Ppp4r2 (protein phosphatase 4, regulatory subunit 2) - Rat Genome Database
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Gene: Ppp4r2 (protein phosphatase 4, regulatory subunit 2) Mus musculus
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Symbol: Ppp4r2
Name: protein phosphatase 4, regulatory subunit 2
RGD ID: 1316434
MGI Page MGI
Description: Predicted to have protein phosphatase regulator activity and protein-macromolecule adaptor activity. Involved in hematopoietic progenitor cell differentiation. Localizes to cytoplasm; nucleus; and protein phosphatase 4 complex. Is expressed in several structures, including genitourinary system; gut; and nervous system. Orthologous to human PPP4R2 (protein phosphatase 4 regulatory subunit 2); INTERACTS WITH 1,2-dimethylhydrazine; 3-methylcholanthrene; Aroclor 1254.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BE691708; C230060M08Rik; serine/threonine-protein phosphatase 4 regulatory subunit 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm6039  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396100,810,572 - 100,846,895 (+)NCBIGRCm39mm39
GRCm386100,833,620 - 100,869,934 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6100,833,622 - 100,869,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv376100,783,632 - 100,818,711 (+)NCBIGRCm37mm9NCBIm37
MGSCv366100,799,736 - 100,834,815 (+)NCBImm8
Celera6102,699,131 - 102,733,808 (+)NCBICelera
Cytogenetic Map6D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytoskeleton  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
protein phosphatase 4 complex  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12520002   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20876121  
PMID:21267068   PMID:21873635   PMID:24029230   PMID:24194600   PMID:27626380   PMID:32325033  


Genomics

Comparative Map Data
Ppp4r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396100,810,572 - 100,846,895 (+)NCBIGRCm39mm39
GRCm386100,833,620 - 100,869,934 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6100,833,622 - 100,869,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv376100,783,632 - 100,818,711 (+)NCBIGRCm37mm9NCBIm37
MGSCv366100,799,736 - 100,834,815 (+)NCBImm8
Celera6102,699,131 - 102,733,808 (+)NCBICelera
Cytogenetic Map6D3NCBI
PPP4R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl372,996,803 - 73,069,198 (+)EnsemblGRCh38hg38GRCh38
GRCh38372,996,743 - 73,069,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37373,045,894 - 73,118,349 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37373,045,985 - 73,118,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36373,128,809 - 73,197,701 (+)NCBINCBI36hg18NCBI36
Build 34373,128,808 - 73,197,701NCBI
Celera372,980,269 - 73,049,174 (+)NCBI
Cytogenetic Map3p13NCBI
HuRef373,049,486 - 73,118,531 (+)NCBIHuRef
CHM1_1372,998,763 - 73,071,707 (+)NCBICHM1_1
Ppp4r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24133,454,555 - 133,495,486 (+)NCBI
Rnor_6.0 Ensembl4133,285,552 - 133,323,755 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04133,285,552 - 133,323,755 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04197,767,067 - 197,805,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44135,720,581 - 135,761,507 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14135,965,391 - 136,006,348 (+)NCBI
Celera4122,298,049 - 122,338,902 (+)NCBICelera
Cytogenetic Map4q34NCBI
Ppp4r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542115,165,363 - 15,220,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542115,165,836 - 15,220,509 (-)NCBIChiLan1.0ChiLan1.0
PPP4R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1374,863,935 - 74,935,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl374,835,788 - 74,935,446 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0372,939,529 - 73,012,073 (+)NCBIMhudiblu_PPA_v0panPan3
PPP4R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2019,118,124 - 19,167,264 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12019,116,122 - 19,166,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ppp4r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366033,994,594 - 4,041,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP4R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1354,324,997 - 54,378,277 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11354,324,978 - 54,378,277 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103227906
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12233,937,048 - 34,009,354 (+)NCBI
ChlSab1.1 Ensembl2233,937,050 - 34,009,362 (+)Ensembl
Ppp4r2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247737,501,184 - 7,562,428 (+)NCBI

