Notch2 (notch 2) - Rat Genome Database

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Gene: Notch2 (notch 2) Mus musculus
Analyze
Symbol: Notch2
Name: notch 2
RGD ID: 736047
MGI Page MGI
Description: Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including heart looping; left/right axis specification; and marginal zone B cell differentiation. Acts upstream of or within several processes, including animal organ development; cholangiocyte proliferation; and positive regulation of BMP signaling pathway. Located in cilium and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI853703; Motch B; N; N2; neurogenic locus notch homolog protein 2; Notch gene homolog 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,920,854 - 98,057,683 (+)NCBIGRCm39mm39
GRCm39 Ensembl397,920,843 - 98,057,677 (+)Ensembl
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,013,527 - 98,150,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBImm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buspirone  (ISO)
Butylparaben  (ISO)
C60 fullerene  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
DAPT  (ISO)
DDE  (ISO)
Deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
folic acid  (EXP)
genistein  (ISO)
gentamycin  (ISO)
indometacin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
linuron  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
ochratoxin A  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
sarin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (TAS)
atrial septum morphogenesis  (ISO)
bone remodeling  (ISO)
cell differentiation  (IEA)
cell fate determination  (ISO,TAS)
central nervous system development  (IBA)
cholangiocyte proliferation  (IMP)
ciliary body morphogenesis  (IMP)
defense response to bacterium  (IMP)
determination of left/right symmetry  (IMP)
embryonic limb morphogenesis  (IGI)
glomerular capillary formation  (IEP)
glomerular visceral epithelial cell development  (IEP)
heart looping  (IGI)
hepatocyte proliferation  (IMP)
humoral immune response  (IGI)
in utero embryonic development  (IMP)
inflammatory response to antigenic stimulus  (IGI)
intrahepatic bile duct development  (IMP)
left/right axis specification  (IGI)
liver development  (IMP)
liver morphogenesis  (IMP)
marginal zone B cell differentiation  (IMP)
morphogenesis of an epithelial sheet  (IMP)
multicellular organism growth  (IMP)
myeloid dendritic cell differentiation  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of growth rate  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
Notch signaling pathway  (IC,ISO,TAS)
placenta blood vessel development  (IMP)
placenta development  (IMP)
positive regulation of apoptotic process  (IGI)
positive regulation of BMP signaling pathway  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of Ras protein signal transduction  (ISO)
proximal tubule development  (IEP)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton reorganization  (ISO)
regulation of cell cycle  (ISO)
regulation of developmental process  (IEA)
regulation of osteoclast development  (ISO)
regulation of transcription by RNA polymerase II  (IMP)
regulation of transcription, DNA-templated  (IEA)
skeletal system development  (IBA)
tissue regeneration  (ISO)
wound healing  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior eye segment morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal bile duct development  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal biliary tract morphology  (IAGP)
abnormal blood flow velocity  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal branching involved in pancreas development  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal chorionic plate morphology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal endocrine pancreas morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal glomerular capillary endothelium morphology  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal hyaloid artery morphology  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney papilla morphology  (IAGP)
abnormal kidney pelvis morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic bud formation  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta size  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal sensory neuron morphology  (IAGP)
