1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GRIK4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GSDMC promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to H2BC1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to H2BC21 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HCRTR2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HDAC11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HOXC11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HSBP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IDH2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IER3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGFBPL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to INHBC promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IRF2BPL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ISOC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ITPR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to JPH1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KATNAL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KCTD16 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KCTD3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KIR2DL4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KLF9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KRT75 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LGALS8 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LGI1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LIF promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LIMA1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LINC00173 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LRP11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LSM5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LY6E promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MAPKAP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MBNL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MED13L promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MESP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MGST2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MIDEAS promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MLLT6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MLPH promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MPI promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MRTFB promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MS4A7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MSMB promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MTCL3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MYOF promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MYOM2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NBPF10 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NBPF3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NDST1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NELFCD promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NFE2L2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NMRAL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NXT2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to OSBPL10 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to OTUB2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PAXBP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PCOLCE2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PDCD4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PHACTR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PIGP promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PLEKHA6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to POGZ promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to POTEB promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PPIAL4A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PRPS1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PSG5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PSG9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PWWP3A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RABL2A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RALGAPA2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RANBP2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBBP7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBM24 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBMS2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBSN promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RERG promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RFFL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RGPD5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RGPD6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RGS3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RHOBTB1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RHOH promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RPL11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RTN3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RYR3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to S100P promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SAMD12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SCN3B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SIK3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLC16A6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLC22A23 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLC44A1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLU7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SMAP2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SMARCE1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SNAPIN promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SOCS7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SORL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SOS1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SPON2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SPRED1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SPTLC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SS18 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to STARD13 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to STAT5B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SWSAP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SYCP2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SYT12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TBL1XR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TEAD4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to THBS2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to THEM5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TIPARP promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM116 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM30A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM45B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM97 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMTC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TNK2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRERF1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRIM39 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRIM55 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRIM72 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRPV4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TTC3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to UBE2E1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to UMODL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VEZT promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VIPR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VSTM1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VWCE promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to WBP1L promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to WDR26 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to WEE1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZBTB4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZCCHC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZMAT3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZMIZ1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF281 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF552 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF587 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF695 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF710 promoter]; Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of AHR protein]; Methylcholanthrene results in increased activity of and results in increased degradation of AHR protein; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of AHR protein]; omeprazole sulfide inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; Resveratrol inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]
Methylcholanthrene results in increased expression of AHR protein
Methylcholanthrene results in increased degradation of AHR protein
Methylcholanthrene results in decreased expression of AHR protein
Methylcholanthrene results in increased localization of AHR protein
AHR affects the susceptibility to Methylcholanthrene
[Methylcholanthrene binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [Methylcholanthrene binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A2 mRNA; AHR affects the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of CYP3A11 mRNA]; AHR protein affects the reaction [Methylcholanthrene affects the expression of CYP1A1 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of FMO3 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of XDH protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; Capsaicin inhibits the reaction [Methylcholanthrene results in increased activity of and results in increased localization of AHR protein]; CTNNB1 protein affects the reaction [[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methylcholanthrene binds to and affects the localization of AHR protein; Methylcholanthrene binds to and results in increased activity of AHR protein; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [SRC protein binds to AHR protein]]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene results in increased activity of and results in increased localization of AHR protein; omeprazole sulfide inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; Raloxifene Hydrochloride inhibits the reaction [Methylcholanthrene binds to AHR protein]
[Genistein co-treated with Methylcholanthrene] affects the activity of AHR protein; AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]
Methylcholanthrene results in increased expression of AHR mRNA

PMID:1650214 PMID:1654865 PMID:1658612 PMID:1846074 PMID:2154949 More...

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

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aryl-hydrocarbon receptor repressor

multiple interactions
increases expression

[Tetradecanoylphorbol Acetate co-treated with Methylcholanthrene] results in increased expression of AHRR mRNA
Methylcholanthrene results in increased expression of AHRR mRNA

PMID:9887096 PMID:11423533 PMID:12655030 PMID:14672759

NCBI chr13:74,359,237...74,440,450
Ensembl chr13:74,359,237...74,440,450

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A kinase anchor protein 13

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of AKAP13 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to AKAP13 promoter]

PMID:20348232 PMID:20713471

NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357

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aldo-keto reductase family 1, member A1

increases expression

Methylcholanthrene results in increased expression of AKR1A1 mRNA

NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877

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aldo-keto reductase family 1, member C12

increases expression

Methylcholanthrene results in increased expression of AKR1C12 mRNA

NCBI chr13:4,318,171...4,329,398
Ensembl chr13:4,318,175...4,329,432

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aldo-keto reductase family 1, member C20

increases expression

Methylcholanthrene results in increased expression of AKR1C1 mRNA

NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344

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thymoma viral proto-oncogene 1

increases expression
decreases acetylation
multiple interactions

Methylcholanthrene results in increased expression of AKT1 mRNA
Methylcholanthrene results in decreased acetylation of AKT1 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of AKT1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of AKT1 mRNA]

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

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activated leukocyte cell adhesion molecule

increases expression

Methylcholanthrene results in increased expression of ALCAM mRNA

NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437

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aldehyde dehydrogenase family 3, subfamily A1

increases expression

Methylcholanthrene results in increased expression of ALDH3A1 mRNA

PMID:1416978 PMID:20713471 PMID:28601433

NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247

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angiopoietin-like 2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of ANGPTL2 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to ANGPTL2 promoter]

PMID:20348232 PMID:20713471

NCBI chr 2:33,105,963...33,137,737
Ensembl chr 2:33,106,081...33,137,729

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progressive ankylosis

increases expression

Methylcholanthrene results in increased expression of ANK mRNA

NCBI chr15:27,466,763...27,594,995
Ensembl chr15:27,466,763...27,594,995

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ankyrin 2, brain

decreases expression

Methylcholanthrene results in decreased expression of ANK2 mRNA

NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999

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ankyrin repeat domain 13c

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ANKRD13C promoter]

NCBI chr 3:157,650,886...157,713,671
Ensembl chr 3:157,652,876...157,713,671

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anillin, actin binding protein

increases expression

Methylcholanthrene results in increased expression of ANLN mRNA

NCBI chr 9:22,243,305...22,302,132
Ensembl chr 9:22,243,308...22,300,484

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annexin A8

increases expression

Methylcholanthrene results in increased expression of ANXA8 mRNA

NCBI chr14:33,807,936...33,822,528
Ensembl chr14:33,807,938...33,822,528

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apoptotic peptidase activating factor 1

increases expression

Methylcholanthrene results in increased expression of APAF1 mRNA

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

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adenomatosis polyposis coli down-regulated 1

increases expression

Methylcholanthrene results in increased expression of APCDD1 mRNA

NCBI chr18:63,055,398...63,086,886
Ensembl chr18:63,055,302...63,094,250

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apolipoprotein A-IV

decreases expression

Methylcholanthrene results in decreased expression of APOA4 mRNA

NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757

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apolipoprotein C-I

decreases expression

Methylcholanthrene results in decreased expression of APOC1 mRNA

NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585

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apolipoprotein D

decreases expression

Methylcholanthrene results in decreased expression of APOD mRNA

NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626

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aquaporin 5

increases expression

Methylcholanthrene results in increased expression of AQP5 mRNA

PMID:20713471 PMID:26372666

NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710

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amphiregulin

increases expression

Methylcholanthrene results in increased expression of AREG mRNA

PMID:16257430 PMID:26372666

NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291

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Rho GTPase activating protein 11A

increases expression

Methylcholanthrene results in increased expression of ARHGAP11A mRNA

NCBI chr 2:113,661,837...113,679,006
Ensembl chr 2:113,661,837...113,679,006

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Rho GTPase activating protein 22

increases expression
multiple interactions

Methylcholanthrene results in increased expression of ARHGAP22 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP22 promoter]

PMID:20348232 PMID:20713471

NCBI chr14:32,935,952...33,091,893
Ensembl chr14:32,935,983...33,091,891

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Rho GTPase activating protein 35

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP35 promoter]

NCBI chr 7:16,228,398...16,349,313
Ensembl chr 7:16,227,644...16,348,918

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Rho GTPase activating protein 44

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP44 promoter]

NCBI chr11:64,892,865...65,053,779
Ensembl chr11:64,892,865...65,053,787

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ADP-ribosylation factor-like 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARL3 promoter]

NCBI chr19:46,519,548...46,561,621
Ensembl chr19:46,519,535...46,561,637

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ADP-ribosylation factor-like 6 interacting protein 5

increases expression

Methylcholanthrene results in increased expression of ARL6IP5 mRNA

NCBI chr 6:97,187,753...97,210,276
Ensembl chr 6:97,187,650...97,210,276

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armadillo repeat containing 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARMC12 promoter]

NCBI chr17:28,749,835...28,757,949
Ensembl chr17:28,749,780...28,758,084

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aryl hydrocarbon receptor nuclear translocator

multiple interactions
increases localization
increases expression

[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Methylcholanthrene; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [ARNT protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]
Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]
Methylcholanthrene results in increased localization of ARNT protein
Methylcholanthrene results in increased expression of ARNT mRNA

PMID:11768231 PMID:19951702 PMID:20348232 PMID:20570689 PMID:21756928 More...

NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551

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arrestin, beta 1

increases expression

Methylcholanthrene results in increased expression of ARRB1 mRNA

NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978

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ADP-ribosyltransferase 3

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ART3 mRNA

NCBI chr 5:92,479,659...92,562,487
Ensembl chr 5:92,479,686...92,562,487

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achaete-scute family bHLH transcription factor 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of ASCL1 mRNA

NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522

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anti-silencing function 1B histone chaperone

increases expression

Methylcholanthrene results in increased expression of ASF1B mRNA

NCBI chr 8:84,682,323...84,696,824
Ensembl chr 8:84,682,136...84,696,826

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acid-sensing ion channel 1

increases expression

Methylcholanthrene results in increased expression of ASIC1 mRNA

NCBI chr15:99,568,090...99,599,011
Ensembl chr15:99,568,249...99,599,011

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abnormal spindle microtubule assembly

increases expression

Methylcholanthrene results in increased expression of ASPM mRNA

NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829

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asporin

decreases expression

Methylcholanthrene results in decreased expression of ASPN mRNA

NCBI chr13:49,697,919...49,721,041
Ensembl chr13:49,697,919...49,721,041

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ATPase family, AAA domain containing 2

increases expression

Methylcholanthrene results in increased expression of ATAD2 mRNA

NCBI chr15:57,957,440...57,998,516
Ensembl chr15:57,957,440...57,998,478

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antioxidant 1 copper chaperone

increases expression

Methylcholanthrene results in increased expression of ATOX1 mRNA

NCBI chr11:55,337,463...55,352,034
Ensembl chr11:55,337,467...55,352,065

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ATPase, H+ transporting, lysosomal V1 subunit C2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ATP6V1C2 mRNA

NCBI chr12:17,334,722...17,375,700
Ensembl chr12:17,334,722...17,379,360

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aurora kinase A

increases expression

Methylcholanthrene results in increased expression of AURKA mRNA

NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455

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aurora kinase B

increases expression

Methylcholanthrene results in increased expression of AURKB mRNA

NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490

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BCL2-associated agonist of cell death

increases expression

Methylcholanthrene results in increased expression of BAD mRNA

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

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brain-specific angiogenesis inhibitor 1-associated protein 2

increases expression

Methylcholanthrene results in increased expression of BAIAP2 mRNA

NCBI chr11:119,833,762...119,897,608
Ensembl chr11:119,833,589...119,897,608

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BMP and activin membrane-bound inhibitor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to BAMBI promoter]

NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404

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BCL2-associated X protein

increases expression
multiple interactions
increases methylation

Methylcholanthrene results in increased expression of BAX mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of BAX mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of BAX promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]

PMID:23273579 PMID:29094188

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

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bobby sox HMG box containing

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to BBX promoter]

NCBI chr16:50,012,207...50,252,829
Ensembl chr16:50,012,207...50,252,753

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BCAS3 microtubule associated cell migration factor

decreases expression

Methylcholanthrene results in decreased expression of BCAS3 mRNA

NCBI chr11:85,243,611...85,716,884
Ensembl chr11:85,243,993...85,716,884

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B cell leukemia/lymphoma 10

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of BCL10 mRNA

NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111

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B cell leukemia/lymphoma 2

increases expression
decreases expression

Methylcholanthrene results in increased expression of BCL2 mRNA
Methylcholanthrene results in decreased expression of BCL2 mRNA

PMID:23273579 PMID:35487396

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

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B cell leukemia/lymphoma 2 related protein A1a

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of BCL2A1A mRNA

NCBI chr 9:88,838,973...88,844,469
Ensembl chr 9:88,838,953...88,844,472

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B cell leukemia/lymphoma 6

increases expression
multiple interactions

Methylcholanthrene results in increased expression of BCL6 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to BCL6 promoter]

PMID:20348232 PMID:20713471 PMID:25926378

NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602

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3-hydroxybutyrate dehydrogenase, type 2

decreases expression

Methylcholanthrene results in decreased expression of BDH2 mRNA

NCBI chr 3:134,986,982...135,010,187
Ensembl chr 3:134,986,982...135,010,187

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baculoviral IAP repeat-containing 3

increases expression

Methylcholanthrene results in increased expression of BIRC3 mRNA

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

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baculoviral IAP repeat-containing 5

increases expression

Methylcholanthrene results in increased expression of BIRC5 mRNA

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

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BCL2 modifying factor

increases expression

Methylcholanthrene results in increased expression of BMF mRNA

NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168

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bone morphogenetic protein 15

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of BMP15 mRNA

NCBI chr X:6,226,108...6,232,778
Ensembl chr X:6,226,161...6,232,775

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bone morphogenetic protein 4

decreases expression

Methylcholanthrene results in decreased expression of BMP4 mRNA

NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126

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2,3-bisphosphoglycerate mutase

increases expression

Methylcholanthrene results in increased expression of BPGM mRNA

NCBI chr 6:34,453,291...34,482,071
Ensembl chr 6:34,453,142...34,482,548

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BPI fold containing family A, member 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to BPIFA2 promoter]

NCBI chr 2:153,850,196...153,857,993
Ensembl chr 2:153,850,185...153,857,999

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breast cancer 1, early onset

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein]
Methylcholanthrene results in increased expression of BRCA1 mRNA

PMID:18259752 PMID:20713471

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

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Bri3 binding protein

increases expression

Methylcholanthrene results in increased expression of BRI3BP mRNA

NCBI chr 5:125,518,632...125,537,949
Ensembl chr 5:125,518,632...125,537,434

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BRCA1 interacting protein C-terminal helicase 1

increases expression

Methylcholanthrene results in increased expression of BRIP1 mRNA

NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019

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bone marrow stromal cell antigen 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BST1 mRNA

NCBI chr 5:43,976,235...44,000,810
Ensembl chr 5:43,976,227...44,001,328

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BTG anti-proliferation factor 2

increases expression

Methylcholanthrene results in increased expression of BTG2 mRNA

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

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BUB1, mitotic checkpoint serine/threonine kinase

increases expression

Methylcholanthrene results in increased expression of BUB1 mRNA

NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785

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BUB1B, mitotic checkpoint serine/threonine kinase

increases expression

Methylcholanthrene results in increased expression of BUB1B mRNA

NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072

G

complement component 1, q subcomponent binding protein

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of C1QBP mRNA

NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852

G

complement component 1, s subcomponent 2

increases expression

Methylcholanthrene results in increased expression of C1S2 mRNA

NCBI chr 6:124,601,584...124,613,044
Ensembl chr 6:124,601,584...124,613,044

G

complement component 3

increases expression

Methylcholanthrene results in increased expression of C3 mRNA

PMID:16257430 PMID:29554273

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

complement C4A (Rodgers blood group)

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4A mRNA

NCBI chr17:35,028,069...35,042,436
Ensembl chr17:35,028,069...35,042,440

G

complement C4B (Chido blood group)

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4B mRNA

NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856

G

complement component 6

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of C6 mRNA

NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449

G

calcium channel, voltage-dependent, N type, alpha 1B subunit

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CACNA1B promoter]

NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164

G

calcium channel, voltage-dependent, T type, alpha 1G subunit

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CACNA1G mRNA

NCBI chr11:94,299,217...94,365,226
Ensembl chr11:94,299,217...94,365,024

G

cell adhesion molecule 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of CADM1 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CADM1 gene

NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413

G

calbindin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CALB2 promoter]

NCBI chr 8:110,869,158...110,894,844
Ensembl chr 8:110,864,134...110,894,842

G

calcitonin receptor-like

decreases expression

Methylcholanthrene results in decreased expression of CALCRL mRNA

NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755

G

calmodulin 1

increases expression

Methylcholanthrene results in increased expression of CALM1 mRNA

NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073

G

calreticulin

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CALR mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CALR mRNA]

NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563

G

calcium/calmodulin-dependent protein kinase II, beta

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CAMK2B mRNA

NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362

G

capping actin protein, gelsolin like

increases expression

Methylcholanthrene results in increased expression of CAPG mRNA

NCBI chr 6:72,515,265...72,539,966
Ensembl chr 6:72,521,374...72,539,966

G

carbonic anhydrase 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CA12 promoter]

NCBI chr 9:66,619,026...66,674,127
Ensembl chr 9:66,620,968...66,674,127

G

carbonic anhydrase 8

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CA8 promoter]

NCBI chr 4:8,141,491...8,239,226
Ensembl chr 4:8,143,362...8,239,041

G

calcium/calmodulin dependent serine protein kinase

decreases expression

Methylcholanthrene results in decreased expression of CASK mRNA

NCBI chr X:13,383,319...13,713,020
Ensembl chr X:13,383,319...13,717,606

G

caspase 3

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CASP3 mRNA
Methylcholanthrene inhibits the reaction [3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in increased cleavage of and results in increased activity of CASP3 protein]

PMID:11323195 PMID:11999409 PMID:20713471

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

increases expression
increases methylation
multiple interactions

Methylcholanthrene results in increased expression of CASP9 mRNA
Methylcholanthrene results in increased methylation of CASP9 promoter
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of CASP9 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CASP9 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CASP9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]

PMID:23273579 PMID:29094188

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calpastatin

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CAST promoter]

NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929

G

coiled-coil domain containing 57

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CCDC57 promoter]

NCBI chr11:120,717,355...120,823,703
Ensembl chr11:120,717,355...120,823,698

G

coiled-coil domain containing 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CCDC6 promoter]

NCBI chr10:69,932,709...70,029,030
Ensembl chr10:69,932,951...70,029,030

G

C-C motif chemokine ligand 17

decreases expression

Methylcholanthrene results in decreased expression of CCL17 mRNA

NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664

G

C-C motif chemokine ligand 19

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CCL19 mRNA

NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577

G

C-C motif chemokine ligand 2

increases expression

Methylcholanthrene results in increased expression of CCL2 mRNA

PMID:20713471 PMID:23397585

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 5

decreases expression

Methylcholanthrene results in decreased expression of CCL5 mRNA

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

C-C motif chemokine ligand 7

increases expression

Methylcholanthrene results in increased expression of CCL7 mRNA

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

C-C motif chemokine ligand 8

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CCL8 mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL8 mRNA

PMID:20713471 PMID:23519560

NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625

G

C-C motif chemokine ligand 9

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL9 mRNA

NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462

G

cellular communication network factor 1

increases expression

Methylcholanthrene results in increased expression of CCN1 mRNA

NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736

G

cellular communication network factor 3

increases expression

Methylcholanthrene results in increased expression of CCN3 mRNA

NCBI chr15:54,609,306...54,617,158
Ensembl chr15:54,609,098...54,617,435

G

cellular communication network factor 4

decreases expression

Methylcholanthrene results in decreased expression of CCN4 mRNA

NCBI chr15:66,763,337...66,795,050
Ensembl chr15:66,763,169...66,795,050

G

cellular communication network factor 5

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CCN5 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to CCN5 promoter]

PMID:20348232 PMID:20713471

NCBI chr 2:163,662,724...163,675,066
Ensembl chr 2:163,662,781...163,675,066

G

cyclin A2

increases expression

Methylcholanthrene results in increased expression of CCNA2 mRNA

NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299

G

cyclin B1

increases expression

Methylcholanthrene results in increased expression of CCNB1 mRNA

PMID:20713471 PMID:26372666

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin B2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CCNB2 mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of CCNB2 mRNA]

PMID:20713471 PMID:26372666

NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829

G

cyclin D1

increases expression

Methylcholanthrene results in increased expression of CCND1 mRNA

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin E1

increases expression

Methylcholanthrene results in increased expression of CCNE1 mRNA

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

cyclin E2

increases expression

Methylcholanthrene results in increased expression of CCNE2 mRNA

NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779

G

cyclin G2

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of CCNG2 mRNA]

NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090

G

CD300E molecule

increases expression

Methylcholanthrene results in increased expression of CD300E mRNA

NCBI chr11:114,942,743...114,957,502
Ensembl chr11:114,942,743...114,957,500

G

CD300 molecule like family member B

increases expression

Methylcholanthrene results in increased expression of CD300LB mRNA

NCBI chr11:114,813,605...114,825,197
Ensembl chr11:114,813,607...114,825,212

G

CD3 antigen, delta polypeptide

decreases expression

Methylcholanthrene results in decreased expression of CD3D mRNA

NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637

G

CD44 antigen

multiple interactions
increases expression

[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form
Methylcholanthrene results in increased expression of CD44 mRNA

PMID:15390079 PMID:20713471

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

CD48 antigen

increases expression

Methylcholanthrene results in increased expression of CD48 mRNA

NCBI chr 1:171,508,989...171,532,825
Ensembl chr 1:171,509,577...171,532,826

G

CD5 antigen

increases expression

Methylcholanthrene results in increased expression of CD5 mRNA

NCBI chr19:10,695,471...10,716,390
Ensembl chr19:10,694,480...10,716,366

G

CD55 molecule, decay accelerating factor for complement

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CD55 promoter]

NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481

G

CD59b antigen

increases mutagenesis

Methylcholanthrene results in increased mutagenesis of CD59 protein

NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534

G

CD9 antigen

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of CD9 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA]

NCBI chr 6:125,437,229...125,471,723
Ensembl chr 6:125,437,229...125,471,754

G

CD96 antigen

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CD96 mRNA

NCBI chr16:45,856,015...45,940,611
Ensembl chr16:45,856,020...45,940,614

G

cytidine deaminase

increases expression

Methylcholanthrene results in increased expression of CDA mRNA

NCBI chr 4:138,065,839...138,095,623
Ensembl chr 4:138,065,735...138,095,303

G

cell division cycle 20

increases expression

Methylcholanthrene results in increased expression of CDC20 mRNA

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

cell division cycle 25C

increases expression

Methylcholanthrene results in increased expression of CDC25C mRNA

NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586

G

cell division cycle 45

increases expression

Methylcholanthrene results in increased expression of CDC45 mRNA

NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737

G

cell division cycle 6

increases expression

Methylcholanthrene results in increased expression of CDC6 mRNA

NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766

G

cell division cycle associated 2

increases expression

Methylcholanthrene results in increased expression of CDCA2 mRNA

NCBI chr14:67,910,629...67,953,290
Ensembl chr14:67,913,780...67,953,290

G

cell division cycle associated 3

increases expression

Methylcholanthrene results in increased expression of CDCA3 mRNA

NCBI chr 6:124,806,533...124,810,664
Ensembl chr 6:124,806,510...124,810,664

G

cell division cycle associated 5

increases expression

Methylcholanthrene results in increased expression of CDCA5 mRNA

NCBI chr19:6,135,127...6,141,803
Ensembl chr19:6,135,013...6,141,807

G

cell division cycle associated 8

increases expression

Methylcholanthrene results in increased expression of CDCA8 mRNA

NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104

G

cadherin 1

decreases expression

Methylcholanthrene results in decreased expression of CDH1 protein

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 13

decreases expression

Methylcholanthrene results in decreased expression of CDH13 mRNA

NCBI chr 8:119,010,150...120,051,668
Ensembl chr 8:119,010,472...120,051,660

G

cadherin 2

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of CDH2 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased expression of CDH2 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CDH2 gene

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cadherin 5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CDH5 mRNA

NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143

G

cyclin dependent kinase 2

decreases expression
increases expression
increases acetylation
decreases methylation
multiple interactions

Methylcholanthrene results in decreased expression of CDK2 protein
Methylcholanthrene results in increased expression of CDK2 mRNA
Methylcholanthrene results in increased acetylation of CDK2 promoter
Methylcholanthrene results in decreased methylation of CDK2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased methylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CDK2 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]

PMID:18022818 PMID:29094188

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase inhibitor 1A

increases expression
multiple interactions
increases response to substance

Methylcholanthrene results in increased expression of CDKN1A mRNA
SB 203580 inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A mRNA]
Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]; resveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]
CDKN1A protein results in increased susceptibility to Methylcholanthrene

PMID:15882963 PMID:18022818

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

multiple interactions
increases expression
increases response to substance

Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]; resveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]
CDKN1B protein results in increased susceptibility to Methylcholanthrene

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

CDKN2A interacting protein N-terminal like

increases expression

Methylcholanthrene results in increased expression of CDKN2AIPNL mRNA

NCBI chr11:51,858,458...51,868,163
Ensembl chr11:51,858,488...51,868,161

G

cyclin dependent kinase inhibitor 3

increases expression

Methylcholanthrene results in increased expression of CDKN3 mRNA

NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126

G

chromatin licensing and DNA replication factor 1

increases expression

Methylcholanthrene results in increased expression of CDT1 mRNA

NCBI chr 8:123,294,754...123,299,869
Ensembl chr 8:123,294,754...123,300,293

G

CEA cell adhesion molecule 19

increases expression

Methylcholanthrene results in increased expression of CEACAM19 mRNA

NCBI chr 7:19,609,667...19,621,915
Ensembl chr 7:19,609,667...19,621,890

G

CCAAT/enhancer binding protein alpha

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CEBPA mRNA

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

CCAAT/enhancer binding protein beta

multiple interactions

[Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

centromere protein A

increases expression

Methylcholanthrene results in increased expression of CENPA mRNA

NCBI chr 5:30,824,214...30,832,181
Ensembl chr 5:30,824,121...30,832,174

G

centromere protein E

increases expression

Methylcholanthrene results in increased expression of CENPE mRNA

NCBI chr 3:134,918,324...134,979,301
Ensembl chr 3:134,918,298...134,979,372

G

centromere protein F

increases expression

Methylcholanthrene results in increased expression of CENPF mRNA

NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283

G

centromere protein H

increases expression

Methylcholanthrene results in increased expression of CENPH mRNA

NCBI chr13:100,896,187...100,912,415
Ensembl chr13:100,896,182...100,912,407

G

centromere protein I

increases expression

Methylcholanthrene results in increased expression of CENPI mRNA

NCBI chr X:133,206,777...133,263,853
Ensembl chr X:133,208,833...133,263,388

G

centromere protein K

increases expression

Methylcholanthrene results in increased expression of CENPK mRNA

NCBI chr13:104,365,474...104,386,130
Ensembl chr13:104,365,119...104,388,900

G

centromere protein L

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CENPL promoter]

NCBI chr 1:160,898,337...160,914,294
Ensembl chr 1:160,898,283...160,914,294

G

centromere protein U

increases expression

Methylcholanthrene results in increased expression of CENPU mRNA

NCBI chr 8:47,005,054...47,033,603
Ensembl chr 8:47,005,063...47,033,042

G

centrosomal protein 55

increases expression

Methylcholanthrene results in increased expression of CEP55 mRNA

NCBI chr19:38,043,423...38,062,873
Ensembl chr19:38,043,459...38,062,871

G

centrosomal protein 70

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CEP70 promoter]

NCBI chr 9:99,065,640...99,205,569
Ensembl chr 9:99,125,420...99,182,457

G

carboxylesterase 1D

decreases expression

Methylcholanthrene results in decreased expression of CES1 protein

NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466

G

carboxylesterase 2H

decreases expression

Methylcholanthrene results in decreased expression of CES2 protein

NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810

G

carboxylesterase 3B

increases expression

Methylcholanthrene results in increased expression of CES3 mRNA

NCBI chr 8:105,810,365...105,820,561
Ensembl chr 8:105,810,385...105,820,561

G

cilia and flagella associated protein 61

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CFAP61 promoter]

NCBI chr 2:145,776,677...146,056,955
Ensembl chr 2:145,776,704...146,056,959

G

chromodomain helicase DNA binding protein 1-like

increases expression

Methylcholanthrene results in increased expression of CHD1L mRNA

NCBI chr 3:97,468,056...97,517,538
Ensembl chr 3:97,468,058...97,517,519

G

chromodomain helicase DNA binding protein 8

increases expression

Methylcholanthrene results in increased expression of CHD8 mRNA

NCBI chr14:52,435,608...52,495,499
Ensembl chr14:52,435,608...52,495,237

G

checkpoint with forkhead and ring finger domains

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CHFR mRNA

NCBI chr 5:110,283,599...110,319,839
Ensembl chr 5:110,283,708...110,319,838

G

chitinase 3 like 1

increases expression

Methylcholanthrene results in increased expression of CHI3L1 mRNA

NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919

G

cysteine-rich hydrophobic domain 1

increases expression

Methylcholanthrene results in increased expression of CHIC1 mRNA

NCBI chr X:102,400,009...102,452,698
Ensembl chr X:102,400,082...102,439,698

G

cysteine-rich hydrophobic domain 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CHIC2 mRNA

NCBI chr 5:75,165,665...75,205,302
Ensembl chr 5:75,158,649...75,205,435

G

choline kinase alpha

increases expression

Methylcholanthrene results in increased expression of CHKA mRNA

NCBI chr19:3,901,585...3,944,368
Ensembl chr19:3,901,773...3,944,369

G

choline phosphotransferase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CHPT1 promoter]

NCBI chr10:88,305,376...88,339,855
Ensembl chr10:88,288,607...88,339,935

G

chordin-like 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CHRDL2 promoter]

NCBI chr 7:99,655,611...99,683,935
Ensembl chr 7:99,655,379...99,683,935

G

cholinergic receptor nicotinic beta 1 subunit

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CHRNB1 mRNA

NCBI chr11:69,674,862...69,686,742
Ensembl chr11:69,674,862...69,686,769

G

ciliogenesis associated kinase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CILK1 promoter]

NCBI chr 9:78,016,425...78,079,396
Ensembl chr 9:78,016,474...78,079,389

G

CDGSH iron sulfur domain 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CISD1 promoter]

NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784

G

cytokine inducible SH2-containing protein

decreases expression

Methylcholanthrene results in decreased expression of CISH mRNA

NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983

G

cytoskeleton associated protein 2

increases expression

Methylcholanthrene results in increased expression of CKAP2 mRNA

NCBI chr 8:22,658,168...22,675,835
Ensembl chr 8:22,658,176...22,675,835

G

cytoskeleton associated protein 2-like

increases expression

Methylcholanthrene results in increased expression of CKAP2L mRNA

NCBI chr 2:129,110,130...129,139,148
Ensembl chr 2:129,110,130...129,139,132

G

CDC28 protein kinase regulatory subunit 2

increases expression

Methylcholanthrene results in increased expression of CKS2 mRNA

NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696

G

claudin 17

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CLDN17 promoter]

NCBI chr16:88,302,695...88,303,866
Ensembl chr16:88,302,695...88,303,866

G

CDC-like kinase 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CLK3 promoter]

NCBI chr 9:57,657,904...57,672,397
Ensembl chr 9:57,657,907...57,673,143

G

colipase-like 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CLPSL2 promoter]

NCBI chr17:28,768,461...28,771,592
Ensembl chr17:28,768,385...28,771,594

G

claspin

increases expression

Methylcholanthrene results in increased expression of CLSPN mRNA

NCBI chr 4:126,450,738...126,488,326
Ensembl chr 4:126,450,728...126,487,696

G

c-Maf inducing protein

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CMIP mRNA

NCBI chr 8:117,983,758...118,188,245
Ensembl chr 8:117,983,803...118,186,169

G

consortin, connexin sorting protein

increases expression

Methylcholanthrene results in increased expression of CNST mRNA

NCBI chr 1:179,374,009...179,455,043
Ensembl chr 1:179,373,935...179,455,043

G

contactin 1

increases expression

Methylcholanthrene results in increased expression of CNTN1 mRNA

NCBI chr15:91,949,034...92,239,834
Ensembl chr15:91,949,046...92,239,848

G

collagen, type XI, alpha 1

decreases expression

Methylcholanthrene results in decreased expression of COL11A1 mRNA

NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367

G

collagen, type III, alpha 1

decreases expression

Methylcholanthrene results in decreased expression of COL3A1 mRNA

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

collagen, type V, alpha 1

decreases expression

Methylcholanthrene results in decreased expression of COL5A1 mRNA

NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526

G

collagen, type V, alpha 2

decreases expression

Methylcholanthrene results in decreased expression of COL5A2 mRNA

NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442

G

collagen, type VIII, alpha 1

decreases expression

Methylcholanthrene results in decreased expression of COL8A1 mRNA

NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100

G

coactosin like F-actin binding protein 1

decreases expression

Methylcholanthrene results in decreased expression of COTL1 mRNA

NCBI chr 8:120,535,953...120,567,318
Ensembl chr 8:120,535,961...120,567,283

G

cytochrome c oxidase subunit 4I1

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to COX4I1 promoter]
Methylcholanthrene results in increased expression of COX4I1 mRNA

PMID:20348232 PMID:23273579

NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946

G

coproporphyrinogen oxidase

increases expression

Methylcholanthrene results in increased expression of CPOX mRNA

NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999

G

carnitine palmitoyltransferase 1a, liver

increases expression

Methylcholanthrene results in increased expression of CPT1A protein

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

cAMP responsive element binding protein 1

increases expression

Methylcholanthrene results in increased expression of CREB1 mRNA

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

cAMP responsive element modulator

decreases expression

Methylcholanthrene results in decreased expression of CREM mRNA

NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748

G

v-crk avian sarcoma virus CT10 oncogene homolog-like

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CRKL promoter]

NCBI chr16:17,269,849...17,305,304
Ensembl chr16:17,269,851...17,305,298

G

crystallin, zeta

multiple interactions
increases activity
increases expression

AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Copper inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Lead inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Lead promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]
sanguinarine inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]

PMID:15297030 PMID:19788401

NCBI chr 3:154,302,348...154,328,819
Ensembl chr 3:154,302,348...154,328,819

G

CUB and Sushi multiple domains 3

decreases expression

Methylcholanthrene results in decreased expression of CSMD3 mRNA

NCBI chr15:47,444,034...48,655,954
Ensembl chr15:47,444,033...48,655,459

G

casein beta

multiple interactions

Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of CSN2 mRNA]

NCBI chr 5:87,840,478...87,847,288
Ensembl chr 5:87,840,483...87,847,489

G

cysteine and glycine-rich protein 2

increases expression

Methylcholanthrene results in increased expression of CSRP2 mRNA

NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483

G

catenin alpha 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CTNNA1 promoter]

NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832

G

catenin beta 1

affects response to substance
multiple interactions
increases response to substance

CTNNB1 protein affects the susceptibility to Methylcholanthrene
CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CTNNB1 protein affects the reaction [[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
CTNNB1 protein results in increased susceptibility to Methylcholanthrene

PMID:21498875 PMID:25174530

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cathepsin D

increases expression

Methylcholanthrene results in increased expression of CTSD mRNA

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

CUE domain containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CUEDC1 promoter]

NCBI chr11:87,989,972...88,084,966
Ensembl chr11:87,988,884...88,084,966

G

C-X3-C motif chemokine ligand 1

increases expression

Methylcholanthrene results in increased expression of CX3CL1 mRNA

NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055

G

C-X-C motif chemokine ligand 10

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CXCL10 mRNA

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 12

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CXCL12 mRNA

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

C-X-C motif chemokine ligand 15

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CXCL5 mRNA

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome b5 type B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CYB5B promoter]

NCBI chr 8:107,877,293...107,914,102
Ensembl chr 8:107,877,272...107,914,103

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Methylcholanthrene results in decreased expression of CYP11A1 mRNA

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects expression

Methylcholanthrene affects the expression of CYP17A1 mRNA

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases activity
increases metabolic processing
increases expression
increases methylation
increases acetylation
decreases response to substance
increases expression

[Celsior co-treated with Methylcholanthrene] results in increased expression of CYP1A1 mRNA; [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; [Methylcholanthrene co-treated with Oxygen deficiency] results in increased expression of CYP1A1 mRNA; [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP1A1 mRNA; [Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [NR3C1 protein co-treated with Dexamethasone] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [pirinixic acid co-treated with Methylcholanthrene] results in increased activity of CYP1A1 protein; [pirinixic acid co-treated with Methylcholanthrene] results in increased expression of CYP1A1 mRNA; AHR gene mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of and results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [pirinixic acid results in increased activity of CYP1A1 protein]; Methylcholanthrene promotes the reaction [pirinixic acid results in increased expression of CYP1A1 mRNA]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Oxygen deficiency affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; SPTLC1 protein inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; SPTLC1 protein mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; tyrphostin AG 1024 inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; tyrphostin AG 1024 inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]
Methylcholanthrene results in decreased activity of CYP1A1 protein
Methylcholanthrene results in increased activity of CYP1A1 promoter; Methylcholanthrene results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Methylcholanthrene
[[Methylcholanthrene results in increased expression of CYP1A1 protein] co-treated with [Methylcholanthrene results in increased expression of CYP1A2 protein]] results in decreased susceptibility to 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; [Methylcholanthrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CYP1A1 promoter]; Buthionine Sulfoximine inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Ethoxyquin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; isoimperatorin promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [CYP1A1 protein results in increased oxidation of Toluene]; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein; protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sodium arsenite inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sodium arsenite inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
Methylcholanthrene results in increased expression of CYP1A1 mRNA; Methylcholanthrene results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; [Methylcholanthrene binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [Methylcholanthrene binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR affects the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Methylcholanthrene affects the expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Arsenic inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Arsenic promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Cadmium inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Capsaicin inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Capsaicin inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Chromium inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Chromium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Chromium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; CTNNB1 protein affects the reaction [[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; Cycloheximide promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; CYP1A1 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A2 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Lead inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Lead inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]; Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein; POR gene mutant form inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]
CYP1A1 gene mutant form results in decreased susceptibility to Methylcholanthrene
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:1316759 PMID:1617633 PMID:1994898 PMID:2154949 PMID:3785172 More...

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
affects response to substance
increases activity
increases expression
increases response to substance

[Celsior co-treated with Methylcholanthrene] results in increased expression of CYP1A2 mRNA; [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]
CYP1A2 affects the susceptibility to Methylcholanthrene
[[Methylcholanthrene results in increased expression of CYP1A1 protein] co-treated with [Methylcholanthrene results in increased expression of CYP1A2 protein]] results in decreased susceptibility to 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; [Methylcholanthrene results in increased activity of CYP1A2 protein] which results in increased oxidation of Uroporphyrinogens; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [CYP1A2 protein results in increased oxidation of Toluene]; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein; protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein]
Methylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 protein
[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A2 mRNA; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A1 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A2 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
CYP1A2 gene mutant form results in increased susceptibility to Methylcholanthrene

PMID:1617633 PMID:1994898 PMID:3785172 PMID:4054433 PMID:6749129 More...

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases chemical synthesis
increases metabolic processing
increases expression
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1B1 protein; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased chemical synthesis of Methylcholanthrene metabolite
CYP1B1 protein results in increased metabolism of Methylcholanthrene
Methylcholanthrene results in increased expression of CYP1B1 mRNA; Methylcholanthrene results in increased expression of CYP1B1 protein
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:9783729 PMID:10402558 PMID:11323195 PMID:11328961 PMID:11502733 More...

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions

Methylcholanthrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]

NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065

G

cytochrome P450, family 2, subfamily a, polypeptide 22

increases expression

Methylcholanthrene results in increased expression of CYP2A1 mRNA

PMID:11323195 PMID:19118567 PMID:22934830

NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809

G

cytochrome P450, family 2, subfamily a, polypeptide 4

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CYP2A4 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to CYP2A7 promoter]
Methylcholanthrene results in increased expression of CYP2A3 mRNA

PMID:12845369 PMID:20348232 PMID:22934830 PMID:30503582

NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513

G

cytochrome P450, family 2, subfamily a, polypeptide 5

increases expression

Methylcholanthrene results in increased expression of CYP2A5 mRNA

NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973

G

cytochrome P450, family 2, subfamily b, polypeptide 10

decreases expression

Methylcholanthrene results in decreased expression of CYP2B10 mRNA
Methylcholanthrene results in decreased expression of CYP2B3 mRNA

PMID:11328961 PMID:30503582

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily b, polypeptide 13

multiple interactions
affects expression

Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]
Methylcholanthrene affects the expression of CYP2B2 mRNA

PMID:18486174 PMID:23273579

NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622

G

cytochrome P450, family 2, subfamily b, polypeptide 9

increases expression

Methylcholanthrene results in increased expression of CYP2B9 mRNA

NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086

G

cytochrome P450, family 2, subfamily c, polypeptide 29

increases expression

Methylcholanthrene results in increased expression of CYP2C29 mRNA

NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157

G

cytochrome P450, family 2. subfamily c, polypeptide 37

increases expression

Methylcholanthrene results in increased expression of CYP2C37 mRNA

NCBI chr19:39,980,868...40,000,687
Ensembl chr19:39,980,868...40,000,687

G

cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene

increases expression
multiple interactions
decreases expression

Methylcholanthrene results in increased expression of CYP2C11 mRNA
Methylcholanthrene promotes the reaction [CYP2C11 protein results in increased oxidation of Toluene]
Methylcholanthrene results in decreased expression of CYP2C11 mRNA

PMID:1994898 PMID:10476907 PMID:22978700 PMID:23273579

NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733

G

cytochrome P450, family 2, subfamily d, polypeptide 22

increases expression

Methylcholanthrene results in increased expression of CYP2D4 mRNA

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily d, polypeptide 9

multiple interactions
affects expression
decreases expression
increases expression

Methylcholanthrene results in decreased expression of and results in decreased activity of CYP2D9 protein; POR gene mutant form inhibits the reaction [Methylcholanthrene affects the expression of CYP2D9 protein]
Methylcholanthrene results in decreased expression of CYP2D9 mRNA
Methylcholanthrene results in increased expression of CYP2D9 mRNA

PMID:22978700 PMID:23169610 PMID:30503582

NCBI chr15:82,336,578...82,341,028
Ensembl chr15:82,317,638...82,341,046

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity
decreases expression
increases expression
increases expression

[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; [Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene; [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Methylcholanthrene promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]
Methylcholanthrene results in decreased activity of CYP2E1 protein
Methylcholanthrene results in decreased expression of CYP2E1 mRNA; Methylcholanthrene results in decreased expression of CYP2E1 protein
Methylcholanthrene results in increased expression of CYP2E1 mRNA; Methylcholanthrene results in increased expression of CYP2E1 protein
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:1994898 PMID:3113478 PMID:7493548 PMID:8734847 PMID:9118891 More...

