Cxcl12 (C-X-C motif chemokine ligand 12) - Rat Genome Database

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Gene: Cxcl12 (C-X-C motif chemokine ligand 12) Mus musculus
Analyze
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12 (Ensembl:chemokine (C-X-C motif) ligand 12)
RGD ID: 11280
MGI Page MGI
Description: Enables chemokine activity. Involved in dopaminergic neuron differentiation. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; nervous system development; and positive regulation of intracellular signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12; PB; Pbsf; PBSF/SD; pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; Scyb1; Scyb12; Sdf; SDF-; Sdf1; Sdf1a; Sdf1b; stromal cell-derived factor 1; thymic lymphoma cell-stimulating factor; TLS; Tlsf; Tlsfa; Tlsfb; TP; Tpar1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396117,145,496 - 117,158,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6117,145,496 - 117,158,328 (+)EnsemblGRCm39 Ensembl
GRCm386117,168,535 - 117,181,368 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6117,168,535 - 117,181,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv376117,118,553 - 117,131,386 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366117,134,182 - 117,146,986 (+)NCBIMGSCv36mm8
Celera6118,991,272 - 119,004,105 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map654.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(+/-)-Aegeline  (EXP)
(1->4)-beta-D-glucan  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1-bromopropane  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (EXP,ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
apigenin  (ISO)
aristolochic acid A  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (EXP)
BAY 60-6583  (EXP)
belinostat  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
Brevianamide A  (EXP)
bucladesine  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium atom  (ISO)
calcium phosphate  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP)
capecitabine  (ISO)
carbon nanotube  (EXP)
ceric oxide  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloroprene  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
ciprofibrate  (EXP)
cisplatin  (EXP)
clobetasol  (EXP)
clofibric acid  (ISO)
clomiphene  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
daidzein  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl malate  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
edaravone  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
estrone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenthion  (EXP)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gadodiamide hydrate  (ISO)
genistein  (ISO)
glafenine  (ISO)
Glutathione ethyl ester  (EXP)
glyceollin  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
graphene oxide  (EXP)
GW 1929  (ISO)
heparin  (ISO)
hexadecanoic acid  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
isotretinoin  (ISO)
KN-93  (EXP)
leflunomide  (ISO)
lidocaine  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
loliolide  (ISO)
luteolin  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
melphalan  (ISO)
mestranol  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
ML-7  (ISO)
monodansylcadaverine  (EXP)
Muraglitazar  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naringin  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
okadaic acid  (EXP)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phytoestrogen  (ISO)
Phytolaccoside E  (ISO)
picene  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP)
plerixafor  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
propofol  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP)
tamoxifen  (EXP,ISO)
telmisartan  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenylstannane  (EXP,ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (ISO)
XL147  (EXP)
Y-27632  (ISO)
yohimbine  (EXP)
zalcitabine  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
animal organ regeneration  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
axon guidance  (IBA)
blood vessel endothelial cell migration  (IMP)
brain development  (IDA)
branching involved in blood vessel morphogenesis  (IMP)
cell chemotaxis  (IBA,ISO)
cell-cell adhesion  (IDA)
cellular response to chemokine  (ISO)
chemokine (C-X-C motif) ligand 12 signaling pathway  (ISO)
chemokine-mediated signaling pathway  (IBA,ISO)
chemotaxis  (IEA)
CXCL12-activated CXCR4 signaling pathway  (ISO)
defense response  (IEA)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
dopaminergic neuron differentiation  (IDA)
germ cell development  (IDA)
germ cell migration  (IDA)
immune response  (IEA)
induction of positive chemotaxis  (IBA,IDA)
integrin activation  (ISO)
killing of cells of another organism  (ISO)
motor neuron axon guidance  (IMP)
negative regulation of cell population proliferation  (IGI)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of leukocyte tethering or rolling  (ISO)
neuron migration  (ISO)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of calcium ion import  (IDA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IBA,IDA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemotaxis  (IGI)
positive regulation of dopamine secretion  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IGI)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of myoblast fusion  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IGI)
positive regulation of T cell migration  (ISO)
positive regulation of vasculature development  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell migration  (IDA,IGI)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to peptide hormone  (ISO)
response to ultrasound  (ISO)
T cell chemotaxis  (ISO)
T cell proliferation  (IMP)
telencephalon cell migration  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal common lymphocyte progenitor cell morphology  (IAGP)
abnormal developmental vascular remodeling  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal primordial germ cell migration  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal skin vasculature morphology  (IAGP)
abnormal uterus morphology  (IEA)
abnormal vascular smooth muscle morphology  (IAGP)
decreased B cell number  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pre-pro B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
enlarged uterus  (IEA)
hepatic necrosis  (IAGP)
hydrometra  (IEA)
impaired myelopoiesis  (IAGP)
increased B cell apoptosis  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased neutrophil cell number  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hemorrhage  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
poor arterial differentiation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
thin external granule cell layer  (IAGP)
thrombocytopenia  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Abdul-Muneer PM, etal., Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.
2. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
3. Lentiviral gene transfer of SDF-1alpha to wounds improves diabetic wound healing. Badillo AT, etal., J Surg Res. 2007 Nov;143(1):35-42.
4. The chemokine SDF1 regulates migration of dentate granule cells. Bagri A, etal., Development 2002 Sep;129(18):4249-60.
5. SDF-1 is both necessary and sufficient to promote proliferative retinopathy. Butler JM, etal., J Clin Invest. 2005 Jan;115(1):86-93.
6. A common stromal cell-derived factor-1 chemokine gene variant is associated with the early onset of type 1 diabetes. Dubois-Laforgue D, etal., Diabetes. 2001 May;50(5):1211-3.
7. Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis. Fujinaka H, etal., J Nephrol. 2007 May-Jun;20(3):357-63.
8. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. Havens AM, etal., J Periodontol. 2008 May;79(5):845-53.
9. Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain. Hu XM, etal., Sci Rep. 2017 Jun 21;7(1):4005. doi: 10.1038/s41598-017-04198-3.
10. Association of stromal cell-derived factor 1 genotype with diabetic foot syndrome and macrovascular disease in patients with type 2 diabetes. Humpert PM, etal., Clin Chem. 2006 Jun;52(6):1206-8.
11. Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population. Ide A, etal., Hum Immunol. 2003 Oct;64(10):973-8.
12. CXCL12/SDF-1 over-expression in human insulinomas and its biological relevance. Ilhan A, etal., Mol Cell Endocrinol. 2009 Jan 27;298(1-2):1-10. Epub 2008 Oct 22.
13. Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. Jung KH, etal., Epilepsia. 2009 Mar;50(3):537-49. Epub 2008 Nov 20.
14. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
15. Upregulation of stromal cell-derived factor 1 (SDF-1) expression in microvasculature endothelial cells in retinal ischemia-reperfusion injury. Lai P, etal., Graefes Arch Clin Exp Ophthalmol. 2008 Dec;246(12):1707-13. Epub 2008 Aug 16.
16. Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development. Leng Q, etal., BMC Immunol. 2008 Sep 15;9:51.
17. Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
18. CXCL12 enhances exogenous CD4(+)CD25(+) T cell migration and prevents embryo loss in non-obese diabetic mice. Lin Y, etal., Fertil Steril. 2008 Apr 1.
19. Combined analysis of audiologic performance and the plasma biomarker stromal cell-derived factor 1a in type 2 diabetic patients. Loader B, etal., Otol Neurotol. 2008 Sep;29(6):739-44.
20. Role of stromal-cell derived factor-1 in the development of autoimmune diseases in non-obese diabetic mice. Matin K, etal., Immunology. 2002 Oct;107(2):222-32.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
25. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. Oh SB, etal., J Neurosci. 2001 Jul 15;21(14):5027-35.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1)1: SDF-1 alpha mRNA is selectively induced in rat model of myocardial infarction. Pillarisetti K and Gupta SK, Inflammation 2001 Oct;25(5):293-300.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma. Razmkhah M, etal., Cancer Lett. 2005 Jul 28;225(2):261-6. Epub 2004 Dec 13.