abnormal spleen marginal zone morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
absent hair follicle inner root sheath  (IAGP)
absent marginal zone B cells  (IAGP)
absent mesangial cell  (IAGP)
absent podocytes  (IAGP)
absent sebaceous gland  (IAGP)
aorta stenosis  (IAGP)
arrested T cell differentiation  (IAGP)
atrial septal defect  (IAGP)
cholestasis  (IAGP)
cyanosis  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased compact bone area  (IAGP)
decreased compact bone thickness  (IAGP)
decreased compact bone volume  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased kidney cell proliferation  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased trabecular bone connectivity density  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased transitional stage B cell number  (IAGP)
diluted coat color  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
focal hepatic necrosis  (IAGP)
hair follicle degeneration  (IAGP)
heart hypoplasia  (IAGP)
hemorrhage  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired lung alveolus development  (IAGP)
increased apoptosis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased bone mineralization  (IAGP)
increased bone resorption  (IAGP)
increased bone trabecular spacing  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased hematopoietic cell number  (IAGP)
increased kidney apoptosis  (IAGP)
increased leukemia incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
jaundice  (IAGP)
kidney failure  (IAGP)
kidney hemorrhage  (IAGP)
kidney microaneurysm  (IAGP)
microphthalmia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
ovarian follicular cyst  (IAGP)
ovary hemorrhage  (IAGP)
overriding aortic valve  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
persistent hyperplastic primary vitreous  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
progressive hair loss  (IAGP)
pulmonary artery stenosis  (IAGP)
renal hypoplasia  (IAGP)
scaly skin  (IAGP)
short femur  (IAGP)
skin edema  (IAGP)
small kidney  (IAGP)
small pancreas  (IAGP)
small pituitary gland  (IAGP)
supravalvar pulmonary trunk stenosis  (IAGP)
thick epidermis  (IAGP)
ventricular hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:7609614   PMID:7615640   PMID:7698746   PMID:7918097   PMID:7926761   PMID:8440332   PMID:8645602   PMID:8889548   PMID:8898100   PMID:8917536   PMID:9108364   PMID:9111338  
PMID:9242490   PMID:9291577   PMID:9570965   PMID:9690472   PMID:9690473   PMID:9739106   PMID:9811581   PMID:9858718   PMID:9882480   PMID:10194420   PMID:10349636   PMID:10383933  
PMID:10393120   PMID:10476967   PMID:10508694   PMID:10512203   PMID:10551863   PMID:10615124   PMID:10704869   PMID:10704873   PMID:10825208   PMID:10842072   PMID:10868931   PMID:10878608  
PMID:10932180   PMID:10952889   PMID:10952903   PMID:10958687   PMID:11042159   PMID:11044610   PMID:11076861   PMID:11118901   PMID:11124811   PMID:11171333   PMID:11217851   PMID:11262239  
PMID:11284963   PMID:11401408   PMID:11414760   PMID:11459941   PMID:11466531   PMID:11518718   PMID:11545715   PMID:11578869   PMID:11641270   PMID:11713346   PMID:11731257   PMID:11739954  
PMID:11823422   PMID:11861489   PMID:12167404   PMID:12242712   PMID:12242716   PMID:12244553   PMID:12397111   PMID:12421720   PMID:12441287   PMID:12466851   PMID:12477932   PMID:12496659  
PMID:12520002   PMID:12617809   PMID:12670869   PMID:12730124   PMID:12753744   PMID:12753746   PMID:12787792   PMID:12846471   PMID:12866128   PMID:12904583   PMID:12907456   PMID:12947105  
PMID:12960298   PMID:12971992   PMID:14514757   PMID:14607778   PMID:14610273   PMID:14612407   PMID:14651921   PMID:14660750   PMID:14672936   PMID:14701881   PMID:14702043   PMID:14732396  
PMID:14757642   PMID:14960276   PMID:15019995   PMID:15037319   PMID:15064243   PMID:15068794   PMID:15076712   PMID:15155583   PMID:15187027   PMID:15226394   PMID:15465493   PMID:15465494  
PMID:15499562   PMID:15525534   PMID:15578515   PMID:15625786   PMID:15659488   PMID:15689374   PMID:15821257   PMID:15840001   PMID:15866159   PMID:15882997   PMID:15897231   PMID:15917835  
PMID:16000382   PMID:16120638   PMID:16141072   PMID:16141073   PMID:16169548   PMID:16245338   PMID:16397869   PMID:16458080   PMID:16518823   PMID:16524929   PMID:16602821   PMID:16607638  
