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Gene: CXCL12 (C-X-C motif chemokine ligand 12) Homo sapiens
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Symbol: CXCL12
Name: C-X-C motif chemokine ligand 12
Description: Exhibits CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including integrin activation; negative regulation of apoptotic process; and regulation of leukocyte migration. Localizes to the collagen-containing extracellular matrix and extracellular exosome. Implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Biomarker of diabetic retinopathy; insulinoma; periodontitis; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chemokine (C-X-C motif) ligand 12; intercrine reduced in hepatomas; IRH; PBSF; pre-B cell growth-stimulating factor; SCYB12; SDF-1a; SDF-1b; SDF1; SDF1A; SDF1B; stromal cell-derived factor 1; TLSF; TLSF-a; TLSF-b; TPAR1
Orthologs:
Mus musculus (house mouse) : Cxcl12 (chemokine (C-X-C motif) ligand 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cxcl12 (C-X-C motif chemokine ligand 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cxcl12 (C-X-C motif chemokine ligand 12)
Pan paniscus (bonobo/pygmy chimpanzee) : CXCL12 (C-X-C motif chemokine ligand 12)
Canis lupus familiaris (dog) : CXCL12 (C-X-C motif chemokine ligand 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cxcl12 (C-X-C motif chemokine ligand 12)
Sus scrofa (pig) : CXCL12 (C-X-C motif chemokine ligand 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381044,292,088 - 44,385,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371044,865,601 - 44,880,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361044,185,611 - 44,200,548 (-)NCBINCBI36hg18NCBI36
Build 341044,192,516 - 44,200,551NCBI
Celera1040,869,153 - 40,884,099 (-)NCBI
Cytogenetic Map10q11.21NCBI
HuRef1041,391,945 - 41,406,899 (-)NCBIHuRef
CHM1_11044,904,782 - 44,919,728 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CXCL12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737223
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.