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

Methylcholanthrene results in increased expression of CYP2S1 mRNA

NCBI chr 7:25,501,894...25,515,950
Ensembl chr 7:25,501,900...25,516,338

G

cytochrome P450, family 3, subfamily a, polypeptide 11

multiple interactions
decreases expression
increases expression

AHR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of CYP3A11 mRNA]; Methylcholanthrene inhibits the reaction [POR gene mutant form results in decreased expression of CYP3A11 mRNA]
Methylcholanthrene results in decreased expression of CYP3A11 mRNA; Methylcholanthrene results in decreased expression of CYP3A11 protein
Methylcholanthrene results in increased expression of CYP3A11 mRNA

PMID:22978700 PMID:23846873 PMID:30503582

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

cytochrome P450, family 3, subfamily a, polypeptide 13

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CYP3A5 mRNA
AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP3A5 mRNA]

NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881

G

cytochrome P450, family 3, subfamily a, polypeptide 41A

decreases expression

Methylcholanthrene results in decreased expression of CYP3A41A protein

NCBI chr 5:145,630,859...145,656,946
Ensembl chr 5:145,630,859...145,656,946

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

Methylcholanthrene results in increased expression of CYP4B1 mRNA

NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920

G

cytochrome P450, family 4, subfamily f, polypeptide 16

decreases expression

Methylcholanthrene results in decreased expression of CYP4F6 mRNA

NCBI chr17:32,755,517...32,770,772
Ensembl chr17:32,755,532...32,770,772

G

disabled 2, mitogen-responsive phosphoprotein

increases expression

Methylcholanthrene results in increased expression of DAB2 mRNA

NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

Methylcholanthrene results in decreased expression of DACT1 mRNA

NCBI chr12:71,356,658...71,366,881
Ensembl chr12:71,356,658...71,366,881

G

death associated protein kinase 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of DAPK1 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of DAPK1 promoter
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DAPK1 mRNA

PMID:20970405 PMID:23519560

NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005

G

death-associated protein kinase 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DAPK2 mRNA

NCBI chr 9:66,065,364...66,179,524
Ensembl chr 9:66,065,505...66,179,524

G

deleted in azoospermia-like

decreases expression

Methylcholanthrene results in decreased expression of DAZL mRNA

NCBI chr17:50,586,422...50,600,627
Ensembl chr17:50,586,423...50,600,664

G

drebrin 1

decreases expression

Methylcholanthrene results in decreased expression of DBN1 mRNA

NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924

G

deoxycytidine kinase

increases expression

Methylcholanthrene results in increased expression of DCK mRNA

NCBI chr 5:88,912,872...88,931,136
Ensembl chr 5:88,912,855...88,931,140

G

doublecortin-like kinase 1

decreases expression

Methylcholanthrene results in decreased expression of DCLK1 mRNA

NCBI chr 3:55,149,724...55,446,489
Ensembl chr 3:55,149,785...55,446,489

G

discoidin domain receptor family, member 2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of DDR2 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA]

NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331

G

DEAD box helicase 17

increases expression

Methylcholanthrene results in increased expression of DDX17 mRNA

NCBI chr15:79,411,897...79,430,976
Ensembl chr15:79,411,937...79,430,942

G

DEAD box helicase 4

decreases expression

Methylcholanthrene results in decreased expression of DDX4 mRNA

NCBI chr13:112,734,867...112,790,342
Ensembl chr13:112,734,867...112,789,009

G

DEAD box helicase 5

increases expression
multiple interactions

Methylcholanthrene results in increased expression of DDX5 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]

NCBI chr11:106,671,181...106,680,011
Ensembl chr11:106,671,181...106,680,011

G

defensin beta 46

decreases expression

Methylcholanthrene results in decreased expression of DEFB46 mRNA

NCBI chr 8:19,289,932...19,292,159
Ensembl chr 8:19,289,932...19,292,159

G

delta 4-desaturase, sphingolipid 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DEGS1 promoter]

NCBI chr 1:182,103,529...182,110,366
Ensembl chr 1:182,103,337...182,110,369

G

DEP domain containing 1a

increases expression

Methylcholanthrene results in increased expression of DEPDC1A mRNA

NCBI chr 3:159,201,042...159,235,690
Ensembl chr 3:159,201,070...159,235,592

G

DEP domain containing 1B

increases expression

Methylcholanthrene results in increased expression of DEPDC1B mRNA

NCBI chr13:108,452,592...108,526,100
Ensembl chr13:108,452,866...108,544,316

G

DEP domain containing MTOR-interacting protein

decreases expression

Methylcholanthrene results in decreased expression of DEPTOR mRNA

NCBI chr15:54,975,824...55,122,667
Ensembl chr15:54,975,713...55,122,667

G

dihydrofolate reductase

increases expression

Methylcholanthrene results in increased expression of DHFR mRNA

NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561

G

diaphanous related formin 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DIAPH1 promoter]

NCBI chr18:37,976,654...38,068,573
Ensembl chr18:37,976,654...38,068,529

G

DLG associated protein 5

increases expression

Methylcholanthrene results in increased expression of DLGAP5 mRNA

NCBI chr14:47,625,238...47,655,657
Ensembl chr14:47,625,236...47,655,864

G

delta like canonical Notch ligand 1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of DLL1 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DLL1 mRNA]

NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134

G

dentin matrix protein 1

increases expression

Methylcholanthrene results in increased expression of DMP1 mRNA

NCBI chr 5:104,345,441...104,361,968
Ensembl chr 5:104,350,479...104,361,968

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions
increases methylation
increases acetylation
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of DNAJB6 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DNAJB6 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of DNAJB6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]

NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132

G

DnaJ heat shock protein family (Hsp40) member C9

increases expression

Methylcholanthrene results in increased expression of DNAJC9 mRNA

NCBI chr14:20,434,706...20,438,978
Ensembl chr14:20,434,706...20,438,978

G

DNA methyltransferase 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT1 protein

NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184

G

DNA methyltransferase 3A

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT3A protein

NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443

G

denticleless E3 ubiquitin protein ligase

increases expression

Methylcholanthrene results in increased expression of DTL mRNA

NCBI chr 1:191,269,468...191,307,656
Ensembl chr 1:191,269,468...191,307,656

G

dystrobrevin alpha

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DTNA promoter]

NCBI chr18:23,443,063...23,792,776
Ensembl chr18:23,548,192...23,792,772

G

dual specificity phosphatase 14

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DUSP14 promoter]

NCBI chr11:83,938,859...83,960,016
Ensembl chr11:83,938,867...83,960,087

G

dual specificity phosphatase 4

increases expression

Methylcholanthrene results in increased expression of DUSP4 mRNA

NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048

G

dual specificity phosphatase 6

increases expression

Methylcholanthrene results in increased expression of DUSP6 mRNA

NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351

G

deoxyuridine triphosphatase

increases expression

Methylcholanthrene results in increased expression of DUT mRNA

NCBI chr 2:125,089,168...125,100,969
Ensembl chr 2:125,089,110...125,100,528

G

dual-specificity tyrosine phosphorylation regulated kinase 2

decreases expression

Methylcholanthrene results in decreased expression of DYRK2 mRNA

NCBI chr10:118,691,507...118,725,144
Ensembl chr10:118,691,508...118,706,114

G

E2F transcription factor 7

increases expression

Methylcholanthrene results in increased expression of E2F7 mRNA

NCBI chr10:110,580,799...110,623,245
Ensembl chr10:110,581,300...110,623,245

G

E2F transcription factor 8

increases expression

Methylcholanthrene results in increased expression of E2F8 mRNA

NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344

G

eosinophil-associated, ribonuclease A family, member 2

increases expression

Methylcholanthrene results in increased expression of EAR2 mRNA

NCBI chr14:44,340,111...44,340,988
Ensembl chr14:44,340,111...44,340,991

G

extracellular matrix protein 1

increases expression

Methylcholanthrene results in increased expression of ECM1 mRNA

NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881

G

ect2 oncogene

increases expression

Methylcholanthrene results in increased expression of ECT2 mRNA

NCBI chr 3:27,151,371...27,207,971
Ensembl chr 3:27,151,371...27,208,027

G

ephrin A5

decreases expression

Methylcholanthrene results in decreased expression of EFNA5 mRNA

NCBI chr17:62,909,949...63,188,431
Ensembl chr17:62,911,179...63,188,312

G

ephrin B1

increases expression

Methylcholanthrene results in increased expression of EFNB1 mRNA

NCBI chr X:98,179,667...98,192,628
Ensembl chr X:98,179,736...98,192,597

G

epidermal growth factor receptor

decreases expression

Methylcholanthrene results in decreased expression of EGFR mRNA

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

early growth response 2

increases expression

Methylcholanthrene results in increased expression of EGR2 mRNA

NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018

G

early growth response 3

increases expression

Methylcholanthrene results in increased expression of EGR3 mRNA

NCBI chr14:70,314,766...70,320,062
Ensembl chr14:70,314,652...70,320,063

G

EH-domain containing 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to EHD3 promoter]

NCBI chr17:74,111,836...74,139,088
Ensembl chr17:74,111,129...74,139,089

G

eukaryotic translation initiation factor 1A

increases expression

Methylcholanthrene results in increased expression of EIF1AY mRNA

NCBI chr18:46,730,771...46,743,292
Ensembl chr18:46,730,768...46,749,523

G

eukaryotic translation initiation factor 2B, subunit 2 beta

increases expression

Methylcholanthrene results in increased expression of EIF2B2 mRNA

NCBI chr12:85,266,255...85,273,402
Ensembl chr12:85,266,255...85,273,402

G

eukaryotic translation initiation factor 4E family member 1B

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF4E1B mRNA

NCBI chr13:54,931,807...54,936,272
Ensembl chr13:54,931,811...54,936,272

G

eukaryotic translation initiation factor 4E binding protein 2

increases expression

Methylcholanthrene results in increased expression of EIF4EBP2 mRNA

NCBI chr10:61,268,276...61,288,448
Ensembl chr10:61,264,270...61,288,440

G

engulfment and cell motility 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ELMO1 mRNA

NCBI chr13:20,274,677...20,792,523
Ensembl chr13:20,274,766...20,792,523

G

ELOVL fatty acid elongase 3

increases expression

Methylcholanthrene results in increased expression of ELOVL3 mRNA

NCBI chr19:46,120,336...46,124,133
Ensembl chr19:46,120,336...46,124,133

G

essential meiotic structure-specific endonuclease 1

increases expression

Methylcholanthrene results in increased expression of EME1 mRNA

NCBI chr11:94,535,798...94,544,611
Ensembl chr11:94,535,822...94,544,790

G

epithelial membrane protein 1

increases expression

Methylcholanthrene results in increased expression of EMP1 mRNA

NCBI chr 6:135,339,548...135,360,171
Ensembl chr 6:135,339,543...135,360,171

G

glutamyl aminopeptidase

decreases expression

Methylcholanthrene results in decreased expression of ENPEP mRNA

NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Methylcholanthrene results in decreased expression of ENPP2 mRNA

NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288

G

endothelial PAS domain protein 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of EPAS1 mRNA

NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838

G

Eph receptor B6

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EPHB6 mRNA

NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443

G

epoxide hydrolase 1, microsomal

increases activity
increases expression

Methylcholanthrene results in increased activity of EPHX1 protein
Methylcholanthrene results in increased expression of EPHX1 mRNA

PMID:3621371 PMID:23273579

NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469

G

epoxide hydrolase 2, cytoplasmic

increases activity
increases expression
decreases activity
increases expression

Methylcholanthrene results in increased activity of EPHX2 protein
Methylcholanthrene results in increased expression of EPHX2 mRNA; Methylcholanthrene results in increased expression of EPHX2 protein
Methylcholanthrene results in decreased activity of EPHX2 protein
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:3621371 PMID:19889059 PMID:19889059

NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949

G

epidermal growth factor receptor pathway substrate 15

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to EPS15 promoter]

NCBI chr 4:109,137,372...109,245,014
Ensembl chr 4:109,137,465...109,245,014

G

epidermal growth factor receptor pathway substrate 8

increases expression

Methylcholanthrene results in increased expression of EPS8 mRNA

NCBI chr 6:137,454,242...137,626,262
Ensembl chr 6:137,454,243...137,631,874

G

excision repair cross-complementing rodent repair deficiency, complementation group 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ERCC6 promoter]

NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947

G

excision repair cross-complementing rodent repair deficiency complementation group 6 like

increases expression

Methylcholanthrene results in increased expression of ERCC6L mRNA

NCBI chr X:101,186,426...101,200,697
Ensembl chr X:101,185,322...101,200,697

G

epiregulin

increases expression

Methylcholanthrene results in increased expression of EREG mRNA

NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

Methylcholanthrene results in increased expression of ESCO2 mRNA

NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443

G

extra spindle pole bodies 1, separase

increases expression

Methylcholanthrene results in increased expression of ESPL1 mRNA

NCBI chr15:102,204,688...102,232,792
Ensembl chr15:102,204,701...102,232,792

G

estrogen receptor 1 (alpha)

multiple interactions
affects binding
increases activity
increases expression
decreases expression

fulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA]; Methylcholanthrene binds to and results in increased activity of ESR1 protein; Methylcholanthrene promotes the reaction [AHR protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
Methylcholanthrene binds to ESR1 protein
Methylcholanthrene results in increased activity of ESR1 protein
Methylcholanthrene results in decreased expression of ESR1 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA]

PMID:16257430 PMID:16489053 PMID:16972788 PMID:20348232 PMID:23273579 More...

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

ets variant 1

increases expression

Methylcholanthrene results in increased expression of ETV1 mRNA

NCBI chr12:38,829,655...38,920,484
Ensembl chr12:38,829,379...38,920,483

G

ets variant 5

increases expression

Methylcholanthrene results in increased expression of ETV5 mRNA

NCBI chr16:22,200,063...22,258,320
Ensembl chr16:22,200,059...22,258,469

G

exonuclease 1

increases expression

Methylcholanthrene results in increased expression of EXO1 mRNA

NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055

G

exosome component 9

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to EXOSC9 promoter]

NCBI chr 3:36,606,755...36,619,876
Ensembl chr 3:36,606,755...36,619,876

G

F11 receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of F11R mRNA

NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171

G

fatty acid binding protein 4, adipocyte

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of FABP4 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of FABP4 mRNA

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

Fas cell surface death receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FAS mRNA

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

FCH and double SH3 domains 2

increases expression

Methylcholanthrene results in increased expression of FCHSD2 mRNA

NCBI chr 7:100,757,836...100,933,613
Ensembl chr 7:100,742,070...100,933,612

G

Fc receptor-like 5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of FCRL5 mRNA

NCBI chr 3:87,343,084...87,407,985
Ensembl chr 3:87,343,080...87,407,985

G

farnesyl diphosphate synthetase

decreases expression

Methylcholanthrene results in decreased expression of FDPS mRNA

NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266

G

ferredoxin reductase

increases expression

Methylcholanthrene results in increased expression of FDXR mRNA

NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876

G

fibroblast growth factor 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF1 mRNA

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

fibroblast growth factor 10

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA

NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651

G

fibroblast growth factor 18

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF18 mRNA

NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400

G

fibroblast growth factor 7

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF7 mRNA

NCBI chr 2:125,876,578...125,933,105
Ensembl chr 2:125,876,578...125,933,105

G

fibroblast growth factor receptor 1

increases expression

Methylcholanthrene results in increased expression of FGFR1 mRNA

PMID:20713471 PMID:29554273

NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734

G

fibroblast growth factor receptor 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGFR2 mRNA

NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079

G

fragile histidine triad gene

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter
Methylcholanthrene results in decreased expression of FHIT mRNA

PMID:20970405 PMID:22100608

NCBI chr14:11,307,718...12,919,681
Ensembl chr14:11,307,738...12,919,681

G

fidgetin-like 1

increases expression

Methylcholanthrene results in increased expression of FIGNL1 mRNA

NCBI chr11:11,737,429...11,758,962
Ensembl chr11:11,737,431...11,758,962

G

flavin containing monooxygenase 2

increases expression

Methylcholanthrene results in increased expression of FMO2 mRNA

NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295

G

flavin containing monooxygenase 3

multiple interactions
increases expression
decreases expression

AHR protein affects the reaction [Methylcholanthrene results in increased expression of FMO3 mRNA]; Methylcholanthrene promotes the reaction [TRP53 protein binds to FMO3 5' UTR]
Methylcholanthrene results in decreased expression of FMO3 mRNA

PMID:20570689 PMID:23273579 PMID:23846873 PMID:25926378

NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097

G

fibromodulin

decreases expression

Methylcholanthrene results in decreased expression of FMOD mRNA

NCBI chr 1:133,964,992...133,976,018
Ensembl chr 1:133,964,992...133,976,015

G

fos-like antigen 1

increases expression

Methylcholanthrene results in increased expression of FOSL1 mRNA

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

G

forkhead box M1

affects response to substance

FOXM1 protein affects the susceptibility to Methylcholanthrene

PMID:18345025 PMID:19672312

NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109

G

forkhead box N1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to FOXN1 promoter]

NCBI chr11:78,248,403...78,277,597
Ensembl chr11:78,248,403...78,277,384

G

forkhead box N3

increases expression
multiple interactions

Methylcholanthrene results in increased expression of FOXN3 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of FOXN3 mRNA]

NCBI chr12:99,156,340...99,529,926
Ensembl chr12:99,156,337...99,529,841

G

forkhead box N4

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of FOXN4 mRNA]

NCBI chr 5:114,392,225...114,412,486
Ensembl chr 5:114,392,225...114,411,868

G

forkhead box O3

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA

NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751

G

Fras1 related extracellular matrix protein 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to FREM2 promoter]

NCBI chr 3:53,421,359...53,566,014
Ensembl chr 3:53,421,359...53,564,776

G

FRY like transcription coactivator

increases expression

Methylcholanthrene results in increased expression of FRYL mRNA

NCBI chr 5:73,177,534...73,414,042
Ensembl chr 5:73,177,330...73,413,962

G

follistatin

decreases expression

Methylcholanthrene results in decreased expression of FST mRNA

NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487

G

follistatin-like 1

decreases expression

Methylcholanthrene results in decreased expression of FSTL1 mRNA

NCBI chr16:37,597,417...37,656,878
Ensembl chr16:37,597,235...37,656,876

G

fucosyltransferase 8

increases expression

Methylcholanthrene results in increased expression of FUT8 mRNA

NCBI chr12:77,284,878...77,522,770
Ensembl chr12:77,284,899...77,523,112

G

FXYD domain-containing ion transport regulator 5

increases expression

Methylcholanthrene results in increased expression of FXYD5 mRNA

NCBI chr 7:30,732,153...30,741,565
Ensembl chr 7:30,732,147...30,741,906

G

Fyn proto-oncogene

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FYN mRNA

NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377

G

growth factor receptor bound protein 2-associated protein 2

decreases expression

Methylcholanthrene results in decreased expression of GAB2 mRNA

NCBI chr 7:96,730,958...96,958,158
Ensembl chr 7:96,730,793...96,958,153

G

gamma-aminobutyric acid type A receptor subunit alpha 3

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GABRA3 mRNA

NCBI chr X:71,476,282...71,700,525
Ensembl chr X:71,476,287...71,700,454

G

growth arrest and DNA-damage-inducible 45 alpha

decreases expression

Methylcholanthrene results in decreased expression of GADD45A mRNA

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

polypeptide N-acetylgalactosaminyltransferase 15

increases expression

Methylcholanthrene results in increased expression of GALNT15 mRNA

NCBI chr14:31,750,739...31,784,161
Ensembl chr14:31,750,946...31,784,154

G

polypeptide N-acetylgalactosaminyltransferase 18

decreases expression

Methylcholanthrene results in decreased expression of GALNT18 mRNA

NCBI chr 7:111,070,863...111,379,274
Ensembl chr 7:111,070,868...111,379,184

G

polypeptide N-acetylgalactosaminyltransferase 7

increases expression

Methylcholanthrene results in increased expression of GALNT7 mRNA

NCBI chr 8:57,976,859...58,106,089
Ensembl chr 8:57,976,862...58,106,066

G

growth arrest-specific 2 like 3

increases expression

Methylcholanthrene results in increased expression of GAS2L3 mRNA

NCBI chr10:89,244,684...89,279,935
Ensembl chr10:89,244,685...89,279,829

G

GATA binding protein 6

multiple interactions
increases activity

Methylcholanthrene promotes the reaction [GATA6 protein binds to KRAS exon]
Methylcholanthrene results in increased activity of GATA6 protein

NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635

G

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

increases expression

Methylcholanthrene results in increased expression of GCAT mRNA

NCBI chr15:78,915,074...78,926,731
Ensembl chr15:78,915,074...78,922,553
Ensembl chr15:78,915,074...78,922,553

G

GTP cyclohydrolase 1

increases expression

Methylcholanthrene results in increased expression of GCH1 mRNA

NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870

G

GTP cyclohydrolase I feedback regulator

increases expression

Methylcholanthrene results in increased expression of GCHFR mRNA

NCBI chr 2:118,998,269...119,002,870
Ensembl chr 2:118,998,254...119,002,871

G

growth differentiation factor 9

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of GDF9 mRNA

NCBI chr11:53,321,773...53,328,731
Ensembl chr11:53,321,850...53,328,731

G

glial cell line derived neurotrophic factor

decreases expression

Methylcholanthrene results in decreased expression of GDNF mRNA

NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056

G

glycerophosphodiester phosphodiesterase domain containing 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GDPD4 promoter]

NCBI chr 7:97,569,151...97,698,870
Ensembl chr 7:97,569,162...97,698,870

G

growth hormone

decreases activity

Methylcholanthrene results in decreased activity of GH1 protein

NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691

G

growth hormone receptor

decreases expression
increases expression

Methylcholanthrene results in decreased expression of GHR mRNA
Methylcholanthrene results in increased expression of GHR protein

PMID:22978700 PMID:23169610

NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974

G

GINS complex subunit 3

increases expression

Methylcholanthrene results in increased expression of GINS3 mRNA

NCBI chr 8:96,360,187...96,371,687
Ensembl chr 8:96,360,081...96,371,688

G

GINS complex subunit 4

increases expression

Methylcholanthrene results in increased expression of GINS4 mRNA

NCBI chr 8:23,716,626...23,727,684
Ensembl chr 8:23,716,632...23,727,675

G

gap junction protein, alpha 1

increases expression

Methylcholanthrene results in increased expression of GJA1 mRNA

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

predicted gene, 26504

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of SNORD116 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SNORD116 mRNA