PMID:16840533   PMID:16914494   PMID:17015435   PMID:17030682   PMID:17044085   PMID:17080428   PMID:17194759   PMID:17196193   PMID:17229764   PMID:17261636   PMID:17273555   PMID:17303760  
PMID:17359302   PMID:17366661   PMID:17476283   PMID:17531978   PMID:17572911   PMID:17573339   PMID:17579038   PMID:17658279   PMID:17699740   PMID:17915208   PMID:17919533   PMID:18037398  
PMID:18093989   PMID:18155189   PMID:18156632   PMID:18180309   PMID:18272846   PMID:18297083   PMID:18299578   PMID:18311147   PMID:18330927   PMID:18353145   PMID:18365007   PMID:18410734  
PMID:18458347   PMID:18499801   PMID:18507503   PMID:18635610   PMID:18666240   PMID:18694942   PMID:18708576   PMID:18710934   PMID:18724371   PMID:18801836   PMID:18838555   PMID:18927153  
PMID:18957219   PMID:19020777   PMID:19130928   PMID:19185577   PMID:19211676   PMID:19217325   PMID:19223466   PMID:19369401   PMID:19403103   PMID:19503073   PMID:19530136   PMID:19551907  
PMID:19573812   PMID:19723505   PMID:19797679   PMID:19805515   PMID:19855135   PMID:19897741   PMID:19914171   PMID:19914235   PMID:19915064   PMID:20007915   PMID:20059953   PMID:20069650  
PMID:20156974   PMID:20174635   PMID:20299358   PMID:20335360   PMID:20351182   PMID:20378824   PMID:20440271   PMID:20558824   PMID:20624967   PMID:20727876   PMID:20856205   PMID:20870902  
PMID:20876509   PMID:20971948   PMID:20975697   PMID:21042537   PMID:21084383   PMID:21150899   PMID:21252157   PMID:21257969   PMID:21267068   PMID:21285514   PMID:21297003   PMID:21302255  
PMID:21311046   PMID:21328691   PMID:21402740   PMID:21420948   PMID:21427220   PMID:21437251   PMID:21490058   PMID:21562564   PMID:21633169   PMID:21646720   PMID:21677750   PMID:21693515  
PMID:21703454   PMID:21731673   PMID:21750033   PMID:21779394   PMID:21786021   PMID:21791528   PMID:21795747   PMID:21852398   PMID:21873635   PMID:21909072   PMID:21909092   PMID:21991352  
PMID:22018469   PMID:22109558   PMID:22156581   PMID:22173065   PMID:22190634   PMID:22205705   PMID:22274697   PMID:22293205   PMID:22366192   PMID:22390640   PMID:22396647   PMID:22457635  
PMID:22503540   PMID:22505716   PMID:22560297   PMID:22615412   PMID:22615991   PMID:22652674   PMID:22675208   PMID:22675211   PMID:22717580   PMID:22865640   PMID:22915591   PMID:23079658  
PMID:23079659   PMID:23132245   PMID:23144817   PMID:23175466   PMID:23199335   PMID:23243020   PMID:23264614   PMID:23277114   PMID:23314057   PMID:23315998   PMID:23319657   PMID:23359070  
PMID:23362348   PMID:23362349   PMID:23382219   PMID:23386589   PMID:23406467   PMID:23454750   PMID:23460609   PMID:23467742   PMID:23500150   PMID:23555292   PMID:23604318   PMID:23665443  
PMID:23675950   PMID:23676271   PMID:23791481   PMID:23806616   PMID:23825310   PMID:23884415   PMID:23884446   PMID:23913046   PMID:23918982   PMID:23954203   PMID:23965337   PMID:24015274  
PMID:24145721   PMID:24154525   PMID:24227653   PMID:24323359   PMID:24337118   PMID:24353058   PMID:24398584   PMID:24449835   PMID:24508387   PMID:24509876   PMID:24552588   PMID:24563458  
PMID:24673559   PMID:24711412   PMID:24741061   PMID:24859004   PMID:24952961   PMID:24982181   PMID:25184679   PMID:25257302   PMID:25344724   PMID:25446530   PMID:25501905   PMID:25505333  
PMID:25574842   PMID:25691540   PMID:25715395   PMID:25776744   PMID:25813538   PMID:25835502   PMID:25866967   PMID:25957400   PMID:25977369   PMID:25982147   PMID:25992862   PMID:26034172  
PMID:26062937   PMID:26108693   PMID:26119937   PMID:26147083   PMID:26188077   PMID:26279572   PMID:26293507   PMID:26410627   PMID:26417101   PMID:26450967   PMID:26450968   PMID:26453897  
PMID:26527653   PMID:26542370   PMID:26627824   PMID:26651607   PMID:26669487   PMID:26689699   PMID:26697723   PMID:26792178   PMID:26912775   PMID:26933171   PMID:26940862   PMID:27040987  
PMID:27073171   PMID:27084580   PMID:27097807   PMID:27102824   PMID:27122169   PMID:27141929   PMID:27184845   PMID:27241678   PMID:27351100   PMID:27358050   PMID:27364009   PMID:27510977  
PMID:27564454   PMID:27576369   PMID:27621062   PMID:27631609   PMID:27633993   PMID:27776108   PMID:27855169   PMID:28036337   PMID:28319044   PMID:28323963   PMID:28348230   PMID:28360133  
