Lif (leukemia inhibitory factor) - Rat Genome Database

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Gene: Lif (leukemia inhibitory factor) Mus musculus
Analyze
Symbol: Lif
Name: leukemia inhibitory factor
RGD ID: 736775
MGI Page MGI
Description: Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,1-dichloroethene; 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: d factor; differentiation-stimulating factor; myeloid leukaemia inhibitory factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,207,568 - 4,222,514 (+)NCBIGRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
1,1-dichloroethene  (EXP)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-nitro-1,2-phenylenediamine  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Bardoxolone methyl  (EXP)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzyl alcohol  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
calciol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin a  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
chlorambucil  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clomiphene  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
coumaphos  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (EXP)
diisopropyl fluorophosphate  (EXP,ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
fenamidone  (EXP)
fluoranthene  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
geraniol  (ISO)
glucose  (EXP,ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
herbicide  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
isoflavones  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
limonene  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-Nitrosopyrrolidine  (ISO)
Nicardipine  (ISO)
nickel sulfate  (ISO)
nitric oxide  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
physostigmine  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
SB 203580  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triclosan  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte differentiation  (ISO)
blood vessel remodeling  (IGI)
decidualization  (IDA,IMP)
embryo implantation  (IDA,IMP)
immune response  (IEA)
leukemia inhibitory factor signaling pathway  (IBA,ISO)
lung alveolus development  (IGI)
lung development  (IGI)
lung lobe morphogenesis  (IGI)
lung vasculature development  (IGI)
maternal process involved in female pregnancy  (IMP)
muscle organ morphogenesis  (IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of ERK1 and ERK2 cascade  (IGI)
negative regulation of hormone secretion  (ISO)
negative regulation of meiotic nuclear division  (IDA)
neuron development  (IGI)
positive regulation of astrocyte differentiation  (IDA)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell population proliferation  (IBA,IMP,ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of gene expression  (IGI)
positive regulation of histone H3-K27 acetylation  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of cell differentiation  (IBA,IGI)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO)
regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IDA)
retina development in camera-type eye  (ISO)
spongiotrophoblast differentiation  (IGI)
stem cell differentiation  (IDA)
stem cell population maintenance  (IDA,IGI)
transdifferentiation  (ISO)
trophoblast giant cell differentiation  (IGI)
tyrosine phosphorylation of STAT protein  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal capillary morphology  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal embryo apposition  (IAGP)
abnormal embryo attachment  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal induced retinal neovascularization  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland physiology  (IAGP)
abnormal mitral cell morphology  (IAGP)
abnormal olfactory bulb external plexiform layer morphology  (IAGP)
abnormal olfactory bulb layer morphology  (IAGP)
abnormal olfactory bulb mitral cell layer morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pilomotor reflex  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal retinal vasculature morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal uterine receptivity  (IAGP)
abnormal uterus morphology  (IAGP)
abnormal white fat cell morphology  (IAGP)
absent type I pneumocytes  (IAGP)
atelectasis  (IAGP)
decreased body mass index  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone volume  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased motor neuron number  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased T cell proliferation  (IAGP)
delayed bone ossification  (IAGP)
diarrhea  (IAGP)
failure of embryo implantation  (IAGP)
female infertility  (IAGP)
fragile skeleton  (IAGP)
hepatic necrosis  (IAGP)
