RGD Reference Report - [The expression and significance of SDF-1/CXCR4 biological axis in laryngeal squamous cell carcinoma and lymph node metastasize]. - Rat Genome Database

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[The expression and significance of SDF-1/CXCR4 biological axis in laryngeal squamous cell carcinoma and lymph node metastasize].

Authors: Zhang, Lan  Xiong, Chen  Wu, Yanzhao  Shi, Huijing  Jing, Shanghua  Song, Junjian  Zhao, Zhen  Shan, Baoen 
Citation: Zhang L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Sep;26(18):798-801.
RGD ID: 152177474
Pubmed: PMID:23259294   (View Abstract at PubMed)


OBJECTIVE: To study the correlation between the stromal cell-derived factor (SDF-1) and the receptor fusin (CXCR4) in carcinoma of larynx, and investigate some mechanisms of SDF-1/CXCR4 during the development, invasion and lymph node metastasis of laryngocarcinoma.
METHOD: Detecting the expression of SDF-1 and CXCR4 by immunohistochemical method (SP) in laryngocarcinoma, paraneoplastic tissues, normal laryngeal mucosa and cervical lymph node. Using Kruskal-Wallis H test, chi2 test, Spearman rank correlation analysis and so on to do statistical analysis.
RESULT: The positive expression rate of SDF-1 and CXCR4 in laryngocarcinoma was obviously higher than in paraneoplastic tissues and normal laryngeal mucosa tissues (P < 0.01). And the expression of two proteins was correlated with lymph node metastasis (P < 0.01), clinical stage (P < 0.01) and pathological grading of tumor (P < 0.05). The positive expression rate of SDF-1 and CXCR4 protein in metastasis lymph node tissue was higher than that in non metastasis lymph node tissue (P < 0.01). The expression of SDF-1 is correlated positively with the expression of CXCR4 in laryngocarcinoma.
CONCLUSION: SDF-1 and CXCR4 protein are highly expressed in laryngocarcinoma and in metastasis lymph node tissue. And they are correlated with lymph node metastasis, clinical stage and pathological grading of the tumor. According to the results, the two proteins may relate to infiltration and metastasis of laryngeal squamous cell carcinoma and play a role of synergistic action in the development and invasion of carcinoma of larynx.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
larynx cancer exacerbatesIEP 152177474; 152177474protein:increased expression: mucosa of larynx (human)RGD 
larynx cancer exacerbatesISOCXCL12 (Homo sapiens)152177474; 152177474protein:increased expression: mucosa of larynx (human)RGD 
larynx cancer exacerbatesISOCXCR4 (Homo sapiens)152177474; 152177474protein:increased expression: mucosa of larynx (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl12  (C-X-C motif chemokine ligand 12)
Cxcr4  (C-X-C motif chemokine receptor 4)

Genes (Mus musculus)
Cxcl12  (C-X-C motif chemokine ligand 12)
Cxcr4  (C-X-C motif chemokine receptor 4)

Genes (Homo sapiens)
CXCL12  (C-X-C motif chemokine ligand 12)
CXCR4  (C-X-C motif chemokine receptor 4)


Additional Information