PMID:28402857   PMID:28455376   PMID:28455378   PMID:28489825   PMID:28539333   PMID:28566723   PMID:28592489   PMID:28637720   PMID:28656980   PMID:28669409   PMID:28676438   PMID:28688656  
PMID:28707394   PMID:28733035   PMID:28745029   PMID:28747678   PMID:28856714   PMID:28969912   PMID:29031500   PMID:29033846   PMID:29037852   PMID:29113990   PMID:29126263   PMID:29139178  
PMID:29149593   PMID:29228365   PMID:29326173   PMID:29386140   PMID:29545197   PMID:29545603   PMID:29739871   PMID:29760082   PMID:29853569   PMID:29879109   PMID:29885287   PMID:29915190  
PMID:29940267   PMID:29956664   PMID:30059908   PMID:30085028   PMID:30181175   PMID:30226866   PMID:30242258   PMID:30254141   PMID:30279176   PMID:30284985   PMID:30289388   PMID:30375389  
PMID:30470250   PMID:30514723   PMID:30550785   PMID:30643147   PMID:30675064   PMID:30763736   PMID:30877223   PMID:30951556   PMID:31071093   PMID:31073041   PMID:31202705   PMID:31320326  
PMID:31371452   PMID:31390563   PMID:31479426   PMID:31758376   PMID:31992595   PMID:32023464   PMID:32059775   PMID:32060138   PMID:32147304   PMID:32161758   PMID:32276965   PMID:32325033  
PMID:32423029   PMID:32467237   PMID:32520726   PMID:32708917   PMID:32715474   PMID:32723480   PMID:32756905   PMID:32820046   PMID:32848032   PMID:32878924   PMID:33017398   PMID:33214146  
PMID:33441309   PMID:33597542   PMID:33627749   PMID:34150743  


Genomics

Comparative Map Data
Notch2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,920,854 - 98,057,683 (+)NCBIGRCm39mm39
GRCm39 Ensembl397,920,843 - 98,057,677 (+)Ensembl
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,013,527 - 98,150,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBImm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.42NCBI
NOTCH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,911,553 - 120,100,779 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,911,553 - 120,069,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,454,176 - 120,612,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,255,699 - 120,413,799 (-)NCBINCBI36hg18NCBI36
Build 341120,166,219 - 120,324,318NCBI
Celera1118,684,898 - 118,760,431 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,312,713 - 118,398,477 (-)NCBIHuRef
CHM1_11120,569,670 - 120,727,793 (-)NCBICHM1_1
Notch2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22185,610,594 - 185,744,088 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2185,610,589 - 185,744,088 (+)Ensembl
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
Notch2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBIChiLan1.0ChiLan1.0
NOTCH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,537,162 - 117,612,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBIMhudiblu_PPA_v0panPan3
NOTCH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,854,825 - 57,020,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBI
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBI
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBI
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBI
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBI
LOC101965998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,620,590 - 2,684,163 (-)NCBI
SpeTri2.0NW_004936872454,273 - 539,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,951,507 - 101,150,198 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14100,951,522 - 101,152,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,927,023 - 110,985,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,712,292 - 13,871,784 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603816,342,675 - 16,501,918 (+)NCBIVero_WHO_p1.0
Notch2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477215,572,350 - 15,726,312 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Notch2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37397,939,526 - 97,939,749UniSTSGRCm37
MGSCv37397,949,083 - 97,950,158UniSTSGRCm37
MGSCv37397,950,108 - 97,950,394UniSTSGRCm37
Celera399,545,236 - 99,545,522UniSTS
Celera399,534,747 - 99,534,970UniSTS
Celera399,544,211 - 99,545,286UniSTS
Cytogenetic Map3F2.2UniSTS
cM Map345.6UniSTS
AI853703  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38398,149,952 - 98,150,063UniSTSGRCm38
MGSCv37397,953,875 - 97,953,986UniSTSGRCm37
