Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Top2a (topoisomerase (DNA) II alpha) Mus musculus
Symbol: Top2a
Name: topoisomerase (DNA) II alpha
RGD ID: 62340
Description: Exhibits DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in several processes, including DNA conformation change; embryonic cleavage; and female meiotic nuclear division. Localizes to chromosome, centromeric region; condensed chromosome; and nucleolus. Predicted to colocalize with centriole and nuclear chromosome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 1,4-benzoquinone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, alpha isozyme; Top; Top-2
Homo sapiens (human) : TOP2A (DNA topoisomerase II alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Top2a (DNA topoisomerase II alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2a (DNA topoisomerase II alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2A (DNA topoisomerase II alpha)
Canis lupus familiaris (dog) : TOP2A (DNA topoisomerase II alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2a (DNA topoisomerase II alpha)
Sus scrofa (pig) : TOP2A (DNA topoisomerase II alpha)
Chlorocebus sabaeus (African green monkey) : TOP2A (DNA topoisomerase II alpha)
more info ...
Related Pseudogenes: Gm5362  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391198,883,773 - 98,915,037 (-)NCBI
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIGRCm37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBImm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Top2a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62340
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.