hypoxia  (IAGP)
increased acute inflammation  (IAGP)
increased bone resorption  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating serum amyloid protein level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased eosinophil cell number  (IAGP)
increased growth hormone level  (IAGP)
increased osteoclast cell number  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased type II pneumocyte number  (IAGP)
increased uterine NK cell number  (IAGP)
increased vascular endothelial cell proliferation  (IAGP)
liver hemorrhage  (IAGP)
liver vascular congestion  (IAGP)
muscle hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
slow postnatal weight gain  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin epidermis  (IAGP)
thrombocytopenia  (IAGP)
tremors  (IAGP)
underdeveloped hair follicles  (IAGP)
References

Additional References at PubMed
PMID:1321343   PMID:1457125   PMID:1477476   PMID:1522892   PMID:1561703   PMID:1692837   PMID:2111155   PMID:2119255   PMID:2475312   PMID:3127201   PMID:3128791   PMID:3143918  
PMID:3147726   PMID:3186448   PMID:7507352   PMID:7508917   PMID:7520692   PMID:7525452   PMID:7565937   PMID:7586505   PMID:7595475   PMID:7689430   PMID:7698769   PMID:7743917  
PMID:7826626   PMID:7877978   PMID:7925026   PMID:7957045   PMID:7959007   PMID:8006010   PMID:8020098   PMID:8050491   PMID:8054487   PMID:8064301   PMID:8138038   PMID:8187629  
PMID:8188294   PMID:8207122   PMID:8260605   PMID:8395365   PMID:8401507   PMID:8422244   PMID:8454050   PMID:8497320   PMID:8543809   PMID:8605875   PMID:8607969   PMID:8621407  
PMID:8683100   PMID:8755479   PMID:8765501   PMID:8770940   PMID:8787743   PMID:8793295   PMID:8843390   PMID:9073449   PMID:9124702   PMID:9160706   PMID:9175833   PMID:9226373  
PMID:9240457   PMID:9254611   PMID:9278535   PMID:9298977   PMID:9435283   PMID:9500603   PMID:9564824   PMID:9593715   PMID:9651226   PMID:9662407   PMID:9740023   PMID:9806780  
PMID:9920829   PMID:9924186   PMID:9927325   PMID:10202003   PMID:10205054   PMID:10349636   PMID:10438970   PMID:10455174   PMID:10486560   PMID:10675625   PMID:10704754   PMID:10712626  
PMID:10764413   PMID:10803598   PMID:10922068   PMID:10935540   PMID:11042159   PMID:11045638   PMID:11076861   PMID:11089533   PMID:11160255   PMID:11160399   PMID:11203703   PMID:11217851  
PMID:11279117   PMID:11435700   PMID:11549727   PMID:11567054   PMID:11683174   PMID:11855863   PMID:11897091   PMID:11934677   PMID:11950938   PMID:12007288   PMID:12050136   PMID:12084939  
PMID:12124777   PMID:12392991   PMID:12466851   PMID:12490192   PMID:12591604   PMID:12629183   PMID:12764151   PMID:12782633   PMID:12810593   PMID:12826573   PMID:12860906   PMID:14512435  
PMID:14610273   PMID:14657014   PMID:14695905   PMID:14741342   PMID:14970834   PMID:14976223   PMID:15012602   PMID:15117747   PMID:15148312   PMID:15171696   PMID:15178747   PMID:15246839  
PMID:15292206   PMID:15358627   PMID:15488701   PMID:15519241   PMID:15576827   PMID:15597051   PMID:15618884   PMID:15634701   PMID:15647843   PMID:15673569   PMID:15702085   PMID:15716414  
PMID:15747579   PMID:15785381   PMID:15793565   PMID:15848385   PMID:15985451   PMID:16099433   PMID:16141072   PMID:16141073   PMID:16206277   PMID:16258063   PMID:16291739   PMID:16314487  
PMID:16369772   PMID:16407199   PMID:16452727   PMID:16458863   PMID:16467531   PMID:16498619   PMID:16636663   PMID:16648972   PMID:16682639   PMID:16691571   PMID:16781162   PMID:16790614  
PMID:16987252   PMID:17021343   PMID:17074046   PMID:17108182   PMID:17150369   PMID:17179859   PMID:17249568   PMID:17313947   PMID:17332343   PMID:17356004   PMID:17360716   PMID:17451373  
PMID:17680539   PMID:17935626   PMID:18046411   PMID:18088375   PMID:18239353   PMID:18250427   PMID:18278460   PMID:18287559   PMID:18293407   PMID:18337516   PMID:18385284   PMID:18451094  
PMID:18521186   PMID:18546535   PMID:18548006   PMID:18552402   PMID:18829014   PMID:18841027   PMID:19021297   PMID:19091967   PMID:19105399   PMID:19267953   PMID:19342884   PMID:19541590  
PMID:19571885   PMID:19598242   PMID:19635738   PMID:19646521   PMID:19693290   PMID:19795791   PMID:19819227   PMID:19906980   PMID:19962978   PMID:20091786   PMID:20124728   PMID:20345762  
PMID:20564184   PMID:20598020   PMID:20843830   PMID:20864644   PMID:20962578   PMID:20974049   PMID:21035850   PMID:21094641   PMID:21254450   PMID:21385842   PMID:21402718   PMID:21425410  
PMID:21593477   PMID:21613225   PMID:21677750   PMID:21681859   PMID:21731673   PMID:21785422   PMID:21835648   PMID:21873635   PMID:21930391   PMID:21966484   PMID:22074622   PMID:22100262  
PMID:22143976   PMID:22210859   PMID:22285730   PMID:22454532   PMID:22581855   PMID:22682244   PMID:22774981   PMID:22894638   PMID:22905257   PMID:22949634   PMID:23077604   PMID:23258129  