Celera399,549,058 - 99,549,169UniSTS
Cytogenetic Map3F2.2UniSTS
Whitehead/MRC_RH31118.13UniSTS
UniSTS:234772  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38398,047,178 - 98,047,476UniSTSGRCm38
MGSCv37397,851,101 - 97,851,399UniSTSGRCm37
Celera399,446,130 - 99,446,428UniSTS
Cytogenetic Map3F2.2UniSTS
PMC281641P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38398,138,785 - 98,139,632UniSTSGRCm38
MGSCv37397,942,708 - 97,943,555UniSTSGRCm37
Celera399,537,929 - 99,538,776UniSTS
Cytogenetic Map3F2.2UniSTS
Notch2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38398,145,160 - 98,146,235UniSTSGRCm38
MGSCv37397,949,083 - 97,950,158UniSTSGRCm37
Celera399,544,211 - 99,545,286UniSTS
Cytogenetic Map3F2.2UniSTS
Notch2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.2UniSTS
Notch2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38398,135,603 - 98,135,826UniSTSGRCm38
MGSCv37397,939,526 - 97,939,749UniSTSGRCm37
Celera399,534,747 - 99,534,970UniSTS
Cytogenetic Map3F2.2UniSTS
cM Map345.6UniSTS
Notch2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.2UniSTS
Notch2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38398,146,185 - 98,146,471UniSTSGRCm38
MGSCv37397,950,108 - 97,950,394UniSTSGRCm37
Celera399,545,236 - 99,545,522UniSTS
Cytogenetic Map3F2.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390603910100556821Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
1301277nctm1_mNakano cataract modifier 1 (mouse)Not determined397791322100465744Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1059
Count of miRNA genes:560
Interacting mature miRNAs:684
Transcripts:ENSMUST00000079812
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079812   ⟹   ENSMUSP00000078741
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl397,920,854 - 98,057,677 (+)Ensembl
GRCm38.p6 Ensembl398,013,538 - 98,150,361 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198324
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl397,920,843 - 98,007,975 (+)Ensembl
GRCm38.p6 Ensembl398,013,527 - 98,100,659 (+)Ensembl
RefSeq Acc Id: NM_010928   ⟹   NP_035058
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39397,920,854 - 98,057,683 (+)NCBI
GRCm38398,013,538 - 98,150,367 (+)ENTREZGENE
MGSCv37397,817,461 - 97,954,290 (+)RGD
Celera399,412,506 - 99,549,473 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035058   ⟸   NM_010928
- Peptide Label: precursor
- UniProtKB: O35516 (UniProtKB/Swiss-Prot),   G5E8J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078741   ⟸   ENSMUST00000079812
Protein Domains
ANK_REP_REGION   EGF-like   LNR

Promoters
RGD ID:6834161
Promoter ID:MM_KWN:35459
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_010928,   UC008QPN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36397,817,211 - 97,817,711 (+)MPROMDB
RGD ID:6834160
Promoter ID:MM_KWN:35460
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B6,   Spleen
Transcripts:ENSMUST00000079812,   ENSMUST00000107028
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36397,850,726 - 97,851,532 (+)MPROMDB
RGD ID:6881754
Promoter ID:EPDNEW_M4328
Type:initiation region
Name:Notch2_1
Description:Mus musculus notch 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38398,013,541 - 98,013,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97364 AgrOrtholog
Ensembl Genes ENSMUSG00000027878 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000078741 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079812 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454_notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot
  Notch-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18129 UniProtKB/Swiss-Prot
MGD MGI:97364 ENTREZGENE
NCBI Gene 18129 ENTREZGENE
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Notch2 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot
PRINTS LNOTCHREPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G5E8J0 ENTREZGENE
  NOTC2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U1W7_MOUSE UniProtKB/TrEMBL
  Q6PCM9_MOUSE UniProtKB/TrEMBL
UniProt Secondary G5E8J0 UniProtKB/Swiss-Prot
  Q06008 UniProtKB/Swiss-Prot
  Q60941 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-05 Notch2  notch 2  Notch2  Notch gene homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED