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Gene: Top2a (topoisomerase (DNA) II alpha) Mus musculus
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Symbol: Top2a
Name: topoisomerase (DNA) II alpha
Description: Exhibits DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in several processes, including DNA conformation change; embryonic cleavage; and female meiotic nuclear division. Localizes to the condensed chromosome and nucleolus. Predicted to colocalize with the centriole and nuclear chromosome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH 1,1-dichloroethene; 1,4-benzoquinone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, alpha isozyme; Top-2
Orthologs:
Homo sapiens (human) : TOP2A (DNA topoisomerase II alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Top2a (DNA topoisomerase II alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2a (DNA topoisomerase II alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2A (DNA topoisomerase II alpha)
Canis lupus familiaris (dog) : TOP2A (DNA topoisomerase II alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2a (DNA topoisomerase II alpha)
Sus scrofa (pig) : TOP2A (DNA topoisomerase II alpha)
more info ...
Related Pseudogenes: Gm5362  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIGRCm37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBImm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11 DNCBI
cM Map1162.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Top2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62340
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-09-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.