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Gene: TOP2B (DNA topoisomerase II beta) Homo sapiens
Symbol: TOP2B
Name: DNA topoisomerase II beta
Description: Exhibits several functions, including enzyme binding activity; protein C-terminus binding activity; and protein heterodimerization activity. Involved in DNA topological change and positive regulation of single stranded viral RNA replication via double stranded DNA intermediate. Localizes to the cytosol; nucleoplasm; and viral integration complex. Colocalizes with the heterochromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen MLAA-44; DNA topoisomerase 2-beta; DNA topoisomerase II, 180 kD; DNA topoisomerase II, beta isozyme; top2beta; TOPIIB; topo II beta; topoisomerase (DNA) II beta; topoisomerase (DNA) II beta 180kDa; topoisomerase II beta; topoisomerase IIb; U937 associated antigen
Mus musculus (house mouse) : Top2b (topoisomerase (DNA) II beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Top2b (DNA topoisomerase II beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2b (DNA topoisomerase II beta)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2B (DNA topoisomerase II beta)
Canis lupus familiaris (dog) : TOP2B (DNA topoisomerase II beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2b (DNA topoisomerase II beta)
Sus scrofa (pig) : TOP2B (DNA topoisomerase II beta)
Chlorocebus sabaeus (African green monkey) : TOP2B (DNA topoisomerase II beta)
Heterocephalus glaber (naked mole-rat) : Top2b (DNA topoisomerase II beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl325,597,905 - 25,664,907 (-)EnsemblGRCh38hg38GRCh38
GRCh38325,597,905 - 25,664,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37325,639,396 - 25,706,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36325,614,479 - 25,680,792 (-)NCBINCBI36hg18NCBI36
Build 34325,614,478 - 25,680,792NCBI
Celera325,576,353 - 25,642,666 (-)NCBI
Cytogenetic Map3p24.2NCBI
HuRef325,584,872 - 25,651,422 (-)NCBIHuRef
CHM1_1325,589,386 - 25,655,854 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Cell Lines
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TOP2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350637
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.