NCBI chr 7:59,325,738...59,325,827
Ensembl chr 7:59,325,736...59,325,829

G

predicted gene, 40318

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to S100P promoter]

NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039

G

geminin

increases expression

Methylcholanthrene results in increased expression of GMNN mRNA

NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906

G

guanine nucleotide binding protein (G protein), beta 4

increases expression

Methylcholanthrene results in increased expression of GNB4 mRNA

NCBI chr 3:32,632,736...32,670,813
Ensembl chr 3:32,634,481...32,670,734

G

glycine N-methyltransferase

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of GNMT mRNA
[Methylcholanthrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA

PMID:9261130 PMID:22100608

NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094

G

glypican 1

increases expression

Methylcholanthrene results in increased expression of GPC1 mRNA

NCBI chr 1:92,759,367...92,787,933
Ensembl chr 1:92,759,367...92,788,501

G

glycerophosphocholine phosphodiesterase 1

decreases expression

Methylcholanthrene results in decreased expression of GPCPD1 mRNA

NCBI chr 2:132,371,002...132,420,173
Ensembl chr 2:132,371,002...132,429,649

G

glycoprotein hormone beta 5

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GPHB5 promoter]

NCBI chr12:75,458,494...75,463,555
Ensembl chr12:75,458,496...75,463,555

G

glycoprotein (transmembrane) nmb

increases expression

Methylcholanthrene results in increased expression of GPNMB mRNA

NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863

G

glutathione peroxidase 1

increases expression

Methylcholanthrene results in increased expression of GPX1 mRNA

PMID:23273579 PMID:23712962

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

gene regulated by estrogen in breast cancer protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GREB1 promoter]

NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887

G

glutamate receptor, ionotropic, AMPA3 (alpha 3)

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIA3 mRNA

NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478

G

glutamate receptor, ionotropic, kainate 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GRIK4 promoter]

NCBI chr 9:42,431,708...42,856,296
Ensembl chr 9:42,429,431...42,855,789

G

glutamate receptor, ionotropic, kainate 5 (gamma 2)

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIK5 mRNA

NCBI chr 7:24,709,274...24,775,421
Ensembl chr 7:24,709,274...24,771,771

G

gasdermin C2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GSDMC promoter]

NCBI chr15:63,696,177...63,717,042
Ensembl chr15:63,696,195...63,717,026

G

gasdermin D

increases expression

Methylcholanthrene results in increased expression of GSDMD mRNA

NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257

G

gasdermin E

increases expression

Methylcholanthrene results in increased expression of GSDME mRNA

NCBI chr 6:50,167,013...50,240,837
Ensembl chr 6:50,165,868...50,240,842

G

glutathione reductase

increases activity
increases expression

Methylcholanthrene results in increased activity of GSR protein
Methylcholanthrene results in increased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione synthetase

increases activity
increases expression

Methylcholanthrene results in increased activity of GSS protein
Methylcholanthrene results in increased expression of GSS mRNA

NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730

G

glutathione S-transferase, alpha 2 (Yc2)

increases expression
decreases expression

Methylcholanthrene results in increased expression of GSTA2 mRNA
Methylcholanthrene results in decreased expression of GSTA2 mRNA

PMID:10476907 PMID:11328961 PMID:23273579

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

glutathione S-transferase, alpha 3

decreases expression

Methylcholanthrene results in decreased expression of GSTA1 mRNA

NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885

G

glutathione S-transferase alpha 5

increases expression
multiple interactions

Methylcholanthrene results in increased expression of GSTA2 mRNA
[Methylcholanthrene co-treated with Copper] results in increased activity of GSTA2 protein; Copper inhibits the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]; Lead inhibits the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]

NCBI chr 9:78,197,210...78,212,807
Ensembl chr 9:78,197,205...78,212,807

G

glutathione S-transferase kappa 1

increases expression

Methylcholanthrene results in increased expression of GSTK1 mRNA

NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381

G

glutathione S-transferase, mu 1

increases expression

Methylcholanthrene results in increased expression of GSTM1 mRNA

PMID:11328961 PMID:23273579

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, pi 1

increases expression

Methylcholanthrene results in increased expression of GSTP1 mRNA

PMID:19118567 PMID:23273579

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

G two S phase expressed protein 1

increases expression

Methylcholanthrene results in increased expression of GTSE1 mRNA

NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774

G

GULP, engulfment adaptor PTB domain containing 1

increases expression

Methylcholanthrene results in increased expression of GULP1 mRNA

NCBI chr 1:44,590,540...44,835,998
Ensembl chr 1:44,590,671...44,835,998

G

histocompatibility 2, class II, locus Mb1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of H2-DMB1 mRNA

NCBI chr17:34,372,165...34,379,203
Ensembl chr17:34,372,046...34,379,204

G

histocompatibility 2, class II, locus Mb2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of H2-DMB2 mRNA

NCBI chr17:34,362,203...34,370,527
Ensembl chr17:34,362,281...34,370,529

G

histocompatibility 2, T region locus 24

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of H2-T24 mRNA

NCBI chr17:36,314,363...36,331,689
Ensembl chr17:36,316,587...36,331,452

G

H2A clustered histone 23

increases expression

Methylcholanthrene results in increased expression of H2AC23 mRNA

NCBI chr13:21,994,537...21,995,088
Ensembl chr13:21,994,635...21,995,114

G

H2B clustered histone 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to H2BC1 promoter]

NCBI chr13:24,117,708...24,118,139
Ensembl chr13:24,117,756...24,118,139

G

H3.3 histone B

decreases expression

Methylcholanthrene results in decreased expression of H3F3B mRNA

NCBI chr11:115,912,787...115,921,313
Ensembl chr11:115,912,738...115,918,788

G

3-hydroxyacyl-CoA dehydratase 4

increases expression

Methylcholanthrene results in increased expression of HACD4 mRNA

NCBI chr 4:88,325,924...88,357,175
Ensembl chr 4:88,314,381...88,357,165

G

histone H3 associated protein kinase

increases expression

Methylcholanthrene results in increased expression of HASPIN mRNA

NCBI chr11:73,026,310...73,029,120
Ensembl chr11:73,026,311...73,029,120

G

hemoglobin alpha, adult chain 1

increases expression

Methylcholanthrene results in increased expression of HBA-A1 mRNA

NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465

G

hemopoietic cell kinase

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HCK mRNA

NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361

G

hypocretin (orexin) receptor 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HCRTR2 promoter]

NCBI chr 9:76,133,162...76,230,905
Ensembl chr 9:76,133,162...76,231,138

G

histone deacetylase 11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HDAC11 promoter]

NCBI chr 6:91,133,652...91,151,674
Ensembl chr 6:91,133,647...91,151,674

G

histone deacetylase 5

increases expression

Methylcholanthrene results in increased expression of HDAC5 mRNA

NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992

G

hephaestin

increases expression

Methylcholanthrene results in increased expression of HEPH mRNA

NCBI chr X:95,499,042...95,618,091
Ensembl chr X:95,498,965...95,618,091

G

hes family bHLH transcription factor 1

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HES1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hepatocyte growth factor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HGF mRNA

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

Hedgehog-interacting protein

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HHIP mRNA

NCBI chr 8:80,692,480...80,784,637
Ensembl chr 8:80,692,480...80,784,635

G

hypoxia inducible factor 1, alpha subunit

increases expression

Methylcholanthrene results in increased expression of HIF1A mRNA

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

homeodomain interacting protein kinase 2

decreases expression

Methylcholanthrene results in decreased expression of HIPK2 mRNA

NCBI chr 6:38,664,447...38,853,236
Ensembl chr 6:38,671,325...38,853,099

G

high mobility group AT-hook 1

increases expression

Methylcholanthrene results in increased expression of HMGA1 mRNA

NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648

G

high mobility group AT-hook 2

increases expression

Methylcholanthrene results in increased expression of HMGA2 mRNA

NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

decreases expression

Methylcholanthrene results in decreased expression of HMGCR mRNA

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

decreases expression

Methylcholanthrene results in decreased expression of HMGCS1 mRNA

PMID:20713471 PMID:35487396

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

hyaluronan mediated motility receptor (RHAMM)

increases expression

Methylcholanthrene results in increased expression of HMMR mRNA

NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249

G

heme oxygenase 1

multiple interactions
increases expression

[Methylcholanthrene co-treated with Copper] results in increased expression of HMOX1 mRNA; [Methylcholanthrene co-treated with Lead] results in increased expression of HMOX1 mRNA; [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA
Methylcholanthrene results in increased expression of HMOX1 mRNA

PMID:15297030 PMID:19889059 PMID:22100608

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heterogeneous nuclear ribonucleoprotein A1

multiple interactions

[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein

NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119

G

heterogeneous nuclear ribonucleoprotein A2/B1

multiple interactions

[Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein

NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874

G

homeobox C10

increases expression

Methylcholanthrene results in increased expression of HOXC10 mRNA

NCBI chr15:102,875,231...102,880,333
Ensembl chr15:102,875,231...102,880,328

G

homeobox C11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HOXC11 promoter]

NCBI chr15:102,862,961...102,865,136
Ensembl chr15:102,862,862...102,866,143

G

hippocalcin-like 4

increases expression

Methylcholanthrene results in increased expression of HPCAL4 mRNA

NCBI chr 4:123,077,297...123,088,492
Ensembl chr 4:123,077,020...123,088,494

G

hydroxyprostaglandin dehydrogenase 15 (NAD)

increases expression

Methylcholanthrene results in increased expression of HPGD mRNA

NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078

G

heat shock factor binding protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HSBP1 promoter]

NCBI chr 8:120,071,277...120,075,668
Ensembl chr 8:120,071,227...120,075,661

G

HscB iron-sulfur cluster co-chaperone

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of HSCB mRNA

NCBI chr 5:110,976,945...110,987,647
Ensembl chr 5:110,976,936...110,987,643

G

heat shock protein 90, alpha (cytosolic), class A member 1

increases expression

Methylcholanthrene results in increased expression of HSP90AA1 mRNA

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 1A

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA1A mRNA

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 8

increases expression
multiple interactions

Methylcholanthrene results in increased expression of HSPA8 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HSPA8 mRNA]

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

G

intercellular adhesion molecule 1

multiple interactions
increases expression
increases acetylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of ICAM1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of ICAM1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 2

increases expression

Methylcholanthrene results in increased expression of ID2 mRNA

PMID:20713471 PMID:23397585

NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139

G

inhibitor of DNA binding 3

increases expression

Methylcholanthrene results in increased expression of ID3 mRNA

NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066

G

isocitrate dehydrogenase 2 (NADP+), mitochondrial

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to IDH2 promoter]

NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140

G

isopentenyl-diphosphate delta isomerase

decreases expression

Methylcholanthrene results in decreased expression of IDI1 mRNA

NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487

G

immediate early response 3

increases expression
multiple interactions

Methylcholanthrene results in increased expression of IER3 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to IER3 promoter]

PMID:20348232 PMID:20713471 PMID:22579512

NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815

G

interferon, alpha-inducible protein 27

decreases expression

Methylcholanthrene results in decreased expression of IFI27 mRNA

NCBI chr12:103,400,448...103,406,504
Ensembl chr12:103,400,470...103,406,498

G

interferon-induced protein 44

decreases expression

Methylcholanthrene results in decreased expression of IFI44 mRNA

NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597

G

interferon-induced protein with tetratricopeptide repeats 1

decreases expression

Methylcholanthrene results in decreased expression of IFIT1 mRNA

NCBI chr19:34,618,289...34,627,409
Ensembl chr19:34,618,271...34,627,409

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

Methylcholanthrene results in increased expression of IFIT2 mRNA

NCBI chr19:34,527,961...34,553,934
Ensembl chr19:34,528,094...34,553,819

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Methylcholanthrene results in decreased expression of IFIT3 mRNA

NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131

G

interferon induced transmembrane protein 6

increases expression

Methylcholanthrene results in increased expression of IFITM6 mRNA

NCBI chr 7:140,595,725...140,596,805
Ensembl chr 7:140,595,612...140,597,837

G

interferon beta 1, fibroblast

increases expression

Methylcholanthrene results in increased expression of IFNB1 mRNA

NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011

G

insulin-like growth factor 2

increases methylation
increases acetylation
increases expression
multiple interactions

Methylcholanthrene results in increased methylation of IGF2 promoter
Methylcholanthrene results in increased acetylation of IGF2 promoter
Methylcholanthrene results in increased expression of IGF2 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

insulin-like growth factor binding protein 6

increases expression

Methylcholanthrene results in increased expression of IGFBP6 mRNA

NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946

G

insulin-like growth factor binding protein-like 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to IGFBPL1 promoter]

NCBI chr 4:45,809,507...45,826,827
Ensembl chr 4:45,809,468...45,826,923

G

immunoglobulin heavy chain (J558 family)

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IGH-VJ558 mRNA

G

Immunoglobulin heavy chain (gamma polypeptide)

increases expression

Methylcholanthrene results in increased expression of IGHG mRNA

G

immunoglobulin heavy constant mu

increases expression

Methylcholanthrene results in increased expression of IGHM mRNA

NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350

G

immunoglobulin kappa chain variable 4-91

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IGKV4-91 mRNA

NCBI chr 6:68,745,539...68,746,087
Ensembl chr 6:68,745,539...68,746,087

G

interleukin 12a

increases expression

Methylcholanthrene results in increased expression of IL12A mRNA

NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880

G

interleukin 12 receptor, beta 1

increases expression

Methylcholanthrene results in increased expression of IL12RB1 mRNA

NCBI chr 8:71,261,005...71,276,186
Ensembl chr 8:71,261,093...71,274,068

G

interleukin 18

increases expression

Methylcholanthrene results in increased expression of IL18 mRNA

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 18 receptor 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL18R1 mRNA

NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014

G

interleukin 18 receptor accessory protein

increases expression

Methylcholanthrene results in increased expression of IL18RAP mRNA

NCBI chr 1:40,554,548...40,590,867
Ensembl chr 1:40,554,522...40,590,865

G

interleukin 1 alpha

increases expression

Methylcholanthrene results in increased expression of IL1A mRNA

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

increases expression
multiple interactions

Methylcholanthrene results in increased expression of IL1B mRNA
[Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of IL1B mRNA; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IL1B mRNA]

PMID:14993811 PMID:35487396

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor-like 1

increases expression

Methylcholanthrene results in increased expression of IL1RL1 mRNA

NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575

G

interleukin 6

increases expression
multiple interactions

Methylcholanthrene results in increased expression of IL6 mRNA
[Methylcholanthrene co-treated with TNF protein] results in increased expression of IL6 mRNA

PMID:14993811 PMID:23396138 PMID:29554273

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 signal transducer

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL6ST mRNA

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

interleukin 7 receptor

multiple interactions
increases expression

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL7R mRNA
Methylcholanthrene results in increased expression of IL7R mRNA

NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262

G

IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)

decreases expression

Methylcholanthrene results in decreased expression of IMMP2L mRNA

NCBI chr12:41,074,060...42,002,371
Ensembl chr12:41,074,089...42,002,371

G

inhibin beta-C

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to INHBC promoter]

NCBI chr10:127,192,191...127,206,417
Ensembl chr10:127,192,191...127,206,300

G

insulin II

multiple interactions

Methylcholanthrene promotes the reaction [Glucose results in increased secretion of INS protein alternative form]

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

IQ motif containing GTPase activating protein 3

increases expression

Methylcholanthrene results in increased expression of IQGAP3 mRNA

NCBI chr 3:87,989,309...88,028,355
Ensembl chr 3:87,989,278...88,028,355

G

interferon regulatory factor 2 binding protein-like

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to IRF2BPL promoter]

NCBI chr12:86,927,477...86,931,588
Ensembl chr12:86,927,475...86,931,572

G

insulin receptor substrate 1

decreases expression

Methylcholanthrene results in decreased expression of IRS1 mRNA

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

isochorismatase domain containing 2a

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ISOC2 promoter]

NCBI chr 7:4,880,052...4,898,716
Ensembl chr 7:4,880,152...4,899,972

G

integrin, alpha 10

increases expression

Methylcholanthrene results in increased expression of ITGA10 mRNA

NCBI chr 3:96,552,900...96,571,835
Ensembl chr 3:96,552,900...96,571,835

G

integrin alpha 7

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGA7 mRNA

NCBI chr10:128,769,633...128,794,155
Ensembl chr10:128,769,645...128,794,155

G

integrin beta 5

decreases expression

Methylcholanthrene results in decreased expression of ITGB5 mRNA

NCBI chr16:33,650,021...33,769,708
Ensembl chr16:33,650,035...33,769,708

G

integrin beta 8

multiple interactions
decreases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA]

NCBI chr12:119,121,757...119,202,891
Ensembl chr12:119,121,757...119,202,537

G

integrin, beta-like 1

increases expression

Methylcholanthrene results in increased expression of ITGBL1 mRNA

NCBI chr14:123,897,331...124,215,173
Ensembl chr14:123,897,383...124,213,030

G

inositol 1,4,5-trisphosphate receptor 1

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to ITPR1 promoter]
Methylcholanthrene results in increased expression of ITPR1 mRNA

NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070

G

jagged 1

decreases expression
multiple interactions
increases expression
increases methylation
increases acetylation

Methylcholanthrene results in decreased expression of JAG1 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]

PMID:20713471 PMID:29094188

NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564

G

Janus kinase 2

decreases expression

Methylcholanthrene results in decreased expression of JAK2 mRNA

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

junctophilin 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to JPH1 promoter]

NCBI chr 1:17,012,328...17,168,132
Ensembl chr 1:17,034,784...17,168,113

G

jun proto-oncogene

increases expression

Methylcholanthrene results in increased expression of JUN mRNA

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

katanin p60 subunit A-like 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KATNAL2 promoter]

NCBI chr18:77,063,725...77,135,007
Ensembl chr18:77,064,844...77,135,004

G

potassium channel, subfamily K, member 2

increases expression

Methylcholanthrene results in increased expression of KCNK2 mRNA

NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470

G

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

increases expression

Methylcholanthrene results in increased expression of KCNN4 mRNA

NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115

G

potassium channel tetramerisation domain containing 1

increases expression

Methylcholanthrene results in increased expression of KCTD1 mRNA

NCBI chr18:15,101,742...15,284,503
Ensembl chr18:15,101,742...15,284,503

G

potassium channel tetramerisation domain containing 16

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KCTD16 promoter]

NCBI chr18:40,389,358...40,680,311
Ensembl chr18:40,390,015...40,664,683
Ensembl chr18:40,390,015...40,664,683

G

potassium channel tetramerisation domain containing 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KCTD3 promoter]

NCBI chr 1:188,703,292...188,740,095
Ensembl chr 1:188,703,292...188,740,038

G

potassium channel tetramerisation domain containing 5

decreases expression

Methylcholanthrene results in decreased expression of KCTD5 mRNA

NCBI chr17:24,266,694...24,292,459
Ensembl chr17:24,266,708...24,292,459

G

kinase insert domain protein receptor

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KDR mRNA

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

kelch-like ECH-associated protein 1

increases expression

Methylcholanthrene results in increased expression of KEAP1 mRNA

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

kinesin family member 11

increases expression
multiple interactions

Methylcholanthrene results in increased expression of KIF11 mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA]

PMID:20713471 PMID:26372666

NCBI chr19:37,364,830...37,410,311
Ensembl chr19:37,364,851...37,410,307

G

kinesin family member 18A

increases expression
multiple interactions

Methylcholanthrene results in increased expression of KIF18A mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF18A mRNA]

PMID:20713471 PMID:26372666

NCBI chr 2:109,111,165...109,172,094
Ensembl chr 2:109,111,083...109,172,092

G

kinesin family member 20A

increases expression

Methylcholanthrene results in increased expression of KIF20A mRNA

NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330

G

kinesin family member 22

increases expression

Methylcholanthrene results in increased expression of KIF22 mRNA

NCBI chr 7:126,626,901...126,641,639
Ensembl chr 7:126,626,901...126,641,643

G

kinesin family member 23

increases expression

Methylcholanthrene results in increased expression of KIF23 mRNA

NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056

G

kinesin family member 2C

increases expression

Methylcholanthrene results in increased expression of KIF2C mRNA

PMID:20713471 PMID:26372666

NCBI chr 4:117,016,830...117,039,821
Ensembl chr 4:117,016,836...117,039,836

G

KIT proto-oncogene receptor tyrosine kinase

affects expression

Methylcholanthrene affects the expression of KIT mRNA

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

kit ligand

increases expression

Methylcholanthrene results in increased expression of KITL mRNA

NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278

G

Kruppel-like transcription factor 2 (lung)

increases expression

Methylcholanthrene results in increased expression of KLF2 mRNA

NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500

G

Kruppel-like transcription factor 5

increases expression

Methylcholanthrene results in increased expression of KLF5 mRNA

NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472

G

Kruppel-like transcription factor 9

multiple interactions
decreases expression

Methylcholanthrene promotes the reaction [AHR protein binds to KLF9 promoter]
Methylcholanthrene results in decreased expression of KLF9 mRNA

PMID:20348232 PMID:23397585

NCBI chr19:23,118,590...23,145,493
Ensembl chr19:23,118,590...23,145,498

G

lysine (K)-specific methyltransferase 2E

increases expression

Methylcholanthrene results in increased expression of KMT2E mRNA

NCBI chr 5:23,638,034...23,709,233
Ensembl chr 5:23,639,439...23,709,233

G

kininogen 1

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of KNG1 mRNA; Methylcholanthrene results in decreased expression of KNG1 protein
AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 protein]

NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828

G

kinetochore-localized astrin/SPAG5 binding

increases expression

Methylcholanthrene results in increased expression of KNSTRN mRNA

NCBI chr 2:118,644,470...118,667,691
Ensembl chr 2:118,644,484...118,684,438

G

kinetochore associated 1

increases expression

Methylcholanthrene results in increased expression of KNTC1 mRNA

NCBI chr 5:123,887,755...123,959,656
Ensembl chr 5:123,887,779...123,959,656

G

karyopherin subunit alpha 2

increases expression

Methylcholanthrene results in increased expression of KPNA2 mRNA

NCBI chr11:106,879,455...106,890,351
Ensembl chr11:106,879,455...106,890,367

G

Kirsten rat sarcoma viral oncogene homolog

multiple interactions
increases mutagenesis

Methylcholanthrene promotes the reaction [GATA6 protein binds to KRAS exon]; Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]
Methylcholanthrene results in increased mutagenesis of KRAS gene

PMID:11195466 PMID:16271038 PMID:20101149

NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965

G

keratin 6A

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KRT6A mRNA; [Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of KRT6A mRNA

NCBI chr15:101,598,363...101,602,746
Ensembl chr15:101,598,345...101,602,742

G

keratin 75

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KRT75 promoter]

NCBI chr15:101,471,778...101,482,339
Ensembl chr15:101,471,780...101,482,339

G

laminin, alpha 4

decreases expression

Methylcholanthrene results in decreased expression of LAMA4 mRNA

NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184

G

laminin, alpha 5

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LAMA5 mRNA

NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652

G

laminin, gamma 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LAMC2 mRNA

NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193

G

lecithin cholesterol acyltransferase

decreases expression

Methylcholanthrene results in decreased expression of LCAT mRNA

NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014

G

low density lipoprotein receptor

decreases expression

Methylcholanthrene results in decreased expression of LDLR mRNA

NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215

G

lymphoid enhancer binding factor 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LEF1 mRNA

NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005

G

lectin, galactose binding, soluble 1

increases expression

Methylcholanthrene results in increased expression of LGALS1 mRNA

NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665

G

lectin, galactose-binding, soluble 2

increases expression

Methylcholanthrene results in increased expression of LGALS2 mRNA

NCBI chr15:78,735,060...78,739,729
Ensembl chr15:78,735,060...78,739,729

G

lectin, galactose binding, soluble 3

increases expression

Methylcholanthrene results in increased expression of LGALS3 mRNA

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

G

lectin, galactose binding, soluble 8

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LGALS8 promoter]

NCBI chr13:12,454,283...12,479,857
Ensembl chr13:12,454,296...12,479,825

G

leucine-rich repeat LGI family, member 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LGI1 promoter]

NCBI chr19:38,253,135...38,297,387
Ensembl chr19:38,252,984...38,300,662

G

leukemia inhibitory factor

increases expression
multiple interactions

Methylcholanthrene results in increased expression of LIF mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to LIF promoter]

PMID:20348232 PMID:20713471

NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514

G

LIM domain and actin binding 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LIMA1 promoter]

NCBI chr15:99,676,351...99,773,292
Ensembl chr15:99,676,351...99,773,337

G

lamin B1

increases expression

Methylcholanthrene results in increased expression of LMNB1 mRNA

NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496

G

lemur tyrosine kinase 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of LMTK2 mRNA

NCBI chr 5:144,037,179...144,125,026
Ensembl chr 5:144,037,254...144,125,022

G

lysyl oxidase

decreases expression

Methylcholanthrene results in decreased expression of LOX mRNA

NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939

G

low density lipoprotein receptor-related protein 11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LRP11 promoter]

NCBI chr10:7,465,532...7,501,247
Ensembl chr10:7,465,564...7,501,247

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leucine rich repeat protein 1

increases expression

Methylcholanthrene results in increased expression of LRR1 mRNA

NCBI chr12:69,215,588...69,225,786
Ensembl chr12:69,215,588...69,225,783

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leucine rich repeat containing 8D

increases expression

Methylcholanthrene results in increased expression of LRRC8D mRNA

NCBI chr 5:105,847,829...105,963,081
Ensembl chr 5:105,847,835...105,980,302

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LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Methylcholanthrene results in increased expression of LSM4 mRNA

NCBI chr 8:71,124,663...71,131,402
Ensembl chr 8:71,125,898...71,131,402

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LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LSM5 promoter]

NCBI chr 6:56,678,048...56,681,684
Ensembl chr 6:56,678,048...56,681,695

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LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Methylcholanthrene results in increased expression of LSM6 mRNA

NCBI chr 8:79,531,497...79,547,781
Ensembl chr 8:79,531,494...79,547,769

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latent transforming growth factor beta binding protein 1

increases expression

Methylcholanthrene results in increased expression of LTBP1 mRNA

NCBI chr17:75,312,475...75,699,507
Ensembl chr17:75,312,563...75,699,507

G

lumican

decreases expression

Methylcholanthrene results in decreased expression of LUM mRNA

NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565

G

lymphocyte antigen 6 family member A

increases expression

Methylcholanthrene results in increased expression of LY6A mRNA

NCBI chr15:74,866,726...74,869,880
Ensembl chr15:74,866,726...74,869,880

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lymphocyte antigen 6 family member E

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LY6E promoter]

NCBI chr15:74,826,874...74,831,753
Ensembl chr15:74,826,900...74,831,752

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MAD1 mitotic arrest deficient 1-like 1

increases expression

Methylcholanthrene results in increased expression of MAD1L1 mRNA

NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307

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membrane associated guanylate kinase, WW and PDZ domain containing 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MAGI1 mRNA

NCBI chr 6:93,652,434...94,260,906
Ensembl chr 6:93,652,436...94,260,898

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metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)

decreases expression

Methylcholanthrene results in decreased expression of MALAT1 mRNA

NCBI chr19:5,845,718...5,852,700
Ensembl chr19:5,845,717...5,852,706

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mitogen-activated protein kinase kinase 1

increases expression

Methylcholanthrene results in increased expression of MAP2K1 mRNA

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

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mitogen-activated protein kinase kinase 3

increases expression

Methylcholanthrene results in increased expression of MAP2K3 mRNA

NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637

G

mitogen-activated protein kinase 1

increases expression

Methylcholanthrene results in increased expression of MAPK1 mRNA

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 8

multiple interactions

Methylcholanthrene results in increased phosphorylation of and results in increased activity of MAPK8 protein

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

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mitogen-activated protein kinase associated protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MAPKAP1 promoter]

NCBI chr 2:34,296,783...34,514,970
Ensembl chr 2:34,296,783...34,514,962

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myristoylated alanine rich protein kinase C substrate

decreases expression

Methylcholanthrene results in decreased expression of MARCKS mRNA

NCBI chr10:37,009,239...37,014,922
Ensembl chr10:37,009,371...37,014,916

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microtubule associated serine/threonine kinase-like

increases expression

Methylcholanthrene results in increased expression of MASTL mRNA

NCBI chr 2:23,006,549...23,046,036
Ensembl chr 2:23,005,618...23,046,036

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methionine adenosyltransferase 1A

decreases expression

Methylcholanthrene results in decreased expression of MAT1A mRNA

NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369

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matrilin 2

decreases expression

Methylcholanthrene results in decreased expression of MATN2 mRNA

NCBI chr15:34,306,827...34,436,388
Ensembl chr15:34,306,823...34,436,419

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muscleblind like splicing regulator 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MBNL1 promoter]

NCBI chr 3:60,380,209...60,537,171
Ensembl chr 3:60,380,251...60,537,171

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minichromosome maintenance 10 replication initiation factor

increases expression

Methylcholanthrene results in increased expression of MCM10 mRNA

NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602

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minichromosome maintenance complex component 3

increases expression

Methylcholanthrene results in increased expression of MCM3 mRNA

NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536

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minichromosome maintenance complex component 4

increases expression

Methylcholanthrene results in increased expression of MCM4 mRNA

NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264

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minichromosome maintenance complex component 5

increases expression

Methylcholanthrene results in increased expression of MCM5 mRNA

NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067

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minichromosome maintenance complex component 6

increases expression

Methylcholanthrene results in increased expression of MCM6 mRNA

NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401

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mediator complex subunit 13-like

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MED13L promoter]

NCBI chr 5:118,698,363...118,903,503
Ensembl chr 5:118,698,744...118,903,503

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maternal embryonic leucine zipper kinase

increases expression

Methylcholanthrene results in increased expression of MELK mRNA

NCBI chr 4:44,300,876...44,364,301
Ensembl chr 4:44,300,876...44,364,675

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mesoderm posterior 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MESP1 promoter]

NCBI chr 7:79,441,989...79,443,338
Ensembl chr 7:79,441,989...79,443,536

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microfibrillar-associated protein 3-like

increases expression

Methylcholanthrene results in increased expression of MFAP3L mRNA

NCBI chr 8:61,085,859...61,129,765
Ensembl chr 8:61,085,861...61,129,763

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microsomal glutathione S-transferase 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MGST2 promoter]

NCBI chr 3:51,544,179...51,590,096
Ensembl chr 3:51,567,781...51,590,098

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midline 1

decreases expression

Methylcholanthrene results in decreased expression of MID1 mRNA

NCBI chr X:168,468,178...168,773,692
Ensembl chr X:168,468,195...168,773,794

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mitotic deacetylase associated SANT domain protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MIDEAS promoter]

NCBI chr12:84,195,942...84,265,679
Ensembl chr12:84,195,950...84,265,655

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microRNA 101b

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR101B mRNA

NCBI chr19:29,112,679...29,112,775
Ensembl chr19:29,112,679...29,112,775

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microRNA 122

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR122 mRNA

NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997

G

microRNA 130a

affects expression

Methylcholanthrene affects the expression of MIR130A mRNA

NCBI chr 2:84,571,459...84,571,522
Ensembl chr 2:84,571,459...84,571,522

G

microRNA 130b

decreases expression

Methylcholanthrene results in decreased expression of MIR130B mRNA

NCBI chr16:16,941,925...16,942,006
Ensembl chr16:16,941,925...16,942,006

G

microRNA 144

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR144 mRNA

NCBI chr11:77,963,831...77,963,896
Ensembl chr11:77,963,831...77,963,896

G

microRNA 145a

decreases expression

Methylcholanthrene results in decreased expression of MIR145A mRNA

NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965

G

microRNA 15a

increases expression
multiple interactions

Methylcholanthrene results in increased expression of MIR15A mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR15A mRNA

NCBI chr14:61,869,476...61,869,559
Ensembl chr14:61,869,476...61,869,559

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microRNA 18b

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR18B mRNA

NCBI chr X:51,831,208...51,831,290
Ensembl chr X:51,831,208...51,831,290

G

microRNA 191

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR191 mRNA

NCBI chr 9:108,445,518...108,445,591
Ensembl chr 9:108,445,518...108,445,591

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microRNA 19a

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR19A mRNA

NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513

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microRNA 203

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR203 mRNA

NCBI chr12:112,097,314...112,097,389
Ensembl chr12:112,097,314...112,097,389

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microRNA 206

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR206 mRNA

NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306

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microRNA 210

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR210 mRNA

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

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microRNA 211

decreases expression

Methylcholanthrene results in decreased expression of MIR211 mRNA

NCBI chr 7:63,855,554...63,855,659
Ensembl chr 7:63,855,554...63,855,659

G

microRNA 2137

increases expression

Methylcholanthrene results in increased expression of MIR2137 mRNA

NCBI chr X:72,035,685...72,035,750
Ensembl chr X:72,035,685...72,035,750

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microRNA 29c

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR29C mRNA

NCBI chr 1:194,719,855...194,719,942
Ensembl chr 1:194,719,855...194,719,942

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microRNA 3090

decreases expression

Methylcholanthrene results in decreased expression of MIR3090 mRNA

NCBI chr 2:133,406,628...133,406,714
Ensembl chr 2:133,406,628...133,406,714

G

microRNA 3102

multiple interactions
decreases expression

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR3102 mRNA
Methylcholanthrene results in decreased expression of MIR3102 mRNA

NCBI chr 7:100,531,513...100,531,616
Ensembl chr 7:100,531,513...100,531,616

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microRNA 32

multiple interactions
decreases expression

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR32 mRNA
Methylcholanthrene results in decreased expression of MIR32 mRNA

NCBI chr 4:56,895,229...56,895,298
Ensembl chr 4:56,895,229...56,895,298

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microRNA 340

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR340 mRNA

NCBI chr11:49,960,529...49,960,626
Ensembl chr11:49,960,529...49,960,626

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microRNA 345

affects expression
multiple interactions

Methylcholanthrene affects the expression of MIR345 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR345 mRNA

NCBI chr12:108,802,899...108,802,994
Ensembl chr12:108,802,899...108,802,994

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microRNA 362

increases expression

Methylcholanthrene results in increased expression of MIR362 mRNA

NCBI chr X:7,108,221...7,108,285
Ensembl chr X:7,108,221...7,108,285

G

microRNA 425

decreases expression

Methylcholanthrene results in decreased expression of MIR425 mRNA

NCBI chr 9:108,445,976...108,446,060
Ensembl chr 9:108,445,976...108,446,060

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microRNA 449a

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR449A mRNA

NCBI chr13:113,174,068...113,174,158
Ensembl chr13:113,174,068...113,174,158

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microRNA 466g

increases expression

Methylcholanthrene results in increased expression of MIR466G mRNA

NCBI chr 2:10,519,406...10,519,485
Ensembl chr 2:10,519,406...10,519,485

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microRNA 466o

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR466O mRNA

NCBI chr 2:10,477,351...10,477,434
Ensembl chr 2:10,477,351...10,477,434

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microRNA 497

increases expression

Methylcholanthrene results in increased expression of MIR497 mRNA

NCBI chr11:70,125,543...70,125,626
Ensembl chr11:70,125,543...70,125,626

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microRNA 5099

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR5099 mRNA

NCBI chr12:36,866,204...36,866,277
Ensembl chr12:36,866,204...36,866,277

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microRNA 5112

multiple interactions
increases expression

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR5112 mRNA
Methylcholanthrene results in increased expression of MIR5112 mRNA

NCBI chr18:82,738,406...82,738,465
Ensembl chr18:82,738,406...82,738,465

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microRNA 5119

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR5119 mRNA

NCBI chr11:98,153,432...98,153,488
Ensembl chr11:98,153,432...98,153,488

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microRNA 5121

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR5121 mRNA

NCBI chr 7:44,776,342...44,776,415
Ensembl chr 7:44,776,342...44,776,415

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microRNA 5131

increases expression
multiple interactions

Methylcholanthrene results in increased expression of MIR5131 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR5131 mRNA

NCBI chr14:45,895,418...45,895,510
Ensembl chr14:45,895,418...45,895,510

G

microRNA 5132

decreases expression

Methylcholanthrene results in decreased expression of MIR5132 mRNA

NCBI chr X:73,067,134...73,067,204
Ensembl chr X:73,067,134...73,067,204

G

microRNA 574

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR574 mRNA

NCBI chr 5:65,127,661...65,127,738
Ensembl chr 5:65,127,661...65,127,738

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microRNA 6238

decreases expression

Methylcholanthrene results in decreased expression of MIR6238 mRNA

NCBI chr 7:53,541,509...53,541,637
Ensembl chr 7:53,541,509...53,541,637

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microRNA 6348

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR6348 mRNA

NCBI chr 1:168,318,212...168,318,331
Ensembl chr 1:168,318,212...168,318,331

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microRNA 669c

decreases expression

Methylcholanthrene results in decreased expression of MIR669C mRNA

NCBI chr 2:10,514,107...10,514,215
Ensembl chr 2:10,514,107...10,514,215

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microRNA 669k

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR669K mRNA

NCBI chr 2:10,480,111...10,480,237
Ensembl chr 2:10,480,111...10,480,237

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microRNA 672

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR672 mRNA

NCBI chr X:103,159,781...103,159,880
Ensembl chr X:103,159,781...103,159,880

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microRNA 92-2

decreases expression

Methylcholanthrene results in decreased expression of MIR92-2 mRNA

NCBI chr X:51,830,715...51,830,805
Ensembl chr X:51,830,715...51,830,805

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antigen identified by monoclonal antibody Ki 67

increases expression
multiple interactions

Methylcholanthrene results in increased expression of MKI67 mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of MKI67 mRNA]; Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of MKI67 protein]

PMID:20713471 PMID:26372666

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

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myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MLLT6 promoter]

NCBI chr11:97,553,948...97,576,287
Ensembl chr11:97,554,240...97,576,289

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melanophilin

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MLPH promoter]

NCBI chr 1:90,842,750...90,878,864
Ensembl chr 1:90,842,807...90,878,864

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matrix metallopeptidase 13

increases expression
decreases expression

Methylcholanthrene results in increased expression of MMP13 mRNA
Methylcholanthrene results in decreased expression of MMP13 mRNA

PMID:20713471 PMID:29554273

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

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matrix metallopeptidase 1b (interstitial collagenase)

increases expression

Methylcholanthrene results in increased expression of MMP1 mRNA

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

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matrix metallopeptidase 2

multiple interactions

[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of MMP2 mRNA; [Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

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matrix metallopeptidase 3

increases expression

Methylcholanthrene results in increased expression of MMP3 mRNA

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

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matrix metallopeptidase 9

multiple interactions
decreases expression

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MMP9 mRNA
Methylcholanthrene results in decreased expression of MMP9 mRNA

PMID:23519560 PMID:29554273

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

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mannose phosphate isomerase

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MPI promoter]

NCBI chr 9:57,448,744...57,460,095
Ensembl chr 9:57,451,539...57,460,046

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myeloproliferative leukemia virus oncogene

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MPL mRNA

NCBI chr 4:118,299,609...118,314,771
Ensembl chr 4:118,299,612...118,314,710

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myocardin related transcription factor B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MRTFB promoter]

NCBI chr16:13,073,913...13,235,393
Ensembl chr16:13,074,345...13,235,393

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membrane-spanning 4-domains, subfamily A, member 7

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MS4A7 promoter]

NCBI chr19:11,298,403...11,313,510
Ensembl chr19:11,298,403...11,313,510

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mutS homolog 4

decreases expression

Methylcholanthrene results in decreased expression of MSH4 mRNA

NCBI chr 3:153,562,783...153,611,495
Ensembl chr 3:153,562,786...153,611,775

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mutS homolog 5

decreases expression

Methylcholanthrene results in decreased expression of MSH5 mRNA

NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721

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mesothelin

increases expression

Methylcholanthrene results in increased expression of MSLN mRNA

NCBI chr17:25,967,587...25,973,352
Ensembl chr17:25,967,587...25,973,352

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beta-microseminoprotein

multiple interactions
increases expression
affects binding

Methylcholanthrene promotes the reaction [AHR protein binds to MSMB promoter]
Methylcholanthrene results in increased expression of MSMB mRNA
Methylcholanthrene binds to MSMB protein

PMID:3940634 PMID:20348232

NCBI chr14:31,863,980...31,880,284
Ensembl chr14:31,863,980...31,880,327

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methylsterol monoxygenase 1

decreases expression

Methylcholanthrene results in decreased expression of MSMO1 mRNA

NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826

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metallothionein 2

multiple interactions
increases expression

AHR protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]; Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]; NR3C1 protein affects the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

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MTCL family member 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MTCL3 promoter]

NCBI chr10:29,019,992...29,075,626
Ensembl chr10:29,019,835...29,075,626

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methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MTHFD2 mRNA

NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890

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major urinary protein 2

multiple interactions
decreases expression

POR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of MUP2 mRNA]

PMID:22978700 PMID:23169610

NCBI chr 4:60,135,913...60,139,977
Ensembl chr 4:60,135,932...60,154,289

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MX dynamin-like GTPase 2

decreases expression

Methylcholanthrene results in decreased expression of MX2 mRNA

NCBI chr16:97,337,281...97,362,101
Ensembl chr16:97,336,508...97,362,100

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myeloblastosis oncogene-like 1

affects expression

Methylcholanthrene affects the expression of MYBL1 mRNA

NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434

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myeloblastosis oncogene-like 2

decreases expression

Methylcholanthrene results in decreased expression of MYBL2 mRNA

NCBI chr 2:162,896,246...162,926,608
Ensembl chr 2:162,896,607...162,926,608

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myosin, heavy polypeptide 7, cardiac muscle, beta

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MYH7 mRNA

NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083

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myosin, light polypeptide 9, regulatory

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of MYL9 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MYL9 mRNA

PMID:20713471 PMID:25926378

NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578

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myosin, light polypeptide kinase

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MYLK mRNA

NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790

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myosin ID

decreases expression

Methylcholanthrene results in decreased expression of MYO1D mRNA

NCBI chr11:80,372,945...80,670,881
Ensembl chr11:80,372,952...80,670,851

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myosin VIIA

decreases expression

Methylcholanthrene results in decreased expression of MYO7A mRNA

NCBI chr 7:97,700,261...97,768,730
Ensembl chr 7:97,700,267...97,768,731

G

myoferlin

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MYOF promoter]

NCBI chr19:37,887,484...38,032,025
Ensembl chr19:37,887,484...38,032,025

G

myomesin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MYOM2 promoter]

NCBI chr 8:15,107,653...15,183,410
Ensembl chr 8:15,107,653...15,183,541

G

nuclear autoantigenic sperm protein (histone-binding)

increases expression

Methylcholanthrene results in increased expression of NASP mRNA

NCBI chr 4:116,458,249...116,488,894
Ensembl chr 4:116,458,249...116,485,138

G

neural cell adhesion molecule 1

decreases expression

Methylcholanthrene results in decreased expression of NCAM1 mRNA

NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225

G

non-SMC condensin II complex, subunit G2

increases expression

Methylcholanthrene results in increased expression of NCAPG2 mRNA

NCBI chr12:116,368,969...116,427,152
Ensembl chr12:116,369,022...116,427,351

G

non-SMC condensin I complex, subunit H

increases expression

Methylcholanthrene results in increased expression of NCAPH mRNA

NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874

G

neutrophil cytosolic factor 1

increases expression

Methylcholanthrene results in increased expression of NCF1 mRNA

NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479

G

non-catalytic region of tyrosine kinase adaptor protein 2

decreases expression

Methylcholanthrene results in decreased expression of NCK2 mRNA

NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675

G

NDC80 kinetochore complex component

decreases expression
increases expression

Methylcholanthrene results in decreased expression of NDC80 mRNA
Methylcholanthrene results in increased expression of NDC80 mRNA

