Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Lif (leukemia inhibitory factor) Mus musculus
Symbol: Lif
Name: leukemia inhibitory factor
Description: Exhibits cytokine activity and growth factor activity. Involved in several processes, including animal organ development; generation of neurons; and negative regulation of ERK1 and ERK2 cascade. Localizes to the extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,1-dichloroethene; 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: d factor; differentiation-stimulating factor; myeloid leukaemia inhibitory factor
Homo sapiens (human) : LIF (LIF interleukin 6 family cytokine)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lif (LIF, interleukin 6 family cytokine)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lif (LIF interleukin 6 family cytokine)
Pan paniscus (bonobo/pygmy chimpanzee) : LIF (LIF interleukin 6 family cytokine)
Canis lupus familiaris (dog) : LIF (LIF interleukin 6 family cytokine)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lif (LIF interleukin 6 family cytokine)
Sus scrofa (pig) : LIF (LIF interleukin 6 family cytokine)
Chlorocebus sabaeus (green monkey) : LIF (LIF interleukin 6 family cytokine)
Heterocephalus glaber (naked mole-rat) : Lif (LIF interleukin 6 family cytokine)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl114,257,557 - 4,272,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11 A1NCBI
cM Map112.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lif
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736775
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.