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. Roy I, etal., Cancer Res. 2015 Sep 1;75(17):3529-42. doi: 10.1158/0008-5472.CAN-14-2645.
36. Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development. Sarnowska E, etal., Am J Cancer Res. 2017 Nov 1;7(11):2275-2289. eCollection 2017.
37. Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of Japanese type 1 diabetes. Shigihara T, etal., Ann N Y Acad Sci. 2003 Nov;1005:328-31.
38. Local Upregulation of Stromal Cell-Derived Factor-1 After Ligament Injuries Enhances Homing Rate of Bone Marrow Stromal Cells in Rats. Shimode K, etal., Tissue Eng Part A. 2009 Feb 27.
39. Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. Sun YX, etal., J Cell Biochem. 2003 Jun 1;89(3):462-73.
40. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Tachibana K, etal., Nature 1998 Jun 11;393(6685):591-4.
41. SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. Wang Y, etal., Brain Res. 2008 Feb 21;1195:104-12. Epub 2007 Dec 14.
42. CXCR-7 receptor promotes SDF-1alpha-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus. Wang Y, etal., Brain Res. 2014 Aug 5;1575:78-86. doi: 10.1016/j.brainres.2014.05.035. Epub 2014 Jun 9.
43. Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. Wei FY, etal., PLoS One. 2014 Sep 2;9(9):e106722. doi: 10.1371/journal.pone.0106722. eCollection 2014.
44. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
45. Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Yano T, etal., Diabetes. 2007 Dec;56(12):2946-57. Epub 2007 Sep 18.
46. [Expression of stromal cell-derived factor 1 is increased in the retina of experimental diabetic rats] Yuan YZ, etal., Zhonghua Yan Ke Za Zhi. 2007 Oct;43(10):912-6.
47. [The expression and significance of SDF-1/CXCR4 biological axis in laryngeal squamous cell carcinoma and lymph node metastasize]. Zhang L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Sep;26(18):798-801.
48. CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. Zhao BC, etal., World J Gastroenterol. 2011 May 21;17(19):2389-96. doi: 10.3748/wjg.v17.i19.2389.
49. AMD3100 inhibits epithelial-mesenchymal transition, cell invasion, and metastasis in the liver and the lung through blocking the SDF-1α/CXCR4 signaling pathway in prostate cancer. Zhu WB, etal., J Cell Physiol. 2019 Jul;234(7):11746-11759. doi: 10.1002/jcp.27831. Epub 2018 Dec 7.
50. Chemokine stromal cell-derived factor 1/CXCL12 increases homing of mesenchymal stem cells to injured myocardium and neovascularization following myocardial infarction. Zhuang Y, etal., Chin Med J (Engl). 2009 Jan 20;122(2):183-7.
Additional References at PubMed
PMID:3445877   PMID:7490086   PMID:7982471   PMID:8134392   PMID:8342023   PMID:8751377   PMID:8757135   PMID:8889548   PMID:8962122   PMID:9064327   PMID:9305759   PMID:9634238  
PMID:9689100   PMID:10349636   PMID:10479460   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11093154   PMID:11301003   PMID:11520466   PMID:11756151   PMID:11983855   PMID:12077273  
PMID:12080938   PMID:12171912   PMID:12184921   PMID:12393569   PMID:12414810   PMID:12444109   PMID:12477932   PMID:12496427   PMID:12624490   PMID:12626600   PMID:12684531   PMID:12705474  
PMID:12707343   PMID:12714971   PMID:12805300   PMID:12832536   PMID:12874218   PMID:12900445   PMID:12904583   PMID:12914755   PMID:12932359   PMID:14502291   PMID:14555759   PMID:14638861  
PMID:14681479   PMID:14707114   PMID:14748564   PMID:14757413   PMID:15013630   PMID:15024423   PMID:15054039   PMID:15096537   PMID:15189736   PMID:15282153   PMID:15284120   PMID:15286810  
PMID:15300245   PMID:15381731   PMID:15489334   PMID:15505104   PMID:15533866   PMID:15608062   PMID:15626744   PMID:15647826   PMID:15661637   PMID:15681827   PMID:15718415   PMID:15748167  
PMID:15756692   PMID:15794931   PMID:15840024   PMID:15840658   PMID:15910246   PMID:16037394   PMID:16129397   PMID:16141072   PMID:16141073   PMID:16148115   PMID:16166380   PMID:16170318  
PMID:16198599   PMID:16259636   PMID:16262623   PMID:16302230   PMID:16365450   PMID:16412416   PMID:16424223   PMID:16493048   PMID:16537572   PMID:16545793   PMID:16565405   PMID:16568088  