PMID:20713471 PMID:22579512

NCBI chr17:71,803,095...71,833,852
Ensembl chr17:71,803,095...71,833,852

G

N-myc downstream regulated gene 4

increases expression

Methylcholanthrene results in increased expression of NDRG4 mRNA

NCBI chr 8:96,403,602...96,441,584
Ensembl chr 8:96,403,608...96,441,747

G

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NDST1 promoter]

NCBI chr18:60,817,566...60,907,465
Ensembl chr18:60,817,566...60,881,722

G

neural precursor cell expressed, developmentally down-regulated gene 9

increases expression

Methylcholanthrene results in increased expression of NEDD9 mRNA

NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838

G

NIMA (never in mitosis gene a)-related expressed kinase 2

increases expression

Methylcholanthrene results in increased expression of NEK2 mRNA

NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162

G

negative elongation factor complex member C/D, Th1l

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NELFCD promoter]

NCBI chr 2:174,257,623...174,269,298
Ensembl chr 2:174,257,597...174,269,295

G

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

decreases expression

Methylcholanthrene results in decreased expression of NFATC2 mRNA

NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577

G

nuclear factor, erythroid derived 2, like 2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of NFE2L2 mRNA; Methylcholanthrene results in increased expression of NFE2L2 protein
NFE2L2 protein affects the reaction [Methylcholanthrene results in increased expression of PSMB5 mRNA]
Methylcholanthrene promotes the reaction [AHR protein binds to NFE2L2 promoter]

PMID:16723119 PMID:20348232 PMID:20713471 PMID:23712962

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

increases expression

Methylcholanthrene results in increased expression of NFKBIA mRNA

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

increases expression

Methylcholanthrene results in increased expression of NFKBIZ mRNA

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

G

nuclear transcription factor-Y alpha

multiple interactions
increases activity

Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]
Methylcholanthrene results in increased activity of NFYA protein

NCBI chr17:48,693,917...48,716,782
Ensembl chr17:48,693,913...48,716,934

G

nerve growth factor

increases expression
multiple interactions

Methylcholanthrene results in increased expression of NGF mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NGF mRNA

PMID:20713471 PMID:23519560

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

NHERF family PDZ scaffold protein 2

decreases expression

Methylcholanthrene results in decreased expression of NHERF2 mRNA

NCBI chr17:24,858,255...24,869,279
Ensembl chr17:24,858,260...24,869,301

G

niban apoptosis regulator 1

increases expression

Methylcholanthrene results in increased expression of NIBAN1 mRNA

NCBI chr 1:151,447,215...151,597,690
Ensembl chr 1:151,446,937...151,597,690

G

naked cuticle 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NKD2 mRNA

NCBI chr13:73,966,653...73,995,750
Ensembl chr13:73,966,653...73,995,750

G

NmrA-like family domain containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NMRAL1 promoter]

NCBI chr16:4,529,181...4,537,220
Ensembl chr16:4,527,923...4,537,220

G

NOP58 ribonucleoprotein

increases expression

Methylcholanthrene results in increased expression of NOL5 mRNA

NCBI chr 1:59,724,165...59,751,352
Ensembl chr 1:59,724,130...59,758,203

G

notch 2

increases methylation
decreases acetylation
increases expression
multiple interactions

Methylcholanthrene results in increased methylation of NOTCH2 promoter
Methylcholanthrene results in decreased acetylation of NOTCH2 promoter
Methylcholanthrene results in increased expression of NOTCH2 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of NOTCH2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of NOTCH2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of NOTCH2 promoter]

NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677

G

natriuretic peptide type A

increases expression

3-methylcholanthrene increases expression of mRNA in rat heart

RGD

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

increases expression

3-methylcholanthrene increases expression of mRNA in rat heart

RGD

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases activity
increases expression

Arsenic promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Chromium inhibits the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Chromium inhibits the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]
[protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]; Methylcholanthrene results in increased expression of and results in increased activity of NQO1 protein
Methylcholanthrene results in increased expression of NQO1 mRNA; Methylcholanthrene results in increased expression of NQO1 protein

PMID:4005852 PMID:11323195 PMID:12206817 PMID:15302093 PMID:15337587 More...

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

N-ribosyldihydronicotinamide quinone reductase 2

increases expression

Methylcholanthrene results in increased expression of NQO2 mRNA

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Methylcholanthrene results in increased expression of NR0B2 mRNA

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Methylcholanthrene results in increased expression of NR1H3 mRNA

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 1, group I, member 3

increases expression
affects expression

Methylcholanthrene results in increased expression of NR1I3 mRNA
Methylcholanthrene affects the expression of NR1I3 mRNA

PMID:19118567 PMID:23273579

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

nuclear receptor subfamily 3, group C, member 1

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of NR3C1 protein
[NR3C1 protein co-treated with Dexamethasone] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [NR3C1 protein co-treated with Dexamethasone] results in decreased susceptibility to Methylcholanthrene; NR3C1 protein affects the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]

PMID:1638671 PMID:23994556 PMID:24091107

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Methylcholanthrene results in decreased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

neuronal regeneration related protein

decreases expression

Methylcholanthrene results in decreased expression of NREP mRNA

NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082

G

neuritin 1

increases expression

Methylcholanthrene results in increased expression of NRN1 mRNA

NCBI chr13:36,909,596...36,918,451
Ensembl chr13:36,909,335...36,919,105

G

neurexin II

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NRXN2 mRNA

NCBI chr19:6,468,786...6,583,247
Ensembl chr19:6,468,761...6,594,199

G

NAD(P) dependent steroid dehydrogenase-like

decreases expression

Methylcholanthrene results in decreased expression of NSDHL mRNA

NCBI chr X:71,962,127...72,002,134
Ensembl chr X:71,962,163...72,002,120

G

nudix hydrolase 21

increases expression

Methylcholanthrene results in increased expression of NUDT21 mRNA

NCBI chr 8:94,746,031...94,763,667
Ensembl chr 8:94,742,124...94,763,659

G

nucleolar and spindle associated protein 1

increases expression

Methylcholanthrene results in increased expression of NUSAP1 mRNA

NCBI chr 2:119,449,205...119,480,646
Ensembl chr 2:119,448,779...119,481,725

G

nucleoredoxin

decreases expression

Methylcholanthrene results in decreased expression of NXN mRNA

NCBI chr11:76,148,052...76,289,967
Ensembl chr11:76,148,024...76,289,966

G

nuclear transport factor 2-like export factor 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NXT2 promoter]

NCBI chr X:141,009,766...141,022,696
Ensembl chr X:141,009,766...141,022,688

G

2'-5' oligoadenylate synthetase 1A

decreases expression

Methylcholanthrene results in decreased expression of OAS1A mRNA

NCBI chr 5:121,034,319...121,045,588
Ensembl chr 5:121,034,319...121,045,584

G

osteoglycin

decreases expression

Methylcholanthrene results in decreased expression of OGN mRNA

NCBI chr13:49,761,491...49,777,977
Ensembl chr13:49,761,522...49,777,977

G

Opa interacting protein 5

increases expression

Methylcholanthrene results in increased expression of OIP5 mRNA

NCBI chr 2:119,440,013...119,448,986
Ensembl chr 2:119,439,993...119,448,950

G

olfactomedin 1

increases expression

Methylcholanthrene results in increased expression of OLFM1 mRNA

NCBI chr 2:28,083,105...28,120,748
Ensembl chr 2:28,083,004...28,120,748

G

olfactory receptor family 11 subfamily H member 4B

decreases expression

Methylcholanthrene results in decreased expression of OR11H4 mRNA

NCBI chr14:50,918,148...50,919,102
Ensembl chr14:50,918,114...50,930,663

G

olfactory receptor family 13 subfamily A member 18

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of OR13A18 mRNA

NCBI chr 7:140,181,253...140,191,037
Ensembl chr 7:140,181,182...140,197,591

G

olfactory receptor family 4 subfamily D member 5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of OR4D5 mRNA

NCBI chr 9:40,011,840...40,012,784
Ensembl chr 9:40,007,811...40,025,502

G

olfactory receptor family 6 subfamily S member 1

decreases expression

Methylcholanthrene results in decreased expression of OR6S1 mRNA

NCBI chr14:51,307,768...51,308,899
Ensembl chr14:51,303,758...51,311,892

G

olfactory receptor family 8 subfamily J member 3C

increases expression

Methylcholanthrene results in increased expression of OR8J3C mRNA

NCBI chr 2:86,253,063...86,254,018
Ensembl chr 2:86,250,743...86,257,093

G

oxysterol binding protein-like 10

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to OSBPL10 promoter]

NCBI chr 9:114,807,531...115,062,341
Ensembl chr 9:114,807,637...115,061,293

G

odd-skipped related 2

decreases expression

Methylcholanthrene results in decreased expression of OSR2 mRNA

NCBI chr15:35,296,244...35,303,451
Ensembl chr15:35,296,244...35,303,451

G

OTU domain, ubiquitin aldehyde binding 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to OTUB2 promoter]

NCBI chr12:103,343,244...103,372,609
Ensembl chr12:103,354,941...103,372,609

G

OTU deubiquitinase with linear linkage specificity like

increases expression

Methylcholanthrene results in increased expression of OTULINL mRNA

NCBI chr15:27,655,154...27,681,630
Ensembl chr15:27,655,155...27,681,665

G

purinergic receptor P2X, ligand-gated ion channel, 7

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of P2RX7 mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of P2RX7 mRNA

PMID:20713471 PMID:23519560

NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495

G

purinergic receptor P2Y, G-protein coupled 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of P2RY1 mRNA

NCBI chr 3:60,910,206...60,916,403
Ensembl chr 3:60,910,216...60,916,403

G

phenylalanine hydroxylase

decreases expression

Methylcholanthrene results in decreased expression of PAH mRNA

NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998

G

p21 (RAC1) activated kinase 6

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PAK6 mRNA

NCBI chr 2:118,493,531...118,528,501
Ensembl chr 2:118,493,784...118,528,501

G

protein associated with LIN7 2, MAGUK family member

increases expression

Methylcholanthrene results in increased expression of PALS2 mRNA

NCBI chr 6:50,087,206...50,176,134
Ensembl chr 6:50,087,221...50,175,919

G

par-6 family cell polarity regulator beta

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of PARD6B mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PARD6B mRNA

PMID:20713471 PMID:23519560

NCBI chr 2:167,922,924...167,943,123
Ensembl chr 2:167,922,924...167,943,123

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

Methylcholanthrene inhibits the reaction [3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

PAX3 and PAX7 binding protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PAXBP1 promoter]

NCBI chr16:90,810,925...90,841,267
Ensembl chr16:90,810,925...90,841,431

G

PDZ binding kinase

increases expression

Methylcholanthrene results in increased expression of PBK mRNA

NCBI chr14:66,043,337...66,055,271
Ensembl chr14:66,043,286...66,055,271

G

protocadherin 18

decreases expression

Methylcholanthrene results in decreased expression of PCDH18 mRNA

NCBI chr 3:49,697,745...49,711,723
Ensembl chr 3:49,697,745...49,711,774

G

protocadherin 7

decreases expression

Methylcholanthrene results in decreased expression of PCDH7 mRNA

NCBI chr 5:57,873,487...58,290,578
Ensembl chr 5:57,875,309...58,290,572

G

protocadherin beta 9

decreases expression

Methylcholanthrene results in decreased expression of PCDHB9 mRNA

NCBI chr18:37,533,908...37,536,962
Ensembl chr18:37,533,908...37,536,962

G

phosphoenolpyruvate carboxykinase 1, cytosolic

decreases expression

Methylcholanthrene results in decreased expression of PCK1 mRNA

NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066

G

procollagen C-endopeptidase enhancer 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PCOLCE2 promoter]

NCBI chr 9:95,519,681...95,577,604
Ensembl chr 9:95,519,654...95,580,149

G

programmed cell death 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PDCD4 promoter]

NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291

G

phosphodiesterase 1B, Ca2+-calmodulin dependent

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDE1B mRNA

NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479

G

PDZ and LIM domain 5

decreases expression

Methylcholanthrene results in decreased expression of PDLIM5 mRNA

NCBI chr 3:141,945,346...142,101,480
Ensembl chr 3:141,945,351...142,101,454

G

PDZ domain containing 8

increases expression

Methylcholanthrene results in increased expression of PDZD8 mRNA

NCBI chr19:59,284,516...59,334,212
Ensembl chr19:59,285,610...59,334,212

G

pellino 2

increases expression

Methylcholanthrene results in increased expression of PELI2 mRNA

NCBI chr14:48,358,096...48,519,035
Ensembl chr14:48,358,280...48,519,032

G

platelet factor 4

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PF4 mRNA

NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242

G

phosphoglycerate kinase 2

decreases expression

Methylcholanthrene results in decreased expression of PGK2 mRNA

NCBI chr17:40,517,909...40,519,500
Ensembl chr17:40,517,906...40,519,531

G

progesterone receptor

increases expression
multiple interactions

Methylcholanthrene results in increased expression of PGR mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of PGR protein]

PMID:16257430 PMID:26372666

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

phosphatase and actin regulator 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PHACTR1 promoter]

NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002

G

phosphate regulating endopeptidase homolog, X-linked

increases expression

Methylcholanthrene results in increased expression of PHEX mRNA

NCBI chr X:155,945,071...156,198,282
Ensembl chr X:155,945,071...156,198,308

G

phosphorylase kinase alpha 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PHKA2 mRNA

NCBI chr X:159,284,900...159,384,772
Ensembl chr X:159,285,162...159,381,874

G

phosphatidylinositol glycan anchor biosynthesis, class P

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PIGP promoter]

NCBI chr16:94,159,622...94,171,874
Ensembl chr16:94,159,622...94,172,701

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PIK3CB mRNA

NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PIK3CD mRNA

NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter]

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

phosphoinositide-3-kinase regulatory subunit 5

increases expression

Methylcholanthrene results in increased expression of PIK3R5 mRNA

NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675

G

proviral integration site 2

increases expression

Methylcholanthrene results in increased expression of PIM2 mRNA

NCBI chr X:7,744,545...7,749,671
Ensembl chr X:7,744,501...7,749,671

G

Pbx/knotted 1 homeobox 2

decreases expression

Methylcholanthrene results in decreased expression of PKNOX2 mRNA

NCBI chr 9:36,802,278...37,058,637
Ensembl chr 9:36,802,278...37,058,703

G

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

increases expression

Methylcholanthrene results in increased expression of PLA2G7 mRNA

NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092

G

plasminogen activator, urokinase

increases expression

Methylcholanthrene results in increased expression of PLAU mRNA

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

phospholipase C, gamma 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PLCG2 mRNA

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

G

pleckstrin homology domain containing, family A member 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PLEKHA6 promoter]

NCBI chr 1:133,089,770...133,231,173
Ensembl chr 1:133,091,948...133,231,173

G

pleckstrin homology domain containing, family G (with RhoGef domain) member 2

decreases expression

Methylcholanthrene results in decreased expression of PLEKHG2 mRNA

NCBI chr 7:28,059,028...28,072,818
Ensembl chr 7:28,059,029...28,072,024

G

polo like kinase 3

increases expression

Methylcholanthrene results in increased expression of PLK3 mRNA

NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160

G

polo like kinase 4

increases expression

Methylcholanthrene results in increased expression of PLK4 mRNA

NCBI chr 3:40,754,463...40,771,318
Ensembl chr 3:40,754,454...40,771,318

G

phospholipid phosphatase 3

decreases expression

Methylcholanthrene results in decreased expression of PLPP3 mRNA

NCBI chr 4:105,014,544...105,089,964
Ensembl chr 4:105,014,544...105,089,961

G

pogo transposable element with ZNF domain

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to POGZ promoter]

NCBI chr 3:94,730,289...94,790,888
Ensembl chr 3:94,744,878...94,789,637

G

polymerase (DNA directed), alpha 1

increases expression

Methylcholanthrene results in increased expression of POLA1 mRNA

NCBI chr X:92,348,372...92,675,993
Ensembl chr X:92,348,373...92,675,761

G

polymerase (DNA directed), epsilon 2 (p59 subunit)

increases expression

Methylcholanthrene results in increased expression of POLE2 mRNA

NCBI chr12:69,248,547...69,274,979
Ensembl chr12:69,248,547...69,274,969

G

polymerase (DNA directed), kappa

increases expression

Methylcholanthrene results in increased expression of POLK mRNA; Methylcholanthrene results in increased expression of POLK protein

NCBI chr13:96,617,195...96,679,087
Ensembl chr13:96,617,198...96,679,087

G

paraoxonase 1

multiple interactions
increases activity
increases expression

7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA]
Methylcholanthrene results in increased activity of PON1 protein
Methylcholanthrene results in increased expression of PON1 protein

PMID:11551529 PMID:15169886 PMID:26006071

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

paraoxonase 3

increases expression

Methylcholanthrene results in increased expression of PON3 mRNA

NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286

G

cytochrome p450 oxidoreductase

increases activity
multiple interactions
increases expression
decreases activity

Methylcholanthrene results in increased activity of POR protein
Methylcholanthrene inhibits the reaction [POR gene mutant form results in decreased expression of CYP3A11 mRNA]; Methylcholanthrene results in increased expression of and results in increased activity of POR protein; POR gene mutant form inhibits the reaction [Methylcholanthrene affects the expression of CYP2D9 protein]; POR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of MUP2 mRNA]; POR gene mutant form inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]
Methylcholanthrene results in increased expression of POR mRNA
sanguinarine promotes the reaction [Methylcholanthrene results in decreased activity of POR protein]

PMID:19788401 PMID:22978700 PMID:23169610 PMID:23846873

NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180

G

periostin, osteoblast specific factor

decreases expression

Methylcholanthrene results in decreased expression of POSTN mRNA

NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458

G

peroxisome proliferator activated receptor alpha

increases expression

Methylcholanthrene results in increased expression of PPARA mRNA

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

pro-platelet basic protein

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PPBP mRNA

NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922

G

peptidyl prolyl isomerase H

increases expression

Methylcholanthrene results in increased expression of PPIH mRNA

NCBI chr 4:119,157,207...119,177,720
Ensembl chr 4:119,157,207...119,177,743

G

protein phosphatase 1D magnesium-dependent, delta isoform

increases expression

Methylcholanthrene results in increased expression of PPM1D mRNA

NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892

G

protein phosphatase 4, regulatory subunit 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PPP4R2 mRNA

NCBI chr 6:100,810,596...100,846,891
Ensembl chr 6:100,810,583...100,846,895

G

protein regulator of cytokinesis 1

increases expression

Methylcholanthrene results in increased expression of PRC1 mRNA

NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007

G

PR domain containing 9

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PRDM9 mRNA

NCBI chr17:15,763,334...15,784,636
Ensembl chr17:15,763,341...15,784,616

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PREX1 mRNA

NCBI chr 2:166,408,265...166,555,752
Ensembl chr 2:166,408,262...166,555,752

G

prickle planar cell polarity protein 2

decreases expression

Methylcholanthrene results in decreased expression of PRICKLE2 mRNA

NCBI chr 6:92,347,876...92,683,233
Ensembl chr 6:92,347,889...92,683,136

G

protein kinase, AMP-activated, beta 1 non-catalytic subunit

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB1 promoter]

NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567

G

protein kinase, AMP-activated, beta 2 non-catalytic subunit

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB2 promoter]

NCBI chr 3:97,565,527...97,581,128
Ensembl chr 3:97,565,509...97,581,128

G

protein kinase D3

decreases expression

Methylcholanthrene results in decreased expression of PRKD3 mRNA

NCBI chr17:79,256,834...79,328,245
Ensembl chr17:79,256,834...79,328,245

G

phosphoribosyl pyrophosphate synthetase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PRPS1 promoter]

NCBI chr X:139,357,352...139,376,889
Ensembl chr X:139,357,362...139,376,889

G

proteasome (prosome, macropain) subunit, beta type 5

increases activity
increases expression
multiple interactions

Methylcholanthrene results in increased activity of PSMB5 protein
Methylcholanthrene results in increased expression of PSMB5 mRNA; Methylcholanthrene results in increased expression of PSMB5 protein
NFE2L2 protein affects the reaction [Methylcholanthrene results in increased expression of PSMB5 mRNA]

NCBI chr14:54,851,577...54,855,452
Ensembl chr14:54,851,576...54,855,479

G

proteasome (prosome, macropain) subunit, beta type 6

increases expression

Methylcholanthrene results in increased expression of PSMB6 protein

NCBI chr11:70,416,116...70,418,684
Ensembl chr11:70,416,193...70,418,684

G

proteasome (prosome, macropain) subunit, beta type 7

increases expression

Methylcholanthrene results in increased expression of PSMB7 protein

NCBI chr 2:38,478,058...38,533,964
Ensembl chr 2:38,478,048...38,534,099

G

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

increases expression

Methylcholanthrene results in increased expression of PSMB8 mRNA

NCBI chr17:34,417,169...34,420,428
Ensembl chr17:34,416,695...34,420,428

G

proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

increases expression

Methylcholanthrene results in increased expression of PSME2 mRNA

NCBI chr14:55,824,897...55,828,558
Ensembl chr14:55,824,898...55,828,570

G

proline/serine-rich coiled-coil 1

increases expression

Methylcholanthrene results in increased expression of PSRC1 mRNA

NCBI chr 3:108,291,120...108,295,547
Ensembl chr 3:108,291,155...108,295,547

G

phosphotriesterase related

increases expression

Methylcholanthrene results in increased expression of PTER mRNA

NCBI chr 2:12,928,828...13,008,265
Ensembl chr 2:12,928,852...13,008,266

G

prostaglandin E receptor 4 (subtype EP4)

increases expression

Methylcholanthrene results in increased expression of PTGER4 mRNA

NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668

G

prostaglandin E synthase

increases expression

Methylcholanthrene results in increased expression of PTGES mRNA

NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875

G

prostaglandin F receptor

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of PTGFR mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTGFR mRNA

