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Gene: Notch2 (notch 2) Mus musculus
Symbol: Notch2
Name: notch 2
Description: Exhibits NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including animal organ development; cholangiocyte proliferation; and regulation of transcription by RNA polymerase II. Localizes to the cilium and nucleus. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human NOTCH2 (notch receptor 2); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-chloroethyl) sulfide; ciguatoxin CTX1B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI853703; Motch B; N2; neurogenic locus notch homolog protein 2; Notch gene homolog 2
Homo sapiens (human) : NOTCH2 (notch receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Notch2 (notch receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notch2 (notch receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTCH2 (notch receptor 2)
Canis lupus familiaris (dog) : NOTCH2 (notch receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notch2 (notch receptor 2)
Sus scrofa (pig) : NOTCH2 (notch receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl398,013,527 - 98,150,361 (+)Ensembl
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBImm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3 F2.2NCBI
cM Map342.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Notch2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736047
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.