PMID:16601228   PMID:16602821   PMID:16618794   PMID:16619289   PMID:16627256   PMID:16637021   PMID:16648859   PMID:16648972   PMID:16793890   PMID:16819978   PMID:16863903   PMID:16863905  
PMID:16863910   PMID:16875673   PMID:16931623   PMID:16944452   PMID:16964252   PMID:17077327   PMID:17114479   PMID:17148948   PMID:17174120   PMID:17182777   PMID:17339405   PMID:17360804  
PMID:17374136   PMID:17379762   PMID:17425785   PMID:17439946   PMID:17463394   PMID:17476357   PMID:17522382   PMID:17548653   PMID:17625108   PMID:17641243   PMID:17646584   PMID:17764962  
PMID:17804806   PMID:17823289   PMID:17827391   PMID:17853408   PMID:17885999   PMID:17932320   PMID:17971416   PMID:17971873   PMID:18003726   PMID:18040029   PMID:18040270   PMID:18086932  
PMID:18159948   PMID:18188864   PMID:18192840   PMID:18206727   PMID:18227348   PMID:18234887   PMID:18272682   PMID:18287559   PMID:18292517   PMID:18323525   PMID:18340011   PMID:18378701  
PMID:18421012   PMID:18424631   PMID:18448648   PMID:18464929   PMID:18495324   PMID:18534615   PMID:18579746   PMID:18606818   PMID:18617694   PMID:18627320   PMID:18648536   PMID:18697212  
PMID:18725516   PMID:18763056   PMID:18786922   PMID:18805969   PMID:18827024   PMID:18852294   PMID:18925577   PMID:18940728   PMID:19008373   PMID:19064997   PMID:19103804   PMID:19109194  
PMID:19118738   PMID:19141863   PMID:19155474   PMID:19182665   PMID:19193877   PMID:19248097   PMID:19281787   PMID:19299746   PMID:19301256   PMID:19302186   PMID:19339694   PMID:19353524  
PMID:19407239   PMID:19429788   PMID:19443644   PMID:19462459   PMID:19468708   PMID:19496198   PMID:19502087   PMID:19520808   PMID:19539688   PMID:19627512   PMID:19635473   PMID:19668217  
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PMID:20087418   PMID:20110411   PMID:20151462   PMID:20181837   PMID:20196780   PMID:20305788   PMID:20354171   PMID:20362069   PMID:20362461   PMID:20376342   PMID:20392955   PMID:20417197  
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PMID:23916851   PMID:23982175   PMID:23997015   PMID:24091662   PMID:24101523   PMID:24116850   PMID:24154522   PMID:24174685   PMID:24184055   PMID:24194600   PMID:24226205   PMID:24277834  
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Genomics

Comparative Map Data
Cxcl12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396117,145,496 - 117,158,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6117,145,496 - 117,158,328 (+)EnsemblGRCm39 Ensembl
GRCm386117,168,535 - 117,181,368 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6117,168,535 - 117,181,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv376117,118,553 - 117,131,386 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366117,134,182 - 117,146,986 (+)NCBIMGSCv36mm8
Celera6118,991,272 - 119,004,105 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map654.81NCBI
CXCL12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381044,370,165 - 44,385,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1044,370,165 - 44,386,493 (-)EnsemblGRCh38hg38GRCh38
GRCh371044,865,613 - 44,880,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361044,185,611 - 44,200,548 (-)NCBINCBI36Build 36hg18NCBI36
Build 341044,192,516 - 44,200,551NCBI
Celera1040,869,153 - 40,884,099 (-)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1041,391,945 - 41,406,899 (-)NCBIHuRef
CHM1_11044,904,782 - 44,919,728 (-)NCBICHM1_1
T2T-CHM13v2.01045,251,013 - 45,265,954 (-)NCBIT2T-CHM13v2.0
Cxcl12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,060,781 - 152,073,628 (+)NCBIGRCr8
mRatBN7.24150,388,326 - 150,401,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4150,388,325 - 150,401,168 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4156,650,651 - 156,663,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04152,434,709 - 152,447,550 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,057,585 - 151,070,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04149,261,044 - 149,273,891 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4149,261,044 - 149,273,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04215,195,689 - 215,208,536 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44153,503,576 - 153,516,423 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14153,748,473 - 153,755,186 (+)NCBI