PMID:20713471 PMID:23519560

NCBI chr 3:151,504,247...151,543,165
Ensembl chr 3:151,502,139...151,543,267

G

prostaglandin-endoperoxide synthase 1

increases expression

Methylcholanthrene results in increased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

increases expression

Methylcholanthrene results in increased expression of PTGS2 mRNA

PMID:20713471 PMID:28601433

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

PTK2 protein tyrosine kinase 2

multiple interactions
decreases phosphorylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased phosphorylation of PTK2 protein]

NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129

G

pleiotrophin

decreases expression

Methylcholanthrene results in decreased expression of PTN mRNA

NCBI chr 6:36,691,863...36,787,114
Ensembl chr 6:36,691,864...36,787,155

G

pituitary tumor-transforming gene 1

increases expression

Methylcholanthrene results in increased expression of PTTG1 mRNA

NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078

G

pentraxin related gene

increases expression

Methylcholanthrene results in increased expression of PTX3 mRNA

NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226

G

PWWP domain containing 3A, DNA repair factor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PWWP3A promoter]

NCBI chr10:80,062,265...80,082,415
Ensembl chr10:80,062,268...80,079,737

G

2-phosphoxylose phosphatase 1

increases expression

Methylcholanthrene results in increased expression of PXYLP1 mRNA

NCBI chr 9:96,705,396...96,774,732
Ensembl chr 9:96,705,389...96,774,722

G

Rac family small GTPase 1

increases expression

Methylcholanthrene results in increased expression of RAC1 mRNA

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

Rac GTPase-activating protein 1

increases expression

Methylcholanthrene results in increased expression of RACGAP1 mRNA

NCBI chr15:99,518,377...99,549,504
Ensembl chr15:99,518,377...99,549,537

G

RAD51 recombinase

increases expression

Methylcholanthrene results in increased expression of RAD51 mRNA

NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926

G

RAD51 associated protein 1

increases expression

Methylcholanthrene results in increased expression of RAD51AP1 mRNA

NCBI chr 6:126,900,378...126,916,664
Ensembl chr 6:126,900,013...126,916,550

G

RAD54 like (S. cerevisiae)

increases expression

Methylcholanthrene results in increased expression of RAD54L mRNA

NCBI chr 4:115,951,458...115,980,875
Ensembl chr 4:115,951,461...115,980,887

G

Ral GTPase activating protein, alpha subunit 2 (catalytic)

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RALGAPA2 promoter]

NCBI chr 2:146,079,326...146,354,174
Ensembl chr 2:146,081,799...146,354,264

G

RAN binding protein 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RANBP2 promoter]

NCBI chr10:58,282,674...58,329,977
Ensembl chr10:58,282,742...58,330,178

G

RAS protein activator like 3

increases expression

Methylcholanthrene results in increased expression of RASAL3 mRNA

NCBI chr17:32,609,633...32,622,586
Ensembl chr17:32,609,633...32,622,557

G

Ras association (RalGDS/AF-6) domain family member 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of RASSF1 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of RASSF1 promoter

NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466

G

retinoblastoma binding protein 7, chromatin remodeling factor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBBP7 promoter]

NCBI chr X:161,543,368...161,562,086
Ensembl chr X:161,543,398...161,562,088

G

RNA binding motif protein 24

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBM24 promoter]

NCBI chr13:46,571,664...46,584,575
Ensembl chr13:46,571,910...46,584,571

G

RNA binding motif, single stranded interacting protein 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBMS2 promoter]

NCBI chr10:127,965,339...128,016,166
Ensembl chr10:127,967,427...128,016,166

G

RNA binding motif, single stranded interacting protein

decreases expression

Methylcholanthrene results in decreased expression of RBMS3 mRNA

NCBI chr 9:116,401,814...117,869,900
Ensembl chr 9:116,401,814...117,701,749

G

recombination signal binding protein for immunoglobulin kappa J region

increases expression

Methylcholanthrene results in increased expression of RBPJ mRNA

NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704

G

rabenosyn, RAB effector

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBSN promoter]

NCBI chr 6:92,163,693...92,191,874
Ensembl chr 6:92,163,693...92,191,906

G

RAS-like, estrogen-regulated, growth-inhibitor

multiple interactions
decreases expression

Methylcholanthrene promotes the reaction [AHR protein binds to RERG promoter]
Methylcholanthrene results in decreased expression of RERG mRNA

NCBI chr 6:137,031,822...137,147,494
Ensembl chr 6:137,031,823...137,147,495

G

replication factor C (activator 1) 3

increases expression

Methylcholanthrene results in increased expression of RFC3 mRNA

NCBI chr 5:151,566,282...151,574,673
Ensembl chr 5:151,566,221...151,574,707

G

replication factor C (activator 1) 4

increases expression

Methylcholanthrene results in increased expression of RFC4 mRNA

NCBI chr16:22,932,698...22,946,480
Ensembl chr16:22,932,693...22,946,487

G

ring finger and FYVE like domain containing protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RFFL promoter]

NCBI chr11:82,694,645...82,762,065
Ensembl chr11:82,693,275...82,762,036

G

regulator of G-protein signaling 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RGS3 promoter]

NCBI chr 4:62,478,079...62,621,256
Ensembl chr 4:62,478,084...62,622,238

G

Rho-related BTB domain containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RHOBTB1 promoter]

NCBI chr10:68,987,106...69,127,621
Ensembl chr10:68,987,264...69,127,621

G

ras homolog family member C

increases expression

Methylcholanthrene results in increased expression of RHOC mRNA

NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775

G

ras homolog family member H

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RHOH promoter]

NCBI chr 5:66,018,092...66,054,043
Ensembl chr 5:66,018,556...66,054,043

G

reproductive homeobox 5

decreases expression

Methylcholanthrene results in decreased expression of RHOX5 mRNA

NCBI chr X:36,891,657...36,897,305
Ensembl chr X:36,891,636...36,897,311

G

Ras and Rab interactor 3

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RIN3 mRNA

NCBI chr12:102,248,572...102,358,982
Ensembl chr12:102,249,307...102,357,114

G

Rho family GTPase 3

decreases expression

Methylcholanthrene results in decreased expression of RND3 mRNA

NCBI chr 2:51,020,451...51,039,123
Ensembl chr 2:51,020,450...51,039,123

G

ring finger protein 157

decreases expression

Methylcholanthrene results in decreased expression of RNF157 mRNA

NCBI chr11:116,227,179...116,303,859
Ensembl chr11:116,227,179...116,303,858

G

roundabout guidance receptor 1

decreases expression

Methylcholanthrene results in decreased expression of ROBO1 mRNA

NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983

G

receptor tyrosine kinase-like orphan receptor 1

decreases expression

Methylcholanthrene results in decreased expression of ROR1 mRNA

NCBI chr 4:99,952,988...100,302,003
Ensembl chr 4:99,952,988...100,301,962

G

replication protein A2

increases expression

Methylcholanthrene results in increased expression of RPA2 mRNA

NCBI chr 4:132,495,671...132,506,057
Ensembl chr 4:132,495,643...132,506,063

G

ribosomal protein L11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RPL11 promoter]

NCBI chr 4:135,776,665...135,780,704
Ensembl chr 4:135,755,576...135,780,739

G

ribonucleotide reductase M1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RRM1 mRNA

NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978

G

ribonucleotide reductase M2

increases expression

Methylcholanthrene results in increased expression of RRM2 mRNA

NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145

G

radical S-adenosyl methionine domain containing 2

decreases expression

Methylcholanthrene results in decreased expression of RSAD2 mRNA

NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451

G

reticulon 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RTN3 promoter]

NCBI chr19:7,403,260...7,460,656
Ensembl chr19:7,403,266...7,460,646

G

receptor transporter protein 4

decreases expression

Methylcholanthrene results in decreased expression of RTP4 mRNA

NCBI chr16:23,338,976...23,432,972
Ensembl chr16:23,339,041...23,432,972

G

retinoid X receptor alpha

increases expression

Methylcholanthrene results in increased expression of RXRA mRNA

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

ryanodine receptor 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RYR3 promoter]

NCBI chr 2:112,461,699...113,047,755
Ensembl chr 2:112,461,700...113,047,441

G

sterile alpha motif domain containing 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SAMD12 promoter]

NCBI chr15:53,262,514...53,765,926
Ensembl chr15:53,317,206...53,765,933

G

SAP30 binding protein

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SAP30BP mRNA

NCBI chr11:115,824,477...115,857,547
Ensembl chr11:115,824,108...115,857,551

G

strawberry notch 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SBNO1 mRNA

NCBI chr 5:124,506,765...124,564,059
Ensembl chr 5:124,506,765...124,564,064

G

suppressor of cancer cell invasion

decreases expression

Methylcholanthrene results in decreased expression of SCAI mRNA

NCBI chr 2:38,956,226...39,080,770
Ensembl chr 2:38,956,226...39,080,746

G

secretory carrier membrane protein 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SCAMP2 mRNA

NCBI chr 9:57,468,227...57,496,081
Ensembl chr 9:57,468,226...57,496,078

G

secretoglobin, family 2B, member 26

increases expression

Methylcholanthrene results in increased expression of SCGB2B26 mRNA

NCBI chr 7:33,642,422...33,644,410
Ensembl chr 7:33,642,427...33,644,465

G

sodium channel, voltage-gated, type III, beta

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SCN3B promoter]

NCBI chr 9:40,180,512...40,202,914
Ensembl chr 9:40,180,513...40,202,914

G

selectin, platelet

increases expression

Methylcholanthrene results in increased expression of SELP mRNA

NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595

G

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

increases expression

Methylcholanthrene results in increased expression of SEMA5A mRNA

NCBI chr15:32,244,959...32,696,487
Ensembl chr15:32,244,956...32,696,487

G

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

increases expression

Methylcholanthrene results in increased expression of SEMA6D mRNA

NCBI chr 2:123,931,089...124,509,711
Ensembl chr 2:123,931,889...124,509,690

G

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

increases expression

Methylcholanthrene results in increased expression of SEMA7A mRNA

NCBI chr 9:57,846,879...57,870,148
Ensembl chr 9:57,847,395...57,870,148

G

serine (or cysteine) peptidase inhibitor, clade A, member 3F

decreases expression

Methylcholanthrene results in decreased expression of SERPINA3F mRNA

NCBI chr12:104,180,803...104,187,388
Ensembl chr12:104,180,803...104,187,388

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

increases expression

Methylcholanthrene results in increased expression of SERPINE1 mRNA

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

secreted frizzled-related protein 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP1 mRNA

NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648

G

secreted frizzled-related protein 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP2 mRNA

NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623

G

surfactant associated protein D

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFTPD mRNA

NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106

G

shugoshin 1

increases expression

Methylcholanthrene results in increased expression of SGO1 mRNA

NCBI chr17:53,981,814...53,996,432
Ensembl chr17:53,981,814...53,996,361

G

SHC (Src homology 2 domain containing) family, member 4

increases expression

Methylcholanthrene results in increased expression of SHC4 mRNA

NCBI chr 2:125,469,359...125,566,085
Ensembl chr 2:125,469,367...125,566,068

G

Shc SH2-domain binding protein 1

increases expression

Methylcholanthrene results in increased expression of SHCBP1 mRNA

NCBI chr 8:4,785,976...4,829,549
Ensembl chr 8:4,785,976...4,829,567

G

SIK family kinase 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SIK3 promoter]

NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492

G

sirtuin 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SIRT2 mRNA

NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086

G

SIVA1, apoptosis-inducing factor

increases expression

Methylcholanthrene results in increased expression of SIVA1 mRNA

NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583

G

SKI8 subunit of superkiller complex

increases expression

Methylcholanthrene results in increased expression of SKIC8 mRNA

NCBI chr 9:54,624,437...54,641,833
Ensembl chr 9:54,622,019...54,641,803

G

solute carrier family 13 (sodium-dependent citrate transporter), member 5

increases expression

Methylcholanthrene results in increased expression of SLC13A5 mRNA

NCBI chr11:72,132,816...72,158,092
Ensembl chr11:72,132,815...72,158,048

G

solute carrier family 15 (H+/peptide transporter), member 2

increases expression

Methylcholanthrene results in increased expression of SLC15A2 mRNA

NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324

G

solute carrier family 16 (monocarboxylic acid transporters), member 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLC16A6 promoter]

NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424

G

solute carrier family 22, member 23

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLC22A23 promoter]

NCBI chr13:34,363,141...34,530,666
Ensembl chr13:34,363,141...34,529,165

G

solute carrier family 23 (nucleobase transporters), member 1

increases expression

Methylcholanthrene results in increased expression of SLC23A1 mRNA

NCBI chr18:35,747,657...35,762,900
Ensembl chr18:35,747,657...35,760,297

G

solute carrier family 27 (fatty acid transporter), member 1

increases expression

Methylcholanthrene results in increased expression of SLC27A1 mRNA

NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946

G

solute carrier family 2 (facilitated glucose transporter), member 1

increases expression

Methylcholanthrene results in increased expression of SLC2A1 mRNA

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 44, member 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLC44A1 promoter]

NCBI chr 4:53,440,387...53,622,478
Ensembl chr 4:53,440,413...53,622,478

G

solute carrier family 9 (sodium/hydrogen exchanger), member 9

decreases expression

Methylcholanthrene results in decreased expression of SLC9A9 mRNA

NCBI chr 9:94,551,945...95,112,505
Ensembl chr 9:94,551,962...95,112,498

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SLCO1A4 mRNA

NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925

G

solute carrier organic anion transporter family, member 1b2

increases expression

Methylcholanthrene results in increased expression of SLCO1B2 mRNA

NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372

G

SMC5-SMC6 complex localization factor 2

decreases expression

Methylcholanthrene results in decreased expression of SLF2 mRNA

NCBI chr19:44,906,948...44,972,225
Ensembl chr19:44,919,558...44,972,225

G

schlafen 2

decreases expression

Methylcholanthrene results in decreased expression of SLFN2 mRNA

NCBI chr11:82,955,938...82,961,504
Ensembl chr11:82,955,938...82,961,504

G

schlafen 8

decreases expression

Methylcholanthrene results in decreased expression of SLFN8 mRNA

NCBI chr11:82,892,984...82,911,636
Ensembl chr11:82,892,984...82,911,636

G

schlafen 9

increases expression

Methylcholanthrene results in increased expression of SLFN9 mRNA

NCBI chr11:82,865,142...82,883,041
Ensembl chr11:82,869,216...82,882,656

G

slit guidance ligand 2

decreases expression

Methylcholanthrene results in decreased expression of SLIT2 mRNA

NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075

G

SLU7 splicing factor homolog (S. cerevisiae)

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLU7 promoter]

NCBI chr11:43,324,550...43,338,809
Ensembl chr11:43,324,571...43,338,808

G

Sycp3 like Y-linked

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SLY mRNA

NCBI chr Y:57,195,734...57,221,886
Ensembl chr Y:57,195,716...57,221,890

G

small ArfGAP 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SMAP2 promoter]

NCBI chr 4:120,825,514...120,874,497
Ensembl chr 4:120,825,514...120,874,444

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SMARCE1 promoter]

NCBI chr11:99,099,873...99,121,843
Ensembl chr11:99,099,873...99,121,843

G

sperm motility kinase 2A

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SMOK2A mRNA

NCBI chr17:13,439,959...13,446,701
Ensembl chr17:13,440,075...13,446,545

G

SET and MYND domain containing 3

decreases expression

Methylcholanthrene results in decreased expression of SMYD3 mRNA

NCBI chr 1:178,779,525...179,345,618
Ensembl chr 1:178,779,525...179,345,606

G

SNAP-associated protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SNAPIN promoter]

NCBI chr 3:90,395,333...90,398,320
Ensembl chr 3:90,395,333...90,398,340

G

suppressor of cytokine signaling 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SOCS2 mRNA

NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042

G

suppressor of cytokine signaling 3

multiple interactions
increases expression

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of SOCS3 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of SOCS3 promoter
Methylcholanthrene results in increased expression of SOCS3 mRNA

PMID:20970405 PMID:23169610

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

suppressor of cytokine signaling 7

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SOCS7 promoter]

NCBI chr11:97,253,044...97,289,368
Ensembl chr11:97,253,261...97,289,368

G

superoxide dismutase 1, soluble

increases expression

Methylcholanthrene results in increased expression of SOD1 mRNA

PMID:23273579 PMID:23712962

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

increases expression
decreases expression

Methylcholanthrene results in increased expression of SOD2 mRNA
Methylcholanthrene results in decreased expression of SOD2 mRNA

PMID:23712962 PMID:35487396

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

sortilin-related receptor, LDLR class A repeats-containing

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to SORL1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of SORL1 mRNA]

NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593

G

SOS Ras/Rac guanine nucleotide exchange factor 1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of SOS1 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to SOS1 promoter]

PMID:16619036 PMID:20348232

NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882

G

SRY (sex determining region Y)-box 17

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOX17 mRNA

NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577

G

SRY (sex determining region Y)-box 4

decreases expression

Methylcholanthrene results in decreased expression of SOX4 mRNA

NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696

G

trans-acting transcription factor 1

increases expression
increases acetylation
multiple interactions

Methylcholanthrene results in increased expression of SP1 mRNA
Methylcholanthrene results in increased acetylation of SP1 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

Sp140 nuclear body protein

decreases expression

Methylcholanthrene results in decreased expression of SP140 mRNA

NCBI chr 1:85,515,212...85,572,761
Ensembl chr 1:85,528,099...85,572,758

G

sperm associated antigen 5

increases expression

Methylcholanthrene results in increased expression of SPAG5 mRNA

NCBI chr11:78,192,412...78,213,283
Ensembl chr11:78,192,355...78,213,283

G

SPARC-like 1

decreases expression

Methylcholanthrene results in decreased expression of SPARCL1 mRNA

NCBI chr 5:104,226,974...104,261,954
Ensembl chr 5:104,226,977...104,261,599

G

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)

increases expression

Methylcholanthrene results in increased expression of SPC24 mRNA

NCBI chr 9:21,666,730...21,671,741
Ensembl chr 9:21,666,738...21,671,599

G

SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)

increases expression

Methylcholanthrene results in increased expression of SPC25 mRNA

NCBI chr 2:69,009,753...69,036,583
Ensembl chr 2:69,024,239...69,036,538

G

spindle apparatus coiled-coil protein 1

increases expression

Methylcholanthrene results in increased expression of SPDL1 mRNA

NCBI chr11:34,700,012...34,724,492
Ensembl chr11:34,700,017...34,724,468

G

Spi-B transcription factor (Spi-1/PU.1 related)

increases expression

Methylcholanthrene results in increased expression of SPIB mRNA

NCBI chr 7:44,175,419...44,181,511
Ensembl chr 7:44,175,417...44,181,495

G

spondin 2, extracellular matrix protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SPON2 promoter]

NCBI chr 5:33,370,862...33,375,596
Ensembl chr 5:33,355,528...33,375,799

G

sprouty protein with EVH-1 domain 1, related sequence

increases expression
multiple interactions

Methylcholanthrene results in increased expression of SPRED1 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to SPRED1 promoter]

PMID:20348232 PMID:20713471

NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760

G

sprouty-related EVH1 domain containing 2

increases expression

Methylcholanthrene results in increased expression of SPRED2 mRNA

NCBI chr11:19,874,442...19,974,026
Ensembl chr11:19,874,375...19,974,026

G

sprouty RTK signaling antagonist 2

increases expression

Methylcholanthrene results in increased expression of SPRY2 mRNA

NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253

G

serine palmitoyltransferase, long chain base subunit 1

affects localization
multiple interactions
decreases response to substance

Methylcholanthrene affects the localization of SPTLC1 protein
SPTLC1 protein inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; SPTLC1 protein mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
SPTLC1 protein mutant form results in decreased susceptibility to Methylcholanthrene; SPTLC1 protein results in decreased susceptibility to Methylcholanthrene

NCBI chr13:53,486,784...53,531,401
Ensembl chr13:53,486,784...53,531,433

G

serine palmitoyltransferase, long chain base subunit 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SPTLC2 promoter]

NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129

G

serine palmitoyltransferase, small subunit A

decreases expression

Methylcholanthrene results in decreased expression of SPTSSA mRNA

NCBI chr12:54,692,159...54,703,357
Ensembl chr12:54,692,177...54,703,358

G

Rous sarcoma oncogene

multiple interactions
affects expression

Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [SRC protein binds to AHR protein]]
Methylcholanthrene affects the expression of SRC mRNA

PMID:8937476 PMID:23273579

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

serine and arginine-rich splicing factor 1

multiple interactions

[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein

NCBI chr11:87,937,325...87,944,583
Ensembl chr11:87,938,199...87,944,581

G

SS18, subunit of BAF chromatin remodeling complex

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SS18 promoter]

NCBI chr18:14,758,686...14,817,476
Ensembl chr18:14,757,255...14,815,971

G

spermiogenesis specific transcript on the Y 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SSTY1 mRNA

NCBI chr Y:18,089,167...18,091,551
Ensembl chr Y:18,089,116...18,091,556

G

steroidogenic acute regulatory protein

increases expression

Methylcholanthrene results in increased expression of STAR mRNA

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

StAR related lipid transfer domain containing 13

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to STARD13 promoter]

NCBI chr 5:150,960,975...151,351,780
Ensembl chr 5:150,960,975...151,157,301

G

signal transducer and activator of transcription 2

increases expression

Methylcholanthrene results in increased expression of STAT2 mRNA

NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718

G

signal transducer and activator of transcription 3

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of STAT3 mRNA

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

signal transducer and activator of transcription 5B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to STAT5B promoter]

NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550

G

staufen double-stranded RNA binding protein 2

decreases expression

Methylcholanthrene results in decreased expression of STAU2 mRNA

NCBI chr 1:16,299,027...16,591,228
Ensembl chr 1:16,298,898...16,590,336

G

stathmin 1

increases expression

Methylcholanthrene results in increased expression of STMN1 mRNA

NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154

G

serine/threonine/tyrosine kinase 1

increases expression

Methylcholanthrene results in increased expression of STYK1 mRNA

NCBI chr 6:131,276,096...131,330,532
Ensembl chr 6:131,276,105...131,330,560

G

sulfotransferase family 1E, member 1

decreases expression

Methylcholanthrene results in decreased expression of SULT1E1 mRNA

NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

decreases expression

Methylcholanthrene results in decreased expression of SULT2A1 mRNA

NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334

G

sulfotransferase family 5A, member 1

increases expression
increases activity

Methylcholanthrene results in increased expression of SULT1A1 mRNA
Methylcholanthrene results in increased activity of SULT1A1 protein

NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054

G

SWIM type zinc finger 7 associated protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SWSAP1 promoter]

NCBI chr 9:21,867,049...21,869,566
Ensembl chr 9:21,867,051...21,869,560

G

synaptonemal complex protein 2

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to SYCP2 promoter]
Methylcholanthrene results in increased expression of SYCP2 mRNA

NCBI chr 2:177,987,088...178,051,580
Ensembl chr 2:177,987,086...178,049,478

G

synaptonemal complex protein 3

decreases expression

Methylcholanthrene results in decreased expression of SYCP3 mRNA

NCBI chr10:88,295,449...88,309,098
Ensembl chr10:88,295,431...88,309,098

G

synemin, intermediate filament protein

decreases expression

Methylcholanthrene results in decreased expression of SYNM mRNA

NCBI chr 7:67,379,909...67,409,490
Ensembl chr 7:67,379,908...67,409,490

G

synaptotagmin XII

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SYT12 promoter]

NCBI chr19:4,495,936...4,527,171
Ensembl chr19:4,495,936...4,527,475

G

TRAF family member-associated Nf-kappa B activator

increases expression

Methylcholanthrene results in increased expression of TANK mRNA

NCBI chr 2:61,408,901...61,484,515
Ensembl chr 2:61,408,929...61,484,515

G

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

increases expression

Methylcholanthrene results in increased expression of TAP1 mRNA

NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199

G

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

increases expression

Methylcholanthrene results in increased expression of TAP2 mRNA

NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295

G

transducin (beta)-like 1X-linked receptor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TBL1XR1 promoter]

NCBI chr 3:22,130,756...22,270,758
Ensembl chr 3:22,130,816...22,270,758

G

T-box 3

increases expression

Methylcholanthrene results in increased expression of TBX3 mRNA

NCBI chr 5:119,808,600...119,822,789
Ensembl chr 5:119,808,734...119,822,789

G

transcription factor 19

increases expression

Methylcholanthrene results in increased expression of TCF19 mRNA

NCBI chr17:35,823,627...35,827,730
Ensembl chr17:35,823,631...35,827,721

G

TEA domain family member 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TEAD4 promoter]

NCBI chr 6:128,204,106...128,277,776
Ensembl chr 6:128,201,251...128,277,786

G

trefoil factor 1

increases expression

Methylcholanthrene results in increased expression of TFF1 mRNA

NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251

G

trefoil factor 3, intestinal

decreases expression

Methylcholanthrene results in decreased expression of TFF3 mRNA

NCBI chr17:31,344,280...31,348,585
Ensembl chr17:31,344,280...31,348,620

G

thrombomodulin

increases expression

Methylcholanthrene results in increased expression of THBD mRNA

NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108

G

thrombospondin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to THBS2 promoter]
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA

PMID:20348232 PMID:23519560

NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497

G

thioesterase superfamily member 5

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to THEM5 promoter]

NCBI chr 3:94,249,406...94,254,659
Ensembl chr 3:94,249,406...94,254,659

G

tissue inhibitor of metalloproteinase 1

increases expression

Methylcholanthrene results in increased expression of TIMP1 mRNA

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

multiple interactions

[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 mRNA; [Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 protein

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

tissue inhibitor of metalloproteinase 3

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of TIMP3 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of TIMP3 gene

NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression
multiple interactions

Methylcholanthrene results in increased expression of TIPARP mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to TIPARP promoter]

PMID:20348232 PMID:20713471

NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939

G

timeless interacting protein

increases expression

Methylcholanthrene results in increased expression of TIPIN mRNA

NCBI chr 9:64,188,776...64,212,704
Ensembl chr 9:64,188,863...64,212,706

G

thymidine kinase 1

increases expression

Methylcholanthrene results in increased expression of TK1 mRNA

NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918

G

transmembrane 4 superfamily member 1

increases expression

Methylcholanthrene results in increased expression of TM4SF1 mRNA

NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409
Ensembl chr 3:57,193,032...57,209,409

G

transmembrane protein 116

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM116 promoter]

NCBI chr 5:121,590,643...121,656,601
Ensembl chr 5:121,589,956...121,662,246

G

transmembrane protein 119

increases expression

Methylcholanthrene results in increased expression of TMEM119 mRNA

NCBI chr 5:113,931,790...113,938,457
Ensembl chr 5:113,931,790...113,938,577

G

transmembrane protein 184b

increases expression

Methylcholanthrene results in increased expression of TMEM184B mRNA

NCBI chr15:79,244,884...79,287,503
Ensembl chr15:79,244,884...79,287,769

G

transmembrane protein 30A

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM30A promoter]
Methylcholanthrene results in increased expression of TMEM30A mRNA

NCBI chr 9:79,676,223...79,700,712
Ensembl chr 9:79,676,225...79,700,789

G

transmembrane protein 45b

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM45B promoter]

NCBI chr 9:31,336,445...31,375,534
Ensembl chr 9:31,337,492...31,375,758

G

transmembrane protein 97

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM97 promoter]

NCBI chr11:78,432,643...78,441,561
Ensembl chr11:78,432,643...78,441,603

G

transmembrane and tetratricopeptide repeat containing 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMTC2 promoter]

NCBI chr10:105,023,524...105,410,340
Ensembl chr10:105,023,524...105,410,312

G

tenascin C

decreases expression

Methylcholanthrene results in decreased expression of TNC mRNA

NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252

G

tumor necrosis factor

multiple interactions
increases expression

[Methylcholanthrene co-treated with TNF protein] results in increased expression of IL6 mRNA
Methylcholanthrene results in increased expression of TNF mRNA

PMID:23273579 PMID:23396138 PMID:35487396

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 21

decreases expression

Methylcholanthrene results in decreased expression of TNFRSF21 mRNA

NCBI chr17:43,327,446...43,400,079
Ensembl chr17:43,327,446...43,400,080

G

tumor necrosis factor receptor superfamily, member 22

increases expression

Methylcholanthrene results in increased expression of TNFRSF22 mRNA

NCBI chr 7:143,188,540...143,203,412
Ensembl chr 7:143,188,543...143,203,398

G

tumor necrosis factor receptor superfamily, member 23

increases expression
multiple interactions

Methylcholanthrene results in increased expression of TNFRSF23 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of TNFRSF23 mRNA

PMID:20713471 PMID:25926378

NCBI chr 7:143,219,544...143,239,836
Ensembl chr 7:143,219,546...143,239,609

G

tumor necrosis factor receptor superfamily, member 9

increases expression

Methylcholanthrene results in increased expression of TNFRSF9 mRNA

NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559

G

tyrosine kinase, non-receptor, 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TNK2 promoter]

NCBI chr16:32,462,699...32,502,311
Ensembl chr16:32,462,692...32,502,311

G

topoisomerase (DNA) II alpha

increases expression
multiple interactions

Methylcholanthrene results in increased expression of TOP2A mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA]

PMID:20713471 PMID:26372666

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

tumor protein D52

increases expression

Methylcholanthrene results in increased expression of TPD52 mRNA

NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783

G

protein-tyrosine sulfotransferase 1

increases expression

Methylcholanthrene results in increased expression of TPST1 mRNA

NCBI chr 5:130,102,167...130,164,575
Ensembl chr 5:130,102,167...130,164,570

G

TPX2, microtubule-associated

increases expression

Methylcholanthrene results in increased expression of TPX2 mRNA

NCBI chr 2:152,689,859...152,737,241
Ensembl chr 2:152,689,884...152,737,241

G

TNF receptor-associated factor 1

increases expression

Methylcholanthrene results in increased expression of TRAF1 mRNA

NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784

G

trafficking protein particle complex 9

decreases expression

Methylcholanthrene results in decreased expression of TRAPPC9 mRNA

NCBI chr15:72,461,469...72,933,086
Ensembl chr15:72,461,469...72,933,053

G

transcriptional regulating factor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRERF1 promoter]

NCBI chr17:47,451,868...47,673,250
Ensembl chr17:47,451,801...47,672,883

G

tribbles pseudokinase 2

increases expression

Methylcholanthrene results in increased expression of TRIB2 mRNA

NCBI chr12:15,841,726...15,866,963
Ensembl chr12:15,841,728...15,866,923

G

tripartite motif-containing 39

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRIM39 promoter]

NCBI chr17:36,569,764...36,582,896
Ensembl chr17:36,569,765...36,583,139

G

tripartite motif-containing 55

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRIM55 promoter]

NCBI chr 3:19,698,591...19,746,748
Ensembl chr 3:19,698,611...19,746,756

G

tripartite motif-containing 63

decreases expression

Methylcholanthrene results in decreased expression of TRIM63 mRNA

NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940

G

tripartite motif-containing 72

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRIM72 promoter]

NCBI chr 7:127,602,684...127,610,565
Ensembl chr 7:127,603,121...127,610,205

G

thyroid hormone receptor interactor 13

increases expression

Methylcholanthrene results in increased expression of TRIP13 mRNA

NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903

G

trophinin associated protein

increases expression

Methylcholanthrene results in increased expression of TROAP mRNA

NCBI chr15:98,972,854...98,981,290
Ensembl chr15:98,972,456...98,981,290

G

transformation related protein 53

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [TRP53 protein binds to ABCB1B promoter]; Methylcholanthrene promotes the reaction [TRP53 protein binds to FMO3 5' UTR]; Methylcholanthrene results in increased expression of and results in increased activity of TRP53 protein
Methylcholanthrene results in increased expression of TP53 mRNA

PMID:11096091 PMID:20570689 PMID:23273579

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 inducible nuclear protein 2

decreases expression

Methylcholanthrene results in decreased expression of TRP53INP2 mRNA

NCBI chr 2:155,223,742...155,231,767
Ensembl chr 2:155,222,979...155,231,770

G

transient receptor potential cation channel, subfamily V, member 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRPV4 promoter]

NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482

G

thymic stromal lymphopoietin

increases expression

Methylcholanthrene results in increased expression of TSLP mRNA

NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850

G

tetraspanin 8

increases expression

Methylcholanthrene results in increased expression of TSPAN8 mRNA

NCBI chr10:115,652,722...115,685,798
Ensembl chr10:115,652,737...115,685,798

G

tetratricopeptide repeat domain 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TTC3 promoter]

NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202

G

Ttk protein kinase

increases expression

Methylcholanthrene results in increased expression of TTK mRNA

NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442

G

tubulin, beta 4B class IVB

increases expression

Methylcholanthrene results in increased expression of TUBB4B mRNA

NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714

G

thymidylate synthase

increases expression

Methylcholanthrene results in increased expression of TYMS mRNA

NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615

G

ubiquitin-conjugating enzyme E2C

increases expression

Methylcholanthrene results in increased expression of UBE2C mRNA

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

ubiquitin-conjugating enzyme E2E 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to UBE2E1 promoter]

NCBI chr14:4,137,852...4,186,967
Ensembl chr14:4,137,837...4,186,974

G

ubiquitin-conjugating enzyme E2T

increases expression

Methylcholanthrene results in increased expression of UBE2T mRNA

NCBI chr 1:134,890,303...134,901,918
Ensembl chr 1:134,890,303...134,901,900

G

ubiquitin domain containing 1

increases expression

Methylcholanthrene results in increased expression of UBTD1 mRNA

NCBI chr19:41,970,202...42,023,089
Ensembl chr19:41,970,202...42,023,082

G

uridine-cytidine kinase 2

decreases expression

Methylcholanthrene results in decreased expression of UCK2 mRNA

NCBI chr 1:167,050,464...167,112,657
Ensembl chr 1:167,050,452...167,112,889

G

UDP glucuronosyltransferase 1 family, polypeptide A1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of UGT1A1 mRNA
Methylcholanthrene results in increased expression of UGT1A1 mRNA; Methylcholanthrene results in increased expression of UGT1A1 protein
[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 3,6-dihydroxychrysene; [Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 6-hydroxychrysene
Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of UGT1A1 mRNA]

PMID:1435739 PMID:18203689 PMID:19118567 PMID:33811995

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glycosyltransferase 1 family, polypeptide A10

increases expression

Methylcholanthrene results in increased expression of UGT1A10 mRNA

PMID:19118567 PMID:28601433 PMID:29554273

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

Methylcholanthrene results in increased expression of UGT1A2 mRNA; Methylcholanthrene results in increased expression of UGT1A3 mRNA

PMID:19118567 PMID:28601433

NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A5

increases expression

Methylcholanthrene results in increased expression of UGT1A4 mRNA

NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A6A

increases activity
increases expression

Methylcholanthrene results in increased activity of UGT1A6A protein
Methylcholanthrene results in increased expression of UGT1A6A mRNA

NCBI chr 1:88,062,531...88,147,724
Ensembl chr 1:88,062,531...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

increases expression
increases activity
multiple interactions

Methylcholanthrene results in increased expression of UGT1A6 mRNA
Methylcholanthrene results in increased activity of UGT1A6 protein
[Methylcholanthrene results in increased activity of UGT1A6 protein] which affects the metabolism of Benzene; Methylcholanthrene promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; UGT1A6 protein affects the reaction [Methylcholanthrene results in increased abundance of Ascorbic Acid]
[Methylcholanthrene co-treated with Oxygen deficiency] results in decreased expression of UGT1A6 mRNA; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of UGT1A6 mRNA]

PMID:1981726 PMID:8263600 PMID:11328961 PMID:19023562 PMID:19118567 More...

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP glucuronosyltransferase 1 family, polypeptide A9

increases expression

Methylcholanthrene results in increased expression of UGT1A9 mRNA

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide B34

increases expression

Methylcholanthrene results in increased expression of UGT2B7 mRNA

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

G

uromodulin-like 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to UMODL1 promoter]

NCBI chr17:31,173,614...31,229,684
Ensembl chr17:31,173,614...31,229,684

G

uridine phosphorylase 1

increases expression

Methylcholanthrene results in increased expression of UPP1 mRNA

NCBI chr11:9,068,008...9,086,170
Ensembl chr11:9,068,103...9,086,170

G

ubiquitin specific peptidase 17-like A

affects expression

Methylcholanthrene affects the expression of USP17LA mRNA

NCBI chr 7:104,506,223...104,511,874
Ensembl chr 7:104,506,216...104,511,874

G

ubiquitin specific peptidase 18

decreases expression
increases expression

Methylcholanthrene results in decreased expression of USP18 mRNA
Methylcholanthrene results in increased expression of USP18 mRNA

PMID:20713471 PMID:29554273

NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876

G

ubiquitin specific peptidase 9, X chromosome

increases expression

Methylcholanthrene results in increased expression of USP9X mRNA

NCBI chr X:12,937,221...13,039,567
Ensembl chr X:12,937,737...13,039,567

G

vav 3 oncogene

increases expression

Methylcholanthrene results in increased expression of VAV3 mRNA

NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014

G

vascular cell adhesion molecule 1

affects expression

Methylcholanthrene affects the expression of VCAM1 mRNA

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

vascular endothelial growth factor A

increases expression

Methylcholanthrene results in increased expression of VEGFA mRNA

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vezatin, adherens junctions transmembrane protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VEZT promoter]

NCBI chr10:93,797,384...93,871,661
Ensembl chr10:93,775,027...93,871,679

G

vasoactive intestinal peptide receptor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VIPR1 promoter]

NCBI chr 9:121,471,782...121,502,020
Ensembl chr 9:121,471,782...121,502,020

G

vitrin

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of VIT mRNA

NCBI chr17:78,815,480...78,934,838
Ensembl chr17:78,815,493...78,934,837

G

vomeronasal 1 receptor 121

decreases expression

Methylcholanthrene results in decreased expression of VMN1R121 mRNA

NCBI chr 7:20,831,494...20,832,438
Ensembl chr 7:20,831,494...20,832,438

G

vomeronasal 1 receptor 65

increases expression

Methylcholanthrene results in increased expression of VMN1R65 mRNA

NCBI chr 7:6,010,749...6,014,009
Ensembl chr 7:6,010,749...6,014,009

G

vomeronasal 1 receptor 80

decreases expression

Methylcholanthrene results in decreased expression of VMN1R80 mRNA

NCBI chr 7:11,926,892...11,927,818
Ensembl chr 7:11,923,213...11,937,240

G

von Willebrand factor C and EGF domains

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VWCE promoter]

NCBI chr19:10,611,582...10,643,577
Ensembl chr19:10,611,577...10,643,577

G

Von Willebrand factor

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] affects the expression of VWF mRNA

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

WW domain binding protein 1 like

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to WBP1L promoter]

NCBI chr19:46,587,545...46,645,828
Ensembl chr19:46,587,523...46,645,828

G

WD repeat and FYVE domain containing 4

increases expression

Methylcholanthrene results in increased expression of WDFY4 mRNA

NCBI chr14:32,681,504...32,915,809
Ensembl chr14:32,681,504...32,907,465

G

WD repeat domain 26

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to WDR26 promoter]

NCBI chr 1:181,000,791...181,046,211
Ensembl chr 1:181,000,793...181,039,566

G

WEE 1 homolog 1 (S. pombe)

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to WEE1 promoter]

NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493

G

WW domain-containing oxidoreductase

decreases expression

Methylcholanthrene results in decreased expression of WWOX mRNA

NCBI chr 8:115,166,377...116,079,451
Ensembl chr 8:115,166,395...116,079,447

G

WW domain containing transcription regulator 1

increases expression

Methylcholanthrene results in increased expression of WWTR1 mRNA

NCBI chr 3:57,363,065...57,483,331
Ensembl chr 3:57,363,070...57,483,331

G

xanthine dehydrogenase

multiple interactions
increases activity
increases expression

AHR protein promotes the reaction [Methylcholanthrene results in increased activity of XDH protein]
Methylcholanthrene results in increased expression of XDH mRNA

PMID:11243847 PMID:20713471 PMID:23273579 PMID:29554273

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

G

zinc finger and BTB domain containing 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZBTB4 promoter]

NCBI chr11:69,656,738...69,674,852
Ensembl chr11:69,656,738...69,674,849

G

zinc finger CCCH type containing 8

decreases expression

Methylcholanthrene results in decreased expression of ZC3H8 mRNA

NCBI chr 2:128,768,188...128,786,018
Ensembl chr 2:128,768,188...128,785,997

G

zinc finger, CCHC domain containing 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZCCHC2 promoter]

NCBI chr 1:105,916,929...105,961,807
Ensembl chr 1:105,918,136...105,961,804

G

zinc finger, CCHC domain containing 9

decreases expression

Methylcholanthrene results in decreased expression of ZCCHC9 mRNA

NCBI chr13:91,944,652...91,955,824
Ensembl chr13:91,944,652...91,955,824

G

zinc finger, DHHC domain containing 2

increases expression

Methylcholanthrene results in increased expression of ZDHHC2 mRNA

NCBI chr 8:40,876,526...40,946,178
Ensembl chr 8:40,876,856...40,963,309

G

zinc finger protein 281

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZNF281 promoter]

NCBI chr 1:136,552,639...136,558,129
Ensembl chr 1:136,552,639...136,557,791

G

zinc finger protein 37

decreases expression

Methylcholanthrene results in decreased expression of ZFP37 mRNA

NCBI chr 4:62,107,777...62,126,685
Ensembl chr 4:62,107,777...62,149,284

G

zinc finger protein 467

increases expression

Methylcholanthrene results in increased expression of ZFP467 mRNA

NCBI chr 6:48,404,626...48,422,926
Ensembl chr 6:48,404,631...48,422,759

G

zinc finger protein 521

decreases expression

Methylcholanthrene results in decreased expression of ZFP521 mRNA

NCBI chr18:13,820,070...14,105,812
Ensembl chr18:13,820,070...14,105,844

G

zinc finger protein 710

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZNF710 promoter]

NCBI chr 7:79,674,581...79,742,498
Ensembl chr 7:79,674,562...79,743,921

G

zinc finger matrin type 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZMAT3 promoter]

NCBI chr 3:32,388,941...32,419,814
Ensembl chr 3:32,388,941...32,420,163

G

zinc finger, MIZ-type containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZMIZ1 promoter]

NCBI chr14:25,458,299...25,667,167
Ensembl chr14:25,459,609...25,667,167

G

zwilch kinetochore protein

increases expression

Methylcholanthrene results in increased expression of ZWILCH mRNA

NCBI chr 9:64,044,426...64,080,210
Ensembl chr 9:64,044,426...64,080,386

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22182
role	22167
biological role	22166
aetiopathogenetic role	21269
carcinogenic agent	19692
3-methylcholanthrene	999
11,12-epoxy-3-methylcholanthrene	0
Path 2
Term	Annotations
CHEBI ontology	22182
subatomic particle	22174
composite particle	22174
hadron	22174
baryon	22174
nucleon	22174
atomic nucleus	22174
atom	22174
main group element atom	22108
main group molecular entity	22108
s-block molecular entity	21708
hydrogen molecular entity	21626
hydrides	20762
organic hydride	20315
organic fundamental parent	20315
hydrocarbon	19898
cyclic hydrocarbon	17946
arene	17925
polycyclic arene	17716
ortho- and peri-fused polycyclic arene	16911
3-methylcholanthrene	999
11,12-epoxy-3-methylcholanthrene	0

paths to the root