PMID:23407384   PMID:23409146   PMID:23628590   PMID:23676498   PMID:23788624   PMID:23942233   PMID:23963683   PMID:24006456   PMID:24008729   PMID:24169527   PMID:24310780   PMID:24464633  
PMID:24664722   PMID:24698551   PMID:24859004   PMID:24877624   PMID:25012664   PMID:25031358   PMID:25147827   PMID:25277705   PMID:25341493   PMID:25514345   PMID:25564647   PMID:25635127  
PMID:25639936   PMID:25887270   PMID:26043040   PMID:26092726   PMID:26184908   PMID:26187859   PMID:26272398   PMID:26303070   PMID:26321142   PMID:26395492   PMID:26427868   PMID:26512061  
PMID:26764350   PMID:26865369   PMID:26995887   PMID:27096934   PMID:27227407   PMID:27676194   PMID:28049832   PMID:28122728   PMID:28202523   PMID:28522567   PMID:28698371   PMID:28865476  
PMID:29029363   PMID:29222114   PMID:29391217   PMID:29721979   PMID:30270531   PMID:30996350   PMID:31142168   PMID:31291592   PMID:31740000   PMID:32150249   PMID:32169845   PMID:32651426  
PMID:32719388   PMID:32792620   PMID:33048843  


Genomics

Comparative Map Data
Lif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,207,568 - 4,222,514 (+)NCBIGRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
LIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,240,453 - 30,257,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
Lif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)Ensembl
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
Lif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,489,421 - 4,497,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,489,515 - 4,505,439 (-)NCBIChiLan1.0ChiLan1.0
LIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,078,862 - 29,095,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,078,862 - 29,095,608 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02211,276,576 - 11,282,972 (-)NCBIMhudiblu_PPA_v0panPan3
LIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
Lif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,317,865 - 116,334,346 (-)NCBI
SpeTri2.0NW_004936904410,043 - 413,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,121,261 - 13,127,663 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,121,297 - 13,127,679 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045113,007,597 - 113,025,154 (+)NCBIVero_WHO_p1.0
Lif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247476,558,872 - 6,565,207 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
M63419  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,272,508 - 4,272,633UniSTSGRCm38
MGSCv37114,172,511 - 4,172,636UniSTSGRCm37
Celera114,771,678 - 4,771,803UniSTS
Cytogenetic Map11A1-A2UniSTS
Whitehead/MRC_RH1111.97UniSTS
D11Mit106  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,270,753 - 4,270,883UniSTSGRCm38
MGSCv37114,170,756 - 4,170,886UniSTSGRCm37
Celera114,769,923 - 4,770,053UniSTS
Cytogenetic Map11A1-A2UniSTS
cM Map110.25UniSTS
Whitehead Genetic113.3UniSTS
D11Mit16  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,269,560 - 4,269,681UniSTSGRCm38
MGSCv37114,169,563 - 4,169,684UniSTSGRCm37
Celera114,768,730 - 4,768,851UniSTS
Cytogenetic Map11A1-A2UniSTS
cM Map110.25UniSTS
Whitehead Genetic112.2UniSTS
D11Mit16.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,269,500 - 4,269,611UniSTSGRCm38
MGSCv37114,169,503 - 4,169,614UniSTSGRCm37
Celera114,768,670 - 4,768,781UniSTS
Cytogenetic Map11A1-A2UniSTS
cM Map110.25UniSTS
cM Map11 UniSTS
Whitehead Genetic112.2UniSTS
D11Mit16.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,269,694 - 4,269,823UniSTSGRCm38
MGSCv37114,169,697 - 4,169,826UniSTSGRCm37
Celera114,768,864 - 4,768,993UniSTS
Cytogenetic Map11A1-A2UniSTS
cM Map110.25UniSTS
cM Map11 UniSTS
Whitehead Genetic112.2UniSTS
Lif  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1-A2UniSTS
cM Map110.25UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123930487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11126026374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11126026374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11126026374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1127705234277232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11272035536721472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11330000018200000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11330000018500000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11330000019800000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11330000034600000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11330000044200000Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2983
Count of miRNA genes:662
Interacting mature miRNAs:873
Transcripts:ENSMUST00000040750, ENSMUST00000066283, ENSMUST00000154927
