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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62340
Species: Mus musculus
RGD Object: Gene
Symbol: Top2a
Name: topoisomerase (DNA) II alpha
Acc ID: CHEBI:31355
Term: carboplatin
Definition: A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID: MESH:D016190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2amultiple interactionsISORGD:13527296480464CTDTOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide]

PMID:11325482
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