Position Markers
BE691708  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386100,869,532 - 100,869,639UniSTSGRCm38
MGSCv376100,819,526 - 100,819,633UniSTSGRCm37
Celera6102,734,613 - 102,734,720UniSTS
Cytogenetic Map6D3UniSTS
Whitehead/MRC_RH61013.21UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:533
Count of miRNA genes:373
Interacting mature miRNAs:408
Transcripts:ENSMUST00000063854
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000063854   ⟹   ENSMUSP00000066314
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,833,622 - 100,869,934 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203067
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,866,126 - 100,866,723 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203580   ⟹   ENSMUSP00000145102
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,852,577 - 100,867,622 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203940   ⟹   ENSMUSP00000144898
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,852,536 - 100,866,076 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204001
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,852,485 - 100,865,987 (+)Ensembl
RefSeq Acc Id: NM_182939   ⟹   NP_891984
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396100,810,599 - 100,845,678 (+)NCBI
GRCm386100,833,638 - 100,868,717 (+)NCBI
MGSCv376100,783,632 - 100,818,711 (+)RGD
Celera6102,699,131 - 102,733,808 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506008   ⟹   XP_006506071
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396100,810,572 - 100,846,895 (+)NCBI
GRCm386100,833,620 - 100,869,934 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036166058   ⟹   XP_036021951
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396100,811,002 - 100,846,895 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_891984   ⟸   NM_182939
- UniProtKB: Q0VGB7 (UniProtKB/Swiss-Prot),   A0A0R4J0U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506071   ⟸   XM_006506008
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000145102   ⟸   ENSMUST00000203580
RefSeq Acc Id: ENSMUSP00000144898   ⟸   ENSMUST00000203940
RefSeq Acc Id: ENSMUSP00000066314   ⟸   ENSMUST00000063854
RefSeq Acc Id: XP_036021951   ⟸   XM_036166058
- Peptide Label: isoform X1

Promoters
RGD ID:6839777
Promoter ID:MM_KWN:47057
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung,   MEF_B4
Transcripts:NM_182939
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366100,783,371 - 100,783,871 (+)MPROMDB
RGD ID:6848023
Promoter ID:MM_ACW:42198
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:PPP4R2.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366100,783,974 - 100,784,474 (+)MPROMDB
RGD ID:6839781
Promoter ID:MM_KWN:47058
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2
Transcripts:UC009DCC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366100,801,471 - 100,801,971 (+)MPROMDB
RGD ID:6890552
Promoter ID:EPDNEW_M8727
Type:multiple initiation site
Name:Ppp4r2_1
Description:Mus musculus protein phosphatase 4, regulatory subunit 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386100,833,648 - 100,833,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3027896 AgrOrtholog
Ensembl Genes ENSMUSG00000052144 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000066314 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000144898 UniProtKB/TrEMBL
  ENSMUSP00000145102 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000063854 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000203580 UniProtKB/TrEMBL
  ENSMUST00000203940 UniProtKB/TrEMBL
InterPro PPP4R2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3027896 ENTREZGENE
NCBI Gene 232314 ENTREZGENE
PANTHER PTHR16487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PPP4R2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp4r2 PhenoGen
UniProt A0A0N4SV05_MOUSE UniProtKB/TrEMBL
  A0A0N4SVH3_MOUSE UniProtKB/TrEMBL
  A0A0R4J0U2 ENTREZGENE, UniProtKB/TrEMBL
  A4QMV1_MOUSE UniProtKB/TrEMBL
  PP4R2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BX91_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q4G0D4 UniProtKB/Swiss-Prot
  Q6P6N7 UniProtKB/Swiss-Prot
  Q6PHU6 UniProtKB/Swiss-Prot
  Q8BUU5 UniProtKB/Swiss-Prot