Celera4139,267,343 - 139,280,188 (+)NCBICelera
Cytogenetic Map4q42NCBI
Cxcl12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,929,269 - 1,941,690 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,929,269 - 1,941,690 (-)NCBIChiLan1.0ChiLan1.0
CXCL12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2857,109,201 - 57,125,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11057,114,523 - 57,132,612 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01041,296,975 - 41,384,864 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11044,476,962 - 44,564,231 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1044,552,480 - 44,564,231 (-)Ensemblpanpan1.1panPan2
CXCL12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,895,916 - 2,903,543 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha283,126,200 - 3,137,772 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0283,070,799 - 3,082,409 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl283,070,793 - 3,099,455 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,868,050 - 2,879,621 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,906,153 - 2,917,718 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,043,671 - 3,055,243 (+)NCBIUU_Cfam_GSD_1.0
Cxcl12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721382,545,003 - 82,559,854 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366174,224,131 - 4,238,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366174,224,131 - 4,239,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1491,516,431 - 91,552,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11491,516,383 - 91,543,857 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21499,990,204 - 100,017,171 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1940,005,580 - 40,020,513 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl940,011,439 - 40,020,494 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605646,393,964 - 46,408,906 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcl12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249221,261,228 - 1,273,758 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249221,261,228 - 1,273,755 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcl12
426 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3817
Count of miRNA genes:894
Interacting mature miRNAs:1240
Transcripts:ENSMUST00000073043, ENSMUST00000112866, ENSMUST00000112871, ENSMUST00000134244
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114159241119737532Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse

Markers in Region
Cxcl12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386117,173,512 - 117,174,620UniSTSGRCm38
MGSCv376117,123,530 - 117,124,638UniSTSGRCm37
Celera6118,996,249 - 118,997,357UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.0UniSTS
AI174028  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386117,174,820 - 117,174,924UniSTSGRCm38
MGSCv376117,124,838 - 117,124,942UniSTSGRCm37
Celera6118,997,557 - 118,997,661UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.0UniSTS
Whitehead/MRC_RH61205.12UniSTS
L12030  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386117,179,265 - 117,179,360UniSTSGRCm38
MGSCv376117,129,283 - 117,129,378UniSTSGRCm37
Celera6119,002,002 - 119,002,097UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.0UniSTS
Whitehead/MRC_RH61196.8UniSTS
UniSTS:235532  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386117,177,515 - 117,177,722UniSTSGRCm38
MGSCv376117,127,533 - 117,127,740UniSTSGRCm37
Celera6119,000,252 - 119,000,459UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.0UniSTS
Sdf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386117,181,122 - 117,181,251UniSTSGRCm38
MGSCv376117,131,140 - 117,131,269UniSTSGRCm37
Celera6119,003,859 - 119,003,988UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.0UniSTS
Sdf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386117,174,816 - 117,174,948UniSTSGRCm38
MGSCv376117,124,834 - 117,124,966UniSTSGRCm37
Celera6118,997,553 - 118,997,685UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.0UniSTS
Cxcl12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F1UniSTS
Cxcl12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F1UniSTS
