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Gene: Lif (leukemia inhibitory factor) Mus musculus
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Symbol: Lif
Name: leukemia inhibitory factor
Description: Exhibits cytokine activity and growth factor activity. Involved in several processes, including animal organ development; generation of neurons; and negative regulation of ERK1 and ERK2 cascade. Localizes to the extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,1-dichloroethene; 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: d factor; differentiation-stimulating factor; myeloid leukaemia inhibitory factor
Orthologs:
Homo sapiens (human) : LIF (LIF interleukin 6 family cytokine)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lif (LIF, interleukin 6 family cytokine)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lif (LIF interleukin 6 family cytokine)
Pan paniscus (bonobo/pygmy chimpanzee) : LIF (LIF interleukin 6 family cytokine)
Canis lupus familiaris (dog) : LIF (LIF interleukin 6 family cytokine)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lif (LIF interleukin 6 family cytokine)
Sus scrofa (pig) : LIF (LIF interleukin 6 family cytokine)
Chlorocebus sabaeus (green monkey) : LIF (LIF interleukin 6 family cytokine)
Heterocephalus glaber (naked mole-rat) : Lif (LIF interleukin 6 family cytokine)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl114,257,557 - 4,272,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11 A1NCBI
cM Map112.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lif
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736775
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.