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Gene: Dab2 (disabled 2, mitogen-responsive phosphoprotein) Mus musculus
Symbol: Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Description: Exhibits several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endocytosis; hemopoiesis; and positive regulation of macromolecule metabolic process. Localizes to apical plasma membrane; clathrin coat of coated pit; and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH 1,2-dichloroethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730435J12Rik; AA960054; adaptor molecule disabled-2; AI957090; D15Wsu122e; D630005B22Rik; differentially expressed in ovarian carcinoma 2; disabled homolog 2; Doc-2; Doc2; mitogen-responsive phosphoprotein; p96; RIKEN cDNA D630005B22 gene
Homo sapiens (human) : DAB2 (DAB adaptor protein 2)  Alliance
Rattus norvegicus (Norway rat) : Dab2 (DAB adaptor protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dab2 (DAB adaptor protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DAB2 (DAB adaptor protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dab2 (DAB adaptor protein 2)
Sus scrofa (pig) : DAB2 (DAB adaptor protein 2)
Chlorocebus sabaeus (African green monkey) : DAB2 (DAB adaptor protein 2)
Heterocephalus glaber (naked mole-rat) : Dab2 (DAB adaptor protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl156,299,788 - 6,440,712 (+)EnsemblGRCm38mm10GRCm38
GRCm38156,299,788 - 6,440,715 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37156,249,789 - 6,390,712 (+)NCBIGRCm37mm9NCBIm37
MGSCv36156,247,064 - 6,387,927 (+)NCBImm8
Celera156,148,799 - 6,289,867 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map152.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dab2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731452
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.