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A01670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A01690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP765086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY207460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY209921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY233044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S73374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000040750   ⟹   ENSMUSP00000036853
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,217,095 - 4,222,514 (+)Ensembl
GRCm38.p6 Ensembl114,267,095 - 4,272,514 (+)Ensembl
RefSeq Acc Id: ENSMUST00000066283   ⟹   ENSMUSP00000067066
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,207,557 - 4,222,514 (+)Ensembl
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154927
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,216,796 - 4,218,249 (+)Ensembl
GRCm38.p6 Ensembl114,266,796 - 4,268,249 (+)Ensembl
RefSeq Acc Id: NM_001039537   ⟹   NP_001034626
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,216,796 - 4,222,514 (+)NCBI
GRCm38114,266,796 - 4,272,514 (+)NCBI
MGSCv37114,157,571 - 4,172,517 (+)RGD
Celera114,756,756 - 4,771,684 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008501   ⟹   NP_032527
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,207,568 - 4,222,514 (+)NCBI
GRCm38114,257,568 - 4,272,514 (+)ENTREZGENE
MGSCv37114,157,571 - 4,172,517 (+)RGD
Celera114,756,756 - 4,771,684 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514542   ⟹   XP_006514605
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,214,285 - 4,222,514 (+)NCBI
GRCm38114,264,279 - 4,272,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514543   ⟹   XP_006514606
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,215,224 - 4,222,514 (+)NCBI
GRCm38114,265,218 - 4,272,514 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032527   ⟸   NM_008501
- Peptide Label: isoform a precursor
- UniProtKB: P09056 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001034626   ⟸   NM_001039537
- Peptide Label: isoform b
- UniProtKB: P09056 (UniProtKB/Swiss-Prot),   F8WH42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514606   ⟸   XM_006514543
- Peptide Label: isoform X1
- UniProtKB: P09056 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006514605   ⟸   XM_006514542
- Peptide Label: isoform X1
- UniProtKB: P09056 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000067066   ⟸   ENSMUST00000066283
RefSeq Acc Id: ENSMUSP00000036853   ⟸   ENSMUST00000040750

Promoters
RGD ID:6821177
Promoter ID:MM_KWN:6227
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000109953,   NM_001039537,   OTTMUST00000077315
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,166,551 - 4,167,051 (+)MPROMDB
RGD ID:6848981
Promoter ID:MM_XEF:935
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:NM_022196,   NM_214402
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,167,471 - 4,167,971 (+)MPROMDB
RGD ID:8673790
Promoter ID:EPDNEW_M14926
Type:initiation region
Name:Lif_1
Description:Mus musculus leukemia inhibitory factor , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14927  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,266,535 - 4,266,595EPDNEW
RGD ID:8673792
Promoter ID:EPDNEW_M14927
Type:initiation region
Name:Lif_2
Description:Mus musculus leukemia inhibitory factor , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14926  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,266,807 - 4,266,867EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96787 AgrOrtholog
Ensembl Genes ENSMUSG00000034394 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000036853 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000067066 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040750 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000066283 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Leukemia_IF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukemia_IF/oncostatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukemia_IF/oncostatin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16878 UniProtKB/Swiss-Prot
MGD MGI:96787 ENTREZGENE
NCBI Gene 16878 ENTREZGENE
PANTHER PTHR10633 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIF_OSM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lif PhenoGen
PRINTS LEUKAEMIAIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIF_OSM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LIF_OSM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt F8WH42 ENTREZGENE, UniProtKB/TrEMBL
  LIF_MOUSE UniProtKB/Swiss-Prot
  O35672_MOUSE UniProtKB/TrEMBL
  P09056 ENTREZGENE
  Q3U1H5_MOUSE UniProtKB/TrEMBL