Cxcl12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F1UniSTS
Cxcl12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB610070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB840704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01066961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000073043   ⟹   ENSMUSP00000072800
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6117,145,538 - 117,158,328 (+)Ensembl
GRCm38.p6 Ensembl6117,168,577 - 117,181,367 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112866   ⟹   ENSMUSP00000108487
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6117,145,496 - 117,152,030 (+)Ensembl
GRCm38.p6 Ensembl6117,168,535 - 117,175,069 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112871   ⟹   ENSMUSP00000108492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6117,145,535 - 117,158,327 (+)Ensembl
GRCm38.p6 Ensembl6117,168,574 - 117,181,366 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6117,145,538 - 117,153,088 (+)Ensembl
GRCm38.p6 Ensembl6117,168,577 - 117,176,127 (+)Ensembl
RefSeq Acc Id: NM_001012477   ⟹   NP_001012495
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396117,145,496 - 117,158,329 (+)NCBI
GRCm386117,168,535 - 117,181,368 (+)ENTREZGENE
MGSCv376117,118,553 - 117,131,386 (+)RGD
Celera6118,991,272 - 119,004,105 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013655   ⟹   NP_038683
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396117,145,496 - 117,158,329 (+)NCBI
GRCm386117,168,535 - 117,181,368 (+)ENTREZGENE
MGSCv376117,118,553 - 117,131,386 (+)RGD
Celera6118,991,272 - 119,004,105 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_021704   ⟹   NP_068350
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396117,145,496 - 117,152,030 (+)NCBI
GRCm386117,168,535 - 117,175,069 (+)NCBI
MGSCv376117,118,553 - 117,131,386 (+)RGD
Celera6118,991,272 - 119,004,105 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001012495   ⟸   NM_001012477
- Peptide Label: isoform gamma precursor
- UniProtKB: H7BX38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_038683   ⟸   NM_013655
- Peptide Label: isoform beta precursor
- UniProtKB: Q4FJL5 (UniProtKB/Swiss-Prot),   Q543V6 (UniProtKB/Swiss-Prot),   P40224 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_068350   ⟸   NM_021704
- Peptide Label: isoform alpha precursor
- UniProtKB: P40224 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000072800   ⟸   ENSMUST00000073043
RefSeq Acc Id: ENSMUSP00000108487   ⟸   ENSMUST00000112866
RefSeq Acc Id: ENSMUSP00000108492   ⟸   ENSMUST00000112871
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P40224-F1-model_v2 AlphaFold P40224 1-93 view protein structure

Promoters
RGD ID:6839148
Promoter ID:MM_KWN:47311
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001012477,   NM_013655,   OTTMUST00000054665
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366117,118,571 - 117,119,071 (+)MPROMDB
RGD ID:6890774
Promoter ID:EPDNEW_M8838
Type:initiation region
Name:Cxcl12_1
Description:Mus musculus chemokine (C-X-C motif) ligand 12 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386117,168,574 - 117,168,634EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103556 AgrOrtholog
Ensembl Genes ENSMUSG00000061353 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073043 ENTREZGENE
  ENSMUST00000073043.5 UniProtKB/TrEMBL
  ENSMUST00000112866 ENTREZGENE
  ENSMUST00000112866.8 UniProtKB/Swiss-Prot
  ENSMUST00000112871 ENTREZGENE
  ENSMUST00000112871.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20315 UniProtKB/Swiss-Prot
MGD MGI:103556 ENTREZGENE
NCBI Gene 20315 ENTREZGENE
PANTHER SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROMAL CELL-DERIVED FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcl12 PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H7BX38 ENTREZGENE, UniProtKB/TrEMBL
  P40224 ENTREZGENE
  Q4FJL5 ENTREZGENE
  Q543V6 ENTREZGENE
  SDF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q4FJL5 UniProtKB/Swiss-Prot
  Q543V6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Cxcl12  C-X-C motif chemokine ligand 12  Cxcl12  chemokine (C-X-C motif) ligand 12  Symbol and/or name